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Interactions and microRNA-96-5p Regulation Controls Cell Proliferation During Craniofacial and Dental Development: Implications for 22q11.2 Deletion syndrome","volume":"24","author":"S Gao","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/gt.2016.22","article-title":"A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent","volume":"23","author":"H Cao","year":"2016","journal-title":"Gene Ther"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1242\/dev.138883","article-title":"Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal","volume":"143","author":"Z Sun","year":"2016","journal-title":"Development"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1177\/0022034517716915","article-title":"Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis","volume":"96","author":"RJ Ries","year":"2017","journal-title":"J Dent Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ydbio.2017.07.011","article-title":"Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation","volume":"429","author":"W Yu","year":"2017","journal-title":"Dev Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.stem.2013.12.013","article-title":"Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor","volume":"14","author":"H Zhao","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"J Dong","year":"2007","journal-title":"Cell"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1128\/MCB.19.10.7001","article-title":"Multifunctional Role of the Pitx2 Homeodomain Protein C-Terminal Tail","volume":"19","author":"BA Amendt","year":"1999","journal-title":"Mol Cel Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/(SICI)1097-0177(200005)218:1<195::AID-DVDY17>3.0.CO;2-C","article-title":"The Pitx2 Protein in Mouse Development","volume":"218","author":"TA Hjalt","year":"2000","journal-title":"Dev Dyn"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3727\/000000001783992515","article-title":"Antagonistic Regulation of Dlx2 Expression by PITX2 and Msx2: Implications for Tooth Development","volume":"9","author":"PD Green","year":"2001","journal-title":"Gene Expr"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/hmg\/11.7.743","article-title":"A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome","volume":"11","author":"HM Espinoza","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"25001","DOI":"10.1074\/jbc.M201737200","article-title":"Differential Regulation of Gene Expression by PITX2 Isoforms","volume":"277","author":"CJ Cox","year":"2002","journal-title":"J Biol Chem"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/jcs.01706","article-title":"PITX2, \u00df-catenin, and LEF-1 Interact to Synergistically Regulate the LEF-1 promoter","volume":"118","author":"U Vadlamudi","year":"2005","journal-title":"J Cell Sci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"7560","DOI":"10.1128\/MCB.00315-07","article-title":"PITX2 and -catenin Interactions Regulate Lef-1 Isoform Expression","volume":"27","author":"M Amen","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/nar\/gkm1047","article-title":"Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt\/beta-catenin signaling","volume":"36","author":"M Amen","year":"2008","journal-title":"Nuc Acids Res"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ng1296-392","article-title":"Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome","volume":"14","author":"EV Semina","year":"1996","journal-title":"Nature Genet"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1007\/PL00000647","article-title":"Rieger Syndrome: A Clinical, Molecular and Biochemical Analysis","volume":"57","author":"BA Amendt","year":"2000","journal-title":"Cell Mol Life Sci"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature17959","article-title":"Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury","volume":"534","author":"G Tao","year":"2016","journal-title":"Nature"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1242\/dev.117.2.409","article-title":"The triple origin of skull in higher vertebrates: a study in quail-chick chimeras","volume":"117","author":"GF Couly","year":"1993","journal-title":"Development"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1242\/dev.122.10.3229","article-title":"Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny","volume":"122","author":"G Kontges","year":"1996","journal-title":"Development"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0012-1606(78)90201-4","article-title":"The control of avian cephalic neural crest cytodifferentiation. I. Skeletal and connective tissues","volume":"67","author":"DM Noden","year":"1978","journal-title":"Dev Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1006\/dbio.1994.1211","article-title":"The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos","volume":"164","author":"N Osumi-Yamashita","year":"1994","journal-title":"Dev Biol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0925-4773(98)00082-3","article-title":"Signalling interactions during facial development","volume":"75","author":"P Francis-West","year":"1998","journal-title":"Mech Dev"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ydbio.2009.11.021","article-title":"New directions in craniofacial morphogenesis","volume":"341","author":"HL Szabo-Rogers","year":"2010","journal-title":"Dev Biol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1242\/dev.005132","article-title":"Wnt signaling mediates regional specification in the vertebrate face","volume":"134","author":"SA