{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:45:11Z","timestamp":1790498711241,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1007592","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000}}],"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31401197"],"award-info":[{"award-number":["31401197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140318"],"award-info":[{"award-number":["BK20140318"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Key Laboratory of Translational Research for Neuropsychiatric Diseases","award":["BM2013003"],"award-info":[{"award-number":["BM2013003"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS083373"],"award-info":[{"award-number":["NS083373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS37402"],"award-info":[{"award-number":["NS37402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM077875"],"award-info":[{"award-number":["GM077875"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007592","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T17:25:33Z","timestamp":1535131533000},"page":"e1007592","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Whi2 is a conserved negative regulator of TORC1 in response to low amino acids"],"prefix":"10.1371","volume":"14","author":[{"given":"Xianghui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Dayhoff-Brannigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola L.","family":"Diny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cierra N.","family":"Sing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle A.","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9770-9435","authenticated-orcid":true,"given":"Zachary D.","family":"Stolp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Aouacheria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chih","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-2045","authenticated-orcid":true,"given":"J. Marie","family":"Hardwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-9371","authenticated-orcid":true,"given":"Xinchen","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.molcel.2013.09.026","article-title":"Genome-wide consequences of deleting any single gene","volume":"52","author":"X. Teng","year":"2013","journal-title":"Mol Cell"},{"issue":"29","key":"ref2","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1073\/pnas.0400690101","article-title":"REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma","volume":"101","author":"L. Di Marcotullio","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"31","key":"ref3","doi-asserted-by":"crossref","first-page":"E4288","DOI":"10.1073\/pnas.1502068112","article-title":"MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer","volume":"112","author":"R. Cui","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ana.21121","article-title":"Mutation of a potassium channel-related gene in progressive myoclonic epilepsy","volume":"61","author":"P. Van Bogaert","year":"2007","journal-title":"Ann Neurol"},{"key":"ref5","article-title":"<italic>KCTD7 mutations define a distinct neurodegenerative disorder with defective autophagy (in submission)<\/italic>","author":"K.A. Metz","year":"2018"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/genetics\/96.3.561","article-title":"Small-sized mutants of Saccharomyces cerevisiae","volume":"96","author":"B. L. Carter","year":"1980","journal-title":"Genetics"},{"issue":"7","key":"ref7","first-page":"1797","article-title":"Molecular cloning of WHI2, a gene involved in the regulation of cell proliferation in Saccharomyces cerevisiae","volume":"131","author":"D. J. Saul","year":"1985","journal-title":"J Gen Microbiol"},{"issue":"Pt 6","key":"ref8","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1099\/00221287-143-6-1867","article-title":"Filamentous growth of the budding yeast Saccharomyces cerevisiae induced by overexpression of the WHi2 gene","volume":"143","author":"P. A. Radcliffe","year":"1997","journal-title":"Microbiology"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/(SICI)1097-0061(19970630)13:8<707::AID-YEA130>3.0.CO;2-9","article-title":"Deregulation of CLN1 and CLN2 in the Saccharomyces cerevisiae whi2 mutant","volume":"13","author":"P. Radcliffe","year":"1997","journal-title":"Yeast"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1046\/j.1365-2443.2002.00538.x","article-title":"Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression","volume":"7","author":"D. Kaida","year":"2002","journal-title":"Genes Cells"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1038\/ncomms4101","article-title":"The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein","volume":"5","author":"M. Boeckstaens","year":"2014","journal-title":"Nat Commun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13064-016-0062-1","article-title":"Bacurd1\/Kctd13 and Bacurd2\/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons","volume":"11","author":"I. Gladwyn-Ng","year":"2016","journal-title":"Neural Dev"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jcb.22026","article-title":"KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation","volume":"106","author":"Y. Wang","year":"2009","journal-title":"J Cell Biochem"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.neuron.2011.12.003","article-title":"insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila","volume":"72","author":"N. Stavropoulos","year":"2011","journal-title":"Neuron"},{"issue":"7295","key":"ref15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature08964","article-title":"Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits","volume":"465","author":"J. Schwenk","year":"2010","journal-title":"Nature"},{"issue":"7406","key":"ref16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature11126","article-title":"A