{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:34:39Z","timestamp":1785803679609,"version":"3.56.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1006623","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000}}],"reference-count":197,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI087634"],"award-info":[{"award-number":["R01AI087634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (US)","doi-asserted-by":"crossref","award":["R01AI089854"],"award-info":[{"award-number":["R01AI089854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RC1CA146299"],"award-info":[{"award-number":["RC1CA146299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"national institute of health","award":["R56AI110403"],"award-info":[{"award-number":["R56AI110403"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI121155"],"award-info":[{"award-number":["R01AI121155"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006623","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T18:24:13Z","timestamp":1488219853000},"page":"e1006623","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Differential Sensitivity of Target Genes to Translational Repression by miR-17~92"],"prefix":"10.1371","volume":"13","author":[{"given":"Hyun Yong","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyo","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengda","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-2900","authenticated-orcid":false,"given":"Chao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6632-3297","authenticated-orcid":false,"given":"Xiaojuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Goo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Valentine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-4673","authenticated-orcid":true,"given":"Jennifer M.","family":"Kefauver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujian","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Gonzalez-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovan","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-2010","authenticated-orcid":true,"given":"Gareth J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2809-3187","authenticated-orcid":true,"given":"Tony S.","family":"Mondala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Head","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyeung-Hyeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5417-707X","authenticated-orcid":false,"given":"Nengming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hsien","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuai","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-468X","authenticated-orcid":true,"given":"James R.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-3208","authenticated-orcid":true,"given":"Changchun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.tcb.2015.07.011","article-title":"The Functions of MicroRNAs: mRNA Decay and Translational Repression","volume":"25","author":"HO Iwakawa","year":"2015","journal-title":"Trends Cell Biol"},{"key":"ref2","first-page":"328","article-title":"MicroRNA mechanisms of action: what have we learned from mice?","volume":"6","author":"HY Jin","year":"2015","journal-title":"Frontiers in Genetics"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"S Jonas","year":"2015","journal-title":"Nat Rev Genet"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"B Wightman","year":"1993","journal-title":"Cell"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"RC Lee","year":"1993","journal-title":"Cell"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","article-title":"Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation","volume":"122","author":"S Bagga","year":"2005","journal-title":"Cell"},{"issue":"5770","key":"ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.1122689","article-title":"Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs","volume":"312","author":"AJ Giraldez","year":"2006","journal-title":"Science"},{"issue":"7209","key":"ref8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature07242","article-title":"The impact of microRNAs on protein output","volume":"455","author":"D Baek","year":"2008","journal-title":"Nature"},{"issue":"7209","key":"ref9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature07228","article-title":"Widespread changes in protein synthesis induced by microRNAs","volume":"455","author":"M Selbach","year":"2008","journal-title":"Nature"},{"issue":"7308","key":"ref10","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"H Guo","year":"2010","journal-title":"Nature"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/pmic.200800551","article-title":"Identification of miR-21 targets in breast cancer cells using a quantitative proteomic approach","volume":"9","author":"Y Yang","year":"2009","journal-title":"Proteomics"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1039\/c004401f","article-title":"Identifying targets of miR-143 using a SILAC-based proteomic approach","volume":"6","author":"Y Yang","year":"2010","journal-title":"Mol Biosyst"},{"issue":"6078","key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1215704","article-title":"Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish","volume":"336","author":"AA Bazzini","year":"2012","journal-title":"Science"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molcel.2014.08.028","article-title":"mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues","volume":"56","author":"SW Eichhorn","year":"2014","journal-title":"Mol Cell"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"e24557","DOI":"10.4161\/trla.24557","article-title":"Re-analysis of genome wide data on mammalian microRNA-mediated suppression of gene expression","volume":"1","author":"O Larsson","year":"2013","journal-title":"Translation"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/embor.2012.82","article-title":"Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells","volume":"13","author":"J Bethune","year":"2012","journal-title":"EMBO Rep"},{"issue":"6078","key":"ref17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.1215691","article-title":"miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay","volume":"336","author":"S Djuranovic","year":"2012","journal-title":"Science"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.molcel.2009.08.004","article-title":"Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation","volume":"35","author":"MR Fabian","year":"2009","journal-title":"Mol