{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:14:33Z","timestamp":1790223273766,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1007274","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000}}],"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50NS016367"],"award-info":[{"award-number":["P50NS016367"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS091161"],"award-info":[{"award-number":["R01NS091161"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS049206"],"award-info":[{"award-number":["R01NS049206"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01NS082079"],"award-info":[{"award-number":["U01NS082079"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009187","name":"Medical Research Foundation","doi-asserted-by":"publisher","award":["G0801418"],"award-info":[{"award-number":["G0801418"]}],"id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009187","name":"Medical Research Foundation","doi-asserted-by":"publisher","award":["MR\/L010305\/1"],"award-info":[{"award-number":["MR\/L010305\/1"]}],"id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007274","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T17:26:50Z","timestamp":1526059610000},"page":"e1007274","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Population-specific genetic modification of Huntington's disease in Venezuela"],"prefix":"10.1371","volume":"14","author":[{"given":"Michael J.","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Wan","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Lucente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa C.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared C.","family":"Roach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy","family":"Hood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-0943","authenticated-orcid":true,"given":"Nancy S.","family":"Wexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Jardim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-9412","authenticated-orcid":true,"given":"Peter","family":"Holmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Orth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcy E.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Gusella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-0787","authenticated-orcid":true,"given":"Jong-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","author":"GP Bates","year":"2015","journal-title":"Nature Reviews Disease Primers"},{"key":"ref2","first-page":"320","article-title":"On chorea","volume":"26","author":"G Huntington","year":"1872","journal-title":"Med Surg Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington&apos;s disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.2890209","article-title":"A DNA segment encoding two genes very tightly linked to Huntington&apos;s disease","volume":"238","author":"TC Gilliam","year":"1987","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0092-8674(87)90029-8","article-title":"Localization of the Huntington&apos;s disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere","volume":"50","author":"TC Gilliam","year":"1987","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/306234a0","article-title":"A polymorphic DNA marker genetically linked to Huntington&apos;s disease","volume":"306","author":"JF Gusella","year":"1983","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1212\/WNL.0b013e318249f683","article-title":"CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion","volume":"78","author":"JM Lee","year":"2012","journal-title":"Neurology"},{"key":"ref8","first-page":"16","article-title":"Phenotypic characterization of individuals with 30\u201340 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36\u201339 repeats","volume":"59","author":"DC Rubinsztein","year":"1996","journal-title":"Am J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington&apos;s disease","volume":"369","author":"FO Walker","year":"2007","journal-title":"Lancet"},{"key":"ref10","first-page":"343","article-title":"Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes","volume":"57","author":"B Kremer","year":"1995","journal-title":"Am J Hum Genet"},{"key":"ref11","first-page":"593","article-title":"Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease","volume":"57","author":"NG Ranen","year":"1995","journal-title":"Am J Hum Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jmg.31.5.377","article-title":"Instability of CAG repeats in Huntington&apos;s disease: relation to parental transmission and age of onset","volume":"31","author":"Y Trottier","year":"1994","journal-title":"J Med Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng1093-168","article-title":"De novo expansion of a (CAG)n repeat in sporadic Huntington&apos;s disease","volume":"5","author":"RH Myers","year":"1993","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1399-0004.2006.00668.x","article-title":"Predictive testing for Huntington disease: interpretation and significance of intermediate alleles","volume":"70","author":"A Semaka","year":"2006","journal-title":"Clin Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington&apos;s disease","volume":"4","author":"SE Andrew","year":"1993","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ng0893-387","article-title":"Trinucleotide repeat length instability and age of onset in Huntington&apos;s disease","volume":"4","author":"M Duyao","year":"1993","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/nbdi.1994.0019","article-title":"Huntington&apos;s disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains","volume":"1","author":"F Persichetti","year":"1994","journal-title":"Neurobiol Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng0893-393","article-title":"Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington&apos;s disease","volume":"4","author":"RG Snell","year":"1993","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/ajmg.a.37009","article-title":"Biallelic