{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:13:09Z","timestamp":1791846789660,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.pgen.1006820","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000}}],"reference-count":113,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50AR0608040"],"award-info":[{"award-number":["P50AR0608040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01DE015223"],"award-info":[{"award-number":["5R01DE015223"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5RC2AR058959"],"award-info":[{"award-number":["5RC2AR058959"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P01AR049084"],"award-info":[{"award-number":["5P01AR049084"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30AR053483"],"award-info":[{"award-number":["5P30AR053483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U19AI082714"],"award-info":[{"award-number":["5U19AI082714"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI056363"],"award-info":[{"award-number":["U19AI056363"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DE018209"],"award-info":[{"award-number":["1R01DE018209"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01DE018209"],"award-info":[{"award-number":["5R01DE018209"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["8P20GM103456"],"award-info":[{"award-number":["8P20GM103456"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P30GM110766"],"award-info":[{"award-number":["1P30GM110766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R03AR065786"],"award-info":[{"award-number":["1R03AR065786"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R37AI024717"],"award-info":[{"award-number":["5R37AI024717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P01AI083194"],"award-info":[{"award-number":["5P01AI083194"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["7S10RR027190-02"],"award-info":[{"award-number":["7S10RR027190-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01AI101934"],"award-info":[{"award-number":["1U01AI101934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54GM104938"],"award-info":[{"award-number":["U54GM104938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10RR026735"],"award-info":[{"award-number":["S10RR026735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30GM103510"],"award-info":[{"award-number":["5P30GM103510"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"US Department of Veterans Affairs IMMA 9"},{"DOI":"10.13039\/100000005","name":"USA Department of Defense","doi-asserted-by":"crossref","award":["PR094002"],"award-info":[{"award-number":["PR094002"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American College of Rheumatology Research and Education Foundation\/Abbott Health Professional Graduate Student Preceptorship Award 2009"},{"DOI":"10.13039\/100008907","name":"Oklahoma Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008907","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003392","name":"Sj\u00f6gren\u2019s Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Phileona Foundation"},{"name":"French ministry of health","award":["PHRC N\u00b02006-AOM06133"],"award-info":[{"award-number":["PHRC N\u00b02006-AOM06133"]}]},{"name":"French ministry of research","award":["ANR-2010-BLAN-1133"],"award-info":[{"award-number":["ANR-2010-BLAN-1133"]}]},{"name":"The Strategic Research Program at Helse Bergen, Western Norway Regional Health Authority"},{"name":"The Broegelmann Foundation"},{"DOI":"10.13039\/100009471","name":"Norwegian Foundation for Health and Rehabilitation","doi-asserted-by":"crossref","award":["KFO 250 TP03, WI 1031\/6-1, KFO 250, Z1"],"award-info":[{"award-number":["KFO 250 TP03, WI 1031\/6-1, KFO 250, Z1"]}],"id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["UK G0800629"],"award-info":[{"award-number":["UK G0800629"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The King Gustaf the V-th 80-year Foundation"},{"name":"Knut och Alice Wallenbergs Stiftelse (SE)"},{"DOI":"10.13039\/501100007949","name":"The Swedish Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006820","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T13:28:36Z","timestamp":1498138116000},"page":"e1006820","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":85,"title":["Identification of a Sj\u00f6gren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons"],"prefix":"10.1371","volume":"13","author":[{"given":"He","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove Ragna","family":"Reksten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Ice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indra","family":"Adrianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-2948","authenticated-orcid":true,"given":"Astrid","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiely M.","family":"Grundahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart B.","family":"Glenn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Miceli-Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-1351","authenticated-orcid":true,"given":"Maija-Leena","family":"Eloranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan G.","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse G.","family":"G\u00f8ransson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna","family":"Harboe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Guthridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8195-1876","authenticated-orcid":true,"given":"Kenneth M.