{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T02:46:27Z","timestamp":1786934787447,"version":"build-2736575974"},"reference-count":133,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K01-HL135405-01"],"award-info":[{"award-number":["K01-HL135405-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001465","name":"American Thoracic Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL113338-04"],"award-info":[{"award-number":["R01-HL113338-04"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35-HL135818-01"],"award-info":[{"award-number":["R35-HL135818-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5-R01-HL046380-15"],"award-info":[{"award-number":["5-R01-HL046380-15"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5-KL2-RR024990-05"],"award-info":[{"award-number":["5-KL2-RR024990-05"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-55015"],"award-info":[{"award-number":["N01-HC-55015"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-55018"],"award-info":[{"award-number":["N01-HC-55018"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-55016"],"award-info":[{"award-number":["N01-HC-55016"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-55019"],"award-info":[{"award-number":["N01-HC-55019"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-55020"],"award-info":[{"award-number":["N01-HC-55020"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-55021"],"award-info":[{"award-number":["N01-HC-55021"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201200036C"],"award-info":[{"award-number":["HHSN268201200036C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268200800007C"],"award-info":[{"award-number":["HHSN268200800007C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC55222"],"award-info":[{"award-number":["N01HC55222"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85079"],"award-info":[{"award-number":["N01HC85079"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85080"],"award-info":[{"award-number":["N01HC85080"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85081"],"award-info":[{"award-number":["N01HC85081"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85082"],"award-info":[{"award-number":["N01HC85082"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85083"],"award-info":[{"award-number":["N01HC85083"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC85086"],"award-info":[{"award-number":["N01HC85086"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL080295"],"award-info":[{"award-number":["U01HL080295"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL087652"],"award-info":[{"award-number":["R01HL087652"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL105756"],"award-info":[{"award-number":["R01HL105756"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL103612"],"award-info":[{"award-number":["R01HL103612"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL120393"],"award-info":[{"award-number":["R01HL120393"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL130114"],"award-info":[{"award-number":["R01HL130114"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL085251"],"award-info":[{"award-number":["HL085251"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG023629"],"award-info":[{"award-number":["R01AG023629"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK063491"],"award-info":[{"award-number":["DK063491"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC25195"],"award-info":[{"award-number":["N01HC25195"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N02HL64278"],"award-info":[{"award-number":["N02HL64278"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL53941"],"award-info":[{"award-number":["U01HL53941"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300001I"],"award-info":[{"award-number":["HHSN268201300001I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC65233"],"award-info":[{"award-number":["N01HC65233"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300004I"],"award-info":[{"award-number":["HHSN268201300004I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC65234"],"award-info":[{"award-number":["N01HC65234"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300002I"],"award-info":[{"award-number":["HHSN268201300002I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC65235"],"award-info":[{"award-number":["N01HC65235"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300003I"],"award-info":[{"award-number":["HHSN268201300003I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC65236"],"award-info":[{"award-number":["N01HC65236"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300005I"],"award-info":[{"award-number":["HHSN268201300005I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC65237"],"award-info":[{"award-number":["N01HC65237"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300005C"],"award-info":[{"award-number":["HHSN268201300005C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["AM03"],"award-info":[{"award-number":["AM03"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["MOD03"],"award-info":[{"award-number":["MOD03"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300049C"],"award-info":[{"award-number":["HHSN268201300049C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300050C"],"award-info":[{"award-number":["HHSN268201300050C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300048C"],"award-info":[{"award-number":["