{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:03:06Z","timestamp":1790546586981,"version":"4.1.0"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS054871"],"award-info":[{"award-number":["R01 NS054871"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS060109"],"award-info":[{"award-number":["R01 NS060109"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM102958"],"award-info":[{"award-number":["R01 GM102958"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006357","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T13:41:27Z","timestamp":1476193287000},"page":"e1006357","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-5919","authenticated-orcid":true,"given":"Chen-Jei","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0896-6273(00)80682-0","article-title":"Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog","volume":"22","author":"RJ Wechsler-Reya","year":"1999","journal-title":"Neuron"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0960-9822(99)80195-X","article-title":"Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum","volume":"9","author":"VA Wallace","year":"1999","journal-title":"Curr Biol"},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1242\/dev.126.14.3089","article-title":"Sonic hedgehog regulates the growth and patterning of the cerebellum","volume":"126","author":"N Dahmane","year":"1999","journal-title":"Development"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1242\/dev.02351","article-title":"The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation","volume":"133","author":"JD Corrales","year":"2006","journal-title":"Development"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2004.11.008","article-title":"Medulloblastoma: developmental mechanisms out of control","volume":"11","author":"S Marino","year":"2005","journal-title":"Trends Mol Med"},{"key":"ref6","first-page":"235","article-title":"Cerebellum development and medulloblastoma","volume":"94","author":"MF Roussel","year":"2011","journal-title":"Curr Top Dev Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.neuro.24.1.385","article-title":"The developmental biology of brain tumors","volume":"24","author":"R Wechsler-Reya","year":"2001","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1039\/B910196A","article-title":"Small-molecule modulators of the Sonic Hedgehog signaling pathway","volume":"6","author":"BZ Stanton","year":"2010","journal-title":"Mol Biosyst"},{"issue":"33","key":"ref9","doi-asserted-by":"crossref","first-page":"14132","DOI":"10.1073\/pnas.0907134106","article-title":"Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade","volume":"106","author":"JM Hyman","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1158\/0008-5472.CAN-05-0481","article-title":"Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics","volume":"65","author":"J Romer","year":"2005","journal-title":"Cancer Res"},{"issue":"6962","key":"ref11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"D Huangfu","year":"2003","journal-title":"Nature"},{"issue":"7061","key":"ref12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nature04117","article-title":"Vertebrate Smoothened functions at the primary cilium","volume":"437","author":"KC Corbit","year":"2005","journal-title":"Nature"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pgen.0010053","article-title":"Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function","volume":"1","author":"CJ Haycraft","year":"2005","journal-title":"PLoS Genet"},{"issue":"32","key":"ref14","doi-asserted-by":"crossref","first-page":"11325","DOI":"10.1073\/pnas.0505328102","article-title":"Cilia and Hedgehog responsiveness in the mouse","volume":"102","author":"D Huangfu","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ydbio.2008.02.026","article-title":"Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool","volume":"317","author":"N Spassky","year":"2008","journal-title":"Dev Biol"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1523\/JNEUROSCI.17-11-04159.1997","article-title":"Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O\/E-1 to regulate gene expression: implications for olfactory neuronal development","volume":"17","author":"RY Tsai","year":"1997","journal-title":"J Neurosci"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81561-5","article-title":"OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways","volume":"100","author":"A Hata","year":"2000","journal-title":"Cell"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bbrc.2003.10.053","article-title":"Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes","volume":"311","author":"MC Ku","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cell.2010.06.004","article-title":"NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome","volume":"142","author":"M Holzel","year":"2010","journal-title":"Cell"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ccr.2009.02.023","article-title":"ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome","volume":"15","author":"S Huang","year":"2009","journal-title":"Cancer Cell"},{"issue":"40","key":"ref21","doi-asserted-by":"crossref","first-page":"30814","DOI":"10.1074\/jbc.M110.142869","article-title":"ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression","volume":"285","author":"G Masserdotti","year":"2010","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1038\/ncomms10753","article-title":"Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network","volume":"7","author":"E Signaroldi","year":"2016","journal-title":"Nat Commun"},{"issue":"51","key":"ref23","doi-asserted-by":"crossref","first-page":"19424","DOI":"10.1073\/pnas.0609184103","article-title":"Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation","volume":"103","author":"WA Alcaraz","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ydbio.2007.04.005","article-title":"The transcription factor Zfp423\/OAZ is required for cerebellar development and CNS midline patterning","volume":"307","author":"LE Cheng","year":"2007","journal-title":"Dev Biol"},{"issue":"18","key":"ref25","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1128\/MCB.02255-05","article-title":"Zfp423 is required for normal cerebellar development","volume":"26","author":"S Warming","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"19","key":"ref26","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1093\/hmg\/ddr300","article-title":"Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice","volume":"20","author":"WA Alcaraz","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neuron.2007.04.029","article-title":"Zfp423\/OAZ participates in a developmental switch during olfactory