{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:55:36Z","timestamp":1784660136173,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1006951","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Ki728\/9-1"],"award-info":[{"award-number":["Ki728\/9-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1006951","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T18:17:54Z","timestamp":1502389074000},"page":"e1006951","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-0979","authenticated-orcid":true,"given":"Tobias","family":"Bohnenpoll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna B.","family":"Wittern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-4560","authenticated-orcid":true,"given":"Tamrat M.","family":"Mamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Carina","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Rudat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4626-3300","authenticated-orcid":true,"given":"Marc-Jens","family":"Kleppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Schuster-Gossler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Wojahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo H.-W.","family":"L\u00fcdtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark-Oliver","family":"Trowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-0257","authenticated-orcid":true,"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"key":"ref1","article-title":"The ureter","author":"JT Velardo","year":"1981"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1083\/jcb.111.3.1207","article-title":"Uroplakin I: a 27-kD protein associated with the asymmetric unit membrane of mammalian urothelium","volume":"111","author":"J Yu","year":"1990","journal-title":"J Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.devcel.2013.07.017","article-title":"Retinoid signaling in progenitors controls specification and regeneration of the urothelium","volume":"26","author":"D Gandhi","year":"2013","journal-title":"Dev Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1681\/ASN.2016080849","article-title":"Diversification of Cell Lineages in Ureter Development","volume":"28","author":"T Bohnenpoll","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.semcdb.2014.07.014","article-title":"Ureter growth and differentiation","volume":"36","author":"T Bohnenpoll","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1242\/dev.111.1.145","article-title":"Neonatal seminal vesicle mesenchyme induces a new morphological and functional phenotype in the epithelia of adult ureter and ductus deferens","volume":"111","author":"GR Cunha","year":"1991","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/S0022-5347(01)65545-9","article-title":"Role of mesenchymal-epithelial interactions in normal bladder development","volume":"156","author":"LS Baskin","year":"1996","journal-title":"J Urol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1242\/dev.129.22.5301","article-title":"Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney","volume":"129","author":"J Yu","year":"2002","journal-title":"Development"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.juro.2008.08.117","article-title":"Antagonism of BMP4 signaling disrupts smooth muscle investment of the ureter and ureteropelvic junction","volume":"181","author":"GJ Wang","year":"2009","journal-title":"J Urol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1242\/dev.077388","article-title":"Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter","volume":"139","author":"MO Trowe","year":"2012","journal-title":"Development"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e42245","DOI":"10.1371\/journal.pone.0042245","article-title":"The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis","volume":"7","author":"R Haraguchi","year":"2012","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1242\/dev.022442","article-title":"Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4","volume":"135","author":"X Caubit","year":"2008","journal-title":"Development"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1093\/hmg\/ddq426","article-title":"Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme","volume":"19","author":"R Airik","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1242\/dev.128.24.5099","article-title":"Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation","volume":"128","author":"F Long","year":"2001","journal-title":"Development"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0960-9822(99)80018-9","article-title":"Sonic hedgehog signaling by the patched-smoothened receptor complex","volume":"9","author":"M Murone","year":"1999","journal-title":"Curr Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ydbio.2013.04.036","article-title":"Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate","volume":"380","author":"T Bohnenpoll","year":"2013","journal-title":"Dev Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1101\/gad.1190304","article-title":"Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia","volume":"18","author":"J Jeong","year":"2004","journal-title":"Genes Dev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1003189","DOI":"10.1371\/journal.pgen.1003189","article-title":"Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b","volume":"9","author":"TH Ludtke","year":"2013","journal-title":"PLoS Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"MD Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"ref20","article-title":"Use of LysoTracker to detect programmed cell death in embryos and differentiating embryonic stem cells","author":"JL Fogel","year":"2012","journal-title":"J Vis Exp"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1634\/stemcells.2007-0620","article-title":"Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules","volume":"26","author":"XJ Li","year":"2008","journal-title":"Stem Cells"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1126\/science.280.5369.1603","article-title":"Teratogen-mediated