{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T04:52:11Z","timestamp":1785646331156,"version":"3.56.0"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Belgian Science Policy (Belspo Interuniversity Attraction Poles)","award":["IAP VII-07"],"award-info":[{"award-number":["IAP VII-07"]}]},{"name":"Belgian Science Policy (Belspo Interuniversity Attraction Poles)","award":["IAP VII-07"],"award-info":[{"award-number":["IAP VII-07"]}]},{"name":"Belgian Science Policy (Belspo Interuniversity Attraction Poles)","award":["IAP VII-07"],"award-info":[{"award-number":["IAP VII-07"]}]},{"name":"Queen Elisabeth Medical Foundation, Belgium","award":["GSKE 2008-2010"],"award-info":[{"award-number":["GSKE 2008-2010"]}]},{"name":"Ghent University, Belgium","award":["Concerted Research Actions (GOA 01G01908)"],"award-info":[{"award-number":["Concerted Research Actions (GOA 01G01908)"]}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006243","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T17:51:37Z","timestamp":1472061097000},"page":"e1006243","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-0104","authenticated-orcid":true,"given":"Tim","family":"Pieters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-8570","authenticated-orcid":true,"given":"Steven","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Haenebalcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-7098","authenticated-orcid":true,"given":"Vanessa","family":"Andries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Stryjewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riet","family":"De Rycke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Lemeire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-2054","authenticated-orcid":true,"given":"Tino","family":"Hochepied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Huylebroeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-2458","authenticated-orcid":true,"given":"Geert","family":"Berx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"Stemmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody J.","family":"Haigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda","family":"van Hengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"van Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.cell.2010.10.008","article-title":"Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues","volume":"143","author":"JH Hanna","year":"2010","journal-title":"Cell"},{"issue":"7194","key":"ref2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature06968","article-title":"The ground state of embryonic stem cell self-renewal","volume":"453","author":"QL Ying","year":"2008","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1242\/jcs.146720","article-title":"Role of cell-cell adhesion complexes in embryonic stem cell biology","volume":"127","author":"T Pieters","year":"2014","journal-title":"J Cell Sci"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1002\/stem.134","article-title":"Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal","volume":"27","author":"F Soncin","year":"2009","journal-title":"Stem Cells"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1073\/pnas.91.17.8263","article-title":"E-cadherin null mutant embryos fail to form a trophectoderm epithelium","volume":"91","author":"L Larue","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"issue":"20","key":"ref6","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1242\/dev.050195","article-title":"Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin","volume":"137","author":"RO Stephenson","year":"2010","journal-title":"Development"},{"key":"ref7","first-page":"27","article-title":"The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium","volume":"87","author":"TC Doetschman","year":"1985","journal-title":"J Embryol Exp Morphol"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cell.2008.02.008","article-title":"Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development","volume":"132","author":"CE Murry","year":"2008","journal-title":"Cell"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/nrm3190","article-title":"Discovering pluripotency: 30 years of mouse embryonic stem cells","volume":"12","author":"M Evans","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ncb2260","article-title":"Differential requirement for the dual functions of beta-catenin in embryonic stem cell self-renewal and germ layer formation","volume":"13","author":"N Lyashenko","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1634\/stemcells.2004-0262","article-title":"In vitro differentiation of mouse embryonic stem cells: enrichment of endodermal cells in the embryoid body","volume":"23","author":"D Choi","year":"2005","journal-title":"Stem Cells"},{"issue":"23","key":"ref12","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"F van Roy","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/ncb2314","article-title":"Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells","volume":"13","author":"D ten Berge","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ncb2267","article-title":"Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation","volume":"13","author":"J Wray","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/ncb3264","article-title":"The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition","volume":"17","author":"H Sperber","year":"2015","journal-title":"Nat Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.2741\/4012","article-title":"Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling","volume":"17","author":"T Pieters","year":"2012","journal-title":"Front Biosci"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1083\/jcb.200307111","article-title":"A core function for p120-catenin in cadherin turnover","volume":"163","author":"MA Davis","year":"2003","journal-title":"J Cell Biol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbamcr.2006.08.040","article-title":"p120-ctn: A nexus for contextual signaling via Rho GTPases","volume":"1773","author":"PZ Anastasiadis","year":"2007","journal-title":"Biochim Biophys Acta\u2014Mol Cell Res"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/35023588","article-title":"Inhibition of RhoA by p120 catenin","volume":"2","author":"PZ Anastasiadis","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"26","key":"ref20","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1074\/jbc.M801192200","article-title":"A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease","volume":"283","author":"M Yanagisawa","year":"2008","journal-title":"J Biol