{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:37:54Z","timestamp":1790357874834,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1006587","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000}}],"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["091009"],"award-info":[{"award-number":["091009"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M003493\/1"],"award-info":[{"award-number":["MR\/M003493\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K002996\/1"],"award-info":[{"award-number":["MR\/K002996\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/L009277\/1"],"award-info":[{"award-number":["BB\/L009277\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006587","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:59:27Z","timestamp":1486735167000},"page":"e1006587","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease"],"prefix":"10.1371","volume":"13","author":[{"given":"Katrina","family":"Soderquest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf","family":"Hertweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-7280","authenticated-orcid":true,"given":"Claudia","family":"Giambartolomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9032-3828","authenticated-orcid":true,"given":"Stephen","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimma","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Perucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lude","family":"Franke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-9215","authenticated-orcid":true,"given":"Vincent","family":"Plagnol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-6811","authenticated-orcid":true,"given":"Richard G.","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham M.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"issue":"5","key":"ref1","first-page":"1557","article-title":"CD4 T cells: fates, functions, and faults","volume":"112","author":"J Zhu","year":"2008"},{"issue":"11","key":"ref2","first-page":"777","article-title":"T-bet: a bridge between innate and adaptive immunity","volume":"13","author":"V Lazarevic","year":"2013"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ni.1969","article-title":"T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding ROR\u03b3t","volume":"12","author":"V Lazarevic","year":"2011","journal-title":"Nat Immunol"},{"issue":"12","key":"ref4","first-page":"5925","article-title":"Genome-Wide Regulatory Analysis Reveals That T-bet Controls Th17 Lineage Differentiation through Direct Suppression of IRF4","volume":"191","author":"MR G\u00f6kmen","year":"2013"},{"issue":"3\u20134","key":"ref5","first-page":"197","article-title":"Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases","volume":"33","author":"GS Cooper","year":"2009"},{"issue":"6","key":"ref6","first-page":"1907","article-title":"Direct health care costs of Crohn&apos;s disease and ulcerative colitis in US children and adults","volume":"135","author":"MD Kappelman","year":"2008"},{"issue":"6","key":"ref7","first-page":"567","article-title":"Transcriptional regulation of the mucosal immune system mediated by T-bet","volume":"3","author":"N Powell","year":"2010"},{"issue":"8","key":"ref8","first-page":"1090","article-title":"Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa","volume":"53","author":"I Monteleone","year":"2004"},{"issue":"9","key":"ref9","first-page":"1129","article-title":"The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn&apos;s Disease","volume":"195","author":"MF Neurath","year":"2002"},{"issue":"9","key":"ref10","first-page":"585","article-title":"The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"SL Gaffen","year":"2014"},{"issue":"4","key":"ref11","first-page":"674","article-title":"The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells","volume":"37","author":"N Powell","year":"2012"},{"issue":"25","key":"ref12","first-page":"E2559","article-title":"Nod\/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-\/-.Rag2-\/- (TRUC) mice","volume":"111","author":"J Ermann","year":"2014"},{"issue":"1","key":"ref13","first-page":"33","article-title":"Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system","volume":"131","author":"WS Garrett","year":"2007"},{"issue":"7436","key":"ref14","first-page":"261","article-title":"A T-bet gradient controls the fate and function of CCR6-RORgt+ innate lymphoid cells","volume":"494","author":"CSN Klose","year":"2013"},{"issue":"13","key":"ref15","first-page":"2331","article-title":"Distinct requirements for T-bet in gut innate lymphoid cells","volume":"209","author":"G Sciume","year":"2012"},{"issue":"3","key":"ref16","first-page":"160","article-title":"Autoimmune diseases\u2014connecting risk alleles with molecular traits of the immune system","volume":"17","author":"M Gutierrez-Arcelus","year":"2016"},{"issue":"7145","key":"ref17","first-page":"661","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","year":"2007"},{"issue":"4","key":"ref18","first-page":"295","article-title":"Multiple common variants for celiac disease influencing immune gene expression","volume":"42","author":"PCA Dubois","year":"2010"},{"issue":"5804","key":"ref19","first-page":"1461","article-title":"A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene","volume":"314","author":"RH Duerr","year":"2006"},{"issue":"2","key":"ref20","first-page":"207","article-title":"A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1","volume":"39","author":"J Hampe","year":"2007"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1101\/028688","article-title":"Association mapping of inflammatory bowel disease loci to single variant resolution","author":"H Huang","year":"2015"},{"issue":"7422","key":"ref22","first-page":"119","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"L Jostins","year":"2012"},{"issue":"12","key":"ref23","first-page":"1193","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"G Trynka","year":"2011"},{"issue":"7539","key":"ref24","first-page":"337","article-title":"Genetic