{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:24:54Z","timestamp":1791984294621,"version":"4.4.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD064743"],"award-info":[{"award-number":["R01HD064743"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P30HD03352"],"award-info":[{"award-number":["P30HD03352"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA158283"],"award-info":[{"award-number":["R01CA158283"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD066560"],"award-info":[{"award-number":["R21HD066560"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006129","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T13:37:54Z","timestamp":1467121074000},"page":"e1006129","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome"],"prefix":"10.1371","volume":"12","author":[{"given":"Ronghui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiping","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinni","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-0667","authenticated-orcid":true,"given":"Cassandra","family":"Chiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-4424","authenticated-orcid":true,"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunduz","family":"Keles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1651-2227.1985.tb10993.x","article-title":"Rett&apos;s syndrome: prevalence and impact on progressive severe mental retardation in girls","volume":"74","author":"B Hagberg","year":"1985","journal-title":"Acta Paediatr Scand"},{"issue":"Suppl 1","key":"ref2","first-page":"5","article-title":"Rett syndrome: epidemiology and geographical variability","volume":"6","author":"B Hagberg","year":"1997","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"M Chahrour","year":"2007","journal-title":"Neuron"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"RE Amir","year":"1999","journal-title":"Nat Genet"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2010.01.030","article-title":"Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state","volume":"37","author":"PJ Skene","year":"2010","journal-title":"Mol Cell"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1083\/jcb.200502062","article-title":"Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation","volume":"169","author":"A Brero","year":"2005","journal-title":"The Journal of cell biology"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/iub.386","article-title":"Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin","volume":"62","author":"JC Hansen","year":"2010","journal-title":"IUBMB Life"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.cell.2012.11.022","article-title":"MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system","volume":"151","author":"M Mellen","year":"2012","journal-title":"Cell"},{"issue":"7554","key":"ref9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature14319","article-title":"Disruption of DNA-methylation-dependent long gene repression in Rett syndrome","volume":"522","author":"HW Gabel","year":"2015","journal-title":"Nature"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1074\/jbc.M209923200","article-title":"Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1","volume":"278","author":"H Kimura","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"36","key":"ref11","doi-asserted-by":"crossref","first-page":"34115","DOI":"10.1074\/jbc.M105747200","article-title":"The Ski protein family is required for MeCP2-mediated transcriptional repression","volume":"276","author":"K Kokura","year":"2001","journal-title":"The Journal of biological chemistry"},{"issue":"5599","key":"ref12","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1126\/science.1076469","article-title":"Corepressor-dependent silencing of chromosomal regions encoding neuronal genes","volume":"298","author":"VV Lunyak","year":"2002","journal-title":"Science"},{"issue":"5880","key":"ref13","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"M Chahrour","year":"2008","journal-title":"Science"},{"issue":"16","key":"ref14","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1093\/hmg\/ddq214","article-title":"The MeCP2\/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis","volume":"19","author":"G Forlani","year":"2010","journal-title":"Human molecular genetics"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nn.3434","article-title":"Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR\/SMRT co-repressor","volume":"16","author":"MJ Lyst","year":"2013","journal-title":"Nature neuroscience"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1097-2765(03)00276-4","article-title":"A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos","volume":"12","author":"I Stancheva","year":"2003","journal-title":"Molecular cell"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"PL Jones","year":"1998","journal-title":"Nat Genet"},{"issue":"6683","key":"ref18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"X Nan","year":"1998","journal-title":"Nature"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1074\/jbc.M210256200","article-title":"The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation","volume":"278","author":"F Fuks","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1073\/pnas.0608056104","article-title":"Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation","volume":"104","author":"X Nan","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"16","key":"ref21","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1093\/nar\/gkm599","article-title":"MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation","volume":"35","author":"N