Chem"},{"issue":"13","key":"ref21","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1242\/jcs.01101","article-title":"NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression","volume":"117","author":"KF Kelly","year":"2004","journal-title":"J Cell Sci"},{"issue":"Pt 18","key":"ref22","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1242\/jcs.151944","article-title":"p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation","volume":"127","author":"M Lee","year":"2014","journal-title":"J Cell Sci"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbamcr.2006.08.052","article-title":"Dancing in and out of the nucleus: p120(Ctn) and the transcription factor Kaiso","volume":"1773","author":"JM Daniel","year":"2007","journal-title":"Biochim Biophys Acta\u2014Mol Cell Res"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/geno.1998.5325","article-title":"Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms","volume":"50","author":"A Keirsebilck","year":"1998","journal-title":"Genomics"},{"issue":"48","key":"ref25","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1038\/sj.onc.1208161","article-title":"Emerging roles for p120-catenin in cell adhesion and cancer","volume":"23","author":"AB Reynolds","year":"2004","journal-title":"Oncogene"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"760","DOI":"10.2741\/3956","article-title":"Functions of p120ctn in development and disease","volume":"17","author":"T Pieters","year":"2012","journal-title":"Front Biosci"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbamcr.2015.10.008","article-title":"Phosphorylation and isoform use in p120-catenin during development and tumorigenesis","volume":"1863","author":"JY Hong","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s12015-011-9323-x","article-title":"Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells","volume":"8","author":"T Pieters","year":"2012","journal-title":"Stem Cell Rev Rep"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1242\/dev.122.10.3185","article-title":"A role for cadherins in tissue formation","volume":"122","author":"L Larue","year":"1996","journal-title":"Development"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"e12921","DOI":"10.1371\/journal.pone.0012921","article-title":"Abrogation of E-cadherin-mediated cellular aggregation allows proliferation of pluripotent mouse embryonic stem cells in shake flask bioreactors","volume":"5","author":"L Mohamet","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1083\/jcb.200306001","article-title":"Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells","volume":"163","author":"KY Xiao","year":"2003","journal-title":"J Cell Biol"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.200205115","article-title":"A novel role for p120 catenin in E-cadherin function","volume":"159","author":"RC Ireton","year":"2002","journal-title":"J Cell Biol"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.devcel.2005.12.004","article-title":"Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland","volume":"10","author":"MA Davis","year":"2006","journal-title":"Dev Cell"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2006.05.018","article-title":"p120 Catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins","volume":"51","author":"LP Elia","year":"2006","journal-title":"Neuron"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1073\/pnas.72.4.1441","article-title":"Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro","volume":"72","author":"GR Martin","year":"1975","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1673-8527(09)60064-3","article-title":"Embryoid bodies formation and differentiation from mouse embryonic stem cells in collagen\/Matrigel scaffolds","volume":"37","author":"J Zhou","year":"2010","journal-title":"J Genet Genomics"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s12015-013-9458-z","article-title":"Efficient ROSA26-based conditional and\/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells","volume":"9","author":"L Haenebalcke","year":"2013","journal-title":"Stem Cell Rev"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cell.2010.01.017","article-title":"Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion","volume":"141","author":"N Ishiyama","year":"2010","journal-title":"Cell"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.152.1.111","article-title":"Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding","volume":"152","author":"D Michaelson","year":"2001","journal-title":"J Cell Biol"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0092-8674(95)90169-8","article-title":"Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo","volume":"83","author":"E Coucouvanis","year":"1995","journal-title":"Cell"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.devcel.2006.02.020","article-title":"Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway","volume":"10","author":"C Chazaud","year":"2006","journal-title":"Dev Cell"},{"issue":"18","key":"ref42","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1242\/dev.021519","article-title":"Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst","volume":"135","author":"B Plusa","year":"2008","journal-title":"Development"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/dvg.20298","article-title":"Cell autonomous sorting and surface positioning in the formation of primitive endoderm in embryoid bodies","volume":"45","author":"ME Rula","year":"2007","journal-title":"Genesis"},{"issue":"13","key":"ref44","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1016\/j.biomaterials.2009.01.007","article-title":"Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules","volume":"30","author":"RL Carpenedo","year":"2009","journal-title":"Biomaterials"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1242\/bio.20146254","article-title":"Cell adhesion and sorting in embryoid bodies derived from N- or E-cadherin deficient murine embryonic stem cells","volume":"3","author":"R Moore","year":"2014","journal-title":"Biology open"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ydbio.2014.12.010","article-title":"p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas","volume":"399","author":"AM Hendley","year":"2015","journal-title":"Dev Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"31894","DOI":"10.1074\/jbc.272.50.31894","article-title":"Dephosphorylation of the cadherin-associated p100\/p120 proteins in response to activation of protein kinase C in epithelial cells","volume":"272","author":"MJ Ratcliffe","year":"1997","journal-title":"J