{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:59:41Z","timestamp":1793354381224,"version":"4.5.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G1002279"],"award-info":[{"award-number":["G1002279"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MP-89873"],"award-info":[{"award-number":["MP-89873"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J011673\/1"],"award-info":[{"award-number":["MR\/J011673\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004919","name":"King Abdulaziz City for Science and Technology","doi-asserted-by":"publisher","award":["13-BIO1113-20"],"award-info":[{"award-number":["13-BIO1113-20"]}],"id":[{"id":"10.13039\/501100004919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006470","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T18:28:03Z","timestamp":1484245683000},"page":"e1006470","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice"],"prefix":"10.1371","volume":"13","author":[{"given":"Martina M. A.","family":"Muggenthaler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-8072","authenticated-orcid":true,"given":"Biswajit","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Naimul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-0085","authenticated-orcid":true,"given":"Harold E.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav V.","family":"Harlalka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Patton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-2853","authenticated-orcid":false,"given":"Elijah R.","family":"Behr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-8439","authenticated-orcid":true,"given":"Kenneth","family":"Zahka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eissa","family":"Faqeih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Blakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon","family":"Dolinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Stanier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Salter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Baple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-341X","authenticated-orcid":true,"given":"Fowzan S.","family":"Alkuraya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Crosby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4719-6779","authenticated-orcid":true,"given":"Barbara","family":"Triggs-Raine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-1726","authenticated-orcid":true,"given":"Barry A.","family":"Chioza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"issue":"9703","key":"ref1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"PA Mossey","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1096-8628(19961230)66:4<468::AID-AJMG17>3.0.CO;2-S","article-title":"Phenotypic discordance in a family with monozygotic twins and non-syndromic cleft lip and palate","volume":"66","author":"DF Wyszynski","year":"1996","journal-title":"Am J Med Genet"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1597\/10-178","article-title":"Genetics of nonsyndromic orofacial clefts","volume":"49","author":"F Rahimov","year":"2012","journal-title":"Cleft Palate Craniofac J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-genom-090711-163729","article-title":"The evolution of human genetic studies of cleft lip and cleft palate","volume":"13","author":"ML Marazita","year":"2012","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1597\/12-088","article-title":"Classifying common oral clefts: a new approach after descriptive registration","volume":"51","author":"AJ Luijsterburg","year":"2014","journal-title":"Cleft Palate Craniofac J"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.17796\/jcpd.33.3.c244761467507721","article-title":"Cleft lip and palate: association with other congenital malformations","volume":"33","author":"S Beriaghi","year":"2009","journal-title":"J Clin Pediatr Dent"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ng.2360","article-title":"Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci","volume":"44","author":"KU Ludwig","year":"2012","journal-title":"Nat Genet"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00439-013-1283-6","article-title":"Confirming genes influencing risk to cleft lip with\/without cleft palate in a case-parent trio study","volume":"132","author":"TH Beaty","year":"2013","journal-title":"Hum Genet"},{"key":"ref9","article-title":"A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13","author":"EJ Leslie","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ajhg.2016.02.013","article-title":"Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate","volume":"98","author":"E Mangold","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajhg.2016.02.014","article-title":"A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3","volume":"98","author":"EJ Leslie","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.242","article-title":"Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip","volume":"40","author":"F Rahimov","year":"2008","journal-title":"Nat Genet"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ng.329","article-title":"Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence","volume":"41","author":"S Benko","year":"2009","journal-title":"Nat Genet"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/hmg\/ddt647","article-title":"Disruption