{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:58:45Z","timestamp":1789905525955,"version":"4.0.1"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T00:00:00Z","timestamp":1565827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG038688"],"award-info":[{"award-number":["R01AG038688"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1AG045835"],"award-info":[{"award-number":["RO1AG045835"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Federation for Aging Research (US)"},{"DOI":"10.13039\/100001167","name":"Larry L. Hillblom Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK103729"],"award-info":[{"award-number":["R01DK103729"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM717537"],"award-info":[{"award-number":["T32 GM717537"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1008318","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T13:29:26Z","timestamp":1565875766000},"page":"e1008318","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster"],"prefix":"10.1371","volume":"15","author":[{"given":"Sven","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler A.","family":"Hilsabeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-9977","authenticated-orcid":true,"given":"Kenneth A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0851-3965","authenticated-orcid":true,"given":"Amit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelanjan","family":"Bose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna J.","family":"Brackman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-9271","authenticated-orcid":true,"given":"Jennifer N.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-4457","authenticated-orcid":true,"given":"Mark A.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-6527","authenticated-orcid":true,"given":"David W.","family":"Killilea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-5430","authenticated-orcid":true,"given":"Kathleen","family":"Giacomini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall L.","family":"Stoller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Kapahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"issue":"1","key":"pgen.1008318.ref001","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-physiol-021113-170343","article-title":"The Molecular Physiology of Uric Acid Homeostasis","volume":"77","author":"AK Mandal","year":"2015","journal-title":"Annual Review of Physiology"},{"key":"pgen.1008318.ref002","article-title":"Regulation of mammalian nucleotide metabolism and biosynthesis","author":"AN Lane","year":"2015","journal-title":"Nucleic Acids Research"},{"issue":"10","key":"pgen.1008318.ref003","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1073\/pnas.1320393111","article-title":"Evolutionary history and metabolic insights of ancient mammalian uricases","volume":"111","author":"JT Kratzer","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"pgen.1008318.ref004","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biochi.2015.06.025","article-title":"Uric acid as a modulator of glucose and lipid metabolism","volume":"116","author":"WG Lima","year":"2015","journal-title":"Biochimie"},{"issue":"6","key":"pgen.1008318.ref005","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/molbev\/msq022","article-title":"The Evolutionary Fate of the Genes Encoding the Purine Catabolic Enzymes in Hominoids, Birds, and Reptiles","volume":"27","author":"AC Keebaugh","year":"2010","journal-title":"Molecular Biology and Evolution"},{"issue":"13","key":"pgen.1008318.ref006","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.2174\/1381612811319130011","article-title":"Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk","volume":"19","author":"D Grassi","year":"2013","journal-title":"Current Pharmaceutical Design"},{"issue":"3","key":"pgen.1008318.ref007","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.0000028589.66335.AA","article-title":"Uric Acid, Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity","volume":"40","author":"S Watanabe","year":"2002","journal-title":"Hypertension"},{"issue":"5","key":"pgen.1008318.ref008","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jare.2017.04.008","article-title":"Gout: An old disease in new perspective\u2013A review","volume":"8","author":"G Ragab","year":"2017","journal-title":"Journal of Advanced Research"},{"issue":"10055","key":"pgen.1008318.ref009","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","article-title":"Gout","volume":"388","author":"N Dalbeth","year":"2016","journal-title":"The Lancet"},{"key":"pgen.1008318.ref010","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors","volume":"11","author":"C-F Kuo","year":"2015","journal-title":"Nature Reviews Rheumatology"},{"key":"pgen.1008318.ref011","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1155\/2015\/382918","article-title":"Uric Acid as a Marker of Kidney Disease: Review of the Current Literature","volume":"2015","author":"C Giordano","year":"2015","journal-title":"Disease Markers"},{"key":"pgen.1008318.ref012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejim.2015.11.026","article-title":"Uric acid in metabolic syndrome: From an innocent bystander to a central player","volume":"29","author":"M Kanbay","year":"2016","journal-title":"European Journal of Internal Medicine"},{"issue":"1","key":"pgen.1008318.ref013","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12325-014-0175-z","article-title":"A Review of Uric Acid, Crystal Deposition Disease, and Gout","volume":"32","author":"F Perez-Ruiz","year":"2015","journal-title":"Advances in Therapy"},{"key":"pgen.1008318.ref014","first-page":"7","article-title":"Relationship between Hyperuricemia and Lipid Profiles in US Adults","volume":"2015","author":"T-C