HHSN268201300048C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300046C"],"award-info":[{"award-number":["HHSN268201300046C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201300047C"],"award-info":[{"award-number":["HHSN268201300047C"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM115428"],"award-info":[{"award-number":["U54GM115428"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201500003I"],"award-info":[{"award-number":["HHSN268201500003I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95159"],"award-info":[{"award-number":["N01HC95159"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95160"],"award-info":[{"award-number":["N01HC95160"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95161"],"award-info":[{"award-number":["N01HC95161"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95162"],"award-info":[{"award-number":["N01HC95162"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95163"],"award-info":[{"award-number":["N01HC95163"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95164"],"award-info":[{"award-number":["N01HC95164"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95165"],"award-info":[{"award-number":["N01HC95165"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95166"],"award-info":[{"award-number":["N01HC95166"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95167"],"award-info":[{"award-number":["N01HC95167"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95168"],"award-info":[{"award-number":["N01HC95168"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01HC95169"],"award-info":[{"award-number":["N01HC95169"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1TR000040"],"award-info":[{"award-number":["UL1TR000040"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1TR001079"],"award-info":[{"award-number":["UL1TR001079"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1TR001420"],"award-info":[{"award-number":["UL1TR001420"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1TR001881"],"award-info":[{"award-number":["UL1TR001881"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL56984"],"award-info":[{"award-number":["R01HL56984"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG027810"],"award-info":[{"award-number":["U01AG027810"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG042124"],"award-info":[{"award-number":["U01AG042124"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG042139"],"award-info":[{"award-number":["U01AG042139"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG042140"],"award-info":[{"award-number":["U01AG042140"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG042143"],"award-info":[{"award-number":["U01AG042143"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG042145"],"award-info":[{"award-number":["U01AG042145"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG042168"],"award-info":[{"award-number":["U01AG042168"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U01AR066160"],"award-info":[{"award-number":["U01AR066160"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000128"],"award-info":[{"award-number":["UL1TR000128"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL071194"],"award-info":[{"award-number":["R01HL071194"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL070848"],"award-info":[{"award-number":["R01HL070848"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL070847"],"award-info":[{"award-number":["R01HL070847"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL070842"],"award-info":[{"award-number":["R01HL070842"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL070841"],"award-info":[{"award-number":["R01HL070841"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL070837"],"award-info":[{"award-number":["R01HL070837"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL070838"],"award-info":[{"award-number":["R01HL070838"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL070839"],"award-info":[{"award-number":["R01HL070839"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR051124"],"award-info":[{"award-number":["R01AR051124"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["RC2AR058973"],"award-info":[{"award-number":["RC2AR058973"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK073541"],"award-info":[{"award-number":["R01DK073541"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01DK085501"],"award-info":[{"award-number":["U01DK085501"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI085014"],"award-info":[{"award-number":["R01AI085014"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL102830"],"award-info":[{"award-number":["R01HL102830"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sir Charles Gairdner Research Foundation"},{"DOI":"10.13039\/100008188","name":"Hollywood Private Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008188","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Western Australian Sleep Disorders Research Institute"},{"name":"Centre for Genetic Epidemiology and Biostatistics at the University of Western Australia"},{"DOI":"10.13039\/100012118","name":"Ontario Institute for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012118","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McLaughlin Centre Accelerator Grant from the University of