Cell"},{"issue":"6128","key":"ref19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.1231197","article-title":"Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation","volume":"340","author":"HA Meijer","year":"2013","journal-title":"Science"},{"issue":"7494","key":"ref20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature13007","article-title":"Poly(A)-tail profiling reveals an embryonic switch in translational control","volume":"508","author":"AO Subtelny","year":"2014","journal-title":"Nature"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.molcel.2014.03.036","article-title":"Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression","volume":"54","author":"H Mathys","year":"2014","journal-title":"Mol Cell"},{"issue":"5845","key":"ref22","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1126\/science.1146067","article-title":"MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F","volume":"317","author":"G Mathonnet","year":"2007","journal-title":"Science"},{"issue":"5740","key":"ref23","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.1115079","article-title":"Inhibition of translational initiation by Let-7 MicroRNA in human cells","volume":"309","author":"RS Pillai","year":"2005","journal-title":"Science"},{"issue":"24","key":"ref24","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1038\/emboj.2011.426","article-title":"PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro","volume":"30","author":"T Fukaya","year":"2011","journal-title":"EMBO J"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1073\/pnas.1113350109","article-title":"Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish","volume":"109","author":"Y Mishima","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/emboj.2013.44","article-title":"GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation","volume":"32","author":"L Zekri","year":"2013","journal-title":"EMBO J"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.molcel.2012.09.024","article-title":"MicroRNAs mediate gene silencing via multiple different pathways in drosophila","volume":"48","author":"T Fukaya","year":"2012","journal-title":"Mol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"MR Fabian","year":"2010","journal-title":"Annu Rev Biochem"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nsmb.2296","article-title":"The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC","volume":"19","author":"MR Fabian","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1101\/sqb.2006.71.038","article-title":"Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells","volume":"71","author":"SN Bhattacharyya","year":"2006","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"14","key":"ref31","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1101\/gad.215939.113","article-title":"Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates","volume":"27","author":"FV Karginov","year":"2013","journal-title":"Genes Dev"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1261\/rna.033308.112","article-title":"Disease-linked microRNA-21 exhibits drastically reduced mRNA binding and silencing activity in healthy mouse liver","volume":"18","author":"JR Androsavich","year":"2012","journal-title":"RNA"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"BP Lewis","year":"2003","journal-title":"Cell"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"A Krek","year":"2005","journal-title":"Nat Genet"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2010.03.009","article-title":"Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP","volume":"141","author":"M Hafner","year":"2010","journal-title":"Cell"},{"issue":"7254","key":"ref36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature08170","article-title":"Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps","volume":"460","author":"SW Chi","year":"2009","journal-title":"Nature"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cell.2012.04.005","article-title":"Roles for MicroRNAs in Conferring Robustness to Biological Processes","volume":"149","author":"MS Ebert","year":"2012","journal-title":"Cell"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"DP Bartel","year":"2009","journal-title":"Cell"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.molcel.2012.10.002","article-title":"Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting","volume":"48","author":"GB Loeb","year":"2012","journal-title":"Mol Cell"},{"issue":"17","key":"ref40","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1038\/emboj.2013.178","article-title":"MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways","volume":"32","author":"HY Jin","year":"2013","journal-title":"EMBO J"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.immuni.2015.04.022","article-title":"A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner","volume":"43","author":"LF Lu","year":"2015","journal-title":"Immunity"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1084\/jem.20140338","article-title":"The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation","volume":"211","author":"D Lu","year":"2014","journal-title":"J Exp Med"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.devcel.2014.12.018","article-title":"The let-7 microRNA directs vulval development through a single target","volume":"32","author":"M Ecsedi","year":"2015","journal-title":"Dev Cell"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2008.12.027","article-title":"MicroRNA Control in the Immune System: Basic Principles","volume":"136","author":"C Xiao","year":"2009","journal-title":"Cell"},{"key":"ref45","first-page":"340","article-title":"Transfection of microRNA mimics should be used with caution","volume":"6","author":"HY Jin","year":"2015","journal-title":"Frontiers in Genetics"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/15476286.2015.1020270","article-title":"Passenger strand loading in overexpression experiments using microRNA mimics","volume":"12","author":"R Sokilde","year":"2015","journal-title":"RNA Biol"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1261\/rna.054072.115","article-title":"Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner","volume":"22","author":"MA Goldgraben","year":"2016","journal-title":"RNA"},{"issue":"368","key":"ref48","doi-asserted-by":"crossref","first-page":"re2","DOI":"10.1126\/scisignal.2005813","article-title":"Outside the coding genome, mammalian microRNAs confer structural and functional complexity","volume":"8","author":"V