{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:45:21Z","timestamp":1782931521105,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pgen.1007048","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000}}],"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC13107"],"award-info":[{"award-number":["DC13107"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (US)","doi-asserted-by":"crossref","award":["R01 DC010856-01"],"award-info":[{"award-number":["R01 DC010856-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute on Deafness and Other Communication Disorders (US)","award":["DC000059"],"award-info":[{"award-number":["DC000059"]}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007048","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T13:37:09Z","timestamp":1508765829000},"page":"e1007048","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Role of Neuropilin-1\/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea"],"prefix":"10.1371","volume":"13","author":[{"given":"Pezhman","family":"Salehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3793-0407","authenticated-orcid":true,"given":"Marshall X.","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Gundimeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2445-3349","authenticated-orcid":true,"given":"Leah","family":"Michelle Baum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homero","family":"Lael Cantu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Lavinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-6515","authenticated-orcid":true,"given":"Litao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Myint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-1137","authenticated-orcid":true,"given":"Charlene","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1621-4965","authenticated-orcid":true,"given":"Angeliki Maria","family":"Nikolakopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Abdala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-8697","authenticated-orcid":true,"given":"Matthew William","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Matthew","family":"Coate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-4459","authenticated-orcid":true,"given":"Rick A.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/ggi.12124","article-title":"Current status of auditory aging and anti-aging research","volume":"14","author":"Q Ruan","year":"2014","journal-title":"Geriatr Gerontol Int"},{"key":"ref2","article-title":"Genetics of Deafness: Karger","author":"HT Vona B","year":"2016","journal-title":"Genetics of Deafness: Karger"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/archotol.125.6.654","article-title":"Genetic associations in age-related hearing thresholds","volume":"125","author":"GA Gates","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ejhg.2014.56","article-title":"Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment","volume":"23","author":"E Fransen","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/geno.2000.6377","article-title":"A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice","volume":"70","author":"KR Johnson","year":"2000","journal-title":"Genomics"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ygeno.2008.06.007","article-title":"A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA\/2J mice","volume":"92","author":"KR Johnson","year":"2008","journal-title":"Genomics"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.neurobiolaging.2011.05.009","article-title":"Association of a citrate synthase missense mutation with age-related hearing loss in A\/J mice","volume":"33","author":"KR Johnson","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.neurobiolaging.2007.12.011","article-title":"A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A\/J mice","volume":"30","author":"QY Zheng","year":"2009","journal-title":"Neurobiol Aging"},{"issue":"3","key":"ref9","first-page":"3335","article-title":"Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis","volume":"15","author":"Kang EY Ohmen j","year":"2014","journal-title":"J Assoc res Otolaryngol"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07830","article-title":"Neuropilin-2\/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons","volume":"4","author":"TM Coate","year":"2015","journal-title":"Elife"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0896-6273(95)90261-9","article-title":"A family of molecules related to collapsin in the embryonic chick nervous system","volume":"14","author":"Y Luo","year":"1995","journal-title":"Neuron"},{"issue":"25","key":"ref12","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1523\/JNEUROSCI.5964-11.2012","article-title":"Differing semaphorin 3A concentrations trigger distinct signaling mechanisms in growth cone collapse","volume":"32","author":"RP Manns","year":"2012","journal-title":"J Neurosci"},{"issue":"14","key":"ref13","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/dev.014902","article-title":"Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos","volume":"135","author":"EA Jones","year":"2008","journal-title":"Development"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.semcdb.2013.04.003","article-title":"Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells","volume":"24","author":"TM Coate","year":"2013","journal-title":"Semin Cell Dev Biol"},{"issue":"Pt B","key":"ref15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.heares.2015.07.015","article-title":"Cochlear afferent innervation