Toronto"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007739","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T17:25:18Z","timestamp":1555435518000},"page":"e1007739","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-0673","authenticated-orcid":true,"given":"Brian E.","family":"Cade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9510-4923","authenticated-orcid":true,"given":"Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne M.","family":"Stilp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Louie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ancoli-Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raanan","family":"Arens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-7704","authenticated-orcid":true,"given":"Richard","family":"Barfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Below","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Conomos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis C.","family":"Frazier-Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina A.","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Gleason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-8751","authenticated-orcid":true,"given":"Daniel J.","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Hillman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Craig","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-0228","authenticated-orcid":true,"given":"David J.","family":"Lederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4079-7494","authenticated-orcid":true,"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose S.","family":"Loredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5021-1648","authenticated-orcid":true,"given":"Sutapa","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9142-5172","authenticated-orcid":true,"given":"Sanjay R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun M.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto R.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neomi A.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-8860","authenticated-orcid":true,"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent D.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis C.","family":"Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-5348","authenticated-orcid":true,"given":"Craig L.","family":"Hanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-3055","authenticated-orcid":true,"given":"Lyle J.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-1723","authenticated-orcid":true,"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Tranah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamil R.","family":"Sunyaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2572-4040","authenticated-orcid":true,"given":"Cathy C.","family":"Laurie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00415-003-1005-4","article-title":"Cognitive impairment in chronic obstructive pulmonary disease\u2013a neuropsychological and spect study","volume":"250","author":"R. Antonelli Incalzi","year":"2003","journal-title":"J Neurol"},{"key":"ref2","first-page":"613","article-title":"Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women","volume":"306","author":"K. Yaffe","year":"2011","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1165\/rcmb.2014-0135OC","article-title":"Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease","volume":"51","author":"M.-L.N. McDonald","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00408-014-9563-z","article-title":"Genetic influence on capillary oxygen saturation: a twin study","volume":"192","author":"D.L. Tarnoki","year":"2014","journal-title":"Lung"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/icb\/icj004","article-title":"Andean, Tibetan, and Ethiopian patterns of adaptation to high-altitude hypoxia","volume":"46","author":"C.M. Beall","year":"2006","journal-title":"Integr Comp Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/gepi.21957","article-title":"Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses","volume":"40","author":"J. Liang","year":"2016","journal-title":"Genet Epidemiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jacc.2006.08.060","article-title":"Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation","volume":"49","author":"A.S. Gami","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1164\/rccm.201201-0130OC","article-title":"Sleep-disordered breathing and cancer mortality: results from the Wisconsin Sleep Cohort Study","volume":"186","author":"F.J. Nieto","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1164\/rccm.201209-1671OC","article-title":"Association between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort","volume":"187","author":"F. Campos-Rodriguez","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.5665\/sleep.6004","article-title":"Sleep Apnea and Cancer: Analysis of a Nationwide Population Sample","volume":"39","author":"D. Gozal","year":"2016","journal-title":"Sleep"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/jsr.12321","article-title":"Minimal nocturnal oxygen saturation predicts future subclinical carotid atherosclerosis: the Wisconsin sleep cohort","volume":"24","author":"S.I. Gunnarsson","year":"2015","journal-title":"J. Sleep Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1001599","DOI":"10.1371\/journal.pmed.1001599","article-title":"Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study","volume":"11","author":"T. Kendzerska","year":"2014","journal-title":"PLoS Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/eurheartj\/ehv624","article-title":"Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients","volume":"37","author":"O. Oldenburg","year":"2016","journal-title":"Eur