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Genet"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fgene.2015.00025","article-title":"Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges","volume":"6","author":"S Tual-Chalot","year":"2015","journal-title":"Front Genet"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0896-6273(01)00215-X","article-title":"nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures","volume":"29","author":"YD Chung","year":"2001","journal-title":"Neuron"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1534\/genetics.113.156323","article-title":"The extracellular matrix protein artichoke is required for integrity of ciliated mechanosensory and chemosensory organs in Drosophila embryos","volume":"196","author":"M Andres","year":"2014","journal-title":"Genetics"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ydbio.2006.04.462","article-title":"Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis","volume":"296","author":"C Krause","year":"2006","journal-title":"Developmental Biology"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1534\/genetics.108.099531","article-title":"Drosophila convoluted\/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization","volume":"181","author":"LE Swanson","year":"2009","journal-title":"Genetics"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1681\/ASN.2006080882","article-title":"Dual action of neutrophil gelatinase-associated lipocalin","volume":"18","author":"KM Schmidt-Ott","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1093\/hmg\/ddq205","article-title":"A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure","volume":"19","author":"I Bernascone","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of <italic>Caenorhabditis elegans<\/italic>","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref88","first-page":"1","article-title":"Genetic balancers","author":"ML Edgley","year":"2006","journal-title":"Wormbook"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/ncb1101-983","article-title":"Cooperative regulation of AJM-1 controls junctional integrity in <italic>Caenorhabditis elegans<\/italic> epithelia","volume":"3","author":"M Koppen","year":"2001","journal-title":"Nature Cell Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1371\/journal.pbio.0050237","article-title":"High-throughput in vivo analysis of gene expression in Caenorhabditis elegans","volume":"5","author":"R Hunt-Newbury","year":"2007","journal-title":"PLoS Biol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1534\/genetics.112.144204","article-title":"CloudMap: a cloud-based pipeline for analysis of mutant genome sequences","volume":"192","author":"G Minevich","year":"2012","journal-title":"Genetics"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1242\/dev.128.15.2857","article-title":"EGL-38 Pax regulates the ovo-related gene <italic>lin-48<\/italic> during <italic>Caenorhabditis elegans<\/italic> organ development","volume":"128","author":"AD Johnson","year":"2001","journal-title":"Development"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1128\/MCB.17.4.2301","article-title":"cis regulatory requirements for hypodermal cell-specific expression of the <italic>Caenorhabditis elegans<\/italic> cuticle collagen gene <italic>dpy-7<\/italic>","volume":"17","author":"JS Gilleard","year":"1997","journal-title":"Molecular & Cellular Biology"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"34412","DOI":"10.1074\/jbc.M704134200","article-title":"<italic>Caenorhabditis elegans<\/italic> glutamate transporters influence synaptic function and behavior at sites distant from the synapse","volume":"282","author":"I Mano","year":"2007","journal-title":"J Biol Chem"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/genetics\/135.2.385","article-title":"Sequence requirements for myosin gene expression and regulation in <italic>Caenorhabditis elegans<\/italic>","volume":"135","author":"PG Okkema","year":"1993","journal-title":"Genetics"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2012.08.001","article-title":"A genome-scale resource for in vivo tag-based protein function exploration in <italic>C<\/italic>. <italic>elegans<\/italic>","volume":"150","author":"M Sarov","year":"2012","journal-title":"Cell"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0091-679X(08)61397-7","article-title":"Electron microscopy and three-dimensional image reconstruction","volume":"48","author":"DH Hall","year":"1995","journal-title":"Methods Cell Biol"},{"key":"ref98","first-page":"203","article-title":"Preservation of C. elegans tissue via high-pressure freezing and freeze-substitution for ultrastructural analysis and immunocytochemistry","volume":"351","author":"RM Weimer","year":"2006","journal-title":"Methods in Molecular Biology"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","author":"C Steentoft","year":"2013","journal-title":"EMBO J"},{"issue":"Pt 3","key":"ref100","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj3270625","article-title":"Furin: a mammalian subtilisin\/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins","volume":"327","author":"K Nakayama","year":"1997","journal-title":"Biochem J"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ydbio.2006.08.037","article-title":"Chondroitin acts in the guidance of gonadal distal tip cells in <italic>C<\/italic>. <italic>elegans<\/italic>","volume":"300","author":"N Suzuki","year":"2006","journal-title":"Dev 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