{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:44:39Z","timestamp":1778942679404,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pgen.1006936","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000}}],"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15PRE24480130"],"award-info":[{"award-number":["15PRE24480130"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY011298"],"award-info":[{"award-number":["R01EY011298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY017168"],"award-info":[{"award-number":["R01EY017168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006936","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T14:15:24Z","timestamp":1501251324000},"page":"e1006936","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Nuclear\/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7689-3496","authenticated-orcid":true,"given":"Charles Anthony","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Autumn N.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Rebagliati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-7715","authenticated-orcid":true,"given":"Xitiz","family":"Chamling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8108-8782","authenticated-orcid":true,"given":"Charles C.","family":"Searby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Baye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-0835","authenticated-orcid":true,"given":"Val C.","family":"Sheffield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane C.","family":"Slusarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"issue":"5","key":"ref1","first-page":"667","article-title":"Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer&apos;s vesicle cilia function","volume":"15","author":"H-J Yen","year":"2006","journal-title":"HumMolGenet"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2007.03.053","article-title":"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis","volume":"129","author":"MV Nachury","year":"2007","journal-title":"Cell"},{"issue":"19","key":"ref3","first-page":"3858","article-title":"Bardet\u2014Biedl syndrome proteins control the cilia length through regulation of actin polymerization","volume":"22","author":"V Hernandez-Hernandez","year":"2013","journal-title":"HumMolGenet"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/79116","article-title":"Mutations in MKKS cause Bardet-Biedl syndrome","volume":"26","author":"AM Slavotinek","year":"2000","journal-title":"Nature genetics"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ajmg.a.30406","article-title":"Clinical and genetic epidemiology of Bardet\u2014Biedl syndrome in Newfoundland: A 22-year prospective, population-based, cohort study","volume":"132A","author":"SJ Moore","year":"2005","journal-title":"American Journal of Medical Genetics Part A"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/humu.21480","article-title":"BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition","volume":"32","author":"C Deveault","year":"2011","journal-title":"Human mutation"},{"issue":"0","key":"ref7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.visres.2012.08.005","article-title":"Phenotypic expression of Bardet\u2014Biedl syndrome in patients homozygous for the common M390R mutation in the BBS1 gene","volume":"75","author":"KF Cox","year":"2012","journal-title":"Vision Res"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"e1005890","DOI":"10.1371\/journal.pgen.1005890","article-title":"The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane","volume":"12","author":"D-F Guo","year":"2016","journal-title":"PLoS Genet"},{"key":"ref9","article-title":"Mutations in C8ORF37 cause Bardet Biedl syndrome (BBS21)","author":"E Heon","year":"2016","journal-title":"HumMolGenet"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ng1771","article-title":"BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus","volume":"38","author":"C Stoetzel","year":"2006","journal-title":"Nature genetics"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1073\/pnas.0910268107","article-title":"BBS6, BBS10, and BBS12 form a complex with CCT\/TRiC family chaperonins and mediate BBSome assembly","volume":"107","author":"S Seo","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00439-002-0733-3","article-title":"Mutation analysis of the MKKS gene in McKusick-Kaufman syndrome and selected Bardet-Biedl syndrome patients","volume":"110","author":"A Slavotinek","year":"2002","journal-title":"Human genetics"},{"key":"ref13","unstructured":"Slavotinek AM. McKusick-Kaufman syndrome. 1993."