Agarwal","year":"2007","journal-title":"Nucleic acids research"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.devcel.2009.12.017","article-title":"ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain","volume":"18","author":"KD Kernohan","year":"2010","journal-title":"Dev Cell"},{"key":"ref23","article-title":"Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2","author":"JI Young","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/BSR20100124","article-title":"A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing","volume":"31","author":"SW Long","year":"2011","journal-title":"Biosci Rep"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.devcel.2014.01.032","article-title":"MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8\/Drosha Complex","volume":"28","author":"TL Cheng","year":"2014","journal-title":"Dev Cell"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuron.2006.09.017","article-title":"Splicing regulation in neurologic disease","volume":"52","author":"DD Licatalosi","year":"2006","journal-title":"Neuron"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.96.10.5598","article-title":"Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements","volume":"96","author":"I D'Souza","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2008.03.031","article-title":"SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing","volume":"133","author":"Z Zhang","year":"2008","journal-title":"Cell"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nn.2866","article-title":"Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory","volume":"14","author":"H Li","year":"2011","journal-title":"Nature neuroscience"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/ng0906-962","article-title":"Testing for association between MeCP2 and the brahma-associated SWI\/SNF chromatin-remodeling complex","volume":"38","author":"K Hu","year":"2006","journal-title":"Nat Genet"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/ng1516","article-title":"Brahma links the SWI\/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing","volume":"37","author":"KN Harikrishnan","year":"2005","journal-title":"Nature genetics"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1158\/1541-7786.MCR-11-0314","article-title":"The stress oncoprotein LEDGF\/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity","volume":"10","author":"LS Leoh","year":"2012","journal-title":"Mol Cancer Res"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.4161\/rna.26921","article-title":"Chromatin context and ncRNA highlight targets of MeCP2 in brain","volume":"10","author":"SS Maxwell","year":"2013","journal-title":"RNA Biol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"MD Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"17","key":"ref35","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1073\/pnas.1505909112","article-title":"MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome","volume":"112","author":"L Chen","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nmeth.1528","article-title":"Analysis and design of RNA sequencing experiments for identifying isoform regulation","volume":"7","author":"Y Katz","year":"2010","journal-title":"Nature methods"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1038\/ncomms4078","article-title":"The splicing activator DAZAP1 integrates splicing control into MEK\/Erk-regulated cell proliferation and migration","volume":"5","author":"R Choudhury","year":"2014","journal-title":"Nature communications"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccr.2014.07.010","article-title":"The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression","volume":"26","author":"Y Wang","year":"2014","journal-title":"Cancer Cell"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.molcel.2015.09.005","article-title":"SRSF1-Regulated Alternative Splicing in Breast Cancer","volume":"60","author":"O Anczukow","year":"2015","journal-title":"Mol Cell"},{"issue":"12","key":"ref40","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1186\/s13059-014-0551-7","article-title":"Transcriptome-wide modulation of splicing by the exon junction complex","volume":"15","author":"Z Wang","year":"2014","journal-title":"Genome Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/1471-2164-15-284","article-title":"ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases","volume":"15","author":"L Shen","year":"2014","journal-title":"BMC Genomics"},{"issue":"6146","key":"ref42","doi-asserted-by":"crossref","first-page":"1237905","DOI":"10.1126\/science.1237905","article-title":"Global epigenomic reconfiguration during mammalian brain development","volume":"341","author":"R Lister","year":"2013","journal-title":"Science"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2005.07.021","article-title":"DNA binding selectivity of MeCP2 due to a requirement for A\/T sequences adjacent to methyl-CpG","volume":"19","author":"RJ Klose","year":"2005","journal-title":"Mol Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1038\/ncomms11025","article-title":"Sequence features accurately predict genome-wide MeCP2 binding in vivo","volume":"7","author":"HT Rube","year":"2016","journal-title":"Nat Commun"},{"issue":"6915","key":"ref45","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","article-title":"Initial sequencing and comparative analysis of the mouse genome","volume":"420","author":"RH Waterston","year":"2002","journal-title":"Nature"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0896-6273(91)90176-Z","article-title":"Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing","volume":"6","author":"H