{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:27:42Z","timestamp":1793237262037,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1008727","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000}}],"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["4183-00312"],"award-info":[{"award-number":["4183-00312"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1008727","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T14:41:28Z","timestamp":1587998488000},"page":"e1008727","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl\/LZTR1 and NF1 in GABAergic sleep control"],"prefix":"10.1371","volume":"16","author":[{"given":"Gianna W.","family":"Maurer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Malita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-101X","authenticated-orcid":true,"given":"Stanislav","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-114X","authenticated-orcid":true,"given":"Takashi","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-0766","authenticated-orcid":true,"given":"Thomas M.","family":"Werge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-7196","authenticated-orcid":true,"given":"Kenneth A.","family":"Halberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2479-1241","authenticated-orcid":true,"given":"Michael J.","family":"Texada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-9941","authenticated-orcid":true,"given":"Kim","family":"Rewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"issue":"5823","key":"pgen.1008727.ref001","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1126\/science.1138659","article-title":"Strong association of de novo copy number mutations with autism","volume":"316","author":"J Sebat","year":"2007","journal-title":"Science (New York, NY)"},{"issue":"7210","key":"pgen.1008727.ref002","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature07229","article-title":"Large recurrent microdeletions associated with schizophrenia","volume":"455","author":"H Stefansson","year":"2008","journal-title":"Nature"},{"issue":"10","key":"pgen.1008727.ref003","first-page":"2215","article-title":"The psychosocial impact of 22q11 deletion syndrome on patients and families: A systematic review. American journal of medical genetics","volume":"176","author":"OK Vo","year":"2018","journal-title":"Part A"},{"issue":"6","key":"pgen.1008727.ref004","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.02.039","article-title":"CNVs: harbingers of a rare variant revolution in psychiatric genetics","volume":"148","author":"D Malhotra","year":"2012","journal-title":"Cell"},{"issue":"1","key":"pgen.1008727.ref005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1503\/jpn.150381","article-title":"Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice","volume":"42","author":"M Didriksen","year":"2017","journal-title":"J Psychiatry Neurosci"},{"issue":"1","key":"pgen.1008727.ref006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ddrr.2","article-title":"Velo-cardio-facial syndrome: 30 Years of study","volume":"14","author":"RJ Shprintzen","year":"2008","journal-title":"Developmental disabilities research reviews"},{"issue":"3","key":"pgen.1008727.ref007","first-page":"186","article-title":"Sleep disorders in psychiatric practice","volume":"4","author":"W Szelenberger","year":"2005","journal-title":"World psychiatry: official journal of the World Psychiatric Association (WPA)"},{"issue":"5","key":"pgen.1008727.ref008","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.neubiorev.2009.11.017","article-title":"Circadian rhythms and sleep in children with autism","volume":"34","author":"G. Glickman","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"issue":"11","key":"pgen.1008727.ref009","doi-asserted-by":"crossref","first-page":"939","DOI":"10.2165\/00023210-200822110-00004","article-title":"Sleep disturbances in patients with schizophrenia: impact and effect of antipsychotics","volume":"22","author":"S. Cohrs","year":"2008","journal-title":"CNS drugs"},{"issue":"9","key":"pgen.1008727.ref010","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1176\/appi.ajp.160.9.1580","article-title":"The schizophrenia phenotype in 22q11 deletion syndrome","volume":"160","author":"AS Bassett","year":"2003","journal-title":"The American journal of psychiatry"},{"key":"pgen.1008727.ref011","first-page":"1","article-title":"Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS)","volume":"2019","author":"HA Moulding","journal-title":"Psychol Med"},{"issue":"9393","key":"pgen.1008727.ref012","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/S0140-6736(03)14632-6","article-title":"Role of TBX1 in human del22q11.2 syndrome","volume":"362","author":"H Yagi","year":"2003","journal-title":"Lancet (London, England)"},{"issue":"1","key":"pgen.1008727.ref013","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0896-6273(00)80877-6","article-title":"Rest in Drosophila is a sleep-like state","volume":"25","author":"JC Hendricks","year":"2000","journal-title":"Neuron"},{"issue":"5459","key":"pgen.1008727.ref014","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1126\/science.287.5459.1834","article-title":"Correlates of sleep and waking in Drosophila melanogaster","volume":"287","author":"PJ Shaw","year":"2000","journal-title":"Science (New York, NY)"},{"issue":"8","key":"pgen.1008727.ref015","doi-asserted-by":"crossref","first-page":"e1001367","DOI":"10.1371\/journal.pbio.1001367","article-title":"CULLIN-3 