mutations in huntington disease: A new case with just one affected parent, review of the literature and terminology","volume":"167A","author":"WR Uhlmann","year":"2015","journal-title":"Am J Med Genet A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/brain\/awg077","article-title":"Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course","volume":"126","author":"F Squitieri","year":"2003","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajhg.2015.12.018","article-title":"The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease","volume":"98","author":"JW Keum","year":"2016","journal-title":"Am J Hum Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/mds.26006","article-title":"Animal models of Huntington&apos;s disease for translation to the clinic: best practices","volume":"29","author":"L Menalled","year":"2014","journal-title":"Mov Disord"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0092-8674(95)90542-1","article-title":"Targeted disruption of the Huntington&apos;s disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes","volume":"81","author":"J Nasir","year":"1995","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/8.1.115","article-title":"Length-dependent gametic CAG repeat instability in the Huntington&apos;s disease knock-in mouse","volume":"8","author":"VC Wheeler","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng1297-404","article-title":"Huntingtin is required for neurogenesis and is not impaired by the Huntington&apos;s disease CAG expansion","volume":"17","author":"JK White","year":"1997","journal-title":"Nat Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ng1095-155","article-title":"Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington&apos;s disease gene homologue","volume":"11","author":"S Zeitlin","year":"1995","journal-title":"Nat Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/hmg\/ddt176","article-title":"Dominant effects of the Huntington&apos;s disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy","volume":"22","author":"JM Lee","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2015.07.003","article-title":"Identification of Genetic Factors that Modify Clinical Onset of Huntington&apos;s Disease","volume":"162","year":"2015","journal-title":"Cell"},{"key":"ref29","article-title":"Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington&apos;s disease and spinocerebellar ataxia","author":"MS Keiser","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ajmg.a.20190","article-title":"Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease","volume":"119A","author":"L Djousse","year":"2003","journal-title":"Am J Med Genet A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1086\/378133","article-title":"A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study","volume":"73","author":"JL Li","year":"2003","journal-title":"Am J Hum Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington&apos;s disease age of onset","volume":"101","author":"NS Wexler","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ejhg.2013.2","article-title":"Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes","volume":"21","author":"FK Baine","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ajhg.2012.01.005","article-title":"Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region","volume":"90","author":"JM Lee","year":"2012","journal-title":"Am J Hum Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/ng0592-99","article-title":"The Huntington&apos;s disease candidate region exhibits many different haplotypes","volume":"1","author":"ME MacDonald","year":"1992","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ajmg.b.32289","article-title":"Haplotype analysis of the 4p16.3 region in Portuguese families with Huntington&apos;s disease","volume":"168B","author":"EM Ramos","year":"2015","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ajhg.2009.02.003","article-title":"CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup","volume":"84","author":"SC Warby","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ejhg.2017.125","article-title":"Haplotype-based stratification of Huntington&apos;s disease","volume":"25","author":"MJ Chao","year":"2017","journal-title":"Eur J Hum Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/mds.26001","article-title":"Genetic modifiers of Huntington&apos;s disease","volume":"29","author":"JF Gusella","year":"2014","journal-title":"Mov Disord"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1093\/hmg\/ddx286","article-title":"A modifier of Huntington&apos;s disease onset at the MLH1 locus","volume":"26","author":"JM Lee","year":"2017","journal-title":"Hum Mol Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3233\/JHD-150169","article-title":"The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington&apos;s Disease","volume":"4","author":"K Correia","year":"2015","journal-title":"J Huntingtons Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"166","DOI":"10.14802\/jmd.16022","article-title":"Survival of Korean Huntington&apos;s Disease Patients","volume":"9","author":"HJ Kim","year":"2016","journal-title":"J Mov Disord"},{"key":"ref43","first-page":"4566","article-title":"Permanent inactivation of Huntington&apos;s disease mutation by personalized allele-specific CRISPR\/Cas9","volume":"25","author":"JW Shin","year":"2016","journal-title":"Hum Mol Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1126\/science.1116848","article-title":"Regulation of mammalian tooth cusp patterning by ectodin","volume":"309","author":"Y Kassai","year":"2005","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1091\/mbc.e07-05-0433","article-title":"A human bone morphogenetic protein antagonist is down-regulated in renal cancer","volume":"19","author":"KR Blish","year":"2008","journal-title":"Mol