{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:35:16Z","timestamp":1774506916248,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pgen.1007642","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007093"],"award-info":[{"award-number":["T32HL007093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000952","name":"Paul G. Allen Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007642","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T17:26:03Z","timestamp":1536945963000},"page":"e1007642","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-5886","authenticated-orcid":true,"given":"Matthew R.","family":"Hart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-8431","authenticated-orcid":true,"given":"Donovan J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-0180","authenticated-orcid":true,"given":"Christopher C.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Neff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-8084","authenticated-orcid":true,"given":"Michael","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-1680","authenticated-orcid":true,"given":"Marshall S.","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1056\/NEJMra1400972","article-title":"Acute Lymphoblastic Leukemia in Children","volume":"373","author":"SP Hunger","year":"2015","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11899-011-0094-x","article-title":"Late effects of childhood leukemia therapy","volume":"6","author":"JM Fulbright","year":"2011","journal-title":"Curr Hematol Malig Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1182\/blood-2014-11-551481","article-title":"How I treat acute lymphoblastic leukemia in older adolescents and young adults","volume":"125","author":"E Curran","year":"2015","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1215134","article-title":"Chimeric antigen receptor-modified T cells for acute lymphoid leukemia","volume":"368","author":"SA Grupp","year":"2013","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1182\/blood-2014-12-575688","article-title":"Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia","volume":"126","author":"R Somasundaram","year":"2015","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1182\/blood-2009-01-198911","article-title":"Differentiation therapy of leukemia: 3 decades of development","volume":"113","author":"D Nowak","year":"2009","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1182\/blood-2007-07-102798","article-title":"Acute promyelocytic leukemia: from highly fatal to highly curable","volume":"111","author":"ZY Wang","year":"2008","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1172\/JCI61203","article-title":"Molecular genetics of B-precursor acute lymphoblastic leukemia","volume":"122","author":"CG Mullighan","year":"2012","journal-title":"J Clin Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"CG Mullighan","year":"2007","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/sj.leu.2404691","article-title":"High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression","volume":"21","author":"RP Kuiper","year":"2007","journal-title":"Leukemia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1158\/0008-5472.CAN-11-1874","article-title":"The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease","volume":"71","author":"P O\u2019Brien","year":"2011","journal-title":"Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/onc.2011.291","article-title":"Dominant-negative mechanism of leukemogenic PAX5 fusions","volume":"31","author":"N Kawamata","year":"2012","journal-title":"Oncogene"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/ng.2754","article-title":"A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia","volume":"45","author":"S Shah","year":"2013","journal-title":"Nat Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/leu.2013.363","article-title":"Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A","volume":"28","author":"F Auer","year":"2014","journal-title":"Leukemia"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.4049\/jimmunol.180.3.1719","article-title":"Identification of Pax5 target genes in early B cell differentiation","volume":"180","author":"C Pridans","year":"2008","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1101\/gad.11.4.476","article-title":"Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus","volume":"11","author":"SL Nutt","year":"1997","journal-title":"Genes Dev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20101947","article-title":"Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia","volume":"208","author":"LM Heltemes-Harris","year":"2011","journal-title":"J Exp Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1101\/gad.240416.114","article-title":"Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia","volume":"28","author":"GJ Liu","year":"2014","journal-title":"Genes Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature21076","article-title":"Metabolic gatekeeper function of B-lymphoid transcription factors","volume":"542","author":"LN Chan","year":"2017","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/leu.2012.293","article-title":"B-lineage transcription factors and cooperating gene lesions required for leukemia development","volume":"27","author":"E Tijchon","year":"2013","journal-title":"Leukemia"},{"key":"ref21","first-page":"2","article-title":"Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles","volume":"4","author":"F Fontaine","year":"2015","journal-title":"Cell Regen (Lond)"},{"key":"ref22","article-title":"Delivery technologies for genome editing","author":"H Yin","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/j.seminhematol.2008.09.010","article-title":"Leukemia stem cells and human acute lymphoblastic