neurogenesis","volume":"54","author":"LE Cheng","year":"2007","journal-title":"Neuron"},{"issue":"7288","key":"ref28","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nature08816","article-title":"Transcriptional control of preadipocyte determination by Zfp423","volume":"464","author":"RK Gupta","year":"2010","journal-title":"Nature"},{"issue":"6217","key":"ref29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.1260972","article-title":"Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection","volume":"347","author":"LJ Zhang","year":"2015","journal-title":"Science"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cell.2012.06.028","article-title":"Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling","volume":"150","author":"M Chaki","year":"2012","journal-title":"Cell"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0896-6273(03)00769-4","article-title":"RORa coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways","volume":"40","author":"DA Gold","year":"2003","journal-title":"Neuron"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"e66514","DOI":"10.1371\/journal.pone.0066514","article-title":"Zfp423 binds autoregulatory sites in p19 cell culture model","volume":"8","author":"YW Cho","year":"2013","journal-title":"PloS One"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/00005072-198509000-00003","article-title":"Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice","volume":"44","author":"PF Jacobsen","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/pmic.200300460","article-title":"Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles","volume":"3","author":"A Peyrl","year":"2003","journal-title":"Proteomics"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1073\/pnas.0812110106","article-title":"Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation","volume":"106","author":"Y Wang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.celrep.2014.03.052","article-title":"Cilia-mediated hedgehog signaling in Drosophila","volume":"7","author":"A Kuzhandaivel","year":"2014","journal-title":"Cell Rep"},{"issue":"36","key":"ref37","doi-asserted-by":"crossref","first-page":"9780","DOI":"10.1523\/JNEUROSCI.5586-06.2007","article-title":"Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool","volume":"27","author":"VV Chizhikov","year":"2007","journal-title":"J Neurosci"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"S Heinz","year":"2010","journal-title":"Mol Cell"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nmeth.1491","article-title":"Comprehensive comparative analysis of strand-specific RNA sequencing methods","volume":"7","author":"JZ Levin","year":"2010","journal-title":"Nat Methods"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"VK Mootha","year":"2003","journal-title":"Nat Genet"},{"issue":"43","key":"ref41","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"ref42","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1128\/MCB.02244-06","article-title":"Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis","volume":"27","author":"D Wiederschain","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"e1000484","DOI":"10.1371\/journal.pgen.1000484","article-title":"Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing","volume":"5","author":"D Concepcion","year":"2009","journal-title":"PLoS Genet"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng1247","article-title":"A natural allele of Nxf1 suppresses retrovirus insertional mutations","volume":"35","author":"JA Floyd","year":"2003","journal-title":"Nat Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.genom.7.080505.115610","article-title":"The ciliopathies: an emerging class of human genetic disorders","volume":"7","author":"JL Badano","year":"2006","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/WCO.0b013e3283444d05","article-title":"Cilia in the nervous system: linking cilia function and neurodevelopmental disorders","volume":"24","author":"JE Lee","year":"2011","journal-title":"Curr Opin Neurol"},{"issue":"Spec No. 2","key":"ref47","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1093\/hmg\/ddi264","article-title":"Genetic basis of Joubert syndrome and related disorders of cerebellar development","volume":"14","author":"CM Louie","year":"2005","journal-title":"Hum Mol Genet"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00467-010-1585-z","article-title":"Nephronophthisis","volume":"26","author":"MT Wolf","year":"2011","journal-title":"Pediatr Nephrol"},{"issue":"5990","key":"ref49","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.1191054","article-title":"A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution","volume":"329","author":"Q Hu","year":"2010","journal-title":"Science"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1083\/jcb.200907126","article-title":"Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium","volume":"187","author":"L Milenkovic","year":"2009","journal-title":"J Cell Biol"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1083\/jcb.104.2.289","article-title":"Microtubules containing acetylated alpha-tubulin in mammalian cells in culture","volume":"104","author":"G Piperno","year":"1987","journal-title":"J Cell Biol"},{"issue":"6887","key":"ref52","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"C Hubbert","year":"2002","journal-title":"Nature"},{"issue":"13","key":"ref53","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/dev.01894","article-title":"Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors","volume":"132","author":"A Liu","year":"2005","journal-title":"Development"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ydbio.2005.08.050","article-title":"Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli","volume":"287","author":"SR May","year":"2005","journal-title":"Dev Biol"},{"issue":"5","key":"ref55","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.devcel.2007.03.004","article-title":"The graded response to Sonic Hedgehog depends on cilia architecture","volume":"12","author":"T Caspary","year":"2007","journal-title":"Dev Cell"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","article-title":"Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella","volume":"151","author":"GJ Pazour","year":"2000","journal-title":"J Cell Biol"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1091\/mbc.12.3.589","article-title":"Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia","volume":"12","author":"PD Taulman","year":"2001","journal-title":"Mol Biol Cell"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/dvdy.21926","article-title":"Tulp3 is a critical repressor of mouse hedgehog signaling","volume":"238","author":"DA