{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:46:42Z","timestamp":1782791202223,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pgen.1007058","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institutes of Health-National Institution on Deafness and Other Communication Disorders (NIH-NIDCD)","doi-asserted-by":"publisher","award":["RO1 DC014105"],"award-info":[{"award-number":["RO1 DC014105"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["P30 DC011735"],"award-info":[{"award-number":["P30 DC011735"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC013807"],"award-info":[{"award-number":["DC013807"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007058","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T18:25:41Z","timestamp":1518027941000},"page":"e1007058","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Gli3 is a negative regulator of Tas1r3-expressing taste cells"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-5373","authenticated-orcid":true,"given":"Yumei","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-0342","authenticated-orcid":true,"given":"Sunil K.","family":"Sukumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Jyotaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Redding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-2887","authenticated-orcid":true,"given":"Robert F.","family":"Margolskee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/chemse\/bjn025","article-title":"Genetic Analysis of Tongue Size and Taste Papillae Number and Size in Recombinant Inbred Strains of Mice","volume":"33","author":"DJ Reiner","year":"2008","journal-title":"Chemical Senses"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002098","article-title":"FGF Signaling Regulates the Number of Posterior Taste Papillae by Controlling Progenitor Field Size","volume":"7","author":"CI Petersen","year":"2011","journal-title":"PLoS Genet"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.neuron.2014.02.022","article-title":"Peripheral Coding of Taste","volume":"81","author":"ER Liman","year":"2014","journal-title":"Neuron"},{"issue":"7117","key":"ref4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature05401","article-title":"The receptors and cells for mammalian taste","volume":"444","author":"J Chandrashekar","year":"2006","journal-title":"Nature"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.201003144","article-title":"The cell biology of taste","volume":"190","author":"N Chaudhari","year":"2010","journal-title":"Journal of Cell Biology"},{"issue":"21","key":"ref6","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1242\/dev.120394","article-title":"Progress and renewal in gustation: new insights into taste bud development","volume":"142","author":"LA Barlow","year":"2015","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/bs.ctdb.2014.11.012","article-title":"Developing and regenerating a sense of taste","volume":"111","author":"LA Barlow","year":"2015","journal-title":"Curr Top Dev Biol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.semcdb.2012.11.002","article-title":"Developing a sense of taste","volume":"24","author":"M Kapsimali","year":"2013","journal-title":"Semin Cell Dev Biol"},{"key":"ref9","first-page":"727","article-title":"Handbook of Olfaction and Gustation","author":"RF Krimm","year":"2015"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"e53399","DOI":"10.1371\/journal.pone.0053399","article-title":"Functional cell types in taste buds have distinct longevities","volume":"8","author":"I Perea-Martinez","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref11","article-title":"Defects in the Peripheral Taste Structure and Function in the MRL\/lpr Mouse Model of Autoimmune Disease","volume":"7","author":"A Kim","year":"2012","journal-title":"Plos One"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0714.2009.00823.x","article-title":"Reduction of type II taste cells correlates with taste dysfunction after X-ray irradiation in mice","volume":"39","author":"M Yamazaki","year":"2010","journal-title":"J Oral Pathol Med"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1523\/JNEUROSCI.4167-11.2012","article-title":"Mechanisms of Taste Bud Cell Loss after Head and Neck Irradiation","volume":"32","author":"HM Nguyen","year":"2012","journal-title":"J Neurosci"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2307\/3572749","article-title":"RADIATION AND AGING EFFECT ON TASTE STRUCTURE AND FUNCTION","volume":"37","author":"AD Conger","year":"1969","journal-title":"Radiation Research"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/gerona\/glr192","article-title":"Age-Related Changes in Mouse Taste Bud Morphology, Hormone Expression, and Taste Responsivity","volume":"67","author":"YK Shin","year":"2012","journal-title":"J Gerontol Ser A-Biol Sci Med Sci"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1741-2358.2007.00165.x","article-title":"Quantitative study of ageing epiglottal taste buds in humans","volume":"24","author":"M Kano","year":"2007","journal-title":"Gerodontology"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0012-1606(02)00048-9","article-title":"Disruption of Sonic hedgehog signaling alters growth and patterning of lingual taste papillae","volume":"255","author":"JMH Hall","year":"2003","journal-title":"Developmental Biology"},{"key":"ref18","first-page":"11","article-title":"Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells","author":"ZJ Cohn","year":"2010","journal-title":"BMC Neurosci"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ydbio.2013.07.022","article-title":"Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance","volume":"382","author":"HX Liu","year":"2013","journal-title":"Developmental Biology"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ydbio.2004.07.042","article-title":"Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development","volume":"276","author":"HX Liu","year":"2004","journal-title":"Developmental Biology"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/chemse\/bjh248","article-title":"A strong nerve dependence of Sonic hedgehog expression in basal cells in mouse taste bud and an autonomous transcriptional control of genes in differentiated