Peng","year":"2015","journal-title":"BioMed Research International"},{"issue":"6","key":"pgen.1008318.ref015","doi-asserted-by":"crossref","first-page":"e0127550","DOI":"10.1371\/journal.pone.0127550","article-title":"Blood-Borne Biomarkers of Mortality Risk: Systematic Review of Cohort Studies","volume":"10","author":"E Barron","year":"2015","journal-title":"PLoS ONE"},{"issue":"7","key":"pgen.1008318.ref016","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/annrheumdis-2016-210588","article-title":"The unclosing premature mortality gap in gout: a general population-based study","volume":"76","author":"MC Fisher","year":"2017","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"10","key":"pgen.1008318.ref017","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/art.30520","article-title":"Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007\u20132008","volume":"63","author":"Y Zhu","year":"2011","journal-title":"Arthritis & Rheumatism"},{"issue":"7","key":"pgen.1008318.ref018","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.amjmed.2011.09.033","article-title":"Comorbidities of Gout and Hyperuricemia in the US General Population: NHANES 2007\u20132008","volume":"125","author":"Y Zhu","year":"2012","journal-title":"The American Journal of Medicine"},{"issue":"1","key":"pgen.1008318.ref019","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-med-080911-105830","article-title":"New Therapies for Gout","volume":"64","author":"DB Crittenden","year":"2013","journal-title":"Annual Review of Medicine"},{"key":"pgen.1008318.ref020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijcard.2015.08.087","article-title":"The treatment of hyperuricemia","volume":"213","author":"M Gliozzi","year":"2016","journal-title":"International journal of cardiology"},{"issue":"2","key":"pgen.1008318.ref021","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.mad.2004.08.026","article-title":"Biological evidence for inheritance of exceptional longevity","volume":"126","author":"G Atzmon","year":"2005","journal-title":"Mechanisms of Ageing and Development"},{"issue":"4","key":"pgen.1008318.ref022","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1532-5415.2012.03902.x","article-title":"Family History of Exceptional Longevity Is Associated with Lower Serum Uric Acid Levels in Ashkenazi Jews","volume":"60","author":"JY-C Lai","year":"2012","journal-title":"Journal of the American Geriatrics Society"},{"issue":"3","key":"pgen.1008318.ref023","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1681\/ASN.2016050576","article-title":"Progress in Understanding the Genetics of Calcium-Containing Nephrolithiasis","volume":"28","author":"JA Sayer","year":"2017","journal-title":"Journal of the American Society of Nephrology"},{"issue":"4","key":"pgen.1008318.ref024","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ki.2011.166","article-title":"Drosophila: a fruitful model for calcium oxalate nephrolithiasis?","volume":"80","author":"F Knauf","year":"2011","journal-title":"Kidney International"},{"key":"pgen.1008318.ref025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2016.12.005","article-title":"Dietary restriction and lifespan: Lessons from invertebrate models","volume":"39","author":"P Kapahi","year":"2017","journal-title":"Ageing research reviews"},{"key":"pgen.1008318.ref026","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-62703-556-9_7","article-title":"Aging studies in Drosophila melanogaster","volume":"1048","author":"Y Sun","year":"2013","journal-title":"Methods in molecular biology (Clifton, NJ)"},{"issue":"1","key":"pgen.1008318.ref027","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ymeth.2014.04.008","article-title":"Studying aging in Drosophila","volume":"68","author":"Y He","year":"2014","journal-title":"Methods (San Diego, Calif)"},{"issue":"11","key":"pgen.1008318.ref028","doi-asserted-by":"crossref","first-page":"F1555","DOI":"10.1152\/ajprenal.00074.2012","article-title":"In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis","volume":"303","author":"T Hirata","year":"2012","journal-title":"American Journal of Physiology-Renal Physiology"},{"issue":"2","key":"pgen.1008318.ref029","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/19336934.2016.1171947","article-title":"Proteomic changes in response to crystal formation in Drosophila Malpighian tubules","volume":"10","author":"VY Chung","year":"2016","journal-title":"Fly"},{"issue":"1","key":"pgen.1008318.ref030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12894-017-0292-5","article-title":"A Drosophila genetic model of nephrolithiasis: transcriptional changes in response to diet induced stone formation","volume":"17","author":"VY Chung","year":"2017","journal-title":"BMC Urology"},{"issue":"4","key":"pgen.1008318.ref031","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ki.2011.80","article-title":"Ethylene glycol induces calcium oxalate crystal deposition in Malpighian tubules: a Drosophila model for nephrolithiasis\/urolithiasis","volume":"80","author":"Y-H Chen","year":"2011","journal-title":"Kidney International"},{"issue":"6","key":"pgen.1008318.ref032","doi-asserted-by":"crossref","first-page":"F1237","DOI":"10.1152\/ajprenal.00521.2010","article-title":"Drosophila provides rapid modeling of renal development, function, and disease","volume":"299","author":"JAT Dow","year":"2010","journal-title":"American Journal of Physiology-Renal Physiology"},{"issue":"5","key":"pgen.1008318.ref033","doi-asserted-by":"crossref","first-page":"e0124150","DOI":"10.1371\/journal.pone.0124150","article-title":"A Drosophila Model Identifies a Critical Role for Zinc in Mineralization for Kidney Stone Disease","volume":"10","author":"T Chi","year":"2015","journal-title":"PLoS