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The effects of cross and self fertilisation in the vegetable kingdom. (J. Murray, 1876).","DOI":"10.5962\/bhl.title.110800"},{"key":"ref2","first-page":"533","article-title":"<italic>Handbook of Statistical Genetics<\/italic>","volume":"1","author":"B. Walsh","year":"2008"},{"key":"ref3","first-page":"783","article-title":"The genetics of inbreeding depression","volume":"10","author":"D. Charlesworth","year":"2009"},{"key":"ref4","unstructured":"Sewall-Wright, S. Evolution and the genetics of populations. Vol. 3: experimental results and evolutionary deductions. (1977)."},{"key":"ref5","first-page":"237","article-title":"Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data","volume":"189","author":"M. C. Keller","year":"2011"},{"key":"ref6","article-title":"Genomic runs of homozygosity record population history and consanguinity","volume":"5","author":"M. Kirin","year":"2010"},{"key":"ref7","first-page":"459","article-title":"Directional dominance on stature and cognition in diverse human populations","volume":"523","author":"P. K. Joshi","year":"2015"},{"key":"ref8","article-title":"Genome-wide autozygosity is associated with lower general cognitive ability","author":"D. P. Howrigan","year":"2015"},{"key":"ref9","first-page":"e103102","article-title":"The Association of Genotype-Based Inbreeding Coefficient with a Range of Physical and Psychological Human Traits","volume":"9","author":"K. J. H. Verweij","year":"2014"},{"key":"ref10","article-title":"Detection and quantification of inbreeding depression for complex traits from SNP data","volume":"114","author":"L. Yengo","year":"2017"},{"key":"ref11","article-title":"No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study","volume":"12","author":"E. C. Johnson","year":"2016"},{"key":"ref12","first-page":"157","article-title":"A recessive genetic model and runs of homozygosity in major depressive disorder","volume":"165","author":"R. A. Power","year":"2014"},{"key":"ref13","first-page":"1011","article-title":"Inbreeding and the genetic complexity of human hypertension","volume":"163","author":"I. Rudan","year":"2003"},{"key":"ref14","first-page":"233","article-title":"Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits","volume":"16","author":"H. Campbell","year":"2007"},{"key":"ref15","first-page":"455","article-title":"Association between autozygosity and major depression: Stratification due to religious assortment","volume":"43","author":"A. Abdellaoui","year":"2013"},{"key":"ref16","first-page":"283","article-title":"Research on religion, spirituality, and mental health: A review","volume":"54","author":"H. G. Koenig","year":"2009"},{"key":"ref17","first-page":"165","article-title":"No evidence for excess runs of homozygosity in bipolar disorder","volume":"19","author":"A. E. Vine","year":"2009"},{"key":"ref18","first-page":"79","article-title":"No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset","volume":"154","author":"E. A. Heron","year":"2014"},{"key":"ref19","first-page":"359","article-title":"Runs of Homozygosity in European Populations","volume":"83","author":"R. McQuillan","year":"2008"},{"key":"ref20","article-title":"Runs of homozygosity implicate autozygosity as a schizophrenia risk factor","volume":"8","author":"M. C. Keller","year":"2012"},{"key":"ref21","first-page":"1","article-title":"No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia","volume":"23","author":"D. M. Ruderfer","year":"2014"},{"key":"ref22","article-title":"Reply to Kardos et al.: Estimation of inbreeding depression from SNP data","author":"L. Yengo","year":"2018"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1101\/166298","article-title":"Genome-wide genetic data on ~500,000 UK Biobank participants","author":"C. Bycroft","year":"2017"},{"key":"ref24","first-page":"539","article-title":"Genome-wide association study identifies 74 loci associated with educational attainment","volume":"533","author":"A. Okbay","year":"2016"},{"key":"ref25","first-page":"1125","article-title":"Widening inequality of health in northern England, 1981\u201391","volume":"308","author":"P. Phillimore","year":"1994"},{"key":"ref26","first-page":"419","article-title":"Effects of sociodemographic factors on adherence to breastfeeding and other important infant dietary recommendations","volume":"95","author":"M. Gudnadottir","year":"2006"},{"key":"ref27","article-title":"Educational attainment influences levels of homozygosity through migration and assortative mating","volume":"10","author":"A. Abdellaoui","year":"2015"},{"key":"ref28","first-page":"76","article-title":"GCTA: A tool for genome-wide complex trait