Monyer","year":"1991","journal-title":"Neuron"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cell.2010.11.056","article-title":"Epigenetics in alternative pre-mRNA splicing","volume":"144","author":"RF Luco","year":"2011","journal-title":"Cell"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/cr.2013.110","article-title":"Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition","volume":"23","author":"AK Maunakea","year":"2013","journal-title":"Cell Res"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"e1002717","DOI":"10.1371\/journal.pgen.1002717","article-title":"Psip1\/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing","volume":"8","author":"MM Pradeepa","year":"2012","journal-title":"PLoS Genet"},{"issue":"4976","key":"ref50","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1126\/science.1699275","article-title":"Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS","volume":"249","author":"B Sommer","year":"1990","journal-title":"Science"},{"issue":"5187","key":"ref51","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.7973663","article-title":"A molecular determinant for submillisecond desensitization in glutamate receptors","volume":"266","author":"J Mosbacher","year":"1994","journal-title":"Science"},{"issue":"21","key":"ref52","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1523\/JNEUROSCI.16-21-06634.1996","article-title":"AMPA receptor flip\/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate","volume":"16","author":"KM Partin","year":"1996","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"11","key":"ref53","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nmeth.1379","article-title":"Engineering splicing factors with designed specificities","volume":"6","author":"Y Wang","year":"2009","journal-title":"Nature methods"},{"issue":"16","key":"ref54","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1111\/febs.12367","article-title":"Engineered proteins with Pumilio\/fem-3 mRNA binding factor scaffold to manipulate RNA metabolism","volume":"280","author":"Y Wang","year":"2013","journal-title":"Febs J"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrm3742","article-title":"A day in the life of the spliceosome","volume":"15","author":"AG Matera","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0092-8674(00)81632-3","article-title":"A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing","volume":"95","author":"L Pellizzoni","year":"1998","journal-title":"Cell"},{"issue":"11","key":"ref57","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/nn.3230","article-title":"Divergent roles of ALS-linked proteins FUS\/TLS and TDP-43 intersect in processing long pre-mRNAs","volume":"15","author":"C Lagier-Tourenne","year":"2012","journal-title":"Nature neuroscience"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nsmb.1720","article-title":"Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy","volume":"17","author":"H Du","year":"2010","journal-title":"Nat Struct Mol Biol"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"RZ Chen","year":"2001","journal-title":"Nat Genet"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1743-422X-7-68","article-title":"Characterization of the HIV-1 integrase chromatin- and LEDGF\/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase","volume":"7","author":"Y Zheng","year":"2010","journal-title":"Virol J"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/stem.1950","article-title":"Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons","volume":"33","author":"Y Gao","year":"2015","journal-title":"Stem Cells"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2202-9-42","article-title":"Isolation of neuronal chromatin from brain tissue","volume":"9","author":"Y Jiang","year":"2008","journal-title":"BMC Neurosci"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nature protocols"},{"issue":"9","key":"ref64","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1101\/gr.136184.111","article-title":"ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia","volume":"22","author":"SG Landt","year":"2012","journal-title":"Genome Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e02626","DOI":"10.7554\/eLife.02626","article-title":"Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways","volume":"3","author":"B Ballester","year":"2014","journal-title":"Elife"},{"issue":"495","key":"ref66","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1198\/jasa.2011.ap09706","article-title":"A Statistical Framework for the Analysis of ChIP-Seq Data","volume":"106","author":"PF Kuan","year":"2011","journal-title":"J Am Stat Assoc"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1093\/nar\/gkp1012","article-title":"Sole-Search: an integrated analysis program for peak detection and functional annotation using ChIP-seq data","volume":"38","author":"KR Blahnik","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"ref68","doi-asserted-by":"crossref","first-page":"e25255","DOI":"10.1371\/journal.pone.0025255","article-title":"Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model","volume":"6","author":"G Ananiev","year":"2011","journal-title":"PLoS ONE"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T05:19:59Z","timestamp":1568092799000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006129"}},"subtitle":[],"editor":[{"given":"Tom","family":"Misteli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,28]]},"references-count":68,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006129","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,28]]}}}