inhibition of target tissue response to Shh signaling","volume":"280","author":"MK Cooper","year":"1998","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1101\/gad.1025302","article-title":"Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened","volume":"16","author":"JK Chen","year":"2002","journal-title":"Genes Dev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"PW Ingham","year":"2001","journal-title":"Genes Dev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/17611","article-title":"Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein","volume":"397","author":"PT Chuang","year":"1999","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.124.13.2537","article-title":"Gli1 is a target of Sonic hedgehog that induces ventral neural tube development","volume":"124","author":"J Lee","year":"1997","journal-title":"Development"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1242\/dev.001966","article-title":"Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning","volume":"134","author":"SA Vokes","year":"2007","journal-title":"Development"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1101\/gad.1693008","article-title":"A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb","volume":"22","author":"SA Vokes","year":"2008","journal-title":"Genes Dev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.128.12.2397","article-title":"Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations","volume":"128","author":"M Mahlapuu","year":"2001","journal-title":"Development"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1242\/dev.02252","article-title":"Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production","volume":"133","author":"M Ormestad","year":"2006","journal-title":"Development"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1074\/jbc.M808103200","article-title":"FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine","volume":"284","author":"BB Madison","year":"2009","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/jcb.21441","article-title":"Pod1 induces myofibroblast differentiation in mesenchymal progenitor cells from mouse kidney","volume":"103","author":"M Plotkin","year":"2008","journal-title":"J Cell Biochem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1172\/JCI26027","article-title":"Tbx18 regulates the development of the ureteral mesenchyme","volume":"116","author":"R Airik","year":"2006","journal-title":"J Clin Invest"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1242\/dev.122.10.3141","article-title":"A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo","volume":"122","author":"ST Smith","year":"1996","journal-title":"Development"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"13017","DOI":"10.1073\/pnas.94.24.13017","article-title":"Siamois is required for formation of Spemann&apos;s organizer","volume":"94","author":"DS Kessler","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/326292a0","article-title":"HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells","volume":"326","author":"M Hooper","year":"1987","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e1005328","DOI":"10.1371\/journal.pgen.1005328","article-title":"Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo","volume":"11","author":"K Preusse","year":"2015","journal-title":"PLoS Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.stem.2012.05.023","article-title":"Developmental stage and time dictate the fate of Wnt\/beta-catenin-responsive stem cells in the mammary gland","volume":"11","author":"R van Amerongen","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(00)80133-6","article-title":"The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4","volume":"86","author":"LB Zimmerman","year":"1996","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1242\/dev.02220","article-title":"GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis","volume":"133","author":"MC Hu","year":"2006","journal-title":"Development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1172\/JCI45523","article-title":"GLI3 repressor controls functional development of the mouse ureter","volume":"121","author":"JE Cain","year":"2011","journal-title":"J Clin Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1242\/dev.01576","article-title":"Epithelial hedgehog signals pattern the intestinal crypt-villus axis","volume":"132","author":"BB Madison","year":"2005","journal-title":"Development"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ydbio.2011.04.025","article-title":"Hedgehog signaling controls homeostasis of adult intestinal smooth muscle","volume":"355","author":"WJ Zacharias","year":"2011","journal-title":"Dev Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/bies.10221","article-title":"How the community effect orchestrates muscle differentiation","volume":"25","author":"M Buckingham","year":"2003","journal-title":"Bioessays"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1523-1755.2003.00834.x","article-title":"Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development","volume":"63","author":"Y Miyazaki","year":"2003","journal-title":"Kidney Int"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1242\/dev.004234","article-title":"Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling","volume":"134","author":"A Brenner-Anantharam","year":"2007","journal-title":"Development"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1242\/dev.127.7.1387","article-title":"Murine forkhead\/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract","volume":"127","author":"T Kume","year":"2000","journal-title":"Development"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0022-5347(06)00616-1","article-title":"Global gene expression patterns in mouse wolffian duct development","volume":"176","author":"G Mingin","year":"2006","journal-title":"J Urol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrg2523","article-title":"The evolution of Fox genes and their role in development and