Brugmann","year":"2007","journal-title":"Development"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0925-4773(99)00095-7","article-title":"Expression of Wnt signalling pathway genes during tooth development","volume":"85","author":"I Sarkar","year":"1999","journal-title":"Mech Dev"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.devcel.2011.08.005","article-title":"A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis","volume":"21","author":"E Ferretti","year":"2011","journal-title":"Dev Cell"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1242\/dev.103093","article-title":"TGF\u03b2 regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate","volume":"141","author":"J Iwata","year":"2014","journal-title":"Development"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000337619","article-title":"Wnt signaling in lip and palate development","volume":"16","author":"F He","year":"2012","journal-title":"Front Oral Biol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/dvdy.20723","article-title":"Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice","volume":"235","author":"Y Lan","year":"2006","journal-title":"Dev Dyn"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1242\/dev.075796","article-title":"Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development","volume":"139","author":"YR Jin","year":"2012","journal-title":"Development"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/0022034510363373","article-title":"Wnt\/\u00df-catenin signaling in oral tissue development and disease","volume":"89","author":"F Liu","year":"2010","journal-title":"J Dent Res"},{"issue":"1","key":"ref101","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ydbio.2009.07.015","article-title":"Wnt\/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development","volume":"334","author":"J Chen","year":"2009","journal-title":"Dev Biol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/dvdy.23755","article-title":"Asymmetric requirement of surface epithelial \u00df-catenin during the upper and lower jaw development","volume":"241","author":"Y Sun","year":"2012","journal-title":"Dev Dyn"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ydbio.2010.11.004","article-title":"The canonical Wnt\/\u00df-catenin signaling pathway regulates Fgf signaling for early facial development","volume":"349","author":"Y Wang","year":"2011","journal-title":"Dev Biol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.devcel.2011.04.010","article-title":"\u00df-catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4","volume":"20","author":"H Paek","year":"2011","journal-title":"Dev Cell"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"e1004479","DOI":"10.1371\/journal.pgen.1004479","article-title":"Wnt signaling interacts with bmp and edn1 to regualte dorsal-ventral patterning and growth of the craniofacial skeleton","volume":"10","author":"C Alexander","year":"2014","journal-title":"PLoS Genet"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1242\/dev.02281","article-title":"Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development","volume":"133","author":"JK Eberhart","year":"2006","journal-title":"Development"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1093\/genetics\/142.4.1305","article-title":"Quantitative trait loci for murine growth","volume":"142","author":"JM Cheverud","year":"1996","journal-title":"Genetics"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.0014-3820.2006.tb01091.x","article-title":"Morphological integration in the carnivoran skull","volume":"60","author":"A Goswami","year":"2006","journal-title":"Evolution"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.joms.2010.02.020","article-title":"Control of life-threatening head and neck hemorrhage after dental extractions: a case report","volume":"68","author":"BL Lieberman","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/icb\/icn076","article-title":"Mouse models and the evolutionary developmental biology of the skull","volume":"48","author":"B Hallgr\u00edmsson","year":"2008","journal-title":"Integr Comp Biol"},{"key":"ref111","first-page":"256","article-title":"The neurocranial basis for facial form and pattern","volume":"43","author":"DH Enlow","year":"1973","journal-title":"Angle Orthod"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1089\/ten.tea.2011.0547","article-title":"Modulating the rigidity and mineralization of collagen gels using poly(lactic-co-glycolic acid) microparticles","volume":"18","author":"RJ DeVolder","year":"2012","journal-title":"Tissue Eng, Part A"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.tcb.2006.09.007","article-title":"Sonic hedgehog signaling in forebrain development and its interactions with pathways that modify its effects","volume":"16","author":"N Bertrand","year":"2006","journal-title":"Trends Cell Biol"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ydbio.2005.04.030","article-title":"Molecular interactions coordinating the development of the forebrain and face","volume":"284","author":"RS Marcucio","year":"2005","journal-title":"Dev Biol"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/dev.099994","article-title":"Embryonic bauplans and the developmental origins of facial diversity and constraint","volume":"141","author":"NM Young","year":"2014","journal-title":"Development"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00401-013-1104-y","article-title":"Hand in glove: brain and skull in development and dysmorphogenesis","volume":"125","author":"JT