{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:15:20Z","timestamp":1792548920945,"version":"4.5.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research (US)","doi-asserted-by":"publisher","award":["F31 DE023017"],"award-info":[{"award-number":["F31 DE023017"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003575","name":"American Association of Anatomists","doi-asserted-by":"publisher","award":["Scholar Post-doctoral Fellowship"],"award-info":[{"award-number":["Scholar Post-doctoral Fellowship"]}],"id":[{"id":"10.13039\/100003575","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32 HD060549"],"award-info":[{"award-number":["T32 HD060549"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research (US)","doi-asserted-by":"publisher","award":["DE025222"],"award-info":[{"award-number":["DE025222"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes","doi-asserted-by":"crossref","award":["#6-FY15-233"],"award-info":[{"award-number":["#6-FY15-233"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research (US)","doi-asserted-by":"publisher","award":["DE016082"],"award-info":[{"award-number":["DE016082"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006187","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T13:29:56Z","timestamp":1469194196000},"page":"e1006187","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":113,"title":["The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3933-6946","authenticated-orcid":true,"given":"Kristin E.","family":"Noack Watt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annita","family":"Achilleos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Neben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Merrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Trainor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/35080045","article-title":"The function and synthesis of ribosomes","volume":"2","author":"DLJ Lafontaine","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1101\/gad.386106","article-title":"The transcriptional activity of RNA polymerase I is a key determinant for the level of all ribosome components","volume":"20","author":"A Lafert\u00e9","year":"2006","journal-title":"Genes & Development"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1101\/gad.1228804","article-title":"A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size","volume":"18","author":"P Jorgensen","year":"2004","journal-title":"Genes & Development"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bbadis.2013.11.010","article-title":"Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders","volume":"1842","author":"PA Trainor","year":"2014","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular Basis of Disease"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1025185","DOI":"10.1080\/21675511.2015.1025185","article-title":"Ribosomopathies: Global process, tissue specific defects","volume":"3","author":"PC Yelick","year":"2015","journal-title":"Rare Diseases"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/ajmg.a.30010","article-title":"Identification of mutations in TCOF1: Use of molecular analysis in the pre- and postnatal diagnosis of Treacher Collins syndrome","volume":"127A","author":"J Dixon","year":"2004","journal-title":"American Journal of Medical Genetics Part A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ejhg.2008.221","article-title":"Treacher Collins syndrome: etiology, pathogenesis and prevention","volume":"17","author":"PA Trainor","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1073\/pnas.94.7.3110","article-title":"TCOF1 gene encodes a putative nucleolar phosphoprotein that exhibits mutations in Treacher Collins Syndrome throughout its coding region","volume":"94","author":"CA Wise","year":"1997","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/hmg\/ddi208","article-title":"The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation","volume":"14","author":"B Gonzales","year":"2005","journal-title":"Human Molecular Genetics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1073\/pnas.0402492101","article-title":"The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor","volume":"101","author":"BC Valdez","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"13403","DOI":"10.1073\/pnas.0603730103","article-title":"Tcof1\/Treacle Is Required for Neural Crest Cell Formation and Proliferation Deficiencies That Cause Craniofacial Abnormalities","volume":"103","author":"J Dixon","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nm1725","article-title":"Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function","volume":"14","author":"NC Jones","year":"2008","journal-title":"Nat Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ng.724","article-title":"Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome","volume":"43","author":"JG Dauwerse","year":"2011","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/gim.2014.12","article-title":"Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome","volume":"16","author":"E Schaefer","year":"2014","journal-title":"Genet Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"12792","DOI":"10.1073\/pnas.0403929101","article-title":"Identification of 315 genes essential for early zebrafish development","volume":"101","author":"A Amsterdam","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1242\/dev.120.3.483","article-title":"Segment and cell type lineage restrictions during pharyngeal arch development in the zebrafish embryo","volume":"120","author":"TF Schilling","year":"1994","journal-title":"Development"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1469-7580.2005.00473.x","article-title":"Relations and interactions