{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:12:12Z","timestamp":1791994332980,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1006609","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Diabetes and Digestive Kidney Diseases (NIDDK)","award":["K23DK090207"],"award-info":[{"award-number":["K23DK090207"]}]},{"name":"National Institute for Diabetes and Digestive Kidney Diseases (NIDDK)","award":["R03DK099564"],"award-info":[{"award-number":["R03DK099564"]}]},{"name":"National Institute for Diabetes and Digestive Kidney Diseases (NIDDK)","award":["R01DK105124"],"award-info":[{"award-number":["R01DK105124"]}]},{"name":"National Institute for Diabetes and Digestive Kidney Diseases (NIDDK)","award":["K01DK106341"],"award-info":[{"award-number":["K01DK106341"]}]},{"name":"National Institute for Diabetes and Digestive Kidney Diseases (NIDDK)","award":["R01DK078244"],"award-info":[{"award-number":["R01DK078244"]}]},{"name":"National Institute for Diabetes and Digestive Kidney Diseases (NIDDK)","award":["R01DK082753"],"award-info":[{"award-number":["R01DK082753"]}]},{"name":"Center for Glomerular Diseases at Columbia University","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006609","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:58:05Z","timestamp":1486735085000},"page":"e1006609","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":130,"title":["GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway"],"prefix":"10.1371","volume":"13","author":[{"given":"Krzysztof","family":"Kiryluk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-7689","authenticated-orcid":true,"given":"Yifu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zina","family":"Moldoveanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Reily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikol","family":"Mladkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhuri","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Fischman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1435-4523","authenticated-orcid":true,"given":"Robert A.","family":"LeDesma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuliana","family":"Ionita-Laza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Eitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rauen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-8901","authenticated-orcid":true,"given":"Francois","family":"Berthoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Floege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Scolari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Julian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G.","family":"Gharavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ajhg.2013.10.024","article-title":"Solving glycosylation disorders: fundamental approaches reveal complicated pathways","volume":"94","author":"HH Freeze","year":"2014","journal-title":"Am J Hum Genet"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/ki.2015.252","article-title":"New developments in the genetics, pathogenesis, and therapy of IgA nephropathy","volume":"88","author":"R Magistroni","year":"2015","journal-title":"Kidney international"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/sj.ki.5002185","article-title":"Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels","volume":"71","author":"Z Moldoveanu","year":"2007","journal-title":"Kidney Int"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1681\/ASN.2005101115","article-title":"O-glycosylation of serum IgD in IgA nephropathy","volume":"17","author":"AC Smith","year":"2006","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"6","key":"ref5","first-page":"1668","article-title":"Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity","volume":"119","author":"H Suzuki","year":"2009","journal-title":"J Clin Invest"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1046\/j.1523-1755.2001.060003969.x","article-title":"Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients","volume":"60","author":"AC Allen","year":"2001","journal-title":"Kidney Int"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1046\/j.1523-1755.2001.0590031077.x","article-title":"Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy","volume":"59","author":"Y Hiki","year":"2001","journal-title":"Kidney international"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1172\/JCI5535","article-title":"Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies","volume":"104","author":"M Tomana","year":"1999","journal-title":"J Clin Invest"},{"issue":"2","key":"ref9","first-page":"629","article-title":"IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1","volume":"118","author":"H Suzuki","year":"2008","journal-title":"J Clin Invest"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/ki.2012.197","article-title":"The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression","volume":"82","author":"N Zhao","year":"2012","journal-title":"Kidney international"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1681\/ASN.2012010053","article-title":"Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy","volume":"23","author":"F Berthoux","year":"2012","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1681\/ASN.2007091052","article-title":"Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy","volume":"19","author":"AG Gharavi","year":"2008","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ki.2011.16","article-title":"Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Sch\u00f6nlein purpura nephritis","volume":"80","author":"K