Olive","year":"2015","journal-title":"Sci Signal"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","article-title":"Targeted deletion reveals essential and overlapping functions of the miR-17~92 family of miRNA clusters","volume":"132","author":"A Ventura","year":"2008","journal-title":"Cell"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1038\/ncomms12207","article-title":"Regulation of B-cell development and tolerance by different members of the miR-17 approximately 92 family microRNAs","volume":"7","author":"M Lai","year":"2016","journal-title":"Nat Commun"},{"issue":"7","key":"ref51","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ng.3321","article-title":"An allelic series of miR-17 approximately 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron","volume":"47","author":"YC Han","year":"2015","journal-title":"Nat Genet"},{"issue":"9","key":"ref52","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1101\/gr.121095.111","article-title":"Synthetic spike-in standards for RNA-seq experiments","volume":"21","author":"L Jiang","year":"2011","journal-title":"Genome Res"},{"issue":"7","key":"ref53","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"A Mortazavi","year":"2008","journal-title":"Nat Methods"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"e1000598","DOI":"10.1371\/journal.pcbi.1000598","article-title":"An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data","volume":"5","author":"D Ramskold","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"V Agarwal","year":"2015","journal-title":"Elife"},{"issue":"20","key":"ref56","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1182\/blood-2011-05-355644","article-title":"Molecular dissection of the miR-17-92 cluster&apos;s critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation","volume":"118","author":"S Jiang","year":"2011","journal-title":"Blood"},{"issue":"8","key":"ref57","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/ni.2642","article-title":"The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression","volume":"14","author":"D Baumjohann","year":"2013","journal-title":"Nat Immunol"},{"issue":"24","key":"ref58","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1101\/gad.1872909","article-title":"Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas","volume":"23","author":"P Mu","year":"2009","journal-title":"Genes Dev"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.intimp.2015.03.041","article-title":"Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation","volume":"28","author":"M Lai","year":"2015","journal-title":"International Immunopharmacology"},{"issue":"12","key":"ref60","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/cdd.2013.125","article-title":"The miR-17\/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease","volume":"20","author":"E Mogilyansky","year":"2013","journal-title":"Cell Death Differ"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/imr.12054","article-title":"mir-17-92: a polycistronic oncomir with pleiotropic functions","volume":"253","author":"V Olive","year":"2013","journal-title":"Immunol Rev"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/PPO.0b013e318258b60a","article-title":"The microRNA-17-92 family of microRNA clusters in development and disease","volume":"18","author":"CP Concepcion","year":"2012","journal-title":"Cancer J"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4161\/cc.27784","article-title":"microRNA-17~92 is a powerful cancer driver and a therapeutic target","volume":"13","author":"HY Jin","year":"2014","journal-title":"Cell Cycle"},{"issue":"23","key":"ref64","doi-asserted-by":"crossref","first-page":"19381","DOI":"10.18632\/oncotarget.4574","article-title":"The MYC\/miR-17-92 axis in lymphoproliferative disorders: A common pathway with therapeutic potential","volume":"6","author":"M Dal Bo","year":"2015","journal-title":"Oncotarget"},{"issue":"11","key":"ref65","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/leu.2016.204","article-title":"Concurrent PI3K and NF-kappaB activation drives B-cell lymphomagenesis","volume":"30","author":"HY Jin","year":"2016","journal-title":"Leukemia"},{"issue":"126","key":"ref66","doi-asserted-by":"crossref","first-page":"ra47","DOI":"10.1126\/scisignal.2000681","article-title":"Ablation of the Kinase NDR1 Predisposes Mice to the Development of T Cell Lymphoma","volume":"3","author":"H Cornils","year":"2010","journal-title":"Sci Signal"},{"issue":"17","key":"ref67","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jnci\/djn253","article-title":"Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes","volume":"100","author":"MY Wu","year":"2008","journal-title":"J Natl Cancer I"},{"issue":"9","key":"ref68","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1128\/MCB.25.9.3535-3542.2005","article-title":"Inactivation of CtIP leads to early embryonic lethality mediated by G(1) restraint and to tumorigenesis haploid insufficiency","volume":"25","author":"PL Chen","year":"2005","journal-title":"Molecular and Cellular Biology"},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0092-8674(95)90170-1","article-title":"A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma","volume":"83","author":"S Winandy","year":"1995","journal-title":"Cell"},{"issue":"4","key":"ref70","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd4505","article-title":"Targeting the translation machinery in cancer","volume":"14","author":"M Bhat","year":"2015","journal-title":"Nat Rev Drug Discov"},{"issue":"5924","key":"ref71","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling","volume":"324","author":"NT Ingolia","year":"2009","journal-title":"Science"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrg3645","article-title":"Ribosome profiling: new views of translation, from single codons to genome scale","volume":"15","author":"NT Ingolia","year":"2014","journal-title":"Nat Rev Genet"},{"issue":"7347","key":"ref73","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"B Schwanhausser","year":"2011","journal-title":"Nature"},{"issue":"12","key":"ref74","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nsmb1173","article-title":"Human let-7a miRNA blocks protein production on actively translating polyribosomes","volume":"13","author":"S Nottrott","year":"2006","journal-title":"Nat Struct Mol Biol"},{"issue":"4","key":"ref75","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.4049\/jimmunol.1203567","article-title":"microRNA-17-92 Regulates