controls TIMELESS oscillations in the Drosophila circadian clock","volume":"10","author":"B Grima","year":"2012","journal-title":"PLoS biology"},{"issue":"6","key":"pgen.1008727.ref016","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.neuron.2011.12.003","article-title":"insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila","volume":"72","author":"N Stavropoulos","year":"2011","journal-title":"Neuron"},{"issue":"12","key":"pgen.1008727.ref017","doi-asserted-by":"crossref","first-page":"e1007623","DOI":"10.1371\/journal.pgen.1007623","article-title":"AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance","volume":"14","author":"S Nagy","year":"2018","journal-title":"PLoS Genet"},{"issue":"1","key":"pgen.1008727.ref018","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1542\/peds.2007-3204","article-title":"Neurofibromatosis type 1 revisited","volume":"123","author":"VC Williams","year":"2009","journal-title":"Pediatrics"},{"issue":"2","key":"pgen.1008727.ref019","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1212\/WNL.0000000000001129","article-title":"Mutations in LZTR1 add to the complex heterogeneity of schwannomatosis","volume":"84","author":"MJ Smith","year":"2015","journal-title":"Neurology"},{"issue":"4","key":"pgen.1008727.ref020","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0092-8674(90)90151-4","article-title":"The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins","volume":"63","author":"R Ballester","year":"1990","journal-title":"Cell"},{"issue":"7","key":"pgen.1008727.ref021","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/hmg\/ddl023","article-title":"Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras","volume":"15","author":"F Hannan","year":"2006","journal-title":"Hum Mol Genet"},{"key":"pgen.1008727.ref022","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/1471-2105-12-357","article-title":"An integrative approach to ortholog prediction for disease-focused and other functional studies","volume":"12","author":"Y Hu","year":"2011","journal-title":"BMC bioinformatics"},{"issue":"7150","key":"pgen.1008727.ref023","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nature05954","article-title":"A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila","volume":"448","author":"G Dietzl","year":"2007","journal-title":"Nature"},{"key":"pgen.1008727.ref024","doi-asserted-by":"crossref","first-page":"10368","DOI":"10.1038\/ncomms10368","article-title":"A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth","volume":"7","author":"JH Vissers","year":"2016","journal-title":"Nat Commun"},{"issue":"2","key":"pgen.1008727.ref025","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1534\/genetics.104.026427","article-title":"The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes","volume":"167","author":"HJ Bellen","year":"2004","journal-title":"Genetics"},{"issue":"5","key":"pgen.1008727.ref026","doi-asserted-by":"crossref","first-page":"e0126986","DOI":"10.1371\/journal.pone.0126986","article-title":"Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster","volume":"10","author":"M Appel","year":"2015","journal-title":"PLoS One"},{"key":"pgen.1008727.ref027","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/NSS.S34842","article-title":"Sleep disturbance in mental health problems and neurodegenerative disease","volume":"5","author":"KN Anderson","year":"2013","journal-title":"Nat Sci Sleep"},{"issue":"6419","key":"pgen.1008727.ref028","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1126\/science.aap7607","article-title":"Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination","volume":"362","author":"M Steklov","year":"2018","journal-title":"Science (New York, NY)"},{"issue":"6419","key":"pgen.1008727.ref029","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.aap8210","article-title":"LZTR1 is a regulator of RAS ubiquitination and signaling","volume":"362","author":"JW Bigenzahn","year":"2018","journal-title":"Science"},{"key":"pgen.1008727.ref030","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.redox.2013.07.003","article-title":"Cullin 3 as a novel target in diverse pathologies","volume":"1","author":"AC Anderica-Romero","year":"2013","journal-title":"Redox biology"},{"issue":"10","key":"pgen.1008727.ref031","doi-asserted-by":"crossref","first-page":"e1003003","DOI":"10.1371\/journal.pgen.1003003","article-title":"Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila","volume":"8","author":"C Pfeiffenberger","year":"2012","journal-title":"PLoS Genet"},{"issue":"1\u20132","key":"pgen.1008727.ref032","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/01677063.2013.791692","article-title":"Lessons from sleeping flies: insights from Drosophila melanogaster on the neuronal circuitry and importance of sleep","volume":"27","author":"S Potdar","year":"2013","journal-title":"Journal of neurogenetics"},{"issue":"22","key":"pgen.1008727.ref033","doi-asserted-by":"crossref","first-page":"12596","DOI":"10.1073\/pnas.221303298","article-title":"A conditional tissue-specific transgene expression system using inducible GAL4","volume":"98","author":"T Osterwalder","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pgen.1008727.ref034","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1210\/jc.2012-1067","article-title":"Update on energy homeostasis and insufficient sleep","volume":"97","author":"PD