Cameron","year":"2009","journal-title":"Dev Dyn"},{"issue":"10","key":"ref59","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1093\/hmg\/ddp113","article-title":"Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling","volume":"18","author":"RX Norman","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"10","key":"ref60","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1093\/hmg\/ddp075","article-title":"Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway","volume":"18","author":"VL Patterson","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"19","key":"ref61","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1101\/gad.1966210","article-title":"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia","volume":"24","author":"S Mukhopadhyay","year":"2010","journal-title":"Genes Dev"},{"issue":"1\u20132","key":"ref62","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cell.2012.12.026","article-title":"The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling","volume":"152","author":"S Mukhopadhyay","year":"2013","journal-title":"Cell"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1073\/pnas.1011410108","article-title":"Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components","volume":"108","author":"J Qin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"22540","DOI":"10.1038\/srep22540","article-title":"Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation","volume":"6","author":"B Jung","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"e0149477","DOI":"10.1371\/journal.pone.0149477","article-title":"Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation","volume":"11","author":"B Jung","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"ref66","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/BC20100035","article-title":"Transcriptional control of genes involved in ciliogenesis: a first step in making cilia","volume":"102","author":"J Thomas","year":"2010","journal-title":"Biol Cell"},{"issue":"7","key":"ref67","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1242\/dev.074666","article-title":"Switching on cilia: transcriptional networks regulating ciliogenesis","volume":"141","author":"SP Choksi","year":"2014","journal-title":"Development"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1097-2765(00)80436-0","article-title":"The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans","volume":"5","author":"P Swoboda","year":"2000","journal-title":"Mol Cell"},{"issue":"23","key":"ref69","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1242\/dev.00148","article-title":"Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation","volume":"129","author":"R Dubruille","year":"2002","journal-title":"Development"},{"issue":"10","key":"ref70","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/MCB.24.10.4417-4427.2004","article-title":"The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification","volume":"24","author":"E Bonnafe","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"95","key":"ref71","doi-asserted-by":"crossref","first-page":"ra70","DOI":"10.1126\/scisignal.2000602","article-title":"The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis","volume":"2","author":"AM Ashique","year":"2009","journal-title":"Sci Signal"},{"issue":"29","key":"ref72","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1073\/pnas.0914241107","article-title":"Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals","volume":"107","author":"BP Piasecki","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1165\/ajrcmb.23.1.4070","article-title":"Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice","volume":"23","author":"SL Brody","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"12","key":"ref74","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/ng.267","article-title":"The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos","volume":"40","author":"JL Stubbs","year":"2008","journal-title":"Nat Genet"},{"issue":"12","key":"ref75","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/ng.263","article-title":"Foxj1 transcription factors are master regulators of the motile ciliogenic program","volume":"40","author":"X Yu","year":"2008","journal-title":"Nat Genet"},{"issue":"24","key":"ref76","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1242\/dev.051714","article-title":"Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling","volume":"137","author":"C Cruz","year":"2010","journal-title":"Development"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ydbio.2014.11.009","article-title":"A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation","volume":"397","author":"H Lu","year":"2015","journal-title":"Dev Biol"},{"issue":"6953","key":"ref78","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature01865","article-title":"Functional genetic analysis of mouse chromosome 11","volume":"425","author":"BT Kile","year":"2003","journal-title":"Nature"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1083\/jcb.100.2.384","article-title":"Neuronal regulation of astroglial morphology and proliferation in vitro","volume":"100","author":"ME Hatten","year":"1985","journal-title":"J Cell Biol"},{"key":"ref80","article-title":"Culturing Nerve Cells","author":"ME Hatten","year":"1998"},{"issue":"21","key":"ref81","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1101\/gad.1025302","article-title":"Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened","volume":"16","author":"JK Chen","year":"2002","journal-title":"Genes Dev"},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"SA Stewart","year":"2003","journal-title":"RNA"},{"issue":"1","key":"ref83","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"9","key":"ref84","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1038\/nprot.2013.099","article-title":"Count-based differential expression analysis of RNA sequencing data using R and Bioconductor","volume":"8","author":"S Anders","year":"2013","journal-title":"Nat Protoc"},{"issue":"1","key":"ref85","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"MD Robinson","year":"2010","journal-title":"Bioinformatics"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T23:43:28Z","timestamp":1657410208000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006357"}},"subtitle":[],"editor":[{"given":"Gregory S.","family":"Barsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,11]]},"references-count":85,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006357","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/046961","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.726835306.793548411","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,11]]}}}