Heart J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.ijcard.2015.11.108","article-title":"Apnea-hypopnea and desaturations in heart failure with reduced ejection fraction: Are we aiming at the right target?","volume":"203","author":"B. Gellen","year":"2016","journal-title":"Int J Cardiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1378\/chest.13-0938","article-title":"Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea","volume":"145","author":"C. Minville","year":"2014","journal-title":"Chest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.rmed.2011.04.003","article-title":"Evaluating nocturnal oxygen desaturation in COPD\u2013revised","volume":"105","author":"Y. Lacasse","year":"2011","journal-title":"Respir Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jpeds.2011.10.008","article-title":"Sleep-disordered breathing is associated with asthma severity in children","volume":"160","author":"K.R. Ross","year":"2012","journal-title":"J Pediatr"},{"key":"ref18","first-page":"41","article-title":"Elevated nocturnal desaturation index predicts mortality in interstitial lung disease","volume":"29","author":"T.J. Corte","year":"2012","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5664\/jcsm.2758","article-title":"Sleep oxygen desaturation predicts survival in idiopathic pulmonary fibrosis","volume":"9","author":"L. Kolilekas","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature14132","article-title":"New genetic loci link adipose and insulin biology to body fat distribution","volume":"518","author":"D. Shungin","year":"2015","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1164\/ajrccm.163.3.9911064","article-title":"Prevalence of sleep-disordered breathing in women: effects of gender","volume":"163","author":"E.O. Bixler","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2147\/NSS.S101186","article-title":"Sex differences in sleep apnea predictors and outcomes from home sleep apnea testing","volume":"8","author":"A. Cairns","year":"2016","journal-title":"Nat Sci Sleep"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1113\/jphysiol.2004.064238","article-title":"The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans","volume":"558","author":"A.S. Jordan","year":"2004","journal-title":"J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/sleep\/33.4.467","article-title":"Sex differences in the association of regional fat distribution with the severity of obstructive sleep apnea","volume":"33","author":"L. Simpson","year":"2010","journal-title":"Sleep"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1164\/rccm.201512-2431OC","article-title":"Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic\/Latino Americans","volume":"194","author":"B.E. Cade","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general U.S. population","volume":"159","author":"J.L. Hankinson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/thx.48.2.125","article-title":"Arousal responses to added inspiratory resistance during REM and non-REM sleep in normal subjects","volume":"48","author":"M. Gugger","year":"1993","journal-title":"Thorax"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.5665\/sleep.5516","article-title":"Upper Airway Collapsibility (Pcrit) and Pharyngeal Dilator Muscle Activity are Sleep-Stage Dependent","volume":"39","author":"J.C. Carberry","year":"2016","journal-title":"Sleep"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41588-017-0009-4","article-title":"Multi-trait analysis of genome-wide association summary statistics using MTAG","volume":"50","author":"P. Turley","year":"2018","journal-title":"Nat. Genet"},{"key":"ref30","first-page":"69","article-title":"The regulation of glycolysis in mammalian erythrocytes","volume":"4","author":"S. Rapoport","year":"1968","journal-title":"Essays Biochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0021-9258(18)51741-5","article-title":"The Relationships between Substrates and Enzymes of Glycolysis in Brain","volume":"239","author":"O.H. Lowry","year":"1964","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1378\/chest.106.3.787","article-title":"Hematocrit levels in sleep apnea","volume":"106","author":"V. Hoffstein","year":"1994","journal-title":"Chest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1113\/EP085036","article-title":"Sea-level haemoglobin concentration is associated with greater exercise capacity in Tibetan males at 4200 m","volume":"100","author":"P.D. Wagner","year":"2015","journal-title":"Exp Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1210\/jc.2017-00619","article-title":"Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep","volume":"102","author":"S. Chopra","year":"2017","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"H.