Kiryluk","year":"2011","journal-title":"Kidney international"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00251-012-0636-y","article-title":"Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers","volume":"64","author":"C Yang","year":"2012","journal-title":"Immunogenetics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7213","DOI":"10.1038\/ncomms8213","article-title":"Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma","volume":"6","author":"B Swaminathan","year":"2015","journal-title":"Nat Commun"},{"issue":"15","key":"ref16","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1093\/hmg\/ddu135","article-title":"IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L","volume":"23","author":"A Viktorin","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ng.644","article-title":"Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency","volume":"42","author":"RC Ferreira","year":"2010","journal-title":"Nature genetics"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"e1003225","DOI":"10.1371\/journal.pgen.1003225","article-title":"Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers","volume":"9","author":"G Lauc","year":"2013","journal-title":"PLoS genetics"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2796.2005.01558.x","article-title":"Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression in immunoglobulin A nephropathy","volume":"258","author":"W Qin","year":"2005","journal-title":"Journal of internal medicine"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","year":"2013","journal-title":"Nature genetics"},{"issue":"26","key":"ref21","doi-asserted-by":"crossref","first-page":"16613","DOI":"10.1073\/pnas.262438199","article-title":"A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase","volume":"99","author":"T Ju","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJMoa1108735","article-title":"Genetically distinct subsets within ANCA-associated vasculitis","volume":"367","author":"PA Lyons","year":"2012","journal-title":"N Engl J Med"},{"issue":"7549","key":"ref23","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nature14125","article-title":"An epigenome-wide association study of total serum immunoglobulin E concentration","volume":"520","author":"L Liang","year":"2015","journal-title":"Nature"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"e1000166","DOI":"10.1371\/journal.pgen.1000166","article-title":"Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus","volume":"4","author":"S Weidinger","year":"2008","journal-title":"PLoS genetics"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI45538","article-title":"Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice","volume":"121","author":"J Fu","year":"2011","journal-title":"J Clin Invest"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4161\/gmic.28622","article-title":"Discordance between changes in the gut microbiota and pathogenicity in a mouse model of spontaneous colitis","volume":"5","author":"ME Perez-Munoz","year":"2014","journal-title":"Gut microbes"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"e113684","DOI":"10.1371\/journal.pone.0113684","article-title":"Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases","volume":"9","author":"D Chang","year":"2014","journal-title":"PloS one"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrgastro.2014.78","article-title":"The role of glycosylation in IBD","volume":"11","author":"E Theodoratou","year":"2014","journal-title":"Nature reviews Gastroenterology & hepatology"},{"issue":"7063","key":"ref29","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/4371252a","article-title":"Protein glycosylation: chaperone mutation in Tn syndrome","volume":"437","author":"T Ju","year":"2005","journal-title":"Nature"},{"issue":"39","key":"ref30","doi-asserted-by":"crossref","first-page":"E4066","DOI":"10.1073\/pnas.1406619111","article-title":"Immature truncated O-glycophenotype of cancer directly induces oncogenic features","volume":"111","author":"P Radhakrishnan","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1681\/ASN.2016020184","article-title":"IgA1 Glycosylation Is Heritable in Healthy Twins","volume":"28","author":"HJ Lomax-Browne","year":"2017","journal-title":"Journal of the American Society of Nephrology"},{"issue":"44","key":"ref32","doi-asserted-by":"crossref","first-page":"16442","DOI":"10.1073\/pnas.0607872103","article-title":"Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene","volume":"103","author":"WS Alexander","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/ije\/dyt179","article-title":"Calculating statistical power in Mendelian randomization studies","volume":"42","author":"MJ Brion","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ng.3118","article-title":"Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens","volume":"46","author":"K Kiryluk","year":"2014","journal-title":"Nature genetics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7270","DOI":"10.1038\/ncomms8270","article-title":"Identification of new susceptibility loci for IgA nephropathy in Han Chinese","volume":"6","author":"M Li","year":"2015","journal-title":"Nat Commun"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/sj.ki.5002185","article-title":"Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels","volume":"71","author":"Z Moldoveanu","year":"2007","journal-title":"Kidney international"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng.787","article-title":"Genome-wide association study identifies susceptibility loci for IgA nephropathy","volume":"43","author":"AG