{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:50:16Z","timestamp":1772175016606,"version":"3.50.1"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T00:00:00Z","timestamp":1479340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006374","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T13:24:55Z","timestamp":1479389095000},"page":"e1006374","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-6183","authenticated-orcid":true,"given":"Ireos","family":"Filipuzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Cotesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Perruccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Knapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Studer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Pries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Riedl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B.","family":"Helliwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina T.","family":"Petrovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Rao","family":"Movva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Sanglard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianshi","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Hoepfner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,11,17]]},"reference":[{"issue":"165","key":"ref1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden Killers: Human Fungal Infections","volume":"4","author":"GD Brown","year":"2012","journal-title":"Science Translational Medicine"},{"issue":"9","key":"ref2","first-page":"9","article-title":"Diagnostic issues, clinical characteristics, and outcomes for patients with fungemia","volume":"49","author":"SS Arendrup MC","year":"2011","journal-title":"Journal of Clinical Microbiology"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2174\/138945011501140115112242","article-title":"Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agents","volume":"15","author":"L Tripathi","year":"2014","journal-title":"Curr Drug Targets"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.micinf.2009.07.002","article-title":"The innate immune response to Aspergillus fumigatus","volume":"11","author":"V Balloy","year":"2009","journal-title":"Microbes and Infection"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.7861\/clinmedicine.13-5-507","article-title":"Invasive fungal infections","volume":"13","author":"W Hope","year":"2013","journal-title":"Clinical Medicine"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1017\/S0269915X03002064","article-title":"Antifungal agents: their diversity and increasing sophistication","volume":"17","author":"FC Odds","year":"2003","journal-title":"Mycologist"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.2174\/092986711794480113","article-title":"New Lead Structures in Antifungal Drug Discovery","volume":"18","author":"Z Sheng","year":"2011","journal-title":"Curr Med Chem"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tim.2010.02.004","article-title":"Therapy for fungal diseases: opportunities and priorities","volume":"18","author":"DWH Denning","year":"2010","journal-title":"Trends in Microbiology"},{"issue":"2","key":"ref9","first-page":"203","article-title":"Echinocandins for the nursery: an update","volume":"14","author":"B Manzoni","year":"2013","journal-title":"Curr Drug Metab"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1128\/AAC.04445-14","article-title":"Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model","volume":"59","author":"A Lepak","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1365-2958.2011.07632.x","article-title":"SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans","volume":"80","author":"M Chayakulkeeree","year":"2011","journal-title":"Molecular Microbiology"},{"issue":"5\u20136","key":"ref12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11046-011-9468-9","article-title":"Unravelling secretion in Cryptococcus neoformans: more than one way to skin a cat","volume":"173","author":"M Rodrigues","year":"2012","journal-title":"Mycopathologia"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1365-2958.2001.02236.x","article-title":"Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans","volume":"39","author":"GM Cox","year":"2001","journal-title":"Molecular Microbiology"},{"issue":"Pt 3","key":"ref14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/BJ20050063","article-title":"Secretion of cryptococcal phospholipase B1 (PLB1) is regulated by a glycosylphosphatidylinositol (GPI) anchor","volume":"389","author":"J Djordjevic","year":"2005","journal-title":"Biochem J"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1128\/EC.5.3.488-498.2006","article-title":"Lipid Rafts in Cryptococcus neoformans Concentrate the Virulence Determinants Phospholipase B1 and Cu\/Zn Superoxide Dismutase","volume":"5","author":"AR Siafakas","year":"2006","journal-title":"Eukaryotic Cell"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1128\/IAI.01351-06","article-title":"Cell Wall Targeting of Laccase of Cryptococcus neoformans during Infection of Mice","volume":"75","author":"SR Waterman","year":"2007","journal-title":"Infection and Immunity"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1128\/IAI.69.9.5589-5596.2001","article-title":"Laccase of Cryptococcus neoformans Is a Cell Wall-Associated Virulence Factor","volume":"69","author":"X Zhu","year":"2001","journal-title":"Infection and Immunity"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nchembio.1389","article-title":"PITPs as targets for selectively interfering with phosphoinositide signaling in cells","volume":"10","author":"AH Nile","year":"2014","journal-title":"Nat Chem Biol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1517\/17425255.2013.789018","article-title":"Anti-Parkinson's disease drugs and pharmacogenetic considerations","volume":"9","author":"JAG Ag\u00fandez","year":"2013","journal-title":"Expert Opinion on Drug Metabolism & Toxicology"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pcd.2015.10.008","article-title":"A review of dopamine agonist therapy in type 2 diabetes and effects on cardio-metabolic