between cranial mesoderm and neural crest populations","volume":"207","author":"DM Noden","year":"2005","journal-title":"Journal of Anatomy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1242\/dev.128.21.4113","article-title":"Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates","volume":"128","author":"KA Dutton","year":"2001","journal-title":"Development"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0925-4773(00)00250-1","article-title":"Expression of zebrafish fkd6 in neural crest-derived glia","volume":"93","author":"RN Kelsh","year":"2000","journal-title":"Mechanisms of Development"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1523\/JNEUROSCI.14-06-03475.1994","article-title":"Combinatorial expression of three zebrafish genes related to distal- less: part of a homeobox gene code for the head","volume":"14","author":"M Akimenko","year":"1994","journal-title":"The Journal of Neuroscience"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1242\/dev.00704","article-title":"The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans","volume":"130","author":"T Piotrowski","year":"2003","journal-title":"Development"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0896-6273(90)90194-K","article-title":"Organization of hindbrain segments in the zebrafish embryo","volume":"4","author":"B Trevarrow","year":"1990","journal-title":"Neuron"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1242\/dev.126.4.827","article-title":"Origin and development of the zebrafish endoderm","volume":"126","author":"RM Warga","year":"1999","journal-title":"Development"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1093\/emboj\/cdg579","article-title":"Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses","volume":"22","author":"CP Rubbi","year":"2003","journal-title":"EMBO J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"13309","DOI":"10.1074\/jbc.M601892200","article-title":"Perturbation of rRNA Synthesis in the bap28 Mutation Leads to Apoptosis Mediated by p53 in the Zebrafish Central Nervous System","volume":"281","author":"M Azuma","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/dvdy.20827","article-title":"Mapping ribosomal RNA transcription activity in the mouse eye","volume":"235","author":"J Qian","year":"2006","journal-title":"Dev Dyn"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1073\/pnas.0406252102","article-title":"tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors","volume":"102","author":"S Berghmans","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref28","article-title":"Syndromes of the Head and Neck","author":"RJ Gorlin","year":"1990"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1002\/ajmg.a.33454","article-title":"Craniofacial birth defects: The role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention","volume":"152A","author":"PA Trainor","year":"2010","journal-title":"American Journal of Medical Genetics Part A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ajmg.c.31375","article-title":"Facial dysostoses: Etiology, pathogenesis and management","volume":"163","author":"PA Trainor","year":"2013","journal-title":"American Journal of Medical Genetics Part C: Seminars in Medical Genetics"},{"key":"ref31","first-page":"90","article-title":"Case with symmetrical congenital notches in the outer part of each lower lid and defective development of the malar bones","volume":"20","author":"E Treacher Collins","year":"1900","journal-title":"Trans Opthalmol Soc UK"},{"key":"ref32","first-page":"143","article-title":"The mandibulofacial dysostosis; a new hereditary syndrome","volume":"27","author":"A Franceschetti","year":"1949","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0007-117X(75)90019-0","article-title":"The pathogenesis of the Treacher Collins syndrome (mandibulofacial dysostosis)","volume":"13","author":"D Poswillo","year":"1975","journal-title":"Br J Oral Surg"},{"key":"ref34","article-title":"A quantitative method for defining high-arched palate using the Tcof1 mutant mouse as a model","author":"ZR Conley","year":"2016","journal-title":"Dev Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ejhg.2008.221","article-title":"Treacher Collins syndrome: etiology, pathogenesis and prevention","volume":"17","author":"PA Trainor","year":"2009","journal-title":"European Journal Of Human Genetics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"13403","DOI":"10.1073\/pnas.0603730103","article-title":"Tcof1\/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities","volume":"103","author":"J Dixon","year":"2006","journal-title":"Proceedings Of The National Academy Of Sciences Of The United States Of America"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nm1725","article-title":"Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function","volume":"14","author":"NC Jones","year":"2008","journal-title":"Nature Medicine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1073\/pnas.0402492101","article-title":"The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor","volume":"101","author":"BC Valdez","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1093\/emboj\/cdg579","article-title":"Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses","volume":"22","author":"CP Rubbi","year":"2003","journal-title":"Embo Journal"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ng.724","article-title":"Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome","volume":"43","author":"JG Dauwerse","year":"2011","journal-title":"Nat Genet"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8623","article-title":"Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III","volume":"6","author":"I Thiffault","year":"2015","journal-title":"Nat