{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:50:26Z","timestamp":1768895426051,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1007222","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000}}],"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK089256"],"award-info":[{"award-number":["DK089256"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007222","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T13:23:35Z","timestamp":1522675415000},"page":"e1007222","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses"],"prefix":"10.1371","volume":"14","author":[{"given":"Thomas J.","family":"Baranski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldi T.","family":"Kraja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0835-4498","authenticated-orcid":true,"given":"Jill L.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra A.","family":"Lenzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid B.","family":"Borecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-0742","authenticated-orcid":true,"given":"Ching-Ti","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Adrienne","family":"Cupples","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari E.","family":"North","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-774X","authenticated-orcid":true,"given":"Michael A.","family":"Province","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature08451","article-title":"Genomic views of distant-acting enhancers","author":"A RE Visel","year":"2009","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/ni0901-842","article-title":"Deletion of a coordinate regulator of type 2 cytokine","author":"M BC Mohrs","year":"2001","journal-title":"Nat Immunol"},{"issue":"7492","key":"ref3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature13138","article-title":"Obesity-associated variants within FTO form long-range functional connections with IRX3","volume":"507","author":"S Smemo","year":"2014","journal-title":"Nature"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1056\/NEJMoa1502214","article-title":"FTO Obesity Variant Circuitry and Adipocyte Browning in Humans","volume":"373","author":"M Claussnitzer","year":"2015","journal-title":"N Engl J Med"},{"issue":"6920","key":"ref5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature01279","article-title":"Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes","volume":"421","author":"K Ashrafi","year":"2003","journal-title":"Nature"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cell.2009.12.027","article-title":"Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate","volume":"140","author":"JA Pospisilik","year":"2010","journal-title":"Cell"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ajhg.2011.01.006","article-title":"Functional screening of Alzheimer pathology genome-wide association signals in Drosophila","volume":"88","author":"JM Shulman","year":"2011","journal-title":"American journal of human genetics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1471-2164-14-136","article-title":"A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX","volume":"14","author":"J Pendse","year":"2013","journal-title":"BMC genomics"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.7150\/ijbs.4568","article-title":"Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice","volume":"8","author":"H Yang","year":"2012","journal-title":"Int J Biol Sci"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"e2559","DOI":"10.1038\/cddis.2016.455","article-title":"Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2","volume":"8","author":"L Tian","year":"2017","journal-title":"Cell Death Dis"},{"issue":"6","key":"ref11","first-page":"340","article-title":"Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging","volume":"120","author":"J Zemva","year":"2012","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"e0137087","DOI":"10.1371\/journal.pone.0137087","article-title":"A Genome-Wide mRNA Screen and Functional Analysis Reveal FOXO3 as a Candidate Gene for Chicken Growth","volume":"10","author":"B Chen","year":"2015","journal-title":"PloS one"},{"issue":"40","key":"ref13","doi-asserted-by":"crossref","first-page":"34567","DOI":"10.1074\/jbc.M111.268292","article-title":"Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle","volume":"286","author":"SS Kulkarni","year":"2011","journal-title":"J Biol Chem"},{"issue":"44","key":"ref14","doi-asserted-by":"crossref","first-page":"36946","DOI":"10.1074\/jbc.M508317200","article-title":"The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes","volume":"280","author":"A Bose","year":"2005","journal-title":"J Biol Chem"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"E105","DOI":"10.1152\/ajpendo.00042.2016","article-title":"Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice","volume":"311","author":"DK Costa","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"239","key":"ref16","doi-asserted-by":"crossref","first-page":"ra62","DOI":"10.1126\/scisignal.2002867","article-title":"A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes","volume":"5","author":"K Jennissen","year":"2012","journal-title":"Sci Signal"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/db11-0255","article-title":"Endothelial NO\/cGMP\/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding","volume":"60","author":"S Tateya","year":"2011","journal-title":"Diabetes"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1210\/ME.2015-1077","article-title":"The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling","volume":"29","author":"MJ Williams","year":"2015","journal-title":"Mol Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.lfs.2016.10.019","article-title":"Fat body remodeling and homeostasis control in Drosophila","volume":"167","author":"H Zheng","year":"2016","journal-title":"Life Sci"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cmet.2005.04.003","article-title":"Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila","volume":"1","author":"S Gronke","year":"2005","journal-title":"Cell Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev-ento-112408-085356","article-title":"Insect fat body: energy, metabolism, and regulation","volume":"55","author":"EL Arrese","year":"2010","journal-title":"Annu Rev Entomol"},{"issue":"24","key":"ref22","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1128\/MCB.00675-09","article-title":"Regulation of fat cell mass by insulin in Drosophila melanogaster","volume":"29","author":"JR DiAngelo","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1242\/dmm.007948","article-title":"A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila","volume":"4","author":"LP Musselman","year":"2011","journal-title":"Disease models & mechanisms"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7102","DOI":"10.1038\/ncomms8102","article-title":"Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism","volume":"6","author":"R Ugrankar","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cell.2010.09.001","article-title":"Long noncoding RNAs with enhancer-like function in human cells","volume":"143","author":"UA Orom","year":"2010","journal-title":"Cell"},{"issue":"19","key":"ref26","doi-asserted-by":"crossref","first-page":"17573","DOI":"10.1074\/jbc.M300311200","article-title":"A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha","volume":"278","author":"CC Johansson","year":"2003","journal-title":"J Biol Chem"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/stem.1041","article-title":"PKA\/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction","volume":"30","author":"K Yamamizu","year":"2012","journal-title":"Stem Cells"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1093\/hmg\/ddx043","article-title":"Conditional eQTL analysis reveals allelic heterogeneity of gene expression","volume":"26","author":"R Jansen","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"HJ Westra","year":"2013","journal-title":"Nat Genet"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ng.686","article-title":"Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index","volume":"42","author":"EK Speliotes","year":"2010","journal-title":"Nature genetics"},{"issue":"7538","key":"ref31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"AE Locke","year":"2015","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/1471-2105-12-357","article-title":"An integrative approach to ortholog prediction for disease-focused and other functional studies","volume":"12","author":"Y Hu","year":"2011","journal-title":"BMC Bioinformatics"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007222","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T16:48:19Z","timestamp":1540226899000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007222"}},"subtitle":[],"editor":[{"given":"Giovanni","family":"Bosco","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,2]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007222","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1007222","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,2]]}}}