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-8380","authenticated-orcid":true,"given":"Marika","family":"Kvarnstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3066-6693","authenticated-orcid":true,"given":"Deborah S.","family":"Cunninghame Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Darise","family":"Farris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chodosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaram","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Weisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swamy","family":"Venuturupalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly S.","family":"Hefner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen D.","family":"Houston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-9149","authenticated-orcid":true,"given":"Andrew J. W.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Radfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan S.","family":"Vista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-0886","authenticated-orcid":true,"given":"Contessa E.","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald U.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Vyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Harley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-869X","authenticated-orcid":true,"given":"Patrick M.","family":"Gaffney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Alevizos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Manuel","family":"Anaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson L.","family":"Rhodus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara M.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney G.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Hal","family":"Scofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Kovats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9403-6503","authenticated-orcid":true,"given":"Lars","family":"R\u00f6nnblom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Rischmueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-7245","authenticated-orcid":true,"given":"Marie","family":"Wahren-Herlenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roald","family":"Omdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-0260","authenticated-orcid":true,"given":"Roland","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-388X","authenticated-orcid":true,"given":"Wan-Fai","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for UK Primary Sj\u00f6gren's Syndrome Registry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-7431","authenticated-orcid":true,"given":"Gunnel","family":"Nordmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Lessard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy L.","family":"Sivils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/art.23177","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I","volume":"58","author":"CG Helmick","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"9482","key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sjogren&apos;s syndrome","volume":"366","author":"RI Fox","year":"2005","journal-title":"Lancet"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00002281-200009000-00007","article-title":"Update in Sjogren syndrome","volume":"12","author":"RI Fox","year":"2000","journal-title":"Curr Opin Rheumatol"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/art.24311","article-title":"Prevalence, severity, and predictors of fatigue in subjects with primary Sjogren&apos;s syndrome","volume":"59","author":"B Segal","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"20","key":"ref5","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1001\/archinte.165.20.2337","article-title":"The risk of lymphoma development in autoimmune diseases: a meta-analysis","volume":"165","author":"E Zintzaras","year":"2005","journal-title":"Arch Intern Med"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/ard.2005.041186","article-title":"Lymphoma and other malignancies in primary Sjogren&apos;s syndrome: a cohort study on cancer incidence and lymphoma predictors","volume":"65","author":"E Theander","year":"2006","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren&apos;s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"C Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/bjo.2003.028340","article-title":"Anti-Ro\/SSA and anti-La\/SSB autoantibodies in the tear fluid of patients with Sjogren&apos;s syndrome","volume":"88","author":"E Toker","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.autrev.2010.09.001","article-title":"The meaning of anti-Ro and anti-La antibodies in primary Sjogren&apos;s syndrome","volume":"10","author":"G Hernandez-Molina","year":"2011","journal-title":"Autoimmun Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jaut.2013.11.001","article-title":"A comprehensive review of autoantibodies in primary Sjogren&apos;s syndrome: clinical phenotypes and regulatory mechanisms","volume":"51","author":"NC Kyriakidis","year":"2014","journal-title":"J Autoimmun"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/art.20254","article-title":"Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG","volume":"50","author":"T Lovgren","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/art.20998","article-title":"Activation of the type I interferon system in primary Sjogren&apos;s syndrome: a possible etiopathogenic mechanism","volume":"52","author":"U Bave","year":"2005","journal-title":"Arthritis Rheumatol"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1002\/art.38082","article-title":"Contrasting mechanisms of interferon-alpha inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists","volume":"65","author":"AE Wiedeman","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nrrheum.2013.110","article-title":"Advances in understanding the pathogenesis of primary Sjogren&apos;s syndrome","volume":"9","author":"G Nocturne","year":"2013","journal-title":"Nat Rev Rheumatol"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren&apos;s