{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:42:00Z","timestamp":1790329320200,"version":"4.1.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1S10RR027564"],"award-info":[{"award-number":["1S10RR027564"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["NIH U19-AI109725"],"award-info":[{"award-number":["NIH U19-AI109725"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K99\/R00-AG039512"],"award-info":[{"award-number":["K99\/R00-AG039512"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21-HD087741"],"award-info":[{"award-number":["R21-HD087741"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["NIH U19-AI109725"],"award-info":[{"award-number":["NIH U19-AI109725"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["NIH P30-DK043351"],"award-info":[{"award-number":["NIH P30-DK043351"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["NIH P30-DK057521"],"award-info":[{"award-number":["NIH P30-DK057521"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM104936"],"award-info":[{"award-number":["P20GM104936"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["JEOL JEM-1400"],"award-info":[{"award-number":["JEOL JEM-1400"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health","award":["P30-GM103326"],"award-info":[{"award-number":["P30-GM103326"]}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1008084","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T13:57:14Z","timestamp":1557151034000},"page":"e1008084","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice"],"prefix":"10.1371","volume":"15","author":[{"given":"Ianina C.","family":"Ferder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-3622","authenticated-orcid":true,"given":"Leslie","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Ohguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-461X","authenticated-orcid":true,"given":"Kara G.","family":"Lassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-788X","authenticated-orcid":true,"given":"Diane","family":"Capen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramnik J.","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4647-5880","authenticated-orcid":true,"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nrg2723","article-title":"Genetics of mammalian meiosis: regulation, dynamics and impact on fertility","volume":"11","author":"MA Handel","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"a002683","DOI":"10.1101\/cshperspect.a002683","article-title":"Molecular regulation of the mitosis\/meiosis decision in multicellular organisms","volume":"3","author":"J. Kimble","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.135.2.469","article-title":"Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene","volume":"135","author":"M Oulad-Abdelghani","year":"1996","journal-title":"J Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"35781","DOI":"10.1074\/jbc.M109.056481","article-title":"STRA8 shuttles between nucleus and cytoplasm and displays transcriptional activity","volume":"284","author":"M Tedesco","year":"2009","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0012-1606(03)00391-9","article-title":"Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave","volume":"262","author":"DB Menke","year":"2003","journal-title":"Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1095\/biolreprod.107.066795","article-title":"in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes","volume":"79","author":"Q Zhou","year":"2008","journal-title":"Biol Reprod"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/ng1919","article-title":"In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication","volume":"38","author":"AE Baltus","year":"2006","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"14976","DOI":"10.1073\/pnas.0807297105","article-title":"Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice","volume":"105","author":"EL Anderson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1242\/jcs.035071","article-title":"STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation","volume":"121","author":"M Mark","year":"2008","journal-title":"J Cell Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-genet-120215-035449","article-title":"Sex Determination in the Mammalian Germline","volume":"51","author":"C Spiller","year":"2017","journal-title":"Annu Rev Genet"},{"key":"ref11","article-title":"Autophagy in mammalian development and differentiation","volume":"12","author":"N Mizushima","year":"2010"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-pathol-020712-163918","article-title":"Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease","volume":"8","author":"L Murrow","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"C Settembre","year":"2011","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.1545107","article-title":"Autophagy suppresses tumor progression by limiting chromosomal instability","volume":"21","author":"R Mathew","year":"2007","journal-title":"Genes Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1101\/gad.1565707","article-title":"Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis","volume":"21","author":"V Karantza-Wadsworth","year":"2007","journal-title":"Genes Dev"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1128\/MCB.01044-14","article-title":"RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1","volume":"35","author":"S Chen","year":"2015","journal-title":"Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/cdd.2013.103","article-title":"Autophagy and genomic integrity","volume":"20","author":"AT Vessoni","year":"2013","journal-title":"Cell Death Differ"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fgene.2016.00204","article-title":"DNA Damage Response and Autophagy: A Meaningful Partnership","volume":"7","author":"AG Eliopoulos","year":"2016","journal-title":"Front Genet"},{"issue":"34","key":"ref19","doi-asserted-by":"crossref","first-page":"56791","DOI":"10.18632\/oncotarget.18221","article-title":"In vivo autophagy and biogenesis of autophagosomes within male haploid cells during spermiogenesis","volume":"8","author":"P Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"N Mizushima","year":"2010","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1681\/ASN.2013040374","article-title":"New autophagy reporter mice reveal dynamics of proximal tubular autophagy","volume":"25","author":"L Li","year":"2014","journal-title":"Journal of the American Society of Nephrology: JASN"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Y Kabeya","year":"2000","journal-title":"EMBO J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200507002","article-title":"p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death","volume":"171","author":"G Bj\u00f8rk\u00f8y","year":"2005","journal-title":"The Journal of Cell Biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","article-title":"In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker","volume":"15","author":"N Mizushima","year":"2004","journal-title":"Mol Biol Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"J Kim","year":"2011","journal-title":"Nature cell biology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and Autophagy","volume":"445","author":"I Tanida","year":"2008","journal-title":"Methods Mol Biol"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1073\/pnas.87.12.4722","article-title":"Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains","volume":"87","author":"A Voronova","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","article-title":"The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator","volume":"110","author":"N