tumour suppressor network relying on the polyamine-hypusine axis","volume":"487","author":"C. Scuoppo","year":"2012","journal-title":"Nature"},{"issue":"23","key":"ref17","doi-asserted-by":"crossref","first-page":"37717","DOI":"10.18632\/oncotarget.17145","article-title":"KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling","volume":"8","author":"R. Tong","year":"2017","journal-title":"Oncotarget"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"380398","DOI":"10.1155\/2014\/380398","article-title":"KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma","volume":"2014","author":"F. Zazzeroni","year":"2014","journal-title":"Biomed Res Int"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1038\/cdd.2008.117","article-title":"Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects","volume":"15","author":"W. C. Cheng","year":"2008","journal-title":"Cell Death Differ"},{"issue":"22","key":"ref20","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1101\/gad.1247904","article-title":"Mitochondrial fission proteins regulate programmed cell death in yeast","volume":"18","author":"Y. Fannjiang","year":"2004","journal-title":"Genes Dev"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1083\/jcb.200503069","article-title":"Viruses activate a genetically conserved cell death pathway in a unicellular organism","volume":"170","author":"I. Ivanovska","year":"2005","journal-title":"J Cell Biol"},{"issue":"Pt 5","key":"ref22","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1242\/jcs.042424","article-title":"Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast","volume":"122","author":"J. E. Leadsham","year":"2009","journal-title":"J Cell Sci"},{"issue":"6136","key":"ref23","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.1232044","article-title":"A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1","volume":"340","author":"L. Bar-Peled","year":"2013","journal-title":"Science"},{"issue":"277","key":"ref24","doi-asserted-by":"crossref","first-page":"ra42","DOI":"10.1126\/scisignal.2004112","article-title":"Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1","volume":"6","author":"N. Panchaud","year":"2013","journal-title":"Sci Signal"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.15252\/embj.201696010","article-title":"Nutrient sensing and TOR signaling in yeast and mammals","volume":"36","author":"A. Gonzalez","year":"2017","journal-title":"EMBO J"},{"issue":"5882","key":"ref26","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Y. Sancak","year":"2008","journal-title":"Science"},{"issue":"6268","key":"ref27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1126\/science.aab2674","article-title":"Sestrin2 is a leucine sensor for the mTORC1 pathway","volume":"351","author":"R. L. Wolfson","year":"2016","journal-title":"Science"},{"issue":"7645","key":"ref28","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature21423","article-title":"KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1","volume":"543","author":"R. L. Wolfson","year":"2017","journal-title":"Nature"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cell.2016.02.035","article-title":"The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway","volume":"165","author":"L. Chantranupong","year":"2016","journal-title":"Cell"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cmet.2017.07.001","article-title":"The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway","volume":"26","author":"R. L. Wolfson","year":"2017","journal-title":"Cell Metab"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncb847","article-title":"Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling","volume":"4","author":"X. Gao","year":"2002","journal-title":"Nat Cell Biol"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1091\/mbc.e15-08-0594","article-title":"TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae","volume":"27","author":"S. Yerlikaya","year":"2016","journal-title":"Mol Biol Cell"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.molcel.2007.04.020","article-title":"Sch9 is a major target of TORC1 in Saccharomyces cerevisiae","volume":"26","author":"J. Urban","year":"2007","journal-title":"Mol Cell"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"e0120250","DOI":"10.1371\/journal.pone.0120250","article-title":"TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae","volume":"10","author":"A. Gonzalez","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"D. H. Kim","year":"2002","journal-title":"Cell"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tibs.2006.04.003","article-title":"Ribosomal protein S6 phosphorylation: from protein synthesis to cell size","volume":"31","author":"I. Ruvinsky","year":"2006","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1534\/genetics.114.168369","article-title":"State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae","volume":"198","author":"J. E. Hughes Hallett","year":"2014","journal-title":"Genetics"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09181","article-title":"Snf1\/AMPK promotes the formation of Kog1\/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast","volume":"4","author":"J. E. Hughes Hallett","year":"2015","journal-title":"Elife"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","article-title":"TSC2 mediates cellular energy response to control cell growth and survival","volume":"115","author":"K. Inoki","year":"2003","journal-title":"Cell"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"D. M. Gwinn","year":"2008","journal-title":"Mol