syndrome","volume":"45","author":"CJ Lessard","year":"2013","journal-title":"Nat Genet"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ng.2779","article-title":"A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren&apos;s syndrome at 7q11.23","volume":"45","author":"Y Li","year":"2013","journal-title":"Nat Genet"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2249.2005.02827.x","article-title":"Viruses contribute to the development of Sjogren&apos;s syndrome","volume":"141","author":"P Youinou","year":"2005","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/BOR.0b013e32836200d2","article-title":"Autoimmunity and infection in Sjogren&apos;s syndrome","volume":"25","author":"A Igoe","year":"2013","journal-title":"Curr Opin Rheumatol"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrrheum.2010.118","article-title":"Pathogenetic mechanisms in the initiation and perpetuation of Sjogren&apos;s syndrome","volume":"6","author":"M Voulgarelis","year":"2010","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1002\/art.39214","article-title":"Prediction of Sjogren&apos;s Syndrome Years Before Diagnosis and Identification of Patients With Early Onset and Severe Disease Course by Autoantibody Profiling","volume":"67","author":"E Theander","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/08916930500484849","article-title":"Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus","volume":"39","author":"BD Poole","year":"2006","journal-title":"Autoimmunity"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00296-012-2504-3","article-title":"EBV reactivation serological profile in primary Sjogren&apos;s syndrome: an underlying trigger of active articular involvement?","volume":"33","author":"SG Pasoto","year":"2013","journal-title":"Rheumatol Int"},{"key":"ref23","article-title":"Long interspersed nuclear element-1 retroelements are expressed in patients with systemic autoimmune disease and induce type I interferon","author":"CP Mavragani","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/rheumatology\/kep149","article-title":"Cytokine and autoantibody profiling related to histopathological features in primary Sjogren&apos;s syndrome","volume":"48","author":"TR Reksten","year":"2009","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"LB Ivashkiv","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"Suppl 1","key":"ref26","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/ar2886","article-title":"Type I interferon in organ-targeted autoimmune and inflammatory diseases","volume":"12","author":"MK Crow","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/BOR.0b013e32835c7e32","article-title":"The interferon signature in autoimmune diseases","volume":"25","author":"L Ronnblom","year":"2013","journal-title":"Curr Opin Rheumatol"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/ard.2006.063412","article-title":"Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients","volume":"66","author":"TC van der Pouw Kraan","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar2912","article-title":"Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment","volume":"12","author":"LG van Baarsen","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"R95","DOI":"10.1186\/ar3819","article-title":"The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients","volume":"14","author":"HG Raterman","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0337679100","article-title":"Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus","volume":"100","author":"EC Baechler","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"e491","DOI":"10.1371\/journal.pmed.0030491","article-title":"Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus","volume":"3","author":"JW Bauer","year":"2006","journal-title":"PLoS Med"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e32832e089e","article-title":"Type I interferon and lupus","volume":"21","author":"L Ronnblom","year":"2009","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/gene.2009.20","article-title":"Peripheral blood gene expression profiling in Sjogren&apos;s syndrome","volume":"10","author":"ES Emamian","year":"2009","journal-title":"Genes & Immunity"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1073\/pnas.0510837103","article-title":"Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren&apos;s syndrome","volume":"103","author":"JE Gottenberg","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/art.21006","article-title":"Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren&apos;s syndrome patients from healthy control subjects","volume":"52","author":"TO Hjelmervik","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jaut.2009.05.001","article-title":"Gene expression and chromosomal location for susceptibility to Sjogren&apos;s syndrome","volume":"33","author":"P Perez","year":"2009","journal-title":"J Autoimmun"},{"key":"ref38","first-page":"290","article-title":"Interferons in Sjogren&apos;s Syndrome: Genes, Mechanisms, and Effects","volume":"4","author":"H Li","year":"2013","journal-title":"Front Immunol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ng.81","article-title":"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci","volume":"40","author":"JB Harley","year":"2008","journal-title":"Nat Genet"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.ajhg.2012.02.023","article-title":"Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study","volume":"90","author":"CJ Lessard","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/ng.582","article-title":"Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci","volume":"42","author":"EA Stahl","year":"2010","journal-title":"Nat Genet"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1002\/art.23142","article-title":"Association