IL-10 Production by Regulatory T Cells and Control of Experimental Autoimmune Encephalomyelitis","volume":"191","author":"D de Kouchkovsky","year":"2013","journal-title":"J Immunol"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"e1005020","DOI":"10.1371\/journal.pgen.1005020","article-title":"microRNAs Regulate Cell-to-Cell Variability of Endogenous Target Gene Expression in Developing Mouse Thymocytes","volume":"11","author":"R Blevins","year":"2015","journal-title":"PLoS Genet"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e00822","DOI":"10.7554\/eLife.00822","article-title":"A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis","volume":"2","author":"V Olive","year":"2013","journal-title":"Elife"},{"issue":"21","key":"ref78","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1038\/emboj.2011.317","article-title":"Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation","volume":"30","author":"V Pospisil","year":"2011","journal-title":"Embo Journal"},{"issue":"9","key":"ref79","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1038\/emboj.2012.63","article-title":"EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency","volume":"31","author":"KJ Riley","year":"2012","journal-title":"EMBO J"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"e0125311","DOI":"10.1371\/journal.pone.0125311","article-title":"miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naive CD4+ T Cells","volume":"10","author":"AV Reddycherla","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"ref81","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.molcel.2014.03.045","article-title":"Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance","volume":"54","author":"R Denzler","year":"2014","journal-title":"Mol Cell"},{"issue":"3","key":"ref82","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molcel.2014.09.018","article-title":"Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition","volume":"56","author":"AD Bosson","year":"2014","journal-title":"Mol Cell"},{"issue":"3","key":"ref83","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/emboj.2008.275","article-title":"Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins","volume":"28","author":"XC Ding","year":"2009","journal-title":"EMBO J"},{"issue":"6","key":"ref84","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni.2891","article-title":"Translational control of immune responses: from transcripts to translatomes","volume":"15","author":"CA Piccirillo","year":"2014","journal-title":"Nat Immunol"},{"issue":"2","key":"ref85","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molcel.2012.04.008","article-title":"Reduced expression of ribosomal proteins relieves microRNA-mediated repression","volume":"46","author":"MM Janas","year":"2012","journal-title":"Mol Cell"},{"issue":"6","key":"ref86","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.immuni.2010.05.009","article-title":"Regulation of microRNA expression and abundance during lymphopoiesis","volume":"32","author":"S Kuchen","year":"2010","journal-title":"Immunity"},{"issue":"5824","key":"ref87","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.1141229","article-title":"Regulation of the germinal center response by microRNA-155","volume":"316","author":"TH Thai","year":"2007","journal-title":"Science"},{"issue":"9","key":"ref88","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1084\/jem.20160204","article-title":"A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells","volume":"213","author":"WH Liu","year":"2016","journal-title":"J Exp Med"},{"issue":"5","key":"ref89","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.immuni.2008.04.002","article-title":"MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation","volume":"28","author":"Y Dorsett","year":"2008","journal-title":"Immunity"},{"issue":"6","key":"ref90","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2007.10.009","article-title":"microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells","volume":"27","author":"E Vigorito","year":"2007","journal-title":"Immunity"},{"issue":"6","key":"ref91","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.immuni.2014.03.014","article-title":"miR-155 Activates Cytokine Gene Expression in Th17 Cells by Regulating the DNA-Binding Protein Jarid2 to Relieve Polycomb-Mediated Repression","volume":"40","author":"TM Escobar","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"ref92","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: Determinants beyond seed pairing","volume":"27","author":"A Grimson","year":"2007","journal-title":"Molecular Cell"},{"issue":"2","key":"ref93","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrm2838","article-title":"The mechanism of eukaryotic translation initiation and principles of its regulation","volume":"11","author":"RJ Jackson","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"ref94","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1261\/rna.2309906","article-title":"Control of mammalian translation by mRNA structure near caps","volume":"12","author":"JR Babendure","year":"2006","journal-title":"RNA"},{"issue":"9","key":"ref95","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1261\/rna.044792.114","article-title":"The role of RNA structure at 5&apos; untranslated region in microRNA-mediated gene regulation","volume":"20","author":"W Gu","year":"2014","journal-title":"RNA"},{"issue":"7516","key":"ref96","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature13485","article-title":"RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer","volume":"513","author":"AL Wolfe","year":"2014","journal-title":"Nature"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"D131","DOI":"10.1093\/nar\/gkp981","article-title":"IRESite\u2014a tool for the examination of viral and cellular internal ribosome entry sites","volume":"38","author":"M Mokrejs","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"ref98","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1073\/pnas.97.4.1536","article-title":"A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity","volume":"97","author":"SA Chappell","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6270","key":"ref99","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad4939","article-title":"Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes","volume":"351","author":"S Weingarten-Gabbay","year":"2016","journal-title":"Science"},{"issue":"37","key":"ref100","doi-asserted-by":"crossref","first-page":"E2424","DOI":"10.1073\/pnas.1207846109","article-title":"Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution","volume":"109","author":"S Lee","year":"2012","journal-title":"P Natl Acad Sci USA"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"W70","DOI":"10.1093\/nar\/gkn188","article-title":"The Vienna RNA Websuite","volume":"36","author":"AR Gruber","year":"2008","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"ref102","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","article-title":"MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb","volume":"131","author":"C Xiao","year":"2007","journal-title":"Cell"},{"issue":"7231","key":"ref103","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nature07598","article-title":"A stress-responsive RNA switch regulates VEGFA expression","volume":"457","author":"PS Ray","year":"2009","journal-title":"Nature"},{"issue":"10","key":"ref104","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb2105","article-title":"A Pumilio-induced RNA structure switch in p27-3&apos; UTR controls miR-221 and miR-222 accessibility","volume":"12","author":"M Kedde","year":"2010","journal-title":"Nat Cell Biol"},{"issue":"11","key":"ref105","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1093\/nar\/gks148","article-title":"HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA","volume":"40","author":"P Kundu","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"20","key":"ref106","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1128\/MCB.05955-11","article-title":"Competitive regulation of nucleolin expression by HuR and miR-494","volume":"31","author":"K Tominaga","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"10","key":"ref107","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"M Kertesz","year":"2007","journal-title":"Nat Genet"},{"issue":"2","key":"ref108","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/bfgp\/elm008","article-title":"Appearances can be deceiving: phenotypes of knockout mice","volume":"6","author":"I Barbaric","year":"2007","journal-title":"Brief Funct Genomic Proteomic"},{"issue":"4","key":"ref109","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1172\/JCI0215043","article-title":"Transcription factor haploinsufficiency: when half a loaf is not enough","volume":"109","author":"JG Seidman","year":"2002","journal-title":"J Clin Invest"},{"issue":"2","key":"ref110","first-page":"105","article-title":"Haploinsufficiency for tumour suppressor genes: when you don&apos;t need to go all the way","volume":"1654","author":"M Santarosa","year":"2004","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"ref111","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.canlet.2005.08.015","article-title":"Tumor development: haploinsufficiency and local network assembly","volume":"240","author":"LB Smilenov","year":"2006","journal-title":"Cancer Lett"},{"issue":"2","key":"ref112","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1083\/jcb.108.2.229","article-title":"The scanning model for translation: an update","volume":"108","author":"M Kozak","year":"1989","journal-title":"J Cell Biol"},{"issue":"3","key":"ref113","doi-asserted-by":"crossref","first-page":"REVIEWS0004","DOI":"10.1186\/gb-2002-3-3-reviews0004","article-title":"Untranslated regions of mRNAs","volume":"3","author":"F Mignone","year":"2002","journal-title":"Genome Biol"},{"issue":"11","key":"ref114","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1128\/MCB.9.11.5134","article-title":"Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs","volume":"9","author":"M Kozak","year":"1989","journal-title":"Mol Cell Biol"},{"issue":"4","key":"ref115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2174\/138920312801619475","article-title":"RNA binding protein\/RNA element interactions and the control of translation","volume":"13","author":"X Pichon","year":"2012","journal-title":"Curr Protein Pept Sci"},{"issue":"4","key":"ref116","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrm3083","article-title":"mRNA helicases: the tacticians of translational control","volume":"12","author":"A Parsyan","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"ref117","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molcel.2014.09.004","article-title":"MicroRNAs block assembly of eIF4F translation initiation complex in Drosophila","volume":"56","author":"T Fukaya","year":"2014","journal-title":"Mol Cell"},{"issue":"1","key":"ref118","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molcel.2014.09.005","article-title":"MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans","volume":"56","author":"A Fukao","year":"2014","journal-title":"Mol Cell"},{"issue":"1","key":"ref119","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/nar\/gks1076","article-title":"miRNA repression of translation in vitro takes place during 43S ribosomal scanning","volume":"41","author":"EP Ricci","year":"2013","journal-title":"Nucleic Acids Research"},{"issue":"11","key":"ref120","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.15252\/embj.201592901","article-title":"miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning","volume":"35","author":"D Kuzuoglu-Ozturk","year":"2016","journal-title":"EMBO J"},{"issue":"7148","key":"ref121","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nature05939","article-title":"A microRNA component of the p53 tumour suppressor network","volume":"447","author":"L He","year":"2007","journal-title":"Nature"},{"issue":"7503","key":"ref122","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature13413","article-title":"miR-34\/449 miRNAs are required for motile ciliogenesis by repressing cp110","volume":"510","author":"R Song","year":"2014","journal-title":"Nature"},{"issue":"7","key":"ref123","doi-asserted-by":"crossref","first-page":"e1002797","DOI":"10.1371\/journal.pgen.1002797","article-title":"Intact p53-Dependent Responses in miR-34-Deficient Mice","volume":"8","author":"CP Concepcion","year":"2012","journal-title":"PLoS Genet"},{"issue":"4","key":"ref124","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2016.04.034","article-title":"Dynamics of Translation of Single mRNA Molecules In Vivo","volume":"165","author":"X Yan","year":"2016","journal-title":"Cell"},{"issue":"1","key":"ref125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/cdd.2014.112","article-title":"The complexity of miRNA-mediated repression","volume":"22","author":"A Wilczynska","year":"2015","journal-title":"Cell