Cell"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"e1004041","DOI":"10.1371\/journal.pgen.1004041","article-title":"Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments","volume":"10","author":"J. Hong","year":"2014","journal-title":"PLoS Genet"},{"issue":"6959","key":"ref42","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature02046","article-title":"Global analysis of protein expression in yeast","volume":"425","author":"S. Ghaemmaghami","year":"2003","journal-title":"Nature"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"e1000515","DOI":"10.1371\/journal.pgen.1000515","article-title":"A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2\/3 complex","volume":"5","author":"T. K. Neklesa","year":"2009","journal-title":"PLoS Genet"},{"issue":"21","key":"ref44","doi-asserted-by":"crossref","first-page":"9450","DOI":"10.1073\/pnas.92.21.9450","article-title":"Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes","volume":"92","author":"M. Stanbrough","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"ref45","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1093\/emboj\/17.23.6924","article-title":"The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease","volume":"17","author":"A. Schmidt","year":"1998","journal-title":"EMBO J"},{"issue":"7","key":"ref46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/ncb1419","article-title":"A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast","volume":"8","author":"M. Gao","year":"2006","journal-title":"Nat Cell Biol"},{"issue":"8","key":"ref47","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1073\/pnas.061034498","article-title":"A comprehensive two-hybrid analysis to explore the yeast protein interactome","volume":"98","author":"T. Ito","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7084","key":"ref48","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature04670","article-title":"Global landscape of protein complexes in the yeast Saccharomyces cerevisiae","volume":"440","author":"N. J. Krogan","year":"2006","journal-title":"Nature"},{"issue":"5898","key":"ref49","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1158684","article-title":"High-quality binary protein interaction map of the yeast interactome network","volume":"322","author":"H. Yu","year":"2008","journal-title":"Science"},{"issue":"6868","key":"ref50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/415180a","article-title":"Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry","volume":"415","author":"Y. Ho","year":"2002","journal-title":"Nature"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0092-8674(87)90223-6","article-title":"Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase","volume":"50","author":"T. Toda","year":"1987","journal-title":"Cell"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/bies.201300002","article-title":"Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development","volume":"35","author":"M. Skoblov","year":"2013","journal-title":"Bioessays"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1096\/fj.12-209502","article-title":"Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis","volume":"26","author":"M. Faryna","year":"2012","journal-title":"FASEB J"},{"issue":"7","key":"ref54","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.humpath.2012.10.013","article-title":"Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor","volume":"44","author":"T. Hasegawa","year":"2013","journal-title":"Hum Pathol"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2013","article-title":"Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation","volume":"12","author":"G. Canettieri","year":"2010","journal-title":"Nat Cell Biol"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.molcel.2009.06.033","article-title":"The Vam6 GEF controls TORC1 by activating the EGO complex","volume":"35","author":"M. Binda","year":"2009","journal-title":"Mol Cell"},{"issue":"36","key":"ref57","doi-asserted-by":"crossref","first-page":"25010","DOI":"10.1074\/jbc.M114.574335","article-title":"Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr\/Rag proteins","volume":"289","author":"D. Stracka","year":"2014","journal-title":"J Biol Chem"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cell.2013.06.041","article-title":"Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A","volume":"154","author":"B. M. Sutter","year":"2013","journal-title":"Cell"},{"issue":"6218","key":"ref59","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1126\/science.1259472","article-title":"Metabolism. Differential regulation of mTORC1 by leucine and glutamine","volume":"347","author":"J. L. Jewell","year":"2015","journal-title":"Science"},{"issue":"6218","key":"ref60","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.1257132","article-title":"Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1","volume":"347","author":"S. Wang","year":"2015","journal-title":"Science"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.molcel.2014.06.002","article-title":"Cytosolic pH regulates cell growth through distinct GTPases, Arf1 and Gtr1, to promote Ras\/PKA and TORC1 activity","volume":"55","author":"R. Dechant","year":"2014","journal-title":"Mol Cell"},{"issue":"5789","key":"ref62","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/288401a0","article-title":"Genes which control cell proliferation in the yeast Saccharomyces