of an IRF5 gene functional polymorphism with Sjogren&apos;s syndrome","volume":"56","author":"C Miceli-Richard","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/gene.2008.94","article-title":"Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjogren&apos;s syndrome","volume":"10","author":"G Nordmark","year":"2009","journal-title":"Genes & Immunity"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1073\/pnas.0911193107","article-title":"Critical role of IRF-5 in regulation of B-cell differentiation","volume":"107","author":"C Lien","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.4049\/jimmunol.1000114","article-title":"NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication","volume":"185","author":"J Wang","year":"2010","journal-title":"J Immunol"},{"issue":"23","key":"ref46","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"LA Hindorff","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","first-page":"232","article-title":"Mapping novel pathways in cardiovascular disease using eQTL data: the past, present, and future of gene expression analysis","volume":"3","author":"RM Gupta","year":"2012","journal-title":"Front Genet"},{"issue":"7414","key":"ref48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"issue":"7","key":"ref49","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1053\/j.gastro.2013.03.001","article-title":"Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine","volume":"144","author":"B Kabakchiev","year":"2013","journal-title":"Gastroenterology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e459","DOI":"10.1038\/tp.2014.96","article-title":"A meta-analysis of gene expression quantitative trait loci in brain","volume":"4","author":"Y Kim","year":"2014","journal-title":"Transl Psychiatry"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1086\/429391","article-title":"Variation in antiviral 2&apos;,5&apos;-oligoadenylate synthetase (2&apos;5&apos;AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene","volume":"76","author":"V Bonnevie-Nielsen","year":"2005","journal-title":"Am J Hum Genet"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"WJ Kent","year":"2002","journal-title":"Genome Res"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1534\/genetics.114.167908","article-title":"Identifying causal variants at loci with multiple signals of association","volume":"198","author":"F Hormozdiari","year":"2014","journal-title":"Genetics"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2121-15-33","article-title":"Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism","volume":"15","author":"KH Kjaer","year":"2014","journal-title":"BMC Cell Biol"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1101\/gr.111211.110","article-title":"RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression","volume":"21","author":"E Lalonde","year":"2011","journal-title":"Genome Res"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.humimm.2012.11.011","article-title":"Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells","volume":"74","author":"S Noguchi","year":"2013","journal-title":"Hum Immunol"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"C Trapnell","year":"2009","journal-title":"Bioinformatics"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"C Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00439-011-1053-2","article-title":"Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis","volume":"131","author":"R Cagliani","year":"2012","journal-title":"Hum Genet"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"e1000321","DOI":"10.1371\/journal.ppat.1000321","article-title":"Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man","volume":"5","author":"JK Lim","year":"2009","journal-title":"PLoS Pathog"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10238-012-0193-6","article-title":"Evaluate the relationship between polymorphisms of OAS1 gene and susceptibility to chronic hepatitis C with high resolution melting analysis","volume":"13","author":"Y Zhao","year":"2013","journal-title":"Clin Exp Med"},{"issue":"6\u20137","key":"ref62","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.biochi.2007.02.003","article-title":"The human 2&apos;-5&apos;oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2&apos;-5&apos; instead of 3&apos;-5&apos; phosphodiester bond formation","volume":"89","author":"AG Hovanessian","year":"2007","journal-title":"Biochimie"},{"issue":"5\u20136","key":"ref63","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cytogfr.2007.06.012","article-title":"A scientific journey through the 2-5A\/RNase L system","volume":"18","author":"RH Silverman","year":"2007","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6259","key":"ref64","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.aac7442","article-title":"The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression","volume":"350","author":"T Hung","year":"2015","journal-title":"Science"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"12","DOI":"10.20411\/pai.v1i1.72","article-title":"Hepatitis Delta Virus Detected in Salivary Glands of Sjogren&apos;s Syndrome Patients and Recapitulates a Sjogren&apos;s Syndrome-Like Phenotype in Vivo","volume":"1","author":"ML Weller","year":"2016","journal-title":"Pathog Immun"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3892\/etm.2016.3267","article-title":"Epitope spreading induced by immunization with synthetic SSB peptides","volume":"12","author":"M Ding","year":"2016","journal-title":"Exp Ther Med"},{"issue":"11","key":"ref67","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.4049\/jimmunol.168.11.5876","article-title":"HLA class II influences the immune response and antibody diversification to Ro60\/Sjogren&apos;s syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules","volume":"168","author":"T Paisansinsup","year":"2002","journal-title":"J Immunol"},{"issue":"1\u20132","key":"ref68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2014.02.004","article-title":"T cell epitope mimicry between Sjogren&apos;s syndrome Antigen A (SSA)\/Ro60 and oral, gut, skin and vaginal bacteria","volume":"152","author":"A Szymula","year":"2014","journal-title":"Clin Immunol"},{"issue":"27","key":"ref69","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1056\/NEJM199912303412707","article-title":"Molecular mimicry and autoimmunity","volume":"341","author":"LJ Albert","year":"1999","journal-title":"N Engl J Med"},{"issue":"11","key":"ref70","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/PL00000644","article-title":"Gene structure and function of the 2&apos;-5&apos;-oligoadenylate synthetase family","volume":"57","author":"J Justesen","year":"2000","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"ref71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/vim.2013.0107","article-title":"Correlation of OAS1 gene polymorphism at exon 7 splice accepter site with interferon-based therapy of HCV infection in Pakistan","volume":"27","author":"M Imran","year":"2014","journal-title":"Viral Immunol"},{"issue":"9","key":"ref72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/vim.2015.0041","article-title":"Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients","volume":"28","author":"NG Bader El Din","year":"2015","journal-title":"Viral Immunol"},{"issue":"52","key":"ref73","doi-asserted-by":"crossref","first-page":"33220","DOI":"10.1074\/jbc.272.52.33220","article-title":"Enzymatic activity of 2&apos;-5&apos;-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein","volume":"272","author":"A Ghosh","year":"1997","journal-title":"J Biol Chem"},{"issue":"35","key":"ref74","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1038\/sj.onc.1208698","article-title":"The 2,5 oligoadenylate synthetase\/RNaseL pathway is a novel effector of BRCA1- and interferon-gamma-mediated apoptosis","volume":"24","author":"PB Mullan","year":"2005","journal-title":"Oncogene"},{"issue":"27","key":"ref75","doi-asserted-by":"crossref","first-page":"25447","DOI":"10.1074\/jbc.M100496200","article-title":"A specific isozyme of 2&apos;-5&apos; oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family","volume":"276","author":"A Ghosh","year":"2001","journal-title":"J Biol Chem"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbrc.2011.12.010","article-title":"SS-A\/Ro52 promotes apoptosis by regulating Bcl-2 production","volume":"417","author":"SN Jauharoh","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref77","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1067\/mlc.2002.120648","article-title":"Regulation of apoptotic cell death by cytokines in a human salivary gland cell line: distinct and synergistic mechanisms in apoptosis induced by tumor necrosis factor alpha and interferon gamma","volume":"139","author":"M Kamachi","year":"2002","journal-title":"J Lab Clin Med"},{"issue":"5","key":"ref78","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0022-2836(03)00055-X","article-title":"Differential action of natural selection on the N and C-terminal domains of 2&apos;-5&apos; oligoadenylate synthetases and the potential nuclease function of the C-terminal domain","volume":"326","author":"IB Rogozin","year":"2003","journal-title":"J Mol Biol"},{"issue":"5","key":"ref79","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1212\/WNL.0b013e3181ebdd2b","article-title":"OAS1: a multiple sclerosis susceptibility gene that influences disease severity","volume":"75","author":"M O'Brien","year":"2010","journal-title":"Neurology"},{"issue":"6","key":"ref80","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","year":"2013","journal-title":"Nat Genet"},{"issue":"5","key":"ref81","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.2337\/diabetes.54.5.1588","article-title":"OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes","volume":"54","author":"LL Field","year":"2005","journal-title":"Diabetes"},{"key":"ref82","article-title":"Interleukin 12 Is Involved in an Interferon Type I Signature Through Crosstalk of CD4+ T Cells and Plasmacytoid Dendritic Cells","volume":"64","author":"C Miceli-Richard","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"11","key":"ref83","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.4049\/jimmunol.157.11.4781","article-title":"Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation","volume":"157","author":"SS Cho","year":"1996","journal-title":"J Immunol"},{"issue":"5589","key":"ref84","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1126\/science.1074900","article-title":"Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection","volume":"297","author":"KB Nguyen","year":"2002","journal-title":"Science"},{"issue":"12","key":"ref85","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.4049\/jimmunol.165.12.6803","article-title":"Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways","volume":"165","author":"VA Lawless","year":"2000","journal-title":"J Immunol"},{"issue":"26","key":"ref86","doi-asserted-by":"crossref","first-page":"23382","DOI":"10.1074\/jbc.M101216200","article-title":"Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes","volume":"276","author":"BJ Barnes","year":"2001","journal-title":"J Biol Chem"},{"issue":"10","key":"ref87","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"H-J Westra","year":"2013","journal-title":"Nat Genet"},{"issue":"7289","key":"ref88","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature08872","article-title":"Understanding mechanisms underlying human gene expression variation with RNA