Biol Chem"},{"issue":"9","key":"ref48","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ncb3227","article-title":"Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity","volume":"17","author":"A Kourtidis","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1083\/jcb.201009141","article-title":"Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling","volume":"192","author":"B Baum","year":"2011","journal-title":"J Cell Biol"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bbamem.2007.09.031","article-title":"Tight junction biogenesis during early development","volume":"1778","author":"JJ Eckert","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1242\/jcs.114.4.695","article-title":"p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion","volume":"114","author":"I Grosheva","year":"2001","journal-title":"J Cell Sci"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1083\/jcb.150.3.567","article-title":"p120 catenin regulates the actin cytoskeleton via Rho family GTPases","volume":"150","author":"NK Noren","year":"2000","journal-title":"J Cell Biol"},{"issue":"Pt 8","key":"ref53","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1242\/jcs.01115","article-title":"Cdc42\u2014the centre of polarity","volume":"117","author":"S Etienne-Manneville","year":"2004","journal-title":"J Cell Sci"},{"issue":"6","key":"ref54","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1083\/jcb.200807020","article-title":"Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis","volume":"183","author":"KP Harris","year":"2008","journal-title":"J Cell Biol"},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1093\/nar\/gkp112","article-title":"Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells","volume":"37","author":"O Nyabi","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"a002899","DOI":"10.1101\/cshperspect.a002899","article-title":"Adherens junction: molecular architecture and regulation","volume":"1","author":"W Meng","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200305137","article-title":"p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions","volume":"163","author":"X Chen","year":"2003","journal-title":"J Cell Biol"},{"issue":"10","key":"ref58","doi-asserted-by":"crossref","first-page":"9512","DOI":"10.1074\/jbc.M310895200","article-title":"A novel interaction between kinesin and p120 modulates p120 localization and function","volume":"279","author":"M Yanagisawa","year":"2004","journal-title":"J Biol Chem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.cell.2008.09.040","article-title":"Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts","volume":"135","author":"W Meng","year":"2008","journal-title":"Cell"},{"issue":"12","key":"ref60","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1128\/MCB.14.12.8333","article-title":"Identification of a new catenin: the tyrosine kinase substrate p120(cas) associates with E-cadherin complexes","volume":"14","author":"AB Reynolds","year":"1994","journal-title":"Mol Cell Biol"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1128\/MCB.19.5.3614","article-title":"The catenin p120(Ctn) interacts with Kaiso, a novel BTB\/POZ domain zinc finger transcription factor","volume":"19","author":"JM Daniel","year":"1999","journal-title":"Mol Cell Biol"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4161\/sgtp.18820","article-title":"Rho GTPases in endoderm development and differentiation","volume":"3","author":"DA Loebel","year":"2012","journal-title":"Small GTPases"},{"key":"ref63","article-title":"p120-catenin controls contractility along the vertical axis of epithelial lateral membranes","author":"HH Yu","year":"2015","journal-title":"J Cell Sci"},{"issue":"17","key":"ref64","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1016\/j.yexcr.2006.07.007","article-title":"p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation","volume":"312","author":"XB Xia","year":"2006","journal-title":"Exp Cell Res"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.scr.2013.08.009","article-title":"Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency","volume":"11","author":"I Bedzhov","year":"2013","journal-title":"Stem cell research"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ccr.2006.09.013","article-title":"Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis","volume":"10","author":"PWB Derksen","year":"2006","journal-title":"Cancer Cell"},{"issue":"10","key":"ref67","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0960-9822(02)70717-3","article-title":"Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination","volume":"6","author":"UA Betz","year":"1996","journal-title":"Curr Biol"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1073\/pnas.0609277104","article-title":"Developmental and adult phenotyping directly from mutant embryonic stem cells","volume":"104","author":"SH George","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/nar\/gkq868","article-title":"Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells","volume":"39","author":"U Sandhu","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"14","key":"ref70","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.1073\/pnas.96.14.7980","article-title":"Nuclear localization of the p120<sup>ctn<\/sup> Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression","volume":"96","author":"J van Hengel","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.celrep.2013.01.016","article-title":"The ROSA26-iPSC mouse: a conditional, inducible, and exchangeable resource for studying cellular (De)differentiation","volume":"3","author":"L Haenebalcke","year":"2013","journal-title":"Cell Rep"},{"issue":"1","key":"ref72","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/gene.1076","article-title":"Efficient FLP recombination in mouse ES cells and oocytes","volume":"31","author":"J Schaft","year":"2001","journal-title":"Genesis"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2144\/99265bm12","article-title":"Mapping of nuclear localization signals by simultaneous fusion to green fluorescent protein and to beta-galactosidase","volume":"26","author":"G Sorg","year":"1999","journal-title":"Biotechniques"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:13:42Z","timestamp":1657152822000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006243"}},"subtitle":[],"editor":[{"given":"Lionel","family":"Larue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":73,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006243","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}