ONE"},{"issue":"5","key":"pgen.1008318.ref034","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.juro.2013.03.010","article-title":"Drosophila melanogaster as an Emerging Translational Model of Human Nephrolithiasis","volume":"190","author":"J Miller","year":"2013","journal-title":"Journal of Urology"},{"issue":"5976","key":"pgen.1008318.ref035","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending Healthy Life Span\u2014From Yeast to Humans","volume":"328","author":"L Fontana","year":"2010","journal-title":"Science"},{"issue":"6","key":"pgen.1008318.ref036","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10522-017-9724-6","article-title":"Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing","volume":"18","author":"L Bettedi","year":"2017","journal-title":"Biogerontology"},{"issue":"1","key":"pgen.1008318.ref037","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1083\/jcb.201707168","article-title":"Regulation of reproduction and longevity by nutrient-sensing pathways","volume":"217","author":"NM Templeman","year":"2018","journal-title":"The Journal of Cell Biology"},{"issue":"8","key":"pgen.1008318.ref038","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tig.2004.06.012","article-title":"Gene expression systems in Drosophila: a synthesis of time and space","volume":"20","author":"SE McGuire","year":"2004","journal-title":"Trends in Genetics"},{"issue":"6","key":"pgen.1008318.ref039","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ng2049","article-title":"Using FlyAtlas to identify better Drosophila melanogaster models of human disease","volume":"39","author":"VR Chintapalli","year":"2007","journal-title":"Nat Genet"},{"issue":"9","key":"pgen.1008318.ref040","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1186\/gb-2004-5-9-r69","article-title":"Function-informed transcriptome analysis of Drosophila renal tubule","volume":"5","author":"J Wang","year":"2004","journal-title":"Genome Biology"},{"issue":"12","key":"pgen.1008318.ref041","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2215\/CJN.05660614","article-title":"Stone Composition as a Function of Age and Sex","volume":"9","author":"JC Lieske","year":"2014","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"suppl_2","key":"pgen.1008318.ref042","first-page":"ii2","article-title":"New insights into the epidemiology of gout","volume":"48","author":"M Doherty","year":"2009","journal-title":"Rheumatology"},{"key":"pgen.1008318.ref043","article-title":"Crystal-proven gout patients have an increased mortality due to cardiovascular diseases, cancer, and infectious diseases especially when having tophi and\/or high serum uric acid levels: a prospective cohort study","author":"IJM Disveld","year":"2019","journal-title":"Clinical Rheumatology"},{"issue":"10","key":"pgen.1008318.ref044","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrrheum.2012.144","article-title":"The genetics of hyperuricaemia and gout","volume":"8","author":"AM Reginato","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"pgen.1008318.ref045","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCGENETICS.109.934455","article-title":"Multiple Genetic Loci Influence Serum Urate and Their Relationship with Gout and Cardiovascular Disease Risk Factors","volume":"3","author":"Q Yang","year":"2010","journal-title":"Circulation Cardiovascular Genetics"},{"issue":"1","key":"pgen.1008318.ref046","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/annrheumdis-2014-205877","article-title":"Twenty-eight loci that influence serum urate levels: analysis of association with gout","volume":"75","author":"AJ Phipps-Green","year":"2016","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"2","key":"pgen.1008318.ref047","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng.2500","article-title":"Genome-wide association analyses identify 18 new loci associated with serum urate concentrations","volume":"45","author":"A K\u00f6ttgen","year":"2013","journal-title":"Nature Genetics"},{"key":"pgen.1008318.ref048","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2147\/IJGM.S24953","article-title":"Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis","volume":"4","author":"S Hassan","year":"2011","journal-title":"International Journal of General Medicine"},{"issue":"11","key":"pgen.1008318.ref049","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1073\/pnas.0409500102","article-title":"HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol","volume":"102","author":"S-I Hung","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"pgen.1008318.ref050","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/cpt.89","article-title":"Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response","volume":"97","author":"C Wen","year":"2015","journal-title":"Clinical Pharmacology & Therapeutics"},{"issue":"9","key":"pgen.1008318.ref051","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrm2234","article-title":"Endocrine regulation of ageing","volume":"8","author":"SJ Russell","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"pgen.1008318.ref052","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/BJ20091181","article-title":"Molecular mechanisms of metabolic regulation by insulin in Drosophila","volume":"425","author":"AA Teleman","year":"2010","journal-title":"Biochemical Journal"},{"issue":"1","key":"pgen.1008318.ref053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20082102","article-title":"Insulin\/IGF-like signalling, the central nervous system and aging","volume":"418","author":"S Broughton","year":"2009","journal-title":"Biochemical Journal"},{"issue":"2","key":"pgen.1008318.ref054","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1534-5807(02)00117-X","article-title":"Drosophila's