},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/75637","article-title":"Mutation of a gene encoding a putative chaperonin causes McKusick-Kaufman syndrome","volume":"25","author":"DL Stone","year":"2000","journal-title":"Nature genetics"},{"issue":"23","key":"ref15","first-page":"3796","article-title":"CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium","volume":"17","author":"J Kim","year":"2008","journal-title":"HumMolGenet"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.devcel.2008.11.001","article-title":"A BBSome subunit links ciliogenesis, microtubule stability, and acetylation","volume":"15","author":"AV Loktev","year":"2008","journal-title":"Developmental cell"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrg2717","article-title":"Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait","volume":"11","author":"AF Wright","year":"2010","journal-title":"Nature Reviews Genetics"},{"issue":"13","key":"ref18","first-page":"1956","article-title":"Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning","volume":"17","author":"MK Tayeh","year":"2008","journal-title":"HumMolGenet"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ydbio.2014.05.020","article-title":"Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms","volume":"392","author":"X Mei","year":"2014","journal-title":"Dev Biol"},{"issue":"8","key":"ref20","first-page":"1467","article-title":"The N-terminal region of centrosomal protein 290 (CEP290) restores vision in a zebrafish model of human blindness","volume":"20","author":"LM Baye","year":"2011","journal-title":"HumMolGenet"},{"issue":"8","key":"ref21","first-page":"1625","article-title":"Functional analysis of BBS3 A89V that results in non-syndromic retinal degeneration","volume":"20","author":"PR Pretorius","year":"2011","journal-title":"HumMolGenet"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"e1000884","DOI":"10.1371\/journal.pgen.1000884","article-title":"Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform","volume":"6","author":"PR Pretorius","year":"2010","journal-title":"PLoS genetics"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1242\/dev.01663","article-title":"Kupffer&apos;s vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut","volume":"132","author":"JJ Essner","year":"2005","journal-title":"Development (09501991)"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1074-5521(97)90257-X","article-title":"Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA","volume":"4","author":"B Wolff","year":"1997","journal-title":"Chemistry & biology"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1091\/mbc.E07-07-0631","article-title":"MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination","volume":"19","author":"S Hirayama","year":"2008","journal-title":"Molecular biology of the cell"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.carpath.2013.09.003","article-title":"SWI\/SNF chromatin-remodeling complexes in cardiovascular development and disease","volume":"23","author":"A Bevilacqua","year":"2014","journal-title":"Cardiovascular Pathology"},{"issue":"1","key":"ref27","first-page":"136","article-title":"SRG3, a core component of mouse SWI\/SNF complex, is essential for extra-embryonic vascular development","volume":"315","author":"D Han","year":"2008","journal-title":"DevBiol"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"e109493","DOI":"10.1371\/journal.pone.0109493","article-title":"BAF200 Is Required for Heart Morphogenesis and Coronary Artery Development","volume":"9","author":"L He","year":"2014","journal-title":"PLoS ONE"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.devcel.2013.04.005","article-title":"Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness","volume":"25","author":"C Tuoc Tran","year":"2013","journal-title":"Developmental Cell"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.4161\/epi.6.12.18492","article-title":"Identification of a core member of the SWI\/SNF complex, BAF155\/SMARCC1, as a human tumor suppressor gene","volume":"6","author":"J DelBove","year":"2011","journal-title":"Epigenetics"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/2045-3701-2-30","article-title":"The nuclear localization of SWI\/SNF proteins is subjected to oxygen regulation","volume":"2","author":"RG Dastidar","year":"2012","journal-title":"Cell & bioscience"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"C913","DOI":"10.1152\/ajpcell.00481.2010","article-title":"Hypoxia elicits broad and systematic changes in protein subcellular localization","volume":"301","author":"RM Henke","year":"2011","journal-title":"American Journal of Physiology-Cell Physiology"},{"issue":"22","key":"ref33","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.1128\/MCB.21.22.7787-7795.2001","article-title":"Srg3, a Mouse Homolog of Yeast SWI3, Is Essential for Early Embryogenesis and Involved in Brain Development","volume":"21","author":"JK Kim","year":"2001","journal-title":"Molecular and Cellular Biology"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1242\/dev.131961","article-title":"The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo","volume":"143","author":"M Panamarova","year":"2016","journal-title":"Development"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/dneu.22142","article-title":"A Unique Missense Allele of BAF155, a Core BAF Chromatin Remodeling Complex Protein, Causes Neural Tube Closure Defects in Mice","volume":"74","author":"L Harmacek","year":"2014","journal-title":"Developmental neurobiology"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S096719940600400X","article-title":"Expression of SRG3, a