taste cells","volume":"29","author":"H Miura","year":"2004","journal-title":"Chemical Senses"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"I50","DOI":"10.1093\/chemse\/bjh108","article-title":"Shh signaling and regulatory gene expression in mouse taste buds","volume":"30","author":"H Miura","year":"2005","journal-title":"Chemical Senses"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1679\/aohc.69.209","article-title":"Cell lineage and differentiation in taste buds","volume":"69","author":"H Miura","year":"2006","journal-title":"Archives of Histology and Cytology"},{"issue":"1\u20132","key":"ref24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0925-4773(01)00414-2","article-title":"Shh and Ptc are associated with taste bud maintenance in the adult mouse","volume":"106","author":"H Miura","year":"2001","journal-title":"Mechanisms of Development"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/dvdy.24121","article-title":"Sonic hedgehog-Expressing Basal Cells Are General Post-Mitotic Precursors of Functional Taste Receptor Cells","volume":"243","author":"H Miura","year":"2014","journal-title":"Dev Dyn"},{"key":"ref26","first-page":"34","article-title":"International Symposium on Olfaction and Taste. Annals of the New York Academy of Sciences","volume":"1170","author":"S Thirumangalathu","year":"2009"},{"issue":"15","key":"ref27","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1242\/dev.107631","article-title":"Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium","volume":"141","author":"D Castillo","year":"2014","journal-title":"Development"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1073\/pnas.0607399104","article-title":"Wnt signaling interacts with Shh to regulate taste papilla development","volume":"104","author":"K Iwatsuki","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ydbio.2008.10.034","article-title":"Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development","volume":"325","author":"JY Kim","year":"2009","journal-title":"Dev Biol"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008151","article-title":"Signaling in cell differentiation and morphogenesis","volume":"4","author":"MA Basson","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"18","key":"ref31","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1101\/gad.1951710","article-title":"Interactions between Hedgehog proteins and their binding partners come into view","volume":"24","author":"PA Beachy","year":"2010","journal-title":"Genes Dev"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/jdb4030023","article-title":"Regulation of Hedgehog Signalling Inside and Outside the Cell","volume":"4","author":"SA Ramsbottom","year":"2016","journal-title":"J Dev Biol"},{"issue":"200","key":"ref33","article-title":"Hedgehog Signaling and the Gli Code in Stem Cells, Cancer, and Metastases","volume":"4","author":"ARI Altaba","year":"2011","journal-title":"Science Signaling"},{"key":"ref34","first-page":"513","article-title":"Annual Review of Cell and Developmental Biology","volume":"27","author":"CC Hui","year":"2011"},{"issue":"21","key":"ref35","doi-asserted-by":"crossref","first-page":"9736","DOI":"10.1073\/pnas.1004602107","article-title":"Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis","volume":"107","author":"EY Lee","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1242\/dev.001966","article-title":"Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning","volume":"134","author":"SA Vokes","year":"2007","journal-title":"Development"},{"issue":"19","key":"ref37","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1101\/gad.1693008","article-title":"A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb","volume":"22","author":"SA Vokes","year":"2008","journal-title":"Genes Dev"},{"issue":"46","key":"ref38","doi-asserted-by":"crossref","first-page":"16401","DOI":"10.1073\/pnas.1409064111","article-title":"Single Lgr5- or Lgr6-expressing taste stem\/progenitor cells generate taste bud cells ex vivo","volume":"111","author":"WW Ren","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/stem.1338","article-title":"Lgr5-EGFP Marks Taste Bud Stem\/Progenitor Cells in Posterior Tongue","volume":"31","author":"KK Yee","year":"2013","journal-title":"Stem Cells"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nn.2820","article-title":"Skn-1a (Pou2f3) specifies taste receptor cell lineage","volume":"14","author":"I Matsumoto","year":"2011","journal-title":"Nat Neurosci"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.devcel.2008.11.010","article-title":"Hedgehog signaling in development and cancer","volume":"15","author":"J Jiang","year":"2008","journal-title":"Dev Cell"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.devcel.2005.12.014","article-title":"Divergence of hedgehog signal transduction mechanism between Drosophila and mammals","volume":"10","author":"M Varjosalo","year":"2006","journal-title":"Dev Cell"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"e1006442","DOI":"10.1371\/journal.pgen.1006442","article-title":"Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog\/GLI Signaling","volume":"12","author":"AN Ermilov","year":"2016","journal-title":"PLoS Genet"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng0393-241","article-title":"A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene","volume":"3","author":"CC Hui","year":"1993","journal-title":"Nat Genet"},{"issue":"14","key":"ref45","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1093\/hmg\/ddn110","article-title":"A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy","volume":"17","author":"I Matera","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/(SICI)1096-9861(19990405)406:2<143::AID-CNE1>3.0.CO;2-X","article-title":"Expression of Sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse","volume":"406","author":"JM Hall","year":"1999","journal-title":"J Comp Neurol"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1152\/jn.00822.2014","article-title":"Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation","volume":"113","author":"A Kumari","year":"2015","journal-title":"Journal of