parameters","volume":"10","author":"EM Lamos","year":"2016","journal-title":"Primary Care Diabetes"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00003088-200645020-00001","article-title":"Pharmacokinetic Optimisation in the Treatment of Parkinson\u2019s Disease","volume":"45","author":"D Nyholm","year":"2013","journal-title":"Clinical Pharmacokinetics"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/head.12746","article-title":"Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review. Headache","volume":"56","author":"IR Patniyot","year":"2016","journal-title":"The Journal of Head and Face Pain"},{"key":"ref23","article-title":"Pharmacological interventions for daytime sleepiness and sleep disorders in Parkinson's disease: Systematic review and meta-analysis","author":"TM Rodrigues","year":"2016","journal-title":"Parkinsonism & Related Disorders"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/head.12033","article-title":"Oral Methylergonovine Maleate for Refractory Migraine and Cluster Headache Prevention. Headache","volume":"53","author":"JR Saper","year":"2013","journal-title":"The Journal of Head and Face Pain"},{"issue":"2","key":"ref25","first-page":"109","article-title":"Complementary medicines in psychiatry","volume":"188","author":"U Werneke","year":"2006","journal-title":"Review of effectiveness and safety"},{"issue":"2\u20133","key":"ref26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.micres.2013.11.004","article-title":"High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions","volume":"169","author":"D Hoepfner","year":"2014","journal-title":"Microbiological Research"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1128\/AAC.01809-12","article-title":"Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents","volume":"57","author":"DL Richie","year":"2013","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1073\/pnas.0307490100","article-title":"Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast","volume":"101","author":"G Giaever","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"23","key":"ref29","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1002\/j.1460-2075.1996.tb01036.x","article-title":"Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis","volume":"15","author":"M Fang","year":"1996","journal-title":"EMBO J"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1083\/jcb.200201037","article-title":"Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex","volume":"157","author":"X Li","year":"2002","journal-title":"The Journal of Cell Biology"},{"issue":"27","key":"ref31","doi-asserted-by":"crossref","first-page":"16635","DOI":"10.1074\/jbc.273.27.16635","article-title":"A Role for Phospholipase D (Pld1p) in Growth, Secretion, and Regulation of Membrane Lipid Synthesis in Yeast","volume":"273","author":"A Sreenivas","year":"1998","journal-title":"Journal of Biological Chemistry"},{"issue":"21","key":"ref32","doi-asserted-by":"crossref","first-page":"12346","DOI":"10.1073\/pnas.95.21.12346","article-title":"Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects","volume":"95","author":"F Xie","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"ref33","doi-asserted-by":"crossref","first-page":"11184","DOI":"10.1016\/S0021-9258(18)99146-5","article-title":"Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae","volume":"266","author":"J Nikawa","year":"1991","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.celrep.2013.01.019","article-title":"A Functional Variomics Tool for Discovering Drug-Resistance Genes and Drug Targets","volume":"3","author":"Z Huang","year":"2013","journal-title":"Cell Reports"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tibs.2009.10.008","article-title":"The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling","volume":"35","author":"VA Bankaitis","year":"2010","journal-title":"Trends in Biochemical Sciences"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molcel.2007.11.026","article-title":"Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily","volume":"29","author":"G Schaaf","year":"2008","journal-title":"Molecular Cell"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1194\/jlr.M066381","article-title":"Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors","volume":"57","author":"D Khan","year":"2016","journal-title":"Journal of Lipid Research"},{"issue":"7391","key":"ref38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"J Barretina","year":"2012","journal-title":"Nature"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"e0120408","DOI":"10.1371\/journal.pone.0120408","article-title":"DISIS: Prediction of Drug Response through an Iterative Sure Independence Screening","volume":"10","author":"Y Fang","year":"2015","journal-title":"PLoS ONE"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1087057105283787","article-title":"Comparison of In Vitro Assays of Cellular Toxicity in the Human Hepatic Cell Line HepG2","volume":"11","author":"S Miret","year":"2006","journal-title":"Journal of Biomolecular Screening"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1128\/AAC.45.11.3065-3069.2001","article-title":"Trends in Antifungal Drug Susceptibility of Cryptococcus neoformans Isolates in the United States: 1992 to 1994 and 1996 to 1998","volume":"45","author":"ME Brandt","year":"2001","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"2","key":"ref42","first-page":"5","article-title":"Immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis: a prospective study","volume":"51","author":"MG Bicanic T","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1586\/eri.09.67","article-title":"New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance","volume":"7","author":"MT Fera","year":"2009","journal-title":"Expert Review of Anti-infective Therapy"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1369-5274(02)00344-2","article-title":"Resistance of human fungal pathogens to antifungal drugs","volume":"5","author":"D Sanglard","year":"2002","journal-title":"Current Opinion in Microbiology"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1365-2958.2003.03281.x","article-title":"Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole","volume":"47","author":"B