of SATB2 or its long-range cis-regulation by SOX9 causes a syndromic form of Pierre Robin sequence","volume":"23","author":"JK Rainger","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ejmg.2014.04.003","article-title":"Genetics of cleft lip and\/or cleft palate: association with other common anomalies","volume":"57","author":"N Seto-Salvia","year":"2014","journal-title":"Eur J Med Genet"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/ajmg.c.31381","article-title":"Genetics of cleft lip and cleft palate","volume":"163C","author":"EJ Leslie","year":"2013","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"12","key":"ref17","first-page":"1437","article-title":"Labio-palatine clefts and congenital cardiopathies","volume":"74","author":"M Voisin","year":"1981","journal-title":"Arch Mal Coeur Vaiss"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1001\/archpedi.1970.02100050240010","article-title":"Cardiac malformations with facial clefts; with observations on the Pierre Robin syndrome","volume":"119","author":"CV Shah","year":"1970","journal-title":"Am J Dis Child"},{"key":"ref19","first-page":"334","article-title":"Congenital malformations and cleft lip and palate","volume":"5","author":"M Pannbacker","year":"1968","journal-title":"Cleft Palate J"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0021-9681(71)90057-9","article-title":"Observations on congenital heart disease in a mortality study of children with cleft lip and palate","volume":"24","author":"M Mackeprang","year":"1971","journal-title":"J Chronic Dis"},{"issue":"1","key":"ref21","first-page":"19","article-title":"The Prevalence of Congenital Heart-Disease among the Population of a Metropolitan Cleft-Lip and Palate Clinic","volume":"18","author":"N Geis","year":"1981","journal-title":"Cleft Palate Journal"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1597\/1545-1569(1990)027<0258:CHAIPW>2.3.CO;2","article-title":"Congenital heart anomalies in patients with clefts of the lip and\/or palate","volume":"27","author":"RK Wyse","year":"1990","journal-title":"Cleft Palate J"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1542\/peds.102.S1.258","article-title":"Report of the New England Regional Infant Cardiac Program, by Donald C. Fyler, MD, Pediatrics, 1980;65(suppl):375\u2013461","volume":"102","author":"CN Talner","year":"1998","journal-title":"Pediatrics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1542\/peds.31.2.255","article-title":"Cortriatriatum: clinical, hemodynamic and pathological studies surgical correction in early life","volume":"31","author":"W Jegier","year":"1963","journal-title":"Pediatrics"},{"key":"ref25","first-page":"188","article-title":"Congenital malformation of the heart: Abnormal septum in the left auricle","volume":"19","author":"WS Church","year":"1868","journal-title":"Transactions of the Pathological Society of London"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1017\/S1047951114000572","article-title":"Cor triatriatum or divided atriums: which approach provides the better understanding?","volume":"25","author":"T Bharucha","year":"2015","journal-title":"Cardiol Young"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/gim.2015.147","article-title":"Accelerating matchmaking of novel dysmorphology syndromes through clinical and genomic characterization of a large cohort","volume":"18","author":"R Shaheen","year":"2016","journal-title":"Genet Med"},{"key":"ref28","article-title":"Diseases of the Heart and Circulation","author":"PH Wood","year":"1956"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1476-7120-6-50","article-title":"Persistent left superior vena cava: a case report and review of literature","volume":"6","author":"SK Goyal","year":"2008","journal-title":"Cardiovasc Ultrasound"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000053366","article-title":"Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees","volume":"52","author":"E Sobel","year":"2001","journal-title":"Hum Hered"},{"key":"ref31","unstructured":"Pan H. CTJ. LMS growth, a Microsoft Excel add-in to ac-cess growth references based on the LMS method. Version 2.77. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.healthforallchildren.co.uk\/\" xlink:type=\"simple\">http:\/\/www.healthforallchildren.co.uk\/<\/ext-link>."},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/(SICI)1097-0258(19980228)17:4<407::AID-SIM742>3.0.CO;2-L","article-title":"British 1990 growth reference centiles for weight, height, body mass index and head circumference fitted by maximum penalized likelihood","volume":"17","author":"TJ Cole","year":"1998","journal-title":"Stat Med"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2011.06.125","article-title":"Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase","volume":"411","author":"B Andre","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0945-053X(01)00170-6","article-title":"Hyal2\u2014less active, but more versatile?","volume":"20","author":"G Lepperdinger","year":"2001","journal-title":"Matrix Biol"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1096\/fj.08-111997","article-title":"Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?","volume":"22","author":"L Jadin","year":"2008","journal-title":"FASEB