leukemia","volume":"46","author":"KM Bernt","year":"2009","journal-title":"Semin Hematol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1073\/pnas.97.9.4475","article-title":"Pax gene diversity in the basal cnidarian Acropora millepora (Cnidaria, Anthozoa): implications for the evolution of the Pax gene family","volume":"97","author":"DJ Miller","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0092-8674(92)90281-G","article-title":"Pax in development","volume":"69","author":"P Gruss","year":"1992","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1101\/gad.240102","article-title":"Nephric lineage specification by Pax2 and Pax8","volume":"16","author":"M Bouchard","year":"2002","journal-title":"Genes Dev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0925-4773(97)00119-6","article-title":"The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2\/5\/8 subfamily","volume":"67","author":"T Czerny","year":"1997","journal-title":"Mech Dev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1242\/dev.127.17.3703","article-title":"Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development","volume":"127","author":"M Bouchard","year":"2000","journal-title":"Development"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1002\/dvdy.22146","article-title":"The PAX258 gene subfamily: a comparative perspective","volume":"238","author":"DK Goode","year":"2009","journal-title":"Dev Dyn"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1073\/pnas.0408840102","article-title":"Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance","volume":"102","author":"Q Cai","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.4049\/jimmunol.179.6.3662","article-title":"Characterization of early stages of human B cell development by gene expression profiling","volume":"179","author":"ME Hystad","year":"2007","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0014-2964(77)90085-8","article-title":"An effective human leukaemic cell line: Reh","volume":"13","author":"C Rosenfeld","year":"1977","journal-title":"Eur J Cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/j.1460-2075.1996.tb00548.x","article-title":"C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8","volume":"15","author":"P D\u00f6rfler","year":"1996","journal-title":"EMBO J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood.V60.6.1305.1305","article-title":"Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes","volume":"60","author":"HW Findley Jr.","year":"1982","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e87602","DOI":"10.1371\/journal.pone.0087602","article-title":"Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein","volume":"9","author":"C Diakos","year":"2014","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1365-2141.2009.07815.x","article-title":"Altered mRNA expression of PAX5 is a common event in acute lymphoblastic leukaemia","volume":"146","author":"A Santoro","year":"2009","journal-title":"Br J Haematol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/intimm\/dxh263","article-title":"Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells","volume":"17","author":"E Jimi","year":"2005","journal-title":"Int Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri2491","article-title":"Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling","volume":"9","author":"S Herzog","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e16053","DOI":"10.1371\/journal.pone.0016053","article-title":"Optimizing optical flow cytometry for cell volume-based sorting and analysis","volume":"6","author":"A Tzur","year":"2011","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1242\/dev.073759","article-title":"Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis","volume":"139","author":"VP Pai","year":"2012","journal-title":"Development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/reg2.48","article-title":"Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation","volume":"3","author":"VP Pai","year":"2016","journal-title":"Regeneration (Oxf)"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0306-4522(99)00023-8","article-title":"Protection of excitotoxic neuronal death by gluconate through blockade of N-methyl-D-aspartate receptors","volume":"92","author":"T Sakaguchi","year":"1999","journal-title":"Neuroscience"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1038\/emboj.2012.155","article-title":"The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis","volume":"31","author":"R Revilla-I-Domingo","year":"2012","journal-title":"EMBO J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1073\/pnas.96.23.13180","article-title":"c-Myc enhances protein synthesis and cell size during B lymphocyte development","volume":"96","author":"BM Iritani","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/physrev.00056.2006","article-title":"Cellular response to hyperosmotic stresses","volume":"87","author":"MB Burg","year":"2007","journal-title":"Physiol Rev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"ra5","DOI":"10.1126\/scisignal.2000081","article-title":"Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5","volume":"2","author":"T Kino","year":"2009","journal-title":"Sci Signal"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"20615","DOI":"10.1074\/jbc.273.32.20615","article-title":"Transcription of the sodium\/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5'-flanking region","volume":"273","author":"JS Rim","year":"1998","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1152\/physiolgenomics.00057.2015","article-title":"RNA-Seq analysis of high NaCl-induced gene expression","volume":"47","author":"Y Izumi","year":"2015","journal-title":"Physiol