chromatin-remodelling factor, in the mouse oocyte and early preimplantation embryos","volume":"15","author":"F Sun","year":"2007","journal-title":"Zygote"},{"issue":"3","key":"ref37","first-page":"274","article-title":"Purification of hearts from zebrafish embryos","volume":"40","author":"CG Burns","year":"2006","journal-title":"Biotechniques"},{"issue":"suppl 2","key":"ref38","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"B Zhang","year":"2005","journal-title":"Nucleic acids research"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1038\/srep41043","article-title":"Isl2b regulates anterior second heart field development in zebrafish","volume":"7","author":"HR Witzel","year":"2017","journal-title":"Scientific Reports"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1152\/physiolgenomics.00015.2010","article-title":"Evolution of the nuclear-encoded cytochrome oxidase subunits in vertebrates","volume":"42","author":"AG Little","year":"2010","journal-title":"Physiological genomics"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nchembio.1481","article-title":"Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39","volume":"10","author":"F Bassilana","year":"2014","journal-title":"Nature chemical biology"},{"issue":"2","key":"ref42","first-page":"247","article-title":"Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development","volume":"406","author":"M Roux","year":"2015","journal-title":"DevBiol"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/jcdd1010003","article-title":"Anterior Hox Genes in Cardiac Development and Great Artery Patterning","volume":"1","author":"B Laforest","year":"2014","journal-title":"Journal of Cardiovascular Development and Disease"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/zeb.2015.1117","article-title":"Retinoic Acid Signaling Is Essential for Valvulogenesis by Affecting Endocardial Cushions Formation in Zebrafish Embryos","volume":"13","author":"J Li","year":"2016","journal-title":"Zebrafish"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbagrm.2014.05.030","article-title":"ZebRA: An overview of retinoic acid signaling during zebrafish development","volume":"1849","author":"E Samarut","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms"},{"issue":"32","key":"ref46","doi-asserted-by":"crossref","first-page":"28533","DOI":"10.1074\/jbc.M111.244327","article-title":"Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish","volume":"286","author":"S Huang","year":"2011","journal-title":"Journal of Biological Chemistry"},{"issue":"6884","key":"ref47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature744","article-title":"Extensive and divergent circadian gene expression in liver and heart","volume":"417","author":"K-F Storch","year":"2002","journal-title":"Nature"},{"key":"ref48","first-page":"397","article-title":"Uncovering the Molecular and Cellular Mechanisms of Heart Development Using the Zebrafish.(Report)","volume":"46","author":"D Staudt","year":"2012","journal-title":"AnnuRevGenet"},{"issue":"6","key":"ref49","first-page":"1140","article-title":"Gene network and familial analyses uncover a gene network involving Tbx5\/Osr1\/Pcsk6 interaction in the second heart field for atrial septation","volume":"25","author":"KK Zhang","year":"2016","journal-title":"HumMolGenet"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1086\/504393","article-title":"DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia\/cardiomyopathy","volume":"79","author":"MM Awad","year":"2006","journal-title":"The American Journal of Human Genetics"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"e1215","DOI":"10.1038\/cddis.2014.181","article-title":"Simultaneous loss of phospholipase C\u03b41 and phospholipase C\u03b43 causes cardiomyocyte apoptosis and cardiomyopathy","volume":"5","author":"Y Nakamura","year":"2014","journal-title":"Cell death & disease"},{"issue":"19","key":"ref52","first-page":"5087","article-title":"Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo","volume":"23","author":"SD Vincent","year":"2014","journal-title":"HumMolGenet"},{"issue":"6958","key":"ref53","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature02028","article-title":"The Wnt\/\u03b2-catenin pathway regulates cardiac valve formation","volume":"425","author":"AF Hurlstone","year":"2003","journal-title":"Nature"},{"issue":"6","key":"ref54","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.celrep.2016.10.027","article-title":"Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells","volume":"17","author":"S Grainger","year":"2016","journal-title":"Cell Reports"},{"issue":"1","key":"ref55","first-page":"35","article-title":"Frzb modulates Wnt-9a-mediated \u03b2-catenin signaling during avian atrioventricular cardiac cushion development","volume":"278","author":"AD Person","year":"2005","journal-title":"DevBiol"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.devcel.2013.01.026","article-title":"Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry","volume":"24","author":"J Veerkamp","year":"2013","journal-title":"Developmental