and epigenetic fine mapping of causal autoimmune disease variants","volume":"518","author":"KK Farh","year":"2015"},{"issue":"7345","key":"ref25","first-page":"43","article-title":"Mapping and analysis of chromatin state dynamics in nine human cell types","volume":"473","author":"J Ernst","year":"2011"},{"issue":"7414","key":"ref26","first-page":"57","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012"},{"issue":"12","key":"ref27","first-page":"1393","article-title":"Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo","volume":"47","author":"MT Maurano","year":"2015"},{"issue":"9","key":"ref28","first-page":"1748","article-title":"Linking disease associations with regulatory information in the human genome","volume":"22","author":"MA Schaub","year":"2012"},{"issue":"4","key":"ref29","first-page":"934","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"D Hnisz","year":"2013"},{"issue":"44","key":"ref30","first-page":"17921","article-title":"Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants","volume":"110","author":"SC Parker","year":"2013"},{"issue":"2","key":"ref31","first-page":"124","article-title":"Chromatin marks identify critical cell types for fine mapping complex trait variants","volume":"45","author":"G Trynka","year":"2013"},{"issue":"4","key":"ref32","first-page":"381","article-title":"Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers","volume":"47","author":"S Onengut-Gumuscu","year":"2015"},{"issue":"5975","key":"ref33","first-page":"235","article-title":"Heritable Individual-Specific and Allele-Specific Chromatin Signatures in Humans","volume":"328","author":"R McDaniell","year":"2010"},{"issue":"7385","key":"ref34","first-page":"390","article-title":"DNase I sensitivity QTLs are a major determinant of human expression variation","volume":"482","author":"JF Degner","year":"2012"},{"key":"ref35","first-page":"e00523","article-title":"Passive and active DNA methylation and the interplay with genetic variation in gene regulation","volume":"2","author":"M Gutierrez-Arcelus","year":"2013"},{"issue":"2","key":"ref36","first-page":"142","article-title":"Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis","volume":"31","author":"Y Liu","year":"2013"},{"issue":"9","key":"ref37","first-page":"e1004663","article-title":"Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels","volume":"10","author":"NE Banovich","year":"2014"},{"issue":"2","key":"ref38","first-page":"170","article-title":"Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus","volume":"20","author":"BM Javierre","year":"2010"},{"issue":"5","key":"ref39","first-page":"458","article-title":"Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms","volume":"12","author":"RC del Rosario","year":"2015"},{"issue":"23","key":"ref40","first-page":"9607","article-title":"Systematic functional regulatory assessment of disease-associated variants","volume":"110","author":"KJ Karczewski","year":"2013"},{"issue":"6159","key":"ref41","first-page":"747","article-title":"Identification of genetic variants that affect histone modifications in human cells","volume":"342","author":"G McVicker","year":"2013"},{"issue":"6159","key":"ref42","first-page":"744","article-title":"Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription","volume":"342","author":"H Kilpinen","year":"2013"},{"issue":"6159","key":"ref43","first-page":"750","article-title":"Extensive variation in chromatin states across humans","volume":"342","author":"M Kasowski","year":"2013"},{"issue":"4","key":"ref44","first-page":"e44","article-title":"Quantitative high-throughput analysis of transcription factor binding specificities","volume":"32","author":"J Linnell","year":"2004"},{"issue":"2","key":"ref45","first-page":"181","article-title":"Sp1 binds to the G allele of the-1087 polymorphism in the IL-10 promoter and promotes IL-10 mRNA transcription and protein production","volume":"11","author":"L Larsson","year":"2010"},{"issue":"7","key":"ref46","first-page":"980","article-title":"A functional polymorphism in the Eta-1 promoter is associated with allele specific binding to the transcription factor Sp1 and elevated gene expression","volume":"43","author":"T Hummelshoj","year":"2006"},{"issue":"5975","key":"ref47","first-page":"232","article-title":"Variation in transcription factor binding among humans","volume":"328","author":"M Kasowski","year":"2010"},{"issue":"4","key":"ref48","first-page":"420","article-title":"Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression","volume":"44","author":"J Schodel","year":"2012"},{"issue":"8","key":"ref49","first-page":"1437","article-title":"Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus","volume":"22","author":"X Zhang","year":"2012"},{"issue":"7307","key":"ref50","first-page":"714","article-title":"From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus","volume":"466","author":"K Musunuru","year":"2010"},{"issue":"3","key":"ref51","first-page":"253","article-title":"Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus","volume":"43","author":"I Adrianto","year":"2011"},{"key":"ref52","first-page":"2756","article-title":"T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex","volume":"15","author":"A Hertweck","year":"2016"},{"issue":"42","key":"ref53","first-page":"17876","article-title":"The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes","volume":"106","author":"RG Jenner","year":"2009"},{"key":"ref54","first-page":"1268","article-title":"T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements","volume":"3","author":"A Kanhere","year":"2012"},{"key":"ref55","unstructured":"Hindorff L, MacArthur J, Morales J, Junkins H, Hall P, Klemm A, et al. A Catalog of Published Genome-Wide Association Studies. Accessed: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.genome.gov\/gwastudies\" xlink:type=\"simple\">http:\/\/www.genome.gov\/gwastudies<\/ext-link>."