cerevisiae","volume":"288","author":"P. E. Sudbery","year":"1980","journal-title":"Nature"},{"issue":"6762","key":"ref63","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/45287","article-title":"The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors","volume":"402","author":"T. Beck","year":"1999","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31981","article-title":"The yeast H(+)-ATPase Pma1 promotes Rag\/Gtr-dependent TORC1 activation in response to H(+)-coupled nutrient uptake","volume":"7","author":"E. Saliba","year":"2018","journal-title":"Elife"},{"issue":"Pt 8","key":"ref65","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1242\/jcs.076406","article-title":"Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2","volume":"124","author":"N. Mendl","year":"2011","journal-title":"J Cell Sci"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2013.05.024","article-title":"The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy","volume":"26","author":"K. Mao","year":"2013","journal-title":"Dev Cell"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00294-016-0613-3","article-title":"Persistence and drug tolerance in pathogenic yeast","volume":"63","author":"R. Bojsen","year":"2017","journal-title":"Curr Genet"},{"issue":"6","key":"ref68","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1094\/MPMI-02-16-0030-R","article-title":"Colletotrichum orbiculare WHI2, a Yeast Stress-Response Regulator Homolog, Controls the Biotrophic Stage of Hemibiotrophic Infection Through TOR Signaling","volume":"29","author":"K. Harata","year":"2016","journal-title":"Mol Plant Microbe Interact"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molcel.2005.05.020","article-title":"The TOR and EGO protein complexes orchestrate microautophagy in yeast","volume":"19","author":"F. Dubouloz","year":"2005","journal-title":"Mol Cell"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1534\/genetics.110.120766","article-title":"System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae","volume":"187","author":"D. Gresham","year":"2011","journal-title":"Genetics"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1038\/s41598-017-04525-8","article-title":"Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae","volume":"7","author":"S. A. Comyn","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"ref72","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ccell.2014.09.008","article-title":"Rab1A is an mTORC1 activator and a colorectal oncogene","volume":"26","author":"J. D. Thomas","year":"2014","journal-title":"Cancer Cell"},{"issue":"6056","key":"ref73","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase","volume":"334","author":"R. Zoncu","year":"2011","journal-title":"Science"},{"issue":"4","key":"ref74","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cmet.2016.03.013","article-title":"Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot","volume":"23","author":"D. C. Goberdhan","year":"2016","journal-title":"Cell Metab"},{"issue":"4","key":"ref75","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nmeth.3795","article-title":"One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy","volume":"13","author":"I. Yofe","year":"2016","journal-title":"Nat Methods"},{"issue":"6","key":"ref76","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/jmedgenet-2012-100859","article-title":"Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene","volume":"49","author":"M. Kousi","year":"2012","journal-title":"J Med Genet"},{"issue":"6","key":"ref77","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.ctrv.2014.02.003","article-title":"Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer","volume":"40","author":"J. Brechbiel","year":"2014","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/ng1296-450","article-title":"Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy","volume":"14","author":"D. D. Shoemaker","year":"1996","journal-title":"Nat Genet"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0378-1119(88)90185-0","article-title":"New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites","volume":"74","author":"R. D. Gietz","year":"1988","journal-title":"Gene"},{"issue":"2","key":"ref80","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2","article-title":"Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications","volume":"14","author":"C. B. Brachmann","year":"1998","journal-title":"Yeast"},{"issue":"1","key":"ref81","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/122.1.19","article-title":"A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae","volume":"122","author":"R. S. Sikorski","year":"1989","journal-title":"Genetics"},{"issue":"9","key":"ref82","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1091\/mbc.5.9.1023","article-title":"The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast","volume":"5","author":"H. Benedetti","year":"1994","journal-title":"Mol Biol Cell"},{"issue":"4","key":"ref83","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.biochi.2010.12.014","article-title":"Molecular organization of the cullin E3 ligase adaptor KCTD11","volume":"93","author":"S. Correale","year":"2011","journal-title":"Biochimie"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007592","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T06:45:01Z","timestamp":1661841901000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007592"}},"subtitle":[],"editor":[{"given":"Peter E.","family":"Sudbery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,24]]},"references-count":83,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007592","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1007592","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,24]]}}}