Penev","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"pgen.1008727.ref035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0301-0082(94)00057-O","article-title":"Restoration of brain energy metabolism as the function of sleep","volume":"45","author":"JH Benington","year":"1995","journal-title":"Prog Neurobiol"},{"issue":"1","key":"pgen.1008727.ref036","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11011-014-9629-x","article-title":"Glycogen metabolism and the homeostatic regulation of sleep","volume":"30","author":"JM Petit","year":"2015","journal-title":"Metab Brain Dis"},{"issue":"1","key":"pgen.1008727.ref037","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.1471-4159.2003.02126.x","article-title":"Glycogen in the brain of Drosophila melanogaster: diurnal rhythm and the effect of rest deprivation","volume":"88","author":"JE Zimmerman","year":"2004","journal-title":"J Neurochem"},{"issue":"2","key":"pgen.1008727.ref038","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/gim.2016.98","article-title":"Obesity in adults with 22q11.2 deletion syndrome","volume":"19","author":"SL Voll","year":"2017","journal-title":"Genet Med"},{"key":"pgen.1008727.ref039","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1196\/annals.1417.033","article-title":"Associations between sleep loss and increased risk of obesity and diabetes","volume":"1129","author":"KL Knutson","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"pgen.1008727.ref040","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0306-4522(02)00034-9","article-title":"GABA mechanisms and sleep","volume":"111","author":"C. Gottesmann","year":"2002","journal-title":"Neuroscience"},{"issue":"3","key":"pgen.1008727.ref041","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nn2046","article-title":"Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila","volume":"11","author":"J Agosto","year":"2008","journal-title":"Nat Neurosci"},{"issue":"4","key":"pgen.1008727.ref042","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.neuron.2008.10.042","article-title":"PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit","volume":"60","author":"KM Parisky","year":"2008","journal-title":"Neuron"},{"issue":"5","key":"pgen.1008727.ref043","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cub.2009.01.040","article-title":"The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila","volume":"19","author":"BY Chung","year":"2009","journal-title":"Curr Biol"},{"issue":"Pt 20","key":"pgen.1008727.ref044","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1242\/jeb.085563","article-title":"GABA(B) receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster","volume":"216","author":"F Gmeiner","year":"2013","journal-title":"J Exp Biol"},{"issue":"20","key":"pgen.1008727.ref045","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.cub.2008.08.033","article-title":"Large ventral lateral neurons modulate arousal and sleep in Drosophila","volume":"18","author":"V Sheeba","year":"2008","journal-title":"Current biology: CB"},{"issue":"6","key":"pgen.1008727.ref046","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.neuron.2007.10.036","article-title":"GABAA receptor RDL inhibits Drosophila olfactory associative learning","volume":"56","author":"X Liu","year":"2007","journal-title":"Neuron"},{"key":"pgen.1008727.ref047","first-page":"4","article-title":"A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster","author":"PR Haynes","year":"2015","journal-title":"Elife"},{"issue":"1","key":"pgen.1008727.ref048","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/sj.mp.4001571","article-title":"Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework","volume":"10","author":"AH Fanous","year":"2005","journal-title":"Mol Psychiatry"},{"issue":"2","key":"pgen.1008727.ref049","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archpsyc.1993.01820140007001","article-title":"The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services","volume":"50","author":"DA Regier","year":"1993","journal-title":"Arch Gen Psychiatry"},{"issue":"24","key":"pgen.1008727.ref050","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1093\/hmg\/ddn307","article-title":"Copy number variations and risk for schizophrenia in 22q11.2 deletion syndrome","volume":"17","author":"AS Bassett","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"1\u20133","key":"pgen.1008727.ref051","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.schres.2011.05.006","article-title":"Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome","volume":"131","author":"CL Clelland","year":"2011","journal-title":"Schizophr Res"},{"issue":"1\u20132","key":"pgen.1008727.ref052","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0167-4781(00)00189-5","article-title":"GNB1L, a gene deleted in the critical region for DiGeorge syndrome on 22q11, encodes a G-protein beta-subunit-like polypeptide","volume":"1494","author":"L Gong","year":"2000","journal-title":"Biochimica et biophysica acta"},{"issue":"1","key":"pgen.1008727.ref053","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ajmg.b.32002","article-title":"Evidence for involvement of GNB1L in autism","volume":"159B","author":"YZ Chen","year":"2012","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"4","key":"pgen.1008727.ref054","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/schbul\/sbn160","article-title":"Supportive evidence for reduced expression of GNB1L in schizophrenia","volume":"36","author":"H