},{"issue":"1","key":"ref56","first-page":"126","article-title":"Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits","volume":"95","author":"JK Pickrell","year":"2014"},{"issue":"4","key":"ref57","first-page":"551","article-title":"CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-\u03b3 Locus","volume":"31","author":"M Sekimata","year":"2009"},{"issue":"6","key":"ref58","first-page":"1271","article-title":"Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization","volume":"38","author":"RD Hawkins","year":"2013"},{"issue":"6","key":"ref59","first-page":"655","article-title":"A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment","volume":"100","author":"SJ Szabo","year":"2000"},{"issue":"4","key":"ref60","first-page":"395","article-title":"Newly identified genetic risk variants for celiac disease related to the immune response","volume":"40","author":"KA Hunt","year":"2008"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn&apos;s disease susceptibility loci","volume":"42","author":"A Franke","year":"2010","journal-title":"Nat Genet"},{"issue":"8","key":"ref62","first-page":"e1002197","article-title":"Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA","volume":"7","author":"VG Cheung","year":"2011"},{"issue":"5","key":"ref63","first-page":"e1004383","article-title":"Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics","volume":"10","author":"C Giambartolomei","year":"2014"},{"key":"ref64","doi-asserted-by":"crossref","DOI":"10.1038\/mi.2016.5","article-title":"T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis","author":"J Zimmermann","year":"2016"},{"key":"ref65","first-page":"11627","article-title":"T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine","volume":"7","author":"T Krausgruber","year":"2016"},{"issue":"13","key":"ref66","first-page":"e87899","article-title":"Characterization of candidate genes in inflammatory bowel disease-associated risk loci","volume":"1","author":"JM Peloquin","year":"2016"},{"issue":"34","key":"ref67","first-page":"12622","article-title":"Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells","volume":"101","author":"M Shnyreva","year":"2004"},{"key":"ref68","first-page":"732","article-title":"Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma","volume":"8","author":"JR Schoenborn","year":"2007"},{"issue":"11","key":"ref69","first-page":"937","article-title":"Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index","volume":"42","author":"EK Speliotes","year":"2010"},{"issue":"4","key":"ref70","first-page":"520","article-title":"Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet","volume":"17","author":"E Stolarczyk","year":"2013"},{"issue":"9","key":"ref71","first-page":"1","article-title":"Model-based Analysis of ChIP-Seq (MACS)","volume":"9","author":"Y Zhang","year":"2008"},{"issue":"10","key":"ref72","first-page":"1","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"RC Gentleman","year":"2004"},{"issue":"1","key":"ref73","first-page":"45","article-title":"An R Package for Analysis of Whole-Genome Association Studies","volume":"64","author":"D Clayton","year":"2007"},{"issue":"7311","key":"ref74","first-page":"52","article-title":"Integrating common and rare genetic variation in diverse human populations","volume":"467","year":"2010"},{"issue":"7414","key":"ref75","first-page":"75","article-title":"The accessible chromatin landscape of the human genome","volume":"489","author":"RE Thurman","year":"2012"},{"issue":"6099","key":"ref76","first-page":"1190","article-title":"Systematic Localization of Common Disease-Associated Variation in Regulatory DNA","volume":"337","author":"MT Maurano","year":"2012"},{"issue":"1","key":"ref77","first-page":"1","article-title":"ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases","volume":"15","author":"L Shen","year":"2014"},{"issue":"20","key":"ref78","first-page":"2741","article-title":"A genotype calling algorithm for the Illumina BeadArray platform","volume":"23","author":"YY Teo","year":"2007"},{"issue":"6","key":"ref79","first-page":"e1000529","article-title":"A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies","volume":"5","author":"BN Howie","year":"2009"},{"issue":"3","key":"ref80","first-page":"559","article-title":"PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses","volume":"81","author":"S Purcell","year":"2007"},{"issue":"10","key":"ref81","first-page":"e108","article-title":"The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote","volume":"41","author":"Y Liao","year":"2013"},{"issue":"7","key":"ref82","first-page":"923","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Y Liao","year":"2014"},{"issue":"12","key":"ref83","first-page":"1","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014"},{"issue":"7","key":"ref84","first-page":"1017","article-title":"FIMO: scanning for occurrences of a given motif","volume":"27","author":"CE Grant","year":"2011"},{"key":"ref85","first-page":"1341","article-title":"Identification of 15 new 23 psoriasis susceptibility loci highlights the role of innate immunity","volume":"44","author":"LC Tsoi","year":"2012"},{"issue":"18","key":"ref86","first-page":"7946","article-title":"Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human","volume":"39","author":"F Birzele","year":"2011"},{"key":"ref87","first-page":"2336","article-title":"Locuszoom: regional visualization of genome-wide association scan results","volume":"26","author":"RJ Pruim","year":"2010"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1006587","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T11:09:14Z","timestamp":1568804954000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006587"}},"subtitle":[],"editor":[{"given":"Christine A.","family":"Wells","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":87,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006587","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1006587","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]}}}