{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:01:05Z","timestamp":1792213265543,"version":"4.4.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1-AG054074"],"award-info":[{"award-number":["RF1-AG054074"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01-AG032984"],"award-info":[{"award-number":["U01-AG032984"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01-AG052410"],"award-info":[{"award-number":["U01-AG052410"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007791","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T13:36:15Z","timestamp":1544016975000},"page":"e1007791","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":198,"title":["Ancestral origin of ApoE \u03b54 Alzheimer disease risk in Puerto Rican and African American populations"],"prefix":"10.1371","volume":"14","author":[{"given":"Farid","family":"Rajabli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briseida E.","family":"Feliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Celis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara L.","family":"Hamilton-Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice L.","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker L.","family":"Bussies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara P.","family":"Manrique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takiyah","family":"Starks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace E.","family":"Byfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina B.","family":"Sierra Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob L.","family":"McCauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heriberto","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2354-4911","authenticated-orcid":true,"given":"Angel","family":"Chinea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-5157","authenticated-orcid":true,"given":"Brian W.","family":"Kunkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Reitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-4225","authenticated-orcid":true,"given":"Lindsay A.","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard D.","family":"Schellenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badri N.","family":"Vardarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery M.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Cuccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4035-9152","authenticated-orcid":true,"given":"Eden R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goldie S.","family":"Byrd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Beecham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7283-8804","authenticated-orcid":true,"given":"Margaret A.","family":"Pericak-Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 Census","volume":"80","author":"LE Hebert","year":"2013","journal-title":"Neurology"},{"key":"ref2","article-title":"Alzheimer Disease Life Course Perspectives on Risk Reduction","author":"AR Borenstein","year":"2016"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"EH Corder","year":"1993","journal-title":"Science"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"EH Corder","year":"1994","journal-title":"Nat Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/mp.2013.194","article-title":"APOE2 enhances neuroprotection against Alzheimer\u2019s disease through multiple molecular mechanisms","volume":"19","author":"C Conejero-Goldberg","year":"2014","journal-title":"Mol Psychiatry"},{"issue":"16","key":"ref6","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis","volume":"278","author":"LA Farrer","year":"1997","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/srep04383","article-title":"Apolipoprotein E gene polymorphism and Alzheimer\u2019s disease in Chinese population: a meta-analysis","volume":"4","author":"M Liu","year":"2014","journal-title":"Sci Rep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/jama.279.10.751","article-title":"The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics","volume":"279","author":"MX Tang","year":"1998","journal-title":"JAMA"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1212\/WNL.56.1.49","article-title":"Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan","volume":"56","author":"MX Tang","year":"2001","journal-title":"Neurology"},{"issue":"3","key":"ref10","first-page":"574","article-title":"Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City","volume":"58","author":"MX Tang","year":"1996","journal-title":"Am J Hum Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/ana.410420418","article-title":"Apolipoprotein E-associated risk for Alzheimer\u2019s disease in the African-American population is genotype dependent","volume":"42","author":"A Sahota","year":"1997","journal-title":"Ann Neurol"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1017\/S1041610214000167","article-title":"APOE \u03b54 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba","volume":"26","author":"HC Hendrie","year":"2014","journal-title":"Int Psychogeriatr"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1001\/archneur.59.4.594","article-title":"Association Between Apolipoprotein E Genotype and Alzheimer Disease in African American Subjects","volume":"59","author":"NR Graff-Radford","year":"2002","journal-title":"Arch Neurol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1385\/JMN:20:3:207","article-title":"Genetic and environmental epidemiology of Alzheimer\u2019s disease in arabs residing in Israel","volume":"20","author":"LA Farrer","year":"2003","journal-title":"J Mol Neurosci"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0304-3940(02)00150-7","article-title":"Apolipoprotein