sequencing","volume":"464","author":"JK Pickrell","year":"2010","journal-title":"Nature"},{"issue":"6175","key":"ref89","doi-asserted-by":"crossref","first-page":"1246949","DOI":"10.1126\/science.1246949","article-title":"Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression","volume":"343","author":"BP Fairfax","year":"2014","journal-title":"Science"},{"issue":"1","key":"ref90","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/annrheumdis-2013-203845","article-title":"Comparison of the American-European Consensus Group Sjogren&apos;s syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort","volume":"73","author":"A Rasmussen","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"ref91","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"3","key":"ref92","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/bioinformatics\/btn647","article-title":"arrayQualityMetrics\u2014a bioconductor package for quality assessment of microarray data","volume":"25","author":"A Kauffmann","year":"2009","journal-title":"Bioinformatics"},{"issue":"3","key":"ref93","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1093\/nar\/gkp942","article-title":"A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data","volume":"38","author":"NL Barbosa-Morais","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref94","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"RA Irizarry","year":"2003","journal-title":"Biostatistics"},{"issue":"1","key":"ref95","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"WE Johnson","year":"2007","journal-title":"Biostatistics"},{"issue":"9","key":"ref96","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software","volume":"20","author":"MJ de Hoon","year":"2004","journal-title":"Bioinformatics"},{"issue":"17","key":"ref97","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","article-title":"Java Treeview\u2014extensible visualization of microarray data","volume":"20","author":"AJ Saldanha","year":"2004","journal-title":"Bioinformatics"},{"issue":"7164","key":"ref98","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature06258","article-title":"A second generation human haplotype map of over 3.1 million SNPs","volume":"449","author":"KA Frazer","year":"2007","journal-title":"Nature"},{"issue":"6","key":"ref99","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"BN Howie","year":"2009","journal-title":"PLoS Genet"},{"issue":"1","key":"ref100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/gm124","article-title":"The 1000 Genomes Project: new opportunities for research and social challenges","volume":"2","author":"M Via","year":"2010","journal-title":"Genome Med"},{"issue":"8","key":"ref101","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"issue":"Pt 2","key":"ref102","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1469-1809.2000.6420171.x","article-title":"Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African-American populations","volume":"64","author":"PM McKeigue","year":"2000","journal-title":"Ann Hum Genet"},{"issue":"5","key":"ref103","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/humu.20695","article-title":"A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications","volume":"29","author":"I Halder","year":"2008","journal-title":"Hum Mutat"},{"issue":"2","key":"ref104","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1207\/s15327906mbr0102_10","article-title":"The Scree test for the number of factors","volume":"1","author":"RB Cattell","year":"1966","journal-title":"Multivariate Behav Res"},{"issue":"17","key":"ref105","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"CJ Willer","year":"2010","journal-title":"Bioinformatics"},{"issue":"2","key":"ref106","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"10","key":"ref107","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","article-title":"Matrix eQTL: ultra fast eQTL analysis via large matrix operations","volume":"28","author":"AA Shabalin","year":"2012","journal-title":"Bioinformatics"},{"issue":"5","key":"ref108","doi-asserted-by":"crossref","first-page":"e1000770","DOI":"10.1371\/journal.pcbi.1000770","article-title":"A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies","volume":"6","author":"O Stegle","year":"2010","journal-title":"PLoS Comput Biol"},{"issue":"10","key":"ref109","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"S Anders","year":"2010","journal-title":"Genome Biol"},{"issue":"2","key":"ref110","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"H Thorvaldsdottir","year":"2013","journal-title":"Brief Bioinform"},{"issue":"4","key":"ref111","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/ar1208","article-title":"Lymphopenia and autoimmune diseases","volume":"6","author":"H Schulze-Koops","year":"2004","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"ref112","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1182\/blood-2008-12-192120","article-title":"Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development","volume":"114","author":"A Le Campion","year":"2009","journal-title":"Blood"},{"issue":"7","key":"ref113","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ni.2319","article-title":"TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation","volume":"13","author":"N Zhang","year":"2012","journal-title":"Nat Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1006820","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T18:50:04Z","timestamp":1719255004000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006820"}},"subtitle":[],"editor":[{"given":"Gosia","family":"Trynka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":113,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006820","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]}}}