Biol Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cytogfr.2005.02.007","article-title":"BMP antagonists: their roles in development and involvement in pathophysiology","volume":"16","author":"M Yanagita","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bbrc.2004.02.075","article-title":"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney","volume":"316","author":"M Yanagita","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ajhg.2015.07.017","article-title":"Sequence-Level Analysis of the Major European Huntington Disease Haplotype","volume":"97","author":"JM Lee","year":"2015","journal-title":"Am J Hum Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrg1691","article-title":"Diseases of unstable repeat expansion: mechanisms and common principles","volume":"6","author":"JR Gatchel","year":"2005","journal-title":"Nat Rev Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.neuro.29.051605.113042","article-title":"Trinucleotide repeat disorders","volume":"30","author":"HT Orr","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/cge.12641","article-title":"Genetic aspects of Huntington&apos;s disease in Latin America. A systematic review","volume":"89","author":"RM Castilhos","year":"2016","journal-title":"Clin Genet"},{"key":"ref52","first-page":"CD006456","article-title":"Therapeutic interventions for symptomatic treatment in Huntington&apos;s disease","author":"T Mestre","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"ref53","first-page":"CD006455","article-title":"Therapeutic interventions for disease progression in Huntington&apos;s disease","author":"T Mestre","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/gepi.20317","article-title":"Genomewide linkage scan reveals novel loci modifying age of onset of Huntington&apos;s disease in the Venezuelan HD kindreds","volume":"32","author":"J Gayan","year":"2008","journal-title":"Genet Epidemiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ydbio.2003.08.011","article-title":"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot","volume":"264","author":"J Laurikkala","year":"2003","journal-title":"Dev Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1756-9966-29-147","article-title":"Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors","volume":"29","author":"KR Blish","year":"2010","journal-title":"J Exp Clin Cancer Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cancergen.2013.04.005","article-title":"SOSTDC1 down-regulation of expression involves CpG methylation and is a potential prognostic marker in gastric cancer","volume":"206","author":"G Gopal","year":"2013","journal-title":"Cancer Genet"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"31780","DOI":"10.18632\/oncotarget.5566","article-title":"Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2","volume":"6","author":"W Liang","year":"2015","journal-title":"Oncotarget"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e9763","DOI":"10.1371\/journal.pone.0009763","article-title":"Genome-wide association of lipid-lowering response to statins in combined study populations","volume":"5","author":"MJ Barber","year":"2010","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"12004","DOI":"10.1073\/pnas.96.21.12004","article-title":"Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes","volume":"96","author":"E Gonzalez","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"19429","DOI":"10.1038\/srep19429","article-title":"Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs","volume":"6","author":"JE Below","year":"2016","journal-title":"Sci Rep"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/hmg\/ddt462","article-title":"Genome-wide association study of ancestry-specific TB risk in the South African Coloured population","volume":"23","author":"ER Chimusa","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/art.30235","article-title":"Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci","volume":"63","author":"J Freudenberg","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1038\/ncomms4983","article-title":"Amerindian-specific regions under positive selection harbour new lipid variants in Latinos","volume":"5","author":"A Ko","year":"2014","journal-title":"Nat Commun"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-008-0590-9","article-title":"Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci","volume":"125","author":"SF Lei","year":"2009","journal-title":"Hum Genet"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12863-016-0387-0","article-title":"Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans","volume":"17","author":"YD Salinas","year":"2016","journal-title":"BMC Genet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajhg.2015.12.003","article-title":"Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic\/Latino Americans","volume":"98","author":"UM Schick","year":"2016","journal-title":"Am J Hum Genet"},{"key":"ref68","first-page":"RRN1184","article-title":"Observing Huntington&apos;s Disease: the European Huntington&apos;s Disease Network&apos;s REGISTRY","volume":"2","author":"M Orth","year":"2010","journal-title":"PLoS Curr"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1176\/appi.ajp.2009.09070973","article-title":"Prevalence of incompletely penetrant Huntington&apos;s disease alleles among individuals with major depressive disorder","volume":"167","author":"RH Perlis","year":"2010","journal-title":"Am J Psychiatry"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007274","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:50:55Z","timestamp":1588971055000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007274"}},"subtitle":[],"editor":[{"given":"Harry T.","family":"Orr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,11]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007274","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1007274","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,11]]}}}