Death Differ"},{"issue":"4","key":"ref126","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ni1575","article-title":"Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes","volume":"9","author":"C Xiao","year":"2008","journal-title":"Nat Immunol"},{"issue":"6","key":"ref127","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/25.6.1317","article-title":"B lymphocyte-specific, Cre-mediated mutagenesis in mice","volume":"25","author":"RC Rickert","year":"1997","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref128","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002484","article-title":"The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines","volume":"8","author":"RL Skalsky","year":"2012","journal-title":"Plos Pathogens"},{"issue":"8","key":"ref129","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/ni.2648","article-title":"MicroRNAs of the miR-17~92 family are critical regulators of T(FH) differentiation","volume":"14","author":"SG Kang","year":"2013","journal-title":"Nat Immunol"},{"issue":"24","key":"ref130","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1101\/gad.1861409","article-title":"miR-19 is a key oncogenic component of mir-17-92","volume":"23","author":"V Olive","year":"2009","journal-title":"Genes Dev"},{"issue":"5","key":"ref131","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/leu.2011.305","article-title":"The miRNA-17~92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K\/AKT pathway activation","volume":"26","author":"E Rao","year":"2012","journal-title":"Leukemia"},{"issue":"4","key":"ref132","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1074\/jbc.M608939200","article-title":"An E2F\/miR-20a autoregulatory feedback loop","volume":"282","author":"Y Sylvestre","year":"2007","journal-title":"J Biol Chem"},{"issue":"7043","key":"ref133","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature03677","article-title":"c-Myc-regulated microRNAs modulate E2F1 expression","volume":"435","author":"KA O'donnell","year":"2005","journal-title":"Nature"},{"issue":"21","key":"ref134","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1128\/MCB.00242-06","article-title":"Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA","volume":"26","author":"A Hossain","year":"2006","journal-title":"Molecular and Cellular Biology"},{"issue":"19","key":"ref135","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1182\/blood-2011-09-378687","article-title":"The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice","volume":"119","author":"YM Li","year":"2012","journal-title":"Blood"},{"issue":"16","key":"ref136","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1101\/gad.17027411","article-title":"miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma","volume":"25","author":"K Conkrite","year":"2011","journal-title":"Gene Dev"},{"issue":"21","key":"ref137","doi-asserted-by":"crossref","first-page":"8547","DOI":"10.1158\/0008-5472.CAN-10-1938","article-title":"The miR-17-92 Cluster of MicroRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence","volume":"70","author":"LX Hong","year":"2010","journal-title":"Cancer Research"},{"issue":"16","key":"ref138","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1093\/nar\/gks521","article-title":"A miR-19 regulon that controls NF-kappa B signaling","volume":"40","author":"MP Gantier","year":"2012","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"ref139","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1158\/0008-5472.CAN-09-3268","article-title":"The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression","volume":"70","author":"P Wong","year":"2010","journal-title":"Cancer Research"},{"issue":"7","key":"ref140","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1128\/MCB.01977-07","article-title":"MicroRNAs in the miR-106b family regulate p21\/CDKN1A and promote cell cycle progression","volume":"28","author":"I Ivanovska","year":"2008","journal-title":"Molecular and Cellular Biology"},{"issue":"22","key":"ref141","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1182\/blood-2012-06-435412","article-title":"MicroRNA-17~92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections","volume":"121","author":"AA Khan","year":"2013","journal-title":"Blood"},{"issue":"25","key":"ref142","doi-asserted-by":"crossref","first-page":"9965","DOI":"10.1073\/pnas.1207327109","article-title":"Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8(+) T-cell differentiation","volume":"109","author":"TQ Wu","year":"2012","journal-title":"P Natl Acad Sci USA"},{"issue":"12","key":"ref143","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/ni.3026","article-title":"A microRNA upregulated in asthma airway T cells promotes T(H)2 cytokine production","volume":"15","author":"LJ Simpson","year":"2014","journal-title":"Nature Immunology"},{"issue":"6","key":"ref144","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1349-7006.2008.00800.x","article-title":"Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells","volume":"99","author":"S Takakura","year":"2008","journal-title":"Cancer Sci"},{"issue":"11","key":"ref145","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/cdd.2011.35","article-title":"HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis","volume":"18","author":"V Glorian","year":"2011","journal-title":"Cell Death Differ"},{"issue":"7","key":"ref146","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069090","article-title":"miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling","volume":"8","author":"AS Collins","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"ref147","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-8-r127","article-title":"The miR-17-5p microRNA is a key regulator of the G1\/S phase cell cycle transition","volume":"9","author":"N Cloonan","year":"2008","journal-title":"Genome Biology"},{"key":"ref148","article-title":"miR-19, a component of the oncogenic miR-17~92 cluster, targets the DNA-end resection factor CtIP","volume":"0","author":"D Huhn","year":"2014","journal-title":"Oncogene"},{"issue":"2","key":"ref149","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ccr.2014.06.014","article-title":"MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State","volume":"26","author":"YL Li","year":"2014","journal-title":"Cancer Cell"},{"issue":"20","key":"ref150","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1158\/0008-5472.CAN-10-2412","article-title":"The Myc-miR-17~92 Axis Blunts TGF beta Signaling