-J. Westra","year":"2013","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature11677","article-title":"Seventy-five genetic loci influencing the human red blood cell","volume":"492","author":"P. van der Harst","year":"2012","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.2337\/db10-0502","article-title":"Common variants at 10 genomic loci influence hemoglobin A\u2081(C) levels via glycemic and nonglycemic pathways","volume":"59","author":"N. Soranzo","year":"2010","journal-title":"Diabetes"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.metabol.2013.11.018","article-title":"Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS)","volume":"63","author":"P. An","year":"2014","journal-title":"Metabolism"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1073\/pnas.59.2.526","article-title":"Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin","volume":"59","author":"R. Benesch","year":"1968","journal-title":"Proc Natl Acad Sci U A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1182\/blood-2005-04-1622","article-title":"The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis","volume":"106","author":"R. van Wijk","year":"2005","journal-title":"Blood"},{"issue":"Pt 3","key":"ref41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj3420597","article-title":"Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: computer simulation and metabolic control analysis","volume":"342","author":"P.J. Mulquiney","year":"1999","journal-title":"Biochem J"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.celrep.2015.05.046","article-title":"mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation","volume":"12","author":"J.-S. Moon","year":"2015","journal-title":"Cell Rep"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1172\/JCI83260","article-title":"Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects","volume":"125","author":"J. Traba","year":"2015","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1183\/13993003.00564-2015","article-title":"NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung","volume":"47","author":"I. Lasithiotaki","year":"2016","journal-title":"Eur Respir J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.4049\/jimmunol.1400368","article-title":"Critical role for the NLRP3 inflammasome during acute lung injury","volume":"192","author":"J.J. Grailer","year":"2014","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12989-016-0162-4","article-title":"The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases","volume":"13","author":"M. Sayan","year":"2016","journal-title":"Part Fibre Toxicol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1165\/rcmb.2015-0222OC","article-title":"Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation","volume":"55","author":"H.W. Stout-Delgado","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/1753465815586335","article-title":"The role of the NLRP3 inflammasome in pulmonary diseases","volume":"9","author":"N. Hosseinian","year":"2015","journal-title":"Ther Adv Respir Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1398-9995.2011.02586.x","article-title":"NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant","volume":"66","author":"A.-G. Besnard","year":"2011","journal-title":"Allergy"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5415\/apallergy.2014.4.4.187","article-title":"Role of inflammasome activation in development and exacerbation of asthma","volume":"4","author":"T.-H. Lee","year":"2014","journal-title":"Asia Pac Allergy"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/cea.12206","article-title":"The NLRP3 inflammasome: role in airway inflammation","volume":"44","author":"H. Im","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.4049\/jimmunol.1200860","article-title":"Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury","volume":"190","author":"J. Wu","year":"2013","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.smrv.2014.07.003","article-title":"Oxidative stress in obstructive sleep apnea and intermittent hypoxia\u2013revisited\u2013the bad ugly and good: implications to the heart and brain","volume":"20","author":"L. Lavie","year":"2015","journal-title":"Sleep Med Rev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1183\/09031936.00150708","article-title":"Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnoea","volume":"33","author":"D.J. Lederer","year":"2009","journal-title":"Eur Respir J"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1513\/AnnalsATS.201701-091OC","article-title":"Obstructive Sleep Apnea and Subclinical Interstitial Lung Disease in MESA","volume":"14","author":"J.S. Kim","year":"2017","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1165\/rcmb.2014-0213OC","article-title":"Effects of chronic intermittent hypoxia on allergen-induced airway inflammation in rats","volume":"52","author":"O. Broytman","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbi.2017.01.012","article-title":"The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide","volume":"62","author":"M.R. Zielinski","year":"2017","journal-title":"Brain Behav Immun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00424-015-1719-z","article-title":"Regulation of carotid body oxygen sensing by hypoxia-inducible factors","volume":"468","author":"N.R. Prabhakar","year":"2016","journal-title":"Pflugers Arch"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2407-6-26","article-title":"Hypoxia-inducible transcription factor-1alpha promotes hypoxia-induced A549 apoptosis via a mechanism that involves the glycolysis pathway","volume":"6","author":"F. Luo","year":"2006","journal-title":"BMC Cancer"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"E.M. Palsson-McDermott","year":"2015","journal-title":"Cell Metab"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1172\/JCI84431","article-title":"HIF1\u03b1 and metabolic reprogramming in inflammation","volume":"126","author":"S.E. Corcoran","year":"2016","journal-title":"J Clin Invest"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e1001665","DOI":"10.1371\/journal.pbio.1001665","article-title":"HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium","volume":"11","author":"T. Eckle","year":"2013","journal-title":"PLoS Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.4049\/jimmunol.162.9.5041","article-title":"Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor","volume":"162","author":"K. Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.4049\/jimmunol.174.9.5351","article-title":"Accessory protein-like is essential for IL-18-mediated signaling","volume":"174","author":"H. Cheung","year":"2005","journal-title":"J Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fimmu.2013.00289","article-title":"Interleukin-18 and IL-18 binding protein","volume":"4","author":"C.A. Dinarello","year":"2013","journal-title":"Front Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/ng.3695","article-title":"Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota","volume":"48","author":"J. Wang","year":"2016","journal-title":"Nat. Genet"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1164\/rccm.200603-316OC","article-title":"Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13","volume":"176","author":"T. Hoshino","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1164\/rccm.201108-1545OC","article-title":"IL-18 induces emphysema and airway and vascular remodeling via IFN-\u03b3, IL-17A, and IL-13","volume":"185","author":"M.-J. Kang","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1164\/rccm.201201-0003OC","article-title":"Inflammasome-regulated cytokines are critical mediators of acute lung injury","volume":"185","author":"T. Dolinay","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1165\/rcmb.2013-0087OC","article-title":"The NLRP3 inflammasome is required for the development of hypoxemia in LPS\/mechanical ventilation acute lung injury","volume":"50","author":"H.D. Jones","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1164\/rccm.200412-1652OC","article-title":"Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea","volume":"172","author":"K. Minoguchi","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1038\/ncomms5753","article-title":"Circadian rhythm reprogramming during lung inflammation","volume":"5","author":"J.A. Haspel","year":"2014","journal-title":"Nat Commun"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"M.F. Moffatt","year":"2010","journal-title":"N Engl J Med"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1091\/mbc.e07-02-0182","article-title":"Hypoxia-induced IL-18 increases hypoxia-inducible factor-1alpha expression through a Rac1-dependent NF-kappaB pathway","volume":"19","author":"J. Kim","year":"2008","journal-title":"Mol Biol Cell"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2353\/ajpath.2006.060058","article-title":"alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis","volume":"169","author":"I. Petrache","year":"2006","journal-title":"Am J Pathol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1161\/ATVBAHA.114.303416","article-title":"Endothelial deletion of phospholipase D2 reduces hypoxic response and pathological angiogenesis","volume":"34","author":"J. Ghim","year":"2014","journal-title":"Arter. Thromb Vasc Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/cne.22753","article-title":"Reelin demarcates a subset of pre-B\u00f6tzinger complex neurons in adult rat","volume":"520","author":"W. Tan","year":"2012","journal-title":"J Comp Neurol"},{"key":"ref78","first-page":"3589","article-title":"Gpr177 regulates pulmonary vasculature development","volume":"140","author":"M. Jiang","year":"2013","journal-title":"Dev. Camb. Engl"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1164\/rccm.201202-0366OC","article-title":"Genome-wide association studies identify CHRNA5\/3 and HTR4 in the development of airflow obstruction","volume":"186","author":"J.B. Wilk","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/resp.13107","article-title":"The overlaps of asthma or COPD with OSA: A focused review","volume":"22","author":"R.L. Owens","year":"2017","journal-title":"Respirol. Carlton Vic"},{"key":"ref81","first-page":"23","article-title":"A pathway-based analysis on the effects of obstructive sleep apnea in modulating visceral fat transcriptome","volume":"36","author":"S.A. Gharib","year":"2013","journal-title":"Sleep"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/ejhg.2016.197","article-title":"Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children","volume":"25","author":"C.R. Marques","year":"2017","journal-title":"Eur J Hum Genet"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1101\/gad.1286005","article-title":"Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine\/threonine phosphatase 4","volume":"19","author":"X. Zhang","year":"2005","journal-title":"Genes Dev"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1126\/science.1198125","article-title":"A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism","volume":"331","author":"D. Feng","year":"2011","journal-title":"Science"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"P.E. Peppard","year":"2013","journal-title":"Am J Epidemiol"},{"key":"ref86","first-page":"1183","article-title":"Principles