Insulin\/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions","volume":"2","author":"JS Britton","year":"2002","journal-title":"Developmental Cell"},{"issue":"2","key":"pgen.1008318.ref055","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/acel.12427","article-title":"Long live FOXO: unraveling the role of FOXO proteins in aging and longevity","volume":"15","author":"R Martins","year":"2016","journal-title":"Aging Cell"},{"issue":"9","key":"pgen.1008318.ref056","doi-asserted-by":"crossref","first-page":"e1004619","DOI":"10.1371\/journal.pgen.1004619","article-title":"Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster","volume":"10","author":"N Alic","year":"2014","journal-title":"PLOS Genetics"},{"key":"pgen.1008318.ref057","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"J Maiuolo","year":"2016","journal-title":"International journal of cardiology"},{"issue":"2","key":"pgen.1008318.ref058","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.freeradbiomed.2010.04.010","article-title":"Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry","volume":"49","author":"W Imaram","year":"2010","journal-title":"Free Radical Biology and Medicine"},{"issue":"6","key":"pgen.1008318.ref059","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1080\/15257770802138558","article-title":"URIC ACID: THE OXIDANT\u2013ANTIOXIDANT PARADOX","volume":"27","author":"YY Sautin","year":"2008","journal-title":"Nucleosides, nucleotides & nucleic acids"},{"key":"pgen.1008318.ref060","doi-asserted-by":"crossref","first-page":"369286","DOI":"10.1155\/2015\/369286","article-title":"Sterile inflammation in Drosophila","volume":"2015","author":"Z Shaukat","year":"2015","journal-title":"Mediators of inflammation"},{"issue":"4","key":"pgen.1008318.ref061","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.it.2005.02.006","article-title":"Regulators of the Toll and Imd pathways in the Drosophila innate immune response","volume":"26","author":"T Tanji","year":"2005","journal-title":"Trends in Immunology"},{"issue":"33","key":"pgen.1008318.ref062","doi-asserted-by":"crossref","first-page":"14715","DOI":"10.1073\/pnas.1009473107","article-title":"Heterodimers of NF-\u03baB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila","volume":"107","author":"T Tanji","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"8","key":"pgen.1008318.ref063","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1074\/jbc.M110.181206","article-title":"Antimicrobial Peptides Increase Tolerance to Oxidant Stress in Drosophila melanogaster","volume":"286","author":"HW Zhao","year":"2011","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"pgen.1008318.ref064","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/ars.2010.3405","article-title":"Forkhead homeobox type O transcription factors in the responses to oxidative stress","volume":"14","author":"P Storz","year":"2011","journal-title":"Antioxidants & redox signaling"},{"issue":"6904","key":"pgen.1008318.ref065","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01036","article-title":"Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress","volume":"419","author":"GJPL Kops","year":"2002","journal-title":"Nature"},{"issue":"5","key":"pgen.1008318.ref066","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/1756-185X.12622","article-title":"The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout","volume":"18","author":"P Towiwat","year":"2015","journal-title":"International Journal of Rheumatic Diseases"},{"issue":"6","key":"pgen.1008318.ref067","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/art.21105","article-title":"The effects of vitamin C supplementation on serum concentrations of uric acid: Results of a randomized controlled trial","volume":"52","author":"H-Y Huang","year":"2005","journal-title":"Arthritis & Rheumatism"},{"issue":"7","key":"pgen.1008318.ref068","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","article-title":"Skyline: an open source document editor for creating and analyzing targeted proteomics experiments","volume":"26","author":"B MacLean","year":"2010","journal-title":"Bioinformatics"},{"key":"pgen.1008318.ref069","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nprot.2012.024","article-title":"A positive\/negative ion\u2013switching, targeted mass spectrometry\u2013based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue","volume":"7","author":"M Yuan","year":"2012","journal-title":"Nature Protocols"},{"issue":"5","key":"pgen.1008318.ref070","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nmeth.2899","article-title":"Quantifying Drosophila food intake: comparative analysis of current methodology","volume":"11","author":"SA Deshpande","year":"2014","journal-title":"Nature methods"},{"issue":"21","key":"pgen.1008318.ref071","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"MJ Machiela","year":"2015","journal-title":"Bioinformatics"},{"issue":"9","key":"pgen.1008318.ref072","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.4161\/cc.28401","article-title":"Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events","volume":"13","author":"RA McCloy","year":"2014","journal-title":"Cell Cycle"}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1008318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:22:16Z","timestamp":1589005336000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1008318"}},"subtitle":[],"editor":[{"given":"William Wei-Hua","family":"Ja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,15]]},"references-count":72,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1008318","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/387779","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,15]]}}}