and Production of Multiple TGF beta-Dependent Antiangiogenic Factors","volume":"70","author":"M Dews","year":"2010","journal-title":"Cancer Research"},{"issue":"5","key":"ref151","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.molcel.2010.11.038","article-title":"The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma","volume":"40","author":"P Mestdagh","year":"2010","journal-title":"Molecular Cell"},{"issue":"Pt 4","key":"ref152","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1242\/jcs.117515","article-title":"MicroRNA-17-92a upregulation by estrogen leads to Bim targeting and inhibition of osteoblast apoptosis","volume":"126","author":"L Guo","year":"2013","journal-title":"J Cell Sci"},{"issue":"2","key":"ref153","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1182\/blood-2008-07-163907","article-title":"MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes","volume":"113","author":"M Inomata","year":"2009","journal-title":"Blood"},{"issue":"12","key":"ref154","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1111\/j.1349-7006.2011.02081.x","article-title":"miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer","volume":"102","author":"A Tsuchida","year":"2011","journal-title":"Cancer Sci"},{"issue":"4","key":"ref155","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1096\/fj.12-221994","article-title":"Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis","volume":"27","author":"LS Danielson","year":"2013","journal-title":"FASEB J"},{"issue":"4","key":"ref156","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nm.3497","article-title":"Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression","volume":"20","author":"JK Mouw","year":"2014","journal-title":"Nat Med"},{"issue":"3","key":"ref157","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ccr.2008.02.013","article-title":"E2F1-regulated microRNAs impair TGF beta-dependent cell-cycle arrest and apoptosis in gastric cancer","volume":"13","author":"F Petrocca","year":"2008","journal-title":"Cancer Cell"},{"issue":"4","key":"ref158","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ncb2037","article-title":"Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia","volume":"12","author":"KJ Mavrakis","year":"2010","journal-title":"Nature Cell Biology"},{"issue":"7","key":"ref159","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"S Volinia","year":"2006","journal-title":"P Natl Acad Sci USA"},{"issue":"12","key":"ref160","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1093\/nar\/gks175","article-title":"MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia","volume":"40","author":"HS Ye","year":"2012","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"ref161","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10549-010-0954-4","article-title":"miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1","volume":"126","author":"HL Li","year":"2011","journal-title":"Breast Cancer Res Tr"},{"issue":"5","key":"ref162","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002236","article-title":"Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM","volume":"3","author":"L Fontana","year":"2008","journal-title":"PLoS One"},{"issue":"35","key":"ref163","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0806202105","article-title":"MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis","volume":"105","author":"F Pichiorri","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref164","doi-asserted-by":"crossref","first-page":"e52555","DOI":"10.1371\/journal.pone.0052555","article-title":"miR-17-5p regulates endocytic trafficking through targeting TBC1D2\/Armus","volume":"7","author":"A Serva","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref165","doi-asserted-by":"crossref","first-page":"835","DOI":"10.7314\/APJCP.2013.14.2.835","article-title":"miR-19a promotes cell growth and tumorigenesis through targeting SOCS1 in gastric cancer","volume":"14","author":"S Qin","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"issue":"10","key":"ref166","doi-asserted-by":"crossref","first-page":"e46799","DOI":"10.1371\/journal.pone.0046799","article-title":"Spi-1, Fli-1 and Fli-3 (miR-17-92) oncogenes contribute to a single oncogenic network controlling cell proliferation in friend erythroleukemia","volume":"7","author":"S Kayali","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"ref167","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.ajpath.2014.01.037","article-title":"Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model","volume":"184","author":"H Jiang","year":"2014","journal-title":"Am J Pathol"},{"issue":"16","key":"ref168","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1182\/blood-2008-09-178707","article-title":"Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation","volume":"113","author":"D Sampath","year":"2009","journal-title":"Blood"},{"issue":"1","key":"ref169","doi-asserted-by":"crossref","first-page":"e52321","DOI":"10.1371\/journal.pone.0052321","article-title":"Focal DNA copy number changes in neuroblastoma target MYCN regulated genes","volume":"8","author":"C Kumps","year":"2013","journal-title":"PLoS One"},{"key":"ref170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1476-4598-13-51","article-title":"TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness","volume":"13","author":"X Lyu","year":"2014","journal-title":"Mol Cancer"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1038\/ncomms7764","article-title":"Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c","volume":"6","author":"S Xu","year":"2015","journal-title":"Nat Commun"},{"issue":"8","key":"ref172","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.celrep.2015.04.050","article-title":"Mir-17 ~ 92 Governs Motor Neuron Subtype Survival by Mediating Nuclear PTEN","volume":"11","author":"YT Tung","year":"2015","journal-title":"Cell Rep"},{"key":"ref173","article-title":"The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-beta Responsive Colon Carcinoma","author":"V Sokolova","year":"2015","journal-title":"J Cell Physiol"},{"issue":"7","key":"ref174","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ng.858","article-title":"A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)","volume":"43","author":"KJ Mavrakis","year":"2011","journal-title":"Nat Genet"},{"issue":"1\u20132","key":"ref175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11010-013-1678-7","article-title":"MiR-17-92 cluster: an apoptosis inducer or proliferation