development","volume":"330","author":"L Delacroix","year":"2015","journal-title":"Hear Res"},{"issue":"20","key":"ref16","doi-asserted-by":"crossref","first-page":"18069","DOI":"10.1074\/jbc.M201681200","article-title":"Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165","volume":"277","author":"C Gu","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1534-5807(03)00169-2","article-title":"Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development","volume":"5","author":"C Gu","year":"2003","journal-title":"Dev Cell"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00003446-199004000-00009","article-title":"The clinical utility of distortion-product otoacoustic emissions","volume":"11","author":"BL Lonsbury-Martin","year":"1990","journal-title":"Ear Hear"},{"issue":"34","key":"ref19","doi-asserted-by":"crossref","first-page":"13686","DOI":"10.1523\/JNEUROSCI.1783-13.2013","article-title":"Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline","volume":"33","author":"Y Sergeyenko","year":"2013","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"ref20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.heares.2011.01.010","article-title":"Ion flow in stria vascularis and the production and regulation of cochlear endolymph and the endolymphatic potential","volume":"277","author":"R Patuzzi","year":"2011","journal-title":"Hear Res"},{"issue":"45","key":"ref21","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding Insult to Injury: Cochlear Nerve Degeneration after \u201cTemporary\u201d Noise-Induced Hearing Loss","volume":"29","author":"SG Kujawa","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.heares.2015.04.014","article-title":"Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue","volume":"327","author":"LM Viana","year":"2015","journal-title":"Hear Res"},{"issue":"30","key":"ref23","doi-asserted-by":"crossref","first-page":"10903","DOI":"10.1523\/JNEUROSCI.2358-11.2011","article-title":"Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly","volume":"31","author":"CC Lu","year":"2011","journal-title":"J Neurosci"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/j.1460-9568.2010.07154.x","article-title":"Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns","volume":"31","author":"C Haupt","year":"2010","journal-title":"Eur J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fnana.2011.00062","article-title":"Signaling mechanisms in cortical axon growth, guidance, and branching","volume":"5","author":"K Kalil","year":"2011","journal-title":"Front Neuroanat"},{"issue":"1\u20132","key":"ref26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.heares.2011.06.002","article-title":"Auditory brainstem responses predict auditory nerve fiber thresholds and frequency selectivity in hearing impaired chinchillas","volume":"280","author":"KS Henry","year":"2011","journal-title":"Hear Res"},{"issue":"47","key":"ref27","doi-asserted-by":"crossref","first-page":"14723","DOI":"10.1073\/pnas.1515228112","article-title":"Unmyelinated type II afferent neurons report cochlear damage","volume":"112","author":"C Liu","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.semcdb.2013.01.001","article-title":"Neuropilin signalling in vessels, neurons and tumours","volume":"24","author":"C Raimondi","year":"2013","journal-title":"Semin Cell Dev Biol"},{"issue":"17","key":"ref29","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1242\/dev.063362","article-title":"VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels","volume":"138","author":"A Cariboni","year":"2011","journal-title":"Development"},{"issue":"48","key":"ref30","doi-asserted-by":"crossref","first-page":"17272","DOI":"10.1073\/pnas.1407227111","article-title":"VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions","volume":"111","author":"VH Guaiquil","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","first-page":"51","article-title":"Cochlear blood flow regulation","volume":"59","author":"P Wangemann","year":"2002","journal-title":"Adv Otorhinolaryngol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2009.02.036","article-title":"Unraveling inner ear induction by gene manipulation using Pax2-Cre BAC transgenic mice","volume":"1277","author":"T Ohyama","year":"2009","journal-title":"Brain Res"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/jnc.12964","article-title":"Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide","volume":"132","author":"U Gundimeda","year":"2015","journal-title":"Journal of neurochemistry"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbrc.2014.01.166","article-title":"Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: Role of 67-kDa laminin receptor and hydrogen peroxide","volume":"445","author":"U Gundimeda","year":"2014","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"45","key":"ref35","doi-asserted-by":"crossref","first-page":"15044","DOI":"10.1523\/JNEUROSCI.3547-10.2010","article-title":"BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea","volume":"30","author":"T Ohyama","year":"2010","journal-title":"J Neurosci"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007048","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T21:32:31Z","timestamp":1540243951000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007048"}},"subtitle":[],"editor":[{"given":"Bruce A.","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007048","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1007048","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}