Neurophysiology"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0012-1606(02)00048-9","article-title":"Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae","volume":"255","author":"JM Hall","year":"2003","journal-title":"Dev Biol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/cam4.350","article-title":"Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds","volume":"4","author":"H Yang","year":"2015","journal-title":"Cancer Med"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2353\/ajpath.2010.091079","article-title":"Sonic Hedgehog Acts as a Negative Regulator of beta-Catenin Signaling in the Adult Tongue Epithelium","volume":"177","author":"FT Schneider","year":"2010","journal-title":"American Journal of Pathology"},{"issue":"7438","key":"ref51","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature11905","article-title":"High salt recruits aversive taste pathways","volume":"494","author":"Y Oka","year":"2013","journal-title":"Nature"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0300-9629(89)90577-X","article-title":"Behavioral discrimination between glutamate and the four basic taste substances in mice","volume":"92","author":"Y Ninomiya","year":"1989","journal-title":"Comp Biochem Physiol A Comp Physiol"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/chemse\/bjs082","article-title":"Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice","volume":"37","author":"A Voigt","year":"2012","journal-title":"Chem Senses"},{"issue":"7574","key":"ref54","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature14984","article-title":"Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration","volume":"526","author":"T Peng","year":"2015","journal-title":"Nature"},{"issue":"18","key":"ref55","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1242\/dev.083691","article-title":"Roles for Hedgehog signaling in adult organ homeostasis and repair","volume":"141","author":"R Petrova","year":"2014","journal-title":"Development"},{"issue":"13","key":"ref56","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1242\/dev.030544","article-title":"Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue","volume":"136","author":"CL Beites","year":"2009","journal-title":"Development"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng1932","article-title":"Wnt-beta-catenin signaling initiates taste papilla development","volume":"39","author":"F Liu","year":"2007","journal-title":"Nature Genet"},{"issue":"9","key":"ref58","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1002\/dvdy.21657","article-title":"Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K\/Akt, MEK\/ERK, and p38 MAPK signaling","volume":"237","author":"HX Liu","year":"2008","journal-title":"Dev Dyn"},{"issue":"7","key":"ref59","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/dvdy.23804","article-title":"Lineage tracing of the endoderm during oral development","volume":"241","author":"M Rothova","year":"2012","journal-title":"Dev Dyn"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.devcel.2012.01.006","article-title":"GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis","volume":"22","author":"J Lopez-Rios","year":"2012","journal-title":"Developmental Cell"},{"issue":"15","key":"ref61","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1073\/pnas.151235798","article-title":"Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha-gustducin","volume":"98","author":"L Ruiz-Avila","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1741-7007-4-7","article-title":"Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25","volume":"4","author":"TR Clapp","year":"2006","journal-title":"Bmc Biology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/ncomms1460","article-title":"Direct visualization of microtubules using a genetic tool to analyse radial progenitor-astrocyte continuum in brain","volume":"2","author":"TY Eom","year":"2011","journal-title":"Nature Communications"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1038\/s41598-017-07746-z","article-title":"Whole transcriptome profiling of taste bud cells","volume":"7","author":"SK Sukumaran","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"7","key":"ref66","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Y Liao","year":"2014","journal-title":"Bioinformatics"},{"issue":"12","key":"ref67","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"issue":"13","key":"ref68","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1073\/pnas.1100495108","article-title":"Glucose transporters and ATP-gated K+ (K-ATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells","volume":"108","author":"KK Yee","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"ref69","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1038\/nprot.2016.097","article-title":"Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation","volume":"11","author":"L Broutier","year":"2016","journal-title":"Nature Protocols"},{"issue":"7","key":"ref70","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1523\/JNEUROSCI.3074-13.2014","article-title":"Interleukin-10 Is Produced by a Specific Subset of Taste Receptor Cells and Critical for Maintaining Structural Integrity of Mouse Taste Buds","volume":"34","author":"P Feng","year":"2014","journal-title":"J Neurosci"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/chemse\/bjv056","article-title":"Maltodextrin Acceptance and Preference in Eight Mouse Strains","volume":"41","author":"RL Poole","year":"2016","journal-title":"Chemical senses"},{"issue":"4","key":"ref72","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1113\/jphysiol.2014.284703","article-title":"Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice","volume":"593","author":"K Yasumatsu","year":"2015","journal-title":"Journal of Physiology-London"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007058","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:15:01Z","timestamp":1589008501000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007058"}},"subtitle":[],"editor":[{"given":"Linda A.","family":"Barlow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,7]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007058","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1007058","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,7]]}}}