and Practice of Sleep Medicine","author":"S. Redline","year":"2011"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","article-title":"The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators","volume":"129","year":"1989","journal-title":"Am. J. Epidemiol"},{"key":"ref88","first-page":"59","article-title":"The Framingham Study: sample selection, follow-up, and methods of analyses","volume":"67","author":"M. Feinleib","year":"1985","journal-title":"Natl Cancer Inst Monogr"},{"key":"ref89","first-page":"1077","article-title":"The Sleep Heart Health Study: design, rationale, and methods","volume":"20","author":"S.F. Quan","year":"1997","journal-title":"Sleep"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/sleep\/21.7.759","article-title":"Methods for obtaining and analyzing unattended polysomnography data for a multicenter study","volume":"21","author":"S. Redline","year":"1998","journal-title":"Sleep"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/ajrccm\/151.3_Pt_1.682","article-title":"The familial aggregation of obstructive sleep apnea","volume":"151","author":"S. Redline","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-Ethnic Study of Atherosclerosis: objectives and design","volume":"156","author":"D.E. Bild","year":"2002","journal-title":"Am J Epidemiol"},{"key":"ref93","first-page":"877","article-title":"Racial\/Ethnic Differences in Sleep Disturbances: The Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"38","author":"X. Chen","year":"2015","journal-title":"Sleep"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cct.2005.05.006","article-title":"Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study\u2013a large observational study of the determinants of fracture in older men","volume":"26","author":"E. Orwoll","year":"2005","journal-title":"Contemp Clin Trials"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1532-5415.2007.01290.x","article-title":"Prevalence and correlates of sleep-disordered breathing in older men: osteoporotic fractures in men sleep study","volume":"55","author":"R. Mehra","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/oxfordjournals.aje.a113677","article-title":"Diabetes among Mexican Americans in Starr County, Texas","volume":"118","author":"C.L. Hanis","year":"1983","journal-title":"Am J Epidemiol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12933-016-0405-6","article-title":"Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas","volume":"15","author":"C.L. Hanis","year":"2016","journal-title":"Cardiovasc Diabetol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3109\/00016480903431139","article-title":"Validation study of portable device for the diagnosis of obstructive sleep apnea according to the new AASM scoring criteria: Watch-PAT 100","volume":"130","author":"J.H. Choi","year":"2010","journal-title":"Acta Otolaryngol. (Stockh.)"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1047-2797(91)90005-W","article-title":"The Cardiovascular Health Study: design and rationale","volume":"1","author":"L.P. Fried","year":"1991","journal-title":"Ann Epidemiol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.annepidem.2010.03.015","article-title":"Design and implementation of the Hispanic Community Health Study\/Study of Latinos","volume":"20","author":"P.D. Sorlie","year":"2010","journal-title":"Ann Epidemiol"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1164\/rccm.201309-1735OC","article-title":"Sleep-disordered breathing in Hispanic\/Latino individuals of diverse backgrounds. The Hispanic Community Health Study\/Study of Latinos","volume":"189","author":"S. Redline","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1378\/chest.128.4.2166","article-title":"Description and validation of the apnea risk evaluation system: a novel method to diagnose sleep apnea-hypopnea in the home","volume":"128","author":"P.R. Westbrook","year":"2005","journal-title":"Chest"},{"issue":"S6","key":"ref103","first-page":"4","article-title":"Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study","volume":"15","author":"H.A.J. Taylor","year":"2005","journal-title":"Ethn Dis"},{"issue":"S6","key":"ref104","first-page":"30","article-title":"Study design for genetic analysis in the Jackson Heart Study","volume":"15","author":"J.G. Wilson","year":"2005","journal-title":"Ethn Dis"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1440-1843.2009.01697.x","article-title":"Validation of Embletta portable diagnostic system for identifying patients with suspected obstructive sleep apnoea syndrome (OSAS)","volume":"15","author":"S.S.S. Ng","year":"2010","journal-title":"Respirol. Carlton Vic"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11325-011-0491-3","article-title":"Cohort profile: the Western Australian Sleep Health Study","volume":"16","author":"S. Mukherjee","year":"2012","journal-title":"Sleep Breath"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/sleep\/21.7.749","article-title":"Reliability of scoring respiratory disturbance indices and sleep staging","volume":"21","author":"C.W. Whitney","year":"1998","journal-title":"Sleep"},{"key":"ref108","article-title":"A reference panel of 64,976 haplotypes for genotype imputation","author":"S. McCarthy","year":"2015","journal-title":"BioRxiv 035170"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","year":"2015","journal-title":"Nature"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"B.N. Howie","year":"2009","journal-title":"PLoS