Preitner","year":"2002","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1080\/15548627.2015.1091140","article-title":"NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy","volume":"11","author":"V Chandra","year":"2015","journal-title":"Autophagy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nm.3213","article-title":"Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy","volume":"19","author":"E Woldt","year":"2013","journal-title":"Nat Med"},{"key":"ref31","article-title":"The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1\/Rev-erbalpha and indirectly via Cebpb\/(C\/ebpbeta) in zebrafish","author":"G Huang","year":"2016","journal-title":"Autophagy"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15891","DOI":"10.18632\/oncotarget.4045","article-title":"Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression","volume":"6","author":"IC Ferder","year":"2015","journal-title":"Oncotarget"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/cdd.2011.33","article-title":"Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death","volume":"18","author":"W Gao","year":"2011","journal-title":"Cell Death Differ"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1074\/jbc.M116.771584","article-title":"Regulation of ULK1 Expression and Autophagy by STAT1","volume":"292","author":"AA Goldberg","year":"2017","journal-title":"J Biol Chem"},{"key":"ref35","first-page":"e001","article-title":"Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism","volume":"8","author":"L Yin","year":"2010","journal-title":"Nucl Recept Signal"},{"issue":"17","key":"ref36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95177","article-title":"REV-ERBalpha ameliorates heart failure through transcription repression","volume":"2","author":"L Zhang","year":"2017","journal-title":"JCI Insight"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4161\/auto.23323","article-title":"The ULK1 complex: sensing nutrient signals for autophagy activation","volume":"9","author":"PM Wong","year":"2013","journal-title":"Autophagy"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1097-2765(00)80404-9","article-title":"The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility","volume":"5","author":"L Yuan","year":"2000","journal-title":"Mol Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"EP Rogakou","year":"1998","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S1097-2765(00)00098-8","article-title":"Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11","volume":"6","author":"F Baudat","year":"2000","journal-title":"Mol Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S1097-2765(00)00097-6","article-title":"The mouse Spo11 gene is required for meiotic chromosome synapsis","volume":"6","author":"PJ Romanienko","year":"2000","journal-title":"Mol Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1097-2765(00)80069-6","article-title":"Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog","volume":"1","author":"DL Pittman","year":"1998","journal-title":"Mol Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1097-2765(00)80070-2","article-title":"The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis","volume":"1","author":"K Yoshida","year":"1998","journal-title":"Mol Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1021\/cb1002575","article-title":"Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB","volume":"6","author":"D Kojetin","year":"2011","journal-title":"ACS Chem Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1126\/science.1071907","article-title":"Sex matters in meiosis","volume":"296","author":"PA Hunt","year":"2002","journal-title":"Science"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1530\/rep.1.00865","article-title":"Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis","volume":"130","author":"MA Morelli","year":"2005","journal-title":"Reproduction"},{"issue":"9","key":"ref47","doi-asserted-by":"crossref","first-page":"e1005531","DOI":"10.1371\/journal.pgen.1005531","article-title":"A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary","volume":"11","author":"YQ Soh","year":"2015","journal-title":"PLoS Genet"},{"issue":"5","key":"ref48","first-page":"2819","article-title":"Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway","volume":"42","author":"X Shen","year":"2018","journal-title":"Int J Mol Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: the interplay of autophagy and apoptosis","volume":"15","author":"G Marino","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/15548627.2016.1149659","article-title":"Distinct temporal requirements for autophagy and the proteasome in yeast meiosis","volume":"12","author":"FP Wen","year":"2016","journal-title":"Autophagy"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/gtc.12320","article-title":"Autophagy is required for efficient meiosis progression and proper meiotic chromosome segregation in fission yeast","volume":"21","author":"H Matsuhara","year":"2016","journal-title":"Genes Cells"},{"issue":"7529","key":"ref52","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature13949","article-title":"Transcriptional regulation of autophagy by an FXR-CREB axis","volume":"516","author":"S Seok","year":"2014","journal-title":"Nature"},{"issue":"11","key":"ref53","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/nrg3573","article-title":"Meiotic recombination in mammals: localization and regulation","volume":"14","author":"F Baudat","year":"2013","journal-title":"Nat Rev Genet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","article-title":"Autophagy Suppresses Tumorigenesis through Elimination of p62","volume":"137","author":"R Mathew","year":"2009","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molcel.2016.05.027","article-title":"Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1\/p62","volume":"63","author":"Y Wang","year":"2016","journal-title":"Molecular Cell"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"13508","DOI":"10.1038\/ncomms13508","article-title":"Autophagy controls centrosome number by degrading Cep63","volume":"7","author":"Y Watanabe","year":"2016","journal-title":"Nat Commun"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2007.10.035","article-title":"Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice","volume":"131","author":"M Komatsu","year":"2007","journal-title":"Cell"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1073\/pnas.1409563112","article-title":"Loss of autophagy causes a synthetic lethal deficiency in DNA repair","volume":"112","author":"EY Liu","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e1906","DOI":"10.1038\/cddis.2015.265","article-title":"In vitro differentiation of germ cells from stem cells: a comparison between primordial germ cells and in vitro derived primordial germ cell-like cells","volume":"6","author":"W Ge","year":"2015","journal-title":"Cell Death Dis"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.cell.2014.11.003","article-title":"Identification of spinal circuits transmitting and gating mechanical pain","volume":"159","author":"B Duan","year":"2014","journal-title":"Cell"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1008084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:13:19Z","timestamp":1589008399000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1008084"}},"subtitle":[],"editor":[{"given":"M\u00f3nica P.","family":"Colai\u00e1covo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,6]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1008084","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,6]]}}}