Richtsmeier","year":"2013","journal-title":"Acta Neuropathol"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.biocel.2010.02.011","article-title":"Cross-talk between transforming growth factor-beta and Wingless\/Int pathways in lung development and disease","volume":"42","author":"P Minoo","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1025811012690","article-title":"TGFbeta and Wnt pathway cross-talk","volume":"23","author":"L Attisano","year":"2004","journal-title":"Cancer Metastasis Rev"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2008.302","article-title":"Signaling cross-talk between TGF-beta\/BMP and other pathways","volume":"19","author":"X Guo","year":"2009","journal-title":"Cell Res"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ydbio.2005.04.014","article-title":"Wnt\/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung","volume":"283","author":"W Shu","year":"2005","journal-title":"Dev Biol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0925-4773(98)00004-5","article-title":"BMP-2\/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm","volume":"71","author":"S Hoppler","year":"1998","journal-title":"Mech Dev"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1242\/dev.025825","article-title":"BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway","volume":"135","author":"N Kamiya","year":"2008","journal-title":"Development"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1073\/pnas.150152697","article-title":"Association of Smads with lymphoid enhancer binding factor 1\/T cell-specifc factor mediates cooperative signaling by the transforming growth factor-b and Wnt pathways","volume":"97","author":"E Labbe","year":"2000","journal-title":"PNAS"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"48805","DOI":"10.1074\/jbc.M305472200","article-title":"Smad4 and b-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2","volume":"278","author":"SM Hussein","year":"2003","journal-title":"J Biol Chem"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1242\/dev.01573","article-title":"Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription","volume":"132","author":"MC Hu","year":"2005","journal-title":"Development"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"H Clevers","year":"2012","journal-title":"Cell"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"BT MacDonald","year":"2009","journal-title":"Dev Cell"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dev.045500","article-title":"Hippo signaling: growth control and beyond","volume":"138","author":"G Halder","year":"2011","journal-title":"Development"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1182\/blood-2011-10-383752","article-title":"Targeting hedgehog in hematologic malignancy","volume":"119","author":"DA Irvine","year":"2012","journal-title":"Blood"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/onc.2011.363","article-title":"Integrating developmental signals: a Hippo in the (path)way","volume":"31","author":"A Mauviel","year":"2012","journal-title":"Oncogene"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"D Pan","year":"2010","journal-title":"Dev Cell"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tcb.2011.10.002","article-title":"Coordinating developmental signaling: novel roles for the Hippo pathway","volume":"22","author":"X Varelas","year":"2012","journal-title":"Trends Cell Biol"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/MCB.01439-10","article-title":"Alk5-mediated transforming growth factor b signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells","volume":"31","author":"H Zhao","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1242\/jcs.067199","article-title":"Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members","volume":"123","author":"JY Hong","year":"2010","journal-title":"J Cell Sci"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2010.11.012","article-title":"The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-\u03b2-SMAD pathway","volume":"19","author":"X Varelas","year":"2010","journal-title":"Dev Cell"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.cell.2012.11.027","article-title":"Role of TAZ as mediator of Wnt signaling","volume":"151","author":"L Azzolin","year":"2012","journal-title":"Cell"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"17","DOI":"10.12703\/P5-17","article-title":"Signal integration in TGF-\u03b2, WNT, and Hippo pathways","volume":"5","author":"L Attisano","year":"2013","journal-title":"F1000Prime Rep"},{"key":"ref138","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrm2902","article-title":"When pathways collide: collaboration and connivance among signalling proteins in development","volume":"11","author":"H McNeill","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref139","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ydbio.2004.05.028","article-title":"Shh and Fgf8 act symergistically to drive cartilage outgrowth during cranial development","volume":"273","author":"A Abzhanov","year":"2004","journal-title":"Dev Biol"},{"key":"ref140","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1158\/0008-5472.CAN-06-2559","article-title":"Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis","volume":"67","author":"E Labb\u00e9","year":"2007","journal-title":"Cancer Res"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ncb1748","article-title":"TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal","volume":"10","author":"X Varelas","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1038\/onc.2010.606","article-title":"TAZ is a novel oncogene in non-small cell lung cancer","volume":"30","author":"Z Zhou","year":"2011","journal-title":"Oncogene"},{"key":"ref143","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.cell.2012.11.026","article-title":"\u03b2-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis","volume":"151","author":"J Rosenbluh","year":"2012","journal-title":"Cell"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/dbio.1997.8672","article-title":"Mouse Otlx2\/RIEG Expression in the Odontogenic Epithelium Precedes Tooth Initiation and Requires Mesenchyme-Derived Signals for Its Maintenance","volume":"189","author":"M-L Mucchielli","year":"1997","journal-title":"Dev Biol"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/dbio.1999.9547","article-title":"Antagonistic Signals between BMP4 and FGF8 Define the Expression of Pitx1 and Pitx2 in Mouse Tooth-Forming Anlage","volume":"217","author":"TR St Amand","year":"2000","journal-title":"Dev Biol"},{"key":"ref146","doi-asserted-by":"crossref","first-page":"11616","DOI":"10.1038\/ncomms11616","article-title":"A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation","volume":"7","author":"K Adhikari","year":"2016","journal-title":"Nat Commun"},{"key":"ref147","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1126\/science.1188021","article-title":"A draft sequence of the Neandertal genome","volume":"328","author":"RE Green","year":"2010","journal-title":"Science"},{"key":"ref148","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jhevol.2017.06.014","article-title":"Facing the facts: The Runx2 gene is associated with variation in facial morphology in primates","volume":"111","author":"TB Ritzman","year":"2017","journal-title":"J Hum Evol"},{"key":"ref149","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1525-142X.2007.00196.x","article-title":"The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora","volume":"9","author":"KE Sears","year":"2007","journal-title":"Evol Dev"},{"key":"ref150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.devcel.2012.05.012","article-title":"Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors","volume":"23","author":"E Juuri","year":"2012","journal-title":"Dev Cell"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1242\/dev.089599","article-title":"Sox2 marks epithelial competence to generate teeth in mammals and reptiles","volume":"140","author":"E Juuri","year":"2013","journal-title":"Development"},{"key":"ref152","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1242\/jcs.046482","article-title":"The Hippo tumor-suppressor pathway regualtes apical-domain size in parallel to tissue growth","volume":"122","author":"F Hamaratoglu","year":"2009","journal-title":"J Cell Sci"},{"key":"ref153","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/0022034514525784","article-title":"YAP Overexpression Affects Tooth Morphogenesis and Enamel Knot Patterning","volume":"93","author":"M Liu","year":"2014","journal-title":"J Dent Res"},{"key":"ref154","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1083\/jcb.201309141","article-title":"Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation","volume":"205","author":"J Huang","year":"2014","journal-title":"J Cell Biol"},{"key":"ref155","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s13238-012-2919-3","article-title":"The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation","volume":"3","author":"H Liu","year":"2012","journal-title":"Protein Cell"},{"key":"ref156","doi-asserted-by":"crossref","first-page":"20120511","DOI":"10.1098\/rsta.2012.0511","article-title":"Quantum ergodicity of random 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Res"},{"key":"ref160","doi-asserted-by":"crossref","first-page":"E65979","DOI":"10.1371\/journal.pone.0065979","article-title":"Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1\/Slc20a1 have an unexpected normal bone mineralization","volume":"8","author":"A Bourgine","year":"2013","journal-title":"PLOS ONE"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0895-6111(02)00011-3","article-title":"Structural MR image processing using the BRAINS2 toolbox","volume":"26","author":"VA Magnotta","year":"2002","journal-title":"Comput Med Imaging Graph"},{"key":"ref162","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.neuroimage.2006.05.006","article-title":"Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis","volume":"32","author":"A MacKenzie-Graham","year":"2006","journal-title":"Neuroimage"},{"key":"ref163","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fninf.2011.00013","article-title":"Nipype: A flexible, lightweight and extensible neuroimaging data processing framework in python","volume":"5","author":"K Gorgolewski","year":"2011","journal-title":"Front Neuroinform"},{"key":"ref164","first-page":"1","article-title":"BRAINSFIT: Mutual information registrations of whole-brain3DImages, using the insight toolkit","volume":"10","author":"H Johnson","year":"2007","journal-title":"Insight J"},{"key":"ref165","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10278-004-1014-6","article-title":"OsiriX: an open-source software for navigating in multidimensional DICOM images","volume":"17","author":"A Rosset","year":"2004","journal-title":"J Digit Imaging"},{"key":"ref166","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007675","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000}}],"container-title":["PLOS 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