J"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1074\/jbc.M112.393629","article-title":"Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction","volume":"288","author":"B Chowdhury","year":"2013","journal-title":"J Biol Chem"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00418-015-1373-8","article-title":"Hyaluronidase 2 (HYAL2) is expressed in endothelial cells, as well as some specialized epithelial cells, and is required for normal hyaluronan catabolism","volume":"145","author":"B Chowdhury","year":"2016","journal-title":"Histochem Cell Biol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.matbio.2011.11.002","article-title":"A comprehensive model of hyaluronan turnover in the mouse","volume":"31","author":"L Jadin","year":"2012","journal-title":"Matrix Biol"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"e90921","DOI":"10.1371\/journal.pone.0090921","article-title":"Knock-down of CD44 regulates endothelial cell differentiation via NFkappaB-mediated chemokine production","volume":"9","author":"B Olofsson","year":"2014","journal-title":"PLoS ONE"},{"issue":"5\u20136","key":"ref40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.mod.2010.03.001","article-title":"Tbx1 is necessary for palatal elongation and elevation","volume":"127","author":"S Goudy","year":"2010","journal-title":"Mech Dev"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/dvdy.10116","article-title":"Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene","volume":"224","author":"MJ Shamblott","year":"2002","journal-title":"Dev Dyn"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI10272","article-title":"Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme","volume":"106","author":"TD Camenisch","year":"2000","journal-title":"J Clin Invest"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/01.RES.0000242561.95978.43","article-title":"Depolymerized hyaluronan induces vascular endothelial growth factor, a negative regulator of developmental epithelial-to-mesenchymal transformation","volume":"99","author":"LS Rodgers","year":"2006","journal-title":"Circ Res"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tcm.2012.10.002","article-title":"Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation","volume":"23","author":"AK Lagendijk","year":"2013","journal-title":"Trends Cardiovasc Med"},{"issue":"21","key":"ref45","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1093\/hmg\/ddp368","article-title":"Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes","volume":"18","author":"E Pauws","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1172\/JCI79271","article-title":"Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis","volume":"125","author":"N Nagy","year":"2015","journal-title":"J Clin Invest"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2217\/imt.14.34","article-title":"Overview of recombinant human hyaluronidase-facilitated subcutaneous infusion of IgG in primary immunodeficiencies","volume":"6","author":"RL Wasserman","year":"2014","journal-title":"Immunotherapy"},{"issue":"4","key":"ref48","first-page":"1203","article-title":"Effective targeting of the tumor microenvironment for cancer therapy","volume":"32","author":"P Jiang","year":"2012","journal-title":"Anticancer Res"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/humu.20383","article-title":"Interactive visual analysis of SNP data for rapid autozygosity mapping in consanguineous families","volume":"27","author":"IM Carr","year":"2006","journal-title":"Hum Mutat"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/ar2001765","article-title":"Conformational analyses of the reaction coordinate of glycosidases","volume":"45","author":"GJ Davies","year":"2012","journal-title":"Acc Chem Res"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"IA Adzhubei","year":"2010","journal-title":"Nat Methods"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nmeth0810-575","article-title":"MutationTaster evaluates disease-causing potential of sequence alterations","volume":"7","author":"JM Schwarz","year":"2010","journal-title":"Nat Methods"},{"issue":"3","key":"ref53","first-page":"153","article-title":"Prevention of aminoglycoside-induced sensorineural hearing loss","volume":"35","author":"J Hochman","year":"2006","journal-title":"J Otolaryngol"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/tera.1420220306","article-title":"Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S","volume":"22","author":"MJ McLeod","year":"1980","journal-title":"Teratology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/0076-6879(87)52075-4","article-title":"Identification of regulatory elements of cloned genes with functional assays","volume":"152","author":"N Rosenthal","year":"1987","journal-title":"Methods Enzymol"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/glycob\/cwn006","article-title":"Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells","volume":"18","author":"R Hemming","year":"2008","journal-title":"Glycobiology"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T12:56:33Z","timestamp":1658408193000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006470"}},"subtitle":[],"editor":[{"given":"Andrew O. M.","family":"Wilkie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006470","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]}}}