Genet"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.ajhg.2015.04.018","article-title":"Improved ancestry estimation for both genotyping and sequencing data using projection procrustes analysis and genotype imputation","volume":"96","author":"C. Wang","year":"2015","journal-title":"Am J Hum Genet"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/ng.2310","article-title":"Genome-wide efficient mixed-model analysis for association studies","volume":"44","author":"X. Zhou","year":"2012","journal-title":"Nat Genet"},{"key":"ref113","unstructured":"Conomos, M.P., Thornton, T.A., Gogarten, S.M., and Brown, L. (2017). GENESIS: GENetic EStimation and Inference in Structured samples (GENESIS): Statistical methods for analyzing genetic data from samples with population structure and\/or relatedness. R package version 2.8.0. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.18129\/B9.bioc.GENESIS\" xlink:type=\"simple\">10.18129\/B9.bioc.GENESIS<\/ext-link><\/comment>"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"C.J. Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/bioinformatics\/btv690","article-title":"LocusExplorer: a user-friendly tool for integrated visualization of human genetic association data and biological annotations","volume":"32","author":"T. Dadaev","year":"2016","journal-title":"Bioinformatics"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/bioinformatics\/btu621","article-title":"EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data","volume":"31","author":"T.W. Winkler","year":"2015","journal-title":"Bioinformatics"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"e26557","DOI":"10.7554\/eLife.26557","article-title":"Bmal1 function in skeletal muscle regulates sleep","volume":"6","author":"J.C. Ehlen","year":"2017","journal-title":"ELife"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"L.D. Ward","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"A. Kundaje","year":"2015","journal-title":"Nature"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.cell.2016.09.037","article-title":"Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters","volume":"167","author":"B.M. Javierre","year":"2016","journal-title":"Cell"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.cell.2016.10.026","article-title":"Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells","volume":"167","author":"L. Chen","year":"2016","journal-title":"Cell"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.celrep.2014.09.023","article-title":"Large-scale identification of coregulated enhancer networks in the adult human brain","volume":"9","author":"M.W. Vermunt","year":"2014","journal-title":"Cell Rep"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature12531","article-title":"Transcriptome and genome sequencing uncovers functional variation in humans","volume":"501","author":"T. Lappalainen","year":"2013","journal-title":"Nature"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","year":"2015","journal-title":"Science"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"1246949","DOI":"10.1126\/science.1246949","article-title":"Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression","volume":"343","author":"B.P. Fairfax","year":"2014","journal-title":"Science"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1126\/science.1249547","article-title":"Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes","volume":"344","author":"T. Raj","year":"2014","journal-title":"Science"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"e10693","DOI":"10.1371\/journal.pone.0010693","article-title":"Genetics and beyond\u2013the transcriptome of human monocytes and disease susceptibility","volume":"5","author":"T. Zeller","year":"2010","journal-title":"PLoS One"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"e1003029","DOI":"10.1371\/journal.pgen.1003029","article-title":"Lung eQTLs to help reveal the molecular underpinnings of asthma","volume":"8","author":"K. Hao","year":"2012","journal-title":"PLoS Genet"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ng.2394","article-title":"Mapping cis- and trans-regulatory effects across multiple tissues in twins","volume":"44","author":"E. Grundberg","year":"2012","journal-title":"Nat. Genet"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/bioinformatics\/bty147","article-title":"A Bayesian framework for multiple trait colocalization from summary association statistics","volume":"34","author":"C. Giambartolomei","year":"2018","journal-title":"Bioinformatics"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics","volume":"9","author":"A.N. Barbeira","year":"2018","journal-title":"Nat Commun"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/bioinformatics\/bty529","article-title":"GIGSEA: Genotype Imputed Gene Set Enrichment Analysis using GWAS Summary Level Data","volume":"35","author":"S. Zhu","year":"2018","journal-title":"Bioinformatics"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T23:25:05Z","timestamp":1721172305000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007739"}},"subtitle":[],"editor":[{"given":"Courtney G.","family":"Montgomery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":133,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007739","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]}}}