enhancer","volume":"380","author":"N Ranji","year":"2013","journal-title":"Mol Cell Biochem"},{"issue":"9","key":"ref176","doi-asserted-by":"crossref","first-page":"e0137887","DOI":"10.1371\/journal.pone.0137887","article-title":"Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression","volume":"10","author":"K Yamamoto","year":"2015","journal-title":"PLoS One"},{"issue":"17","key":"ref177","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1002\/pmic.201000501","article-title":"Identification of direct targets for the miR-17-92 cluster by proteomic analysis","volume":"11","author":"H Kanzaki","year":"2011","journal-title":"Proteomics"},{"issue":"23","key":"ref178","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.4161\/cc.22670","article-title":"MiR-93 enhances angiogenesis and metastasis by targeting LATS2","volume":"11","author":"L Fang","year":"2012","journal-title":"Cell Cycle"},{"issue":"2","key":"ref179","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nchembio.1713","article-title":"miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction","volume":"11","author":"J Imig","year":"2015","journal-title":"Nat Chem Biol"},{"issue":"10","key":"ref180","doi-asserted-by":"crossref","first-page":"8286","DOI":"10.18632\/oncotarget.3221","article-title":"miR-93 promotes cell proliferation in gliomas through activation of PI3K\/Akt signaling pathway","volume":"6","author":"L Jiang","year":"2015","journal-title":"Oncotarget"},{"issue":"8","key":"ref181","doi-asserted-by":"crossref","first-page":"e40938","DOI":"10.1371\/journal.pone.0040938","article-title":"MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs","volume":"7","author":"D Lu","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"ref182","first-page":"9147","article-title":"miR-25 is up-regulated in non-small cell lung cancer and promotes cell proliferation and motility by targeting FBXW7","volume":"8","author":"J Xiang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"ref183","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biopha.2013.11.004","article-title":"miR-92a\/DUSP10\/JNK signalling axis promotes human pancreatic cancer cells proliferation","volume":"68","author":"G He","year":"2014","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"ref184","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1042\/CBI20110089","article-title":"MicroRNA 17\u201392 expressed by a transposone-based vector changes expression level of cell-cycle-related genes","volume":"36","author":"M Attar","year":"2012","journal-title":"Cell Biol Int"},{"issue":"8","key":"ref185","doi-asserted-by":"crossref","first-page":"E1515","DOI":"10.1210\/jc.2012-1450","article-title":"Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells","volume":"97","author":"SC Lin","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref186","doi-asserted-by":"crossref","first-page":"e16138","DOI":"10.1371\/journal.pone.0016138","article-title":"MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC","volume":"6","author":"HI Trompeter","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"ref187","doi-asserted-by":"crossref","first-page":"12339","DOI":"10.1007\/s13277-014-2546-0","article-title":"MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2","volume":"35","author":"S Feng","year":"2014","journal-title":"Tumour Biol"},{"issue":"12","key":"ref188","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12032-014-0347-3","article-title":"MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer","volume":"31","author":"R Zhang","year":"2014","journal-title":"Med Oncol"},{"issue":"1","key":"ref189","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.gene.2015.07.002","article-title":"Downregulation of miR-363 increases drug resistance in cisplatin-treated HepG2 by dysregulating Mcl-1","volume":"572","author":"Y Ou","year":"2015","journal-title":"Gene"},{"key":"ref190","doi-asserted-by":"crossref","first-page":"10397","DOI":"10.1038\/srep10397","article-title":"miR-19b downregulates intestinal SOCS3 to reduce intestinal inflammation in Crohn&apos;s disease","volume":"5","author":"X Cheng","year":"2015","journal-title":"Sci Rep"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"17212","DOI":"10.1038\/srep17212","article-title":"The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia","volume":"5","author":"J Li","year":"2015","journal-title":"Scientific Reports"},{"issue":"9","key":"ref192","doi-asserted-by":"crossref","first-page":"e25454","DOI":"10.1371\/journal.pone.0025454","article-title":"miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase","volume":"6","author":"L Song","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"ref193","doi-asserted-by":"crossref","first-page":"e56592","DOI":"10.1371\/journal.pone.0056592","article-title":"Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer","volume":"8","author":"W Mo","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref194","doi-asserted-by":"crossref","first-page":"e57036","DOI":"10.1371\/journal.pone.0057036","article-title":"MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer","volume":"8","author":"CW Wu","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"ref195","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/onc.2011.296","article-title":"Identification of oncogenic microRNA-17-92\/ZBTB4\/specificity protein axis in breast cancer","volume":"31","author":"K Kim","year":"2012","journal-title":"Oncogene"},{"issue":"8","key":"ref196","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/iub.1051","article-title":"MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cells","volume":"64","author":"Q Wei","year":"2012","journal-title":"IUBMB Life"},{"issue":"1","key":"ref197","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuron.2016.05.034","article-title":"Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain","volume":"91","author":"J Han","year":"2016","journal-title":"Neuron"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1006623","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T18:04:44Z","timestamp":1589047484000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006623"}},"subtitle":[],"editor":[{"given":"Lin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":197,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,2,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006623","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1006623","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]}}}