{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:22:08Z","timestamp":1790695328004,"version":"4.1.0"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["SU2C-AACR-DT1113"],"award-info":[{"award-number":["SU2C-AACR-DT1113"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30-CA008748"],"award-info":[{"award-number":["P30-CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006501","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T13:28:18Z","timestamp":1482240498000},"page":"e1006501","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":120,"title":["Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome"],"prefix":"10.1371","volume":"12","author":[{"given":"Olivia M.","family":"Padovan-Merhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6948-2157","authenticated-orcid":true,"given":"Pichai","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Ostrovnaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-0640","authenticated-orcid":true,"given":"Karthik","family":"Kalletla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn R.","family":"Rubnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-9334","authenticated-orcid":true,"given":"Eric M.","family":"Sanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj M.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael P.","family":"Moss\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5500-0927","authenticated-orcid":true,"given":"Meaghan P.","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5154-3134","authenticated-orcid":true,"given":"Brian","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Maris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-1726","authenticated-orcid":true,"given":"Shakeel","family":"Modak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"ref1","article-title":"Neuroblastoma in older children, adolescents and young adults: A report from the International Neuroblastoma Risk Group project","author":"YP Mosse","year":"2013","journal-title":"Pediatric blood & cancer"},{"key":"ref2","article-title":"Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations","author":"KR Bosse","year":"2015","journal-title":"Cancer"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.pcl.2014.09.015","article-title":"Neuroblastoma: paradigm for precision medicine","volume":"62","author":"MS Irwin","year":"2015","journal-title":"Pediatr Clin North Am"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/jama.2012.228","article-title":"Association of age at diagnosis and genetic mutations in patients with neuroblastoma","volume":"307","author":"NK Cheung","year":"2012","journal-title":"JAMA"},{"issue":"7391","key":"ref5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nature10910","article-title":"Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes","volume":"483","author":"JJ Molenaar","year":"2012","journal-title":"Nature"},{"key":"ref6","article-title":"Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma","author":"M Sausen","year":"2012","journal-title":"Nature Genetics"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng.2529","article-title":"The genetic landscape of high-risk neuroblastoma","volume":"45","author":"TJ Pugh","year":"2013","journal-title":"Nat Genet"},{"issue":"7484","key":"ref8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature12912","article-title":"Discovery and saturation analysis of cancer genes across 21 tumour types","volume":"505","author":"MS Lawrence","year":"2014","journal-title":"Nature"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ng.3333","article-title":"Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations","volume":"47","author":"TF Eleveld","year":"2015","journal-title":"Nat Genet"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ng.3349","article-title":"Mutational dynamics between primary and relapse neuroblastomas","volume":"47","author":"A Schramm","year":"2015","journal-title":"Nat Genet"},{"issue":"25","key":"ref11","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1200\/JCO.2013.54.0674","article-title":"Emergence of New ALK Mutations at Relapse of Neuroblastoma","volume":"32","author":"G Schleiermacher","year":"2014","journal-title":"J Clin Oncol"},{"key":"ref12","article-title":"Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study","author":"MH Harris","year":"2016","journal-title":"JAMA Oncol"},{"key":"ref13","article-title":"Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors","author":"DW Parsons","year":"2016","journal-title":"JAMA Oncol"},{"key":"ref14","article-title":"Multi-Dimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A report from the Center for Cancer Research","author":"W Chang","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/jama.2015.10080","article-title":"Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth","volume":"314","author":"RJ Mody","year":"2015","journal-title":"JAMA"},{"issue":"7215","key":"ref16","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature07261","article-title":"Identification of ALK as a major familial neuroblastoma predisposition gene","volume":"455","author":"YP Mosse","year":"2008","journal-title":"Nature"},{"issue":"24","key":"ref17","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1056\/NEJMoa1508054","article-title":"Germline Mutations in Predisposition Genes in Pediatric Cancer","volume":"373","author":"J Zhang","year":"2015","journal-title":"N Engl J Med"},{"key":"ref18","article-title":"ClinicalTrials.gov","author":"P Yael","year":"2000"},{"key":"ref19","article-title":"ClinicalTrials.gov<\/ext-link>","year":"2000"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nbt.2696","article-title":"Development and Validation of a Clinical Cancer Genomic Profiling Test Based on Massively Parallel DNA Sequencing","volume":"31","author":"GM Frampton","year":"2013","journal-title":"Nat Biotechnol"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:37:04Z","timestamp":1589031424000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006501"}},"subtitle":[],"editor":[{"given":"Katherine","family":"Janeway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006501","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}