disease","volume":"10","author":"S Hannenhalli","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.1073\/pnas.1310430110","article-title":"DNA-binding specificity changes in the evolution of forkhead transcription factors","volume":"110","author":"S Nakagawa","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","article-title":"BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter","author":"TM Mamo","year":"2017","journal-title":"Hum Mol Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.cub.2009.09.057","article-title":"An Hh-dependent pathway in lateral plate mesoderm enables the generation of left\/right asymmetry","volume":"19","author":"CD Tsiairis","year":"2009","journal-title":"Curr Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1242\/dev.004432","article-title":"Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4","volume":"134","author":"J Astorga","year":"2007","journal-title":"Development"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e1004604","DOI":"10.1371\/journal.pgen.1004604","article-title":"Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation","volume":"10","author":"AD Hoffmann","year":"2014","journal-title":"PLoS Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00418-016-1445-4","article-title":"Long-range enhancers modulate Foxf1 transcription in blood vessels of pulmonary vascular network","volume":"146","author":"H Seo","year":"2016","journal-title":"Histochem Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1242\/dev.02228","article-title":"The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity","volume":"133","author":"J Cayuso","year":"2006","journal-title":"Development"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"27053","DOI":"10.1074\/jbc.M303723200","article-title":"Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals","volume":"278","author":"Z Wang","year":"2003","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1256804","article-title":"Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1\/TSC2 tumor suppressor complex","volume":"18","author":"J Brugarolas","year":"2004","journal-title":"Genes Dev"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ajmg.1320070110","article-title":"Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus and postaxial polydactyly\u2014a new syndrome? Part I: clinical, causal, and pathogenetic considerations","volume":"7","author":"JG Hall","year":"1980","journal-title":"Am J Med Genet"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1681\/ASN.2006111282","article-title":"SIX2 and BMP4 mutations associate with anomalous kidney development","volume":"19","author":"S Weber","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.ajhg.2009.05.005","article-title":"Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations","volume":"84","author":"P Stankiewicz","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/humu.22313","article-title":"Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain","volume":"34","author":"P Sen","year":"2013","journal-title":"Hum Mutat"},{"key":"ref63","first-page":"919","article-title":"Congenital alveolar dysplasia of the lungs","volume":"24","author":"MH Mac","year":"1948","journal-title":"Am J Pathol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/jmg.35.1.58","article-title":"Familial persistent pulmonary hypertension of the newborn resulting from misalignment of the pulmonary vessels (congenital alveolar capillary dysplasia)","volume":"35","author":"HB Vassal","year":"1998","journal-title":"J Med Genet"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jpeds.2004.06.081","article-title":"Expanding the phenotype of alveolar capillary dysplasia (ACD)","volume":"145","author":"P Sen","year":"2004","journal-title":"J Pediatr"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/humu.22859","article-title":"Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER\/VACTERL Association","volume":"36","author":"AC Hilger","year":"2015","journal-title":"Hum Mutat"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s00467-016-3335-3","article-title":"Underlying genetic factors of the VATER\/VACTERL association with special emphasis on the &quot;Renal&quot; phenotype","volume":"31","author":"H Reutter","year":"2016","journal-title":"Pediatr Nephrol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00018-011-0884-2","article-title":"Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation","volume":"69","author":"R Singh","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ydbio.2010.03.014","article-title":"Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse","volume":"342","author":"MO Trowe","year":"2010","journal-title":"Dev Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0076-6879(93)25025-W","article-title":"Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts","volume":"225","author":"DG Wilkinson","year":"1993","journal-title":"Methods Enzymol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/002215540104900101","article-title":"Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol","volume":"49","author":"AF Moorman","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1101\/gad.300104","article-title":"The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments","volume":"18","author":"M Bussen","year":"2004","journal-title":"Genes Dev"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1006951","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T00:00:00Z","timestamp":1503360000000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1006951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:40:03Z","timestamp":1659314403000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1006951"}},"subtitle":[],"editor":[{"given":"Licia","family":"Selleri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,10]]},"references-count":72,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1006951","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1006951","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,10]]}}}