Commun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ng0296-130","article-title":"Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome","volume":"12","year":"1996","journal-title":"Nat Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/gim.2014.12","article-title":"Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome","volume":"16","author":"E Schaefer","year":"2014","journal-title":"Genet Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ajhg.2015.03.011","article-title":"Acrofacial Dysostosis, Cincinnati Type, a Mandibulofacial Dysostosis Syndrome with Limb Anomalies, Is Caused by POLR1A Dysfunction","volume":"96","author":"KN Weaver","year":"2015","journal-title":"The American Journal of Human Genetics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nature12712","article-title":"RNA polymerase I structure and transcription regulation","volume":"502","author":"C Engel","year":"2013","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature12636","article-title":"Crystal structure of the 14-subunit RNA polymerase I","volume":"502","author":"C Fernandez-Tornero","year":"2013","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1128\/MCB.14.11.7414","article-title":"The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes","volume":"14","author":"V Marechal","year":"1994","journal-title":"Molecular and Cellular Biology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1182\/blood-2008-01-132290","article-title":"Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family","volume":"112","author":"N Danilova","year":"2008","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e4152","DOI":"10.1371\/journal.pone.0004152","article-title":"Loss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response","volume":"4","author":"A Chakraborty","year":"2009","journal-title":"PLoS ONE"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nm.2063","article-title":"A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome","volume":"16","author":"JL Barlow","year":"2010","journal-title":"Nat Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.exphem.2011.11.007","article-title":"Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation","volume":"40","author":"AM Taylor","year":"2012","journal-title":"Experimental Hematology"},{"key":"ref52","article-title":"Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate","author":"F Scala","year":"2015","journal-title":"Oncogene"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1182\/blood-2009-10-178129","article-title":"Ribosomopathies: human disorders of ribosome dysfunction","volume":"115","author":"A Narla","year":"2010","journal-title":"Blood"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ajhg.2008.11.004","article-title":"Ribosomal Protein L5 and L11 Mutations Are Associated with Cleft Palate and Abnormal Thumbs in Diamond-Blackfan Anemia Patients","volume":"83","author":"HT Gazda","year":"2008","journal-title":"American journal of human genetics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2141.2010.08396.x","article-title":"Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects","volume":"152","author":"N Danilova","year":"2011","journal-title":"British Journal of Haematology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1182\/blood-2011-08-371963","article-title":"Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia","volume":"118","author":"P Jaako","year":"2011","journal-title":"Blood"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2011.03.028","article-title":"Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning","volume":"145","author":"N Kondrashov","year":"2011","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1093\/hmg\/ddu282","article-title":"Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription","volume":"23","author":"CL Neben","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nature05473","article-title":"Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2","volume":"445","author":"DW Young","year":"2007","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrg3001","article-title":"Transcription by RNA polymerase III: more complex than we thought","volume":"12","author":"RJ White","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"10328","DOI":"10.1038\/ncomms10328","article-title":"Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation","volume":"7","author":"D Sakai","year":"2016","journal-title":"Nat Commun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e1002566","DOI":"10.1371\/journal.pgen.1002566","article-title":"Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells","volume":"8","author":"D Sakai","year":"2012","journal-title":"PLoS Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"CB Kimmel","year":"1995","journal-title":"Developmental Dynamics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/10520290701333558","article-title":"A two-color acid-free cartilage and bone stain for zebrafish larvae","volume":"82","author":"M Walker","year":"2007","journal-title":"Biotechnic & Histochemistry"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1371\/journal.pbio.0020244","article-title":"An Integrin-Dependent Role of Pouch Endoderm in Hyoid Cartilage Development","volume":"2","author":"JG Crump","year":"2004","journal-title":"PLoS Biol"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T13:50:26Z","timestamp":1656856226000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006187"}},"subtitle":[],"editor":[{"given":"Jeffrey M.","family":"Lipton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":65,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006187","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,22]]}}}