E4 and tau allele frequencies among Choctaw Indians","volume":"324","author":"JN Henderson","year":"2002","journal-title":"Neurosci Lett"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1212\/WNL.55.5.731","article-title":"The very high prevalence of AD in an Arab population is not explained by APOE epsilon4 allele frequency","volume":"55","author":"A Bowirrat","year":"2000","journal-title":"Neurology"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1186\/s40246-014-0023-x","article-title":"Self-reported race\/ethnicity in the age of genomic research: its potential impact on understanding health disparities","volume":"9","author":"TB Mersha","year":"2015","journal-title":"Hum Genomics"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"e6821","DOI":"10.1371\/journal.pone.0006821","article-title":"Genetic ancestry, social classification, and racial inequalities in blood pressure in Southeastern Puerto Rico","volume":"4","author":"CC Gravlee","year":"2009","journal-title":"PLoS One"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.2105\/AJPH.2013.301370","article-title":"Socioeconomic status and lung cancer: unraveling the contribution of genetic admixture","volume":"103","author":"MC Aldrich","year":"2013","journal-title":"Am J Public Health"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3233\/JAD-160424","article-title":"Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study","volume":"56","author":"B Fenesi","year":"2017","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/gepi.22103","article-title":"Properties of global- and local-ancestry adjustments in genetic association tests in admixed populations","volume":"42","author":"ER Martin","year":"2018","journal-title":"Genet Epidemiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/978-1-4939-7274-6_25","article-title":"The Analysis of Ethnic Mixtures","volume":"1666","author":"X Zhu","year":"2017","journal-title":"Methods Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1001\/jama.2013.2973","article-title":"Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4, and the risk of late-onset Alzheimer disease in African Americans","volume":"309","author":"C Reitz","year":"2013","journal-title":"JAMA"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1212\/NXG.0000000000000079","article-title":"ABCA7 frameshift deletion with Alzheimer disease in African Americans","volume":"2","author":"HN Cukier","year":"2016","journal-title":"Neurol Genet"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"G McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"MS Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1001308","DOI":"10.1371\/journal.pgen.1001308","article-title":"Genome-wide association of familial late-onset Alzheimer\u2019s disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE","volume":"7","author":"EM Wijsman","year":"2011","journal-title":"PLoS Genet"},{"issue":"3","key":"ref28","first-page":"189","article-title":"&quot;Mini-mental state&quot;. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"8","key":"ref29","first-page":"314","article-title":"The Modified Mini-Mental State (3MS) examination","volume":"48","author":"EL Teng","year":"1987","journal-title":"J Clin Psychiatry"},{"issue":"9020","key":"ref30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0140-6736(96)01251-2","article-title":"Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer\u2019s disease","volume":"348","author":"AM Saunders","year":"1996","journal-title":"Lancet"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a toolset for whole-genome association and population-based linkage analysis","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/nprot.2010.116","article-title":"Data quality control in genetic case-control association studies","volume":"5","author":"AC Anderson","year":"2010","journal-title":"Nat Protoc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1038\/ncomms4934","article-title":"Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel","volume":"5","author":"O Delaneau","year":"2014","journal-title":"Nature Communications"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","year":"2015","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajhg.2013.06.020","article-title":"RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference","volume":"93","author":"BK Maples","year":"2013","journal-title":"Am. J. Hum. Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"key":"ref37","unstructured":"Marschner I. glm2: Fitting Generalized Linear Models. R package version 1.1.2.2014;<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/CRAN.R-project.org\/package=glm2\" xlink:type=\"simple\">https:\/\/CRAN.R-project.org\/package=glm2<\/ext-link>"},{"key":"ref38","unstructured":"Vincent JC. gee:Generalized Estimation Equation Solver. R package version 4.13\u201319.2015;<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/CRAN.R-project.org\/package=gee\" xlink:type=\"simple\">https:\/\/CRAN.R-project.org\/package=gee<\/ext-link>"},{"issue":"293","key":"ref39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/01621459.1961.10482090","article-title":"Multiple Comparisons Among Means","volume":"56","author":"OJ Dunn","year":"1961","journal-title":"Journal of the American Statistical Association"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:31:51Z","timestamp":1588962711000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007791"}},"subtitle":[],"editor":[{"given":"Gregory S.","family":"Barsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007791","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]}}}