cell"},{"issue":"35","key":"ref57","doi-asserted-by":"crossref","first-page":"14035","DOI":"10.1073\/pnas.1210730109","article-title":"Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development","volume":"109","author":"K Lage","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6265","key":"ref58","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.aac9396","article-title":"De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies","volume":"350","author":"J Homsy","year":"2015","journal-title":"Science"},{"issue":"22","key":"ref59","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.1128\/MCB.21.22.7787-7795.2001","article-title":"Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development","volume":"21","author":"JK Kim","year":"2001","journal-title":"Molecular and cellular biology"},{"issue":"02","key":"ref60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S096719940600400X","article-title":"Expression of SRG3, a chromatin-remodelling factor, in the mouse oocyte and early preimplantation embryos","volume":"15","author":"F Sun","year":"2007","journal-title":"Zygote"},{"key":"ref61","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","author":"M Lek","year":"2015","journal-title":"bioRxiv"},{"issue":"3","key":"ref62","first-page":"208","article-title":"Phenotypic overlap of McKusick\u2010Kaufman syndrome with Bardet\u2010Biedl syndrome: A literature review","volume":"95","author":"AM Slavotinek","year":"2000","journal-title":"AmJMedGenet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-387786-4.00002-6","article-title":"2 The Second Heart Field","volume":"100","author":"RG Kelly","year":"2012","journal-title":"Current topics in developmental biology"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1741-4520.2009.00267.x","article-title":"Second lineage of heart forming region provides new understanding of conotruncal heart defects","volume":"50","author":"Y Nakajima","year":"2010","journal-title":"Congenital anomalies"},{"issue":"1","key":"ref65","first-page":"72","article-title":"Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia","volume":"284","author":"C Ward","year":"2005","journal-title":"DevBiol"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ncb2450","article-title":"A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia","volume":"14","author":"HL Kee","year":"2012","journal-title":"Nature cell biology"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.cell.2016.01.034","article-title":"The nuclear pore complex as a flexible and dynamic gate","volume":"164","author":"KE Knockenhauer","year":"2016","journal-title":"Cell"},{"issue":"7","key":"ref68","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/embor.2012.73","article-title":"The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization","volume":"13","author":"JF Reiter","year":"2012","journal-title":"EMBO reports"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2046-2530-2-11","article-title":"Molecular connections between nuclear and ciliary import processes","volume":"2","author":"HL Kee","year":"2013","journal-title":"Cilia"},{"issue":"Pt 5","key":"ref70","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1242\/jcs.070839","article-title":"Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2","volume":"124","author":"TW Hurd","year":"2011","journal-title":"J Cell Sci"},{"issue":"24","key":"ref71","doi-asserted-by":"crossref","first-page":"20625","DOI":"10.1074\/jbc.M112.341487","article-title":"Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable Bardet-Biedl syndrome protein complex, the BBSome","volume":"287","author":"Q Zhang","year":"2012","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"ref72","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/dev.004713","article-title":"Calcium fluxes in dorsal forerunner cells antagonize \u03b2-catenin and alter left-right patterning","volume":"135","author":"I Schneider","year":"2008","journal-title":"Development"},{"issue":"6121","key":"ref73","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1232033","article-title":"RNA-guided human genome engineering via Cas9","volume":"339","author":"P Mali","year":"2013","journal-title":"Science"},{"key":"ref74","article-title":"Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors","author":"J Hu","year":"2014","journal-title":"Nucleic acids research"},{"issue":"3","key":"ref75","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nbt.2808","article-title":"Improving CRISPR-Cas nuclease specificity using truncated guide RNAs","volume":"32","author":"Y Fu","year":"2014","journal-title":"Nature biotechnology"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1006936","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T16:53:26Z","timestamp":1539968006000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006936"}},"subtitle":[],"editor":[{"given":"Gregory S.","family":"Barsh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":75,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006936","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1006936","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}