analysis","volume":"88","author":"J. Yang","year":"2011"},{"key":"ref29","first-page":"7","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"C. C. Chang","year":"2015"},{"key":"ref30","first-page":"187","article-title":"A fuller theory of \u2018Junctions\u2019 in inbreeding","volume":"8","author":"R. A. Fisher","year":"1954"},{"key":"ref31","first-page":"583","article-title":"Consequences of consanguinity on cognitive behavior","volume":"18","author":"M. Afzal","year":"1988"},{"key":"ref32","article-title":"Evidence of inbreeding depression on human height","volume":"8","author":"R. McQuillan","year":"2012"},{"key":"ref33","first-page":"329","article-title":"The genetic basis of inbreeding depression","volume":"74","author":"B. Charlesworth","year":"1999"},{"key":"ref34","first-page":"1","article-title":"Intelligence Predicts Health and Longevity, but Why?","volume":"13","author":"L. S. Gottfredson","year":"2004"},{"key":"ref35","first-page":"618","article-title":"Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males","volume":"25","author":"K. Stavem","year":"2005"},{"key":"ref36","first-page":"102","article-title":"Impaired pulmonary function as a risk factor for mortality","volume":"116","author":"T. H. Beaty","year":"1982"},{"key":"ref37","first-page":"711","article-title":"Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study","volume":"313","author":"D. J. Hole","year":"1996"},{"key":"ref38","first-page":"418","article-title":"Predictors of mortality in the adult population of Tecumseh: respiratory symptoms, chronic respiratory disease, and ventilatory lung function","volume":"21","author":"M. W. Higgins","year":"1970"},{"key":"ref39","article-title":"Evolutionary Perspectives on Genetic and Environmental Risk Factors for Psychiatric Disorders","author":"M. C. Keller","year":"2018"},{"key":"ref40","first-page":"1288","article-title":"A Comparison of Inbreeding Depression in Life-History and Morphological Traits in Animals","volume":"53","author":"M. A. DeRose","year":"1999"},{"key":"ref41","first-page":"186","article-title":"Attractiveness and sexual behavior: Does attractiveness enhance mating success?","volume":"26","author":"G. Rhodes","year":"2018"},{"key":"ref42","first-page":"79","article-title":"Subjective and objective measures of attractiveness and their relation to sexual behavior and sexual attitudes in university students","volume":"36","author":"J. Weeden","year":"2007"},{"key":"ref43","first-page":"224","article-title":"Long-term Effects of Parents\u2019 Education on Children\u2019s Educational and Occupational Success: Mediation by Family Interactions, Child Aggression, and Teenage Aspirations","volume":"55","author":"E. F. Dubow","year":"2009"},{"key":"ref44","first-page":"47","article-title":"Intergenerational mobility in Britain","volume":"107","author":"L. Dearden","year":"1997"},{"key":"ref45","first-page":"11","article-title":"Religion in Britain: Neither Believing nor Belonging","volume":"39","author":"D. Voas","year":"2005"},{"key":"ref46","first-page":"329","article-title":"Adjusting for heritable covariates can bias effect estimates in genome-wide association studies","volume":"96","author":"H. Aschard","year":"2015"},{"key":"ref47","article-title":"Collider scope: when selection bias can substantially influence observed associations","author":"M. R. Munaf\u00f2","year":"2017"},{"key":"ref48","first-page":"387","article-title":"Using causal diagrams to understand common problems in social epidemiology","author":"M. M. Glymour","year":"2006"},{"key":"ref49","first-page":"300","article-title":"Quantifying biases in causal models: Classical confounding vs collider-stratification bias","volume":"14","author":"S. Greenland","year":"2003"},{"key":"ref50","first-page":"4697","article-title":"Evaluation of inbreeding depression in Holstein cattle using whole-genome SNP markers and alternative measures of genomic inbreeding","volume":"96","author":"D. W. Bjelland","year":"2013"},{"key":"ref51","article-title":"Invited review: Inbreeding in the genomics era: Inbreeding, inbreeding depression, and management of genomic variability","author":"J. T. Howard","year":"2017"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007556","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:19:20Z","timestamp":1540268360000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007556"}},"subtitle":[],"editor":[{"given":"Sharon R.","family":"Browning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,27]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007556","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/291872","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,27]]}}}