Gharavi","year":"2011","journal-title":"Nature genetics"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1214\/09-AOAS281","article-title":"A Spectral Graph Approach to Discovering Genetic Ancestry","volume":"4","author":"AB Lee","year":"2010","journal-title":"Ann Appl Stat"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/gepi.20434","article-title":"Discovering genetic ancestry using spectral graph theory","volume":"34","author":"AB Lee","year":"2010","journal-title":"Genet Epidemiol"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"17","key":"ref41","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"CJ Willer","year":"2010","journal-title":"Bioinformatics"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/gepi.1034","article-title":"Unbiased methods for population-based association studies","volume":"21","author":"B Devlin","year":"2001","journal-title":"Genet Epidemiol"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"e1002765","DOI":"10.1371\/journal.pgen.1002765","article-title":"Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis","volume":"8","author":"K Kiryluk","year":"2012","journal-title":"PLoS genetics"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/gepi.20297","article-title":"Estimation of significance thresholds for genomewide association scans","volume":"32","author":"F Dudbridge","year":"2008","journal-title":"Genet Epidemiol"},{"issue":"7031","key":"ref45","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females","volume":"434","author":"L Carrel","year":"2005","journal-title":"Nature"},{"issue":"16","key":"ref46","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"K Wang","year":"2010","journal-title":"Nucleic acids research"},{"issue":"7261","key":"ref47","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature08250","article-title":"Targeted capture and massively parallel sequencing of 12 human exomes","volume":"461","author":"SB Ng","year":"2009","journal-title":"Nature"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/bioinformatics\/btn653","article-title":"SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms","volume":"25","author":"C Chelala","year":"2009","journal-title":"Bioinformatics"},{"issue":"18","key":"ref49","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1093\/nar\/gks542","article-title":"FunciSNP: an R\/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs","volume":"40","author":"SG Coetzee","year":"2012","journal-title":"Nucleic acids research"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"LD Ward","year":"2012","journal-title":"Nucleic acids research"},{"issue":"17","key":"ref51","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/bioinformatics\/btt356","article-title":"ChroMoS: an integrated web tool for SNP classification, prioritization and functional interpretation","volume":"29","author":"M Barenboim","year":"2013","journal-title":"Bioinformatics"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"HJ Westra","year":"2013","journal-title":"Nature genetics"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ng.2205","article-title":"Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles","volume":"44","author":"BP Fairfax","year":"2012","journal-title":"Nature genetics"},{"issue":"9","key":"ref54","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ng.3367","article-title":"A gene-based association method for mapping traits using reference transcriptome data","volume":"47","author":"ER Gamazon","year":"2015","journal-title":"Nature genetics"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"e1000534","DOI":"10.1371\/journal.pgen.1000534","article-title":"Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions","volume":"5","author":"S Raychaudhuri","year":"2009","journal-title":"PLoS genetics"},{"issue":"8","key":"ref56","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/bioinformatics\/btn086","article-title":"e-LiSe\u2014an online tool for finding needles in the '(Medline) haystack'","volume":"24","author":"A Gladki","year":"2008","journal-title":"Bioinformatics"},{"issue":"13","key":"ref57","doi-asserted-by":"crossref","first-page":"i111","DOI":"10.1093\/bioinformatics\/btr214","article-title":"Discovering and visualizing indirect associations between biomedical concepts","volume":"27","author":"Y Tsuruoka","year":"2011","journal-title":"Bioinformatics"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"e1001273","DOI":"10.1371\/journal.pgen.1001273","article-title":"Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology","volume":"7","author":"EJ Rossin","year":"2011","journal-title":"PLoS genetics"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"D862","DOI":"10.1093\/nar\/gkr967","article-title":"PINA v2.0: mining interactome modules","volume":"40","author":"MJ Cowley","year":"2012","journal-title":"Nucleic acids research"},{"issue":"8","key":"ref60","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1074\/jbc.M113.512277","article-title":"Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes","volume":"289","author":"H Suzuki","year":"2014","journal-title":"The Journal of biological chemistry"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1006609","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T08:19:47Z","timestamp":1719044387000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006609"}},"subtitle":[],"editor":[{"given":"Amanda J.","family":"Myers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006609","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/076414","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]}}}