Posteraro","year":"2003","journal-title":"Molecular Microbiology"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/myc.12449","article-title":"Comparative effectiveness of fungicidal vs. fungistatic therapies for the treatment of paediatric candidaemia","volume":"59","author":"N Vendetti","year":"2016","journal-title":"Mycoses"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4161\/viru.18685","article-title":"Molecular mechanisms of cryptococcal meningitis","volume":"3","author":"T-B Liu","year":"2012","journal-title":"Virulence"},{"issue":"3","key":"ref48","first-page":"e01101","article-title":"Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease","volume":"5","author":"K Vu","year":"2014","journal-title":"mBio"},{"issue":"78","key":"ref49","first-page":"55","article-title":"Virulence mechanisms and Cryptococcus neoformans pathogenesis","author":"JA Alspaugh","year":"2014","journal-title":"Fungal Genetics and Biology"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/6791","article-title":"Genomic profiling of drug sensitivities via induced haploinsufficiency","volume":"21","author":"G Giaever","year":"1999","journal-title":"Nat Genet"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(03)01035-3","article-title":"Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes","volume":"116","author":"PY Lum","year":"2004","journal-title":"Cell"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.chembiol.2011.01.009","article-title":"Confronting the Challenges of Natural Product-Based Antifungal Discovery","volume":"18","author":"T Roemer","year":"2011","journal-title":"Chemistry & Biology"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1091\/mbc.11.6.1989","article-title":"Identification of a Novel Family of Nonclassic Yeast Phosphatidylinositol Transfer Proteins Whose Function Modulates Phospholipase D Activity and Sec14p-independent Cell Growth","volume":"11","author":"X Li","year":"2000","journal-title":"Molecular Biology of the Cell"},{"issue":"11","key":"ref54","doi-asserted-by":"crossref","first-page":"13098","DOI":"10.3390\/molecules171113098","article-title":"Forward Chemical Genetics in Yeast for Discovery of Chemical Probes Targeting Metabolism","volume":"17","author":"R Onge","year":"2012","journal-title":"Molecules"},{"issue":"6666","key":"ref55","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/35179","article-title":"Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol- transfer protein","volume":"391","author":"B Sha","year":"1998","journal-title":"Nature"},{"issue":"6293","key":"ref56","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/347561a0","article-title":"An essential role for a phospholipid transfer protein in yeast Golgi function","volume":"347","author":"VA Bankaitis","year":"1990","journal-title":"Nature"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/10409230500519573","article-title":"The Diverse Biological Functions of Phosphatidylinositol Transfer Proteins in Eukaryotes","volume":"41","author":"SE Phillips","year":"2006","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"issue":"6180","key":"ref58","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1126\/science.1250217","article-title":"Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures","volume":"344","author":"AY Lee","year":"2014","journal-title":"Science (New York, NY)"},{"key":"ref59","first-page":"523","article-title":"Ergot Alkaloids\u2013Current Status and Review of Clinical and Therapeutic Use Compared with Other Oxytocics in Obstetrics and Gynaecology","volume":"56","author":"ANJA De Grooth","year":"1998","journal-title":"Drugs"},{"key":"ref60","first-page":"2","article-title":"Sur la presence d\u2019un nouvel alkaloide, l\u2019ergotinine, dans le seigle egot\u00e9","volume":"81","author":"C Tanret","year":"1875","journal-title":"C R Acad Sci"},{"key":"ref61","first-page":"4","article-title":"Die Bedeutung der Mutterkorn-Alkaloide als Arzneistoffe","volume":"4","author":"A Sinz","year":"2008","journal-title":"Pharm Unserer Zeit"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1526-4610.2003.03034.x","article-title":"Ergotamine and Dihydroergotamine: History, Pharmacology, and Efficacy","volume":"43","author":"SD Silberstein","year":"2003","journal-title":"Headache: The Journal of Head and Face Pain"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1038\/nprot.2007.427","article-title":"Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures","volume":"2","author":"SE Pierce","year":"2007","journal-title":"Nat Protocols"},{"key":"ref64","first-page":"548","article-title":"Automatic Generation of 3D Atomic Coordinates for Organic Molecules","volume":"3","author":"C. Gasteiger JR","year":"1990","journal-title":"Tetrahedron Comp Method"},{"issue":"12","key":"ref65","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1158\/2159-8290.CD-12-0210","article-title":"FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor","volume":"2","author":"V Guagnano","year":"2012","journal-title":"Cancer Discovery"},{"issue":"11","key":"ref66","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0090-9556(24)14938-0","article-title":"Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes","volume":"27","author":"RS Obach","year":"1999","journal-title":"Drug Metabolism and Disposition"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1021\/jm001020e","article-title":"High-Throughput Permeability pH Profile and High-Throughput Alkane\/Water log P with Artificial Membranes","volume":"44","author":"F Wohnsland","year":"2001","journal-title":"Journal of Medicinal Chemistry"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T14:23:46Z","timestamp":1749738226000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006374"}},"subtitle":[],"editor":[{"given":"J. Andrew","family":"Alspaugh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,17]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006374","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726986066.793532995","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,17]]}}}