Genomics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-08-4210","article-title":"A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro","volume":"69","author":"VC Daniel","year":"2009","journal-title":"Cancer Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1038\/sj.onc.1210850","article-title":"The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids","volume":"27","author":"PC De Witt Hamer","year":"2008","journal-title":"Oncogene"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1182\/asheducation-2016.1.302","article-title":"Germ line mutations associated with leukemias","volume":"2016","author":"CC Porter","year":"2016","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/gcc.22201","article-title":"Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan","volume":"53","author":"I Hanada","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e2967","DOI":"10.1038\/cddis.2017.355","article-title":"Hyperosmotic stress enhances cytotoxicity of SMAC mimetics","volume":"8","author":"S Bittner","year":"2017","journal-title":"Cell Death Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0022-3565(25)38904-4","article-title":"Mannitol pharmacokinetics and serum osmolality in dogs and humans","volume":"236","author":"JC Cloyd","year":"1986","journal-title":"J Pharmacol Exp Ther"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1073\/pnas.231623498","article-title":"Rapid activation of G2\/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase","volume":"99","author":"NI Dmitrieva","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.1073096","article-title":"Cancer. Addiction to oncogenes\u2014the Achilles heal of cancer","volume":"297","author":"IB Weinstein","year":"2002","journal-title":"Science"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1182\/blood-2014-12-580068","article-title":"CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia","volume":"125","author":"SL Maude","year":"2015","journal-title":"Blood"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1038\/ncomms12320","article-title":"CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity","volume":"7","author":"E Jacoby","year":"2016","journal-title":"Nat Commun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1021\/acs.molpharmaceut.5b00175","article-title":"Design of Coltuximab Ravtansine, a CD19-Targeting Antibody-Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure-Activity Relationships and Preclinical Evaluation","volume":"12","author":"EE Hong","year":"2015","journal-title":"Mol Pharm"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.4049\/jimmunol.165.9.4884","article-title":"The NFAT-related protein NFATL1 (TonEBP\/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner","volume":"165","author":"J Trama","year":"2000","journal-title":"J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"F1102","DOI":"10.1152\/ajprenal.00225.2004","article-title":"MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals","volume":"287","author":"D Sheikh-Hamad","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"10673","DOI":"10.1073\/pnas.0403139101","article-title":"NFAT5\/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment","volume":"101","author":"WY Go","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/01.PCC.0000149134.61673.77","article-title":"A new challenge in pediatric obesity: pediatric hyperglycemic hyperosmolar syndrome","volume":"6","author":"RM Carchman","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5527\/wjn.v5.i1.20","article-title":"How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?","volume":"5","author":"X Zhou","year":"2016","journal-title":"World J Nephrol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1128\/MCB.22.13.4771-4780.2002","article-title":"Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells","volume":"22","author":"KI Lin","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1158\/1940-6207.CAPR-15-0121-T","article-title":"Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer","volume":"8","author":"EM Al-Hujaily","year":"2015","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12964-017-0168-z","article-title":"The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation","volume":"15","author":"F Wolff","year":"2017","journal-title":"Cell Commun Signal"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1172\/JCI91788","article-title":"Genetic regulation of the RUNX transcription factor family has antitumor effects","volume":"127","author":"K Morita","year":"2017","journal-title":"J Clin Invest"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nn.4508","article-title":"Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy","volume":"20","author":"DR Corey","year":"2017","journal-title":"Nat Neurosci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1038\/ncomms5767","article-title":"Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations","volume":"5","author":"YC Lin","year":"2014","journal-title":"Nat Commun"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"J Barretina","year":"2012","journal-title":"Nature"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"13144","DOI":"10.1073\/pnas.240336397","article-title":"Pax8 has a key role in thyroid cell differentiation","volume":"97","author":"M Pasca di Magliano","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007642","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T09:55:15Z","timestamp":1751882115000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007642"}},"subtitle":[],"editor":[{"given":"Timothy","family":"Graubert","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":73,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007642","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1007642","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,14]]}}}