Ishiguro","year":"2010","journal-title":"Schizophr Bull"},{"issue":"4","key":"pgen.1008727.ref055","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/hmg\/ddm330","article-title":"Strong evidence that GNB1L is associated with schizophrenia","volume":"17","author":"NM Williams","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"3","key":"pgen.1008727.ref056","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1192\/bjp.bp.110.084384","article-title":"Neurodevelopmental hypothesis of schizophrenia","volume":"198","author":"MJ Owen","year":"2011","journal-title":"Br J Psychiatry"},{"key":"pgen.1008727.ref057","article-title":"LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases","author":"T Abe","year":"2019","journal-title":"Cell Death Differ"},{"issue":"5538","key":"pgen.1008727.ref058","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1126\/science.1063097","article-title":"A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras\/MAPK","volume":"293","author":"JA Williams","year":"2001","journal-title":"Science"},{"issue":"2","key":"pgen.1008727.ref059","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/ng.2855","article-title":"Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas","volume":"46","author":"A Piotrowski","year":"2014","journal-title":"Nat Genet"},{"issue":"1","key":"pgen.1008727.ref060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0893-133X(01)00225-1","article-title":"GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder","volume":"25","author":"FM Benes","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"pgen.1008727.ref061","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fpsyt.2017.00118","article-title":"GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies","volume":"8","author":"JC de Jonge","year":"2017","journal-title":"Front Psychiatry"},{"issue":"1","key":"pgen.1008727.ref062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0896-6273(93)90266-T","article-title":"Mushroom bodies and Drosophila learning","volume":"11","author":"RL Davis","year":"1993","journal-title":"Neuron"},{"issue":"7094","key":"pgen.1008727.ref063","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nature04811","article-title":"Sleep in Drosophila is regulated by adult mushroom bodies","volume":"441","author":"WJ Joiner","year":"2006","journal-title":"Nature"},{"issue":"7094","key":"pgen.1008727.ref064","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature04739","article-title":"A dynamic role for the mushroom bodies in promoting sleep in Drosophila","volume":"441","author":"JL Pitman","year":"2006","journal-title":"Nature"},{"issue":"8","key":"pgen.1008727.ref065","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrn2683","article-title":"The genetic and molecular regulation of sleep: from fruit flies to humans","volume":"10","author":"C. Cirelli","year":"2009","journal-title":"Nature reviews Neuroscience"},{"issue":"5829","key":"pgen.1008727.ref066","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/293228a0","article-title":"Genetic modification of potassium channels in Drosophila Shaker mutants","volume":"293","author":"L Salkoff","year":"1981","journal-title":"Nature"},{"issue":"2","key":"pgen.1008727.ref067","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1601-183x.2003.00054.x","article-title":"Increased motor drive and sleep loss in mice lacking Kv3-type potassium channels","volume":"3","author":"F Espinosa","year":"2004","journal-title":"Genes, brain, and behavior"},{"issue":"1","key":"pgen.1008727.ref068","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1038\/s41467-019-10992-6","article-title":"Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling","volume":"10","author":"K Kikuma","year":"2019","journal-title":"Nature communications"},{"issue":"Suppl 5","key":"pgen.1008727.ref069","first-page":"13","article-title":"A physiologic basis for the evolution of pharmacotherapy for insomnia","volume":"68","author":"T. Roth","year":"2007","journal-title":"The Journal of clinical psychiatry"},{"issue":"2","key":"pgen.1008727.ref070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00439-002-0766-7","article-title":"Functional characterization of the new human GABA(A) receptor mutation beta3(R192H)","volume":"111","author":"A Buhr","year":"2002","journal-title":"Human genetics"},{"issue":"4","key":"pgen.1008727.ref071","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/gni035","article-title":"Simple and highly efficient BAC recombineering using galK selection","volume":"33","author":"S Warming","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pgen.1008727.ref072","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12033-009-9142-3","article-title":"A new positive\/negative selection scheme for precise BAC recombineering","volume":"42","author":"S Wang","year":"2009","journal-title":"Mol Biotechnol"},{"issue":"28","key":"pgen.1008727.ref073","doi-asserted-by":"crossref","first-page":"9715","DOI":"10.1073\/pnas.0803697105","article-title":"Tools for neuroanatomy and neurogenetics in Drosophila","volume":"105","author":"BD Pfeiffer","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pgen.1008727.ref074","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1534\/genetics.110.119917","article-title":"Refinement of tools for targeted gene expression in Drosophila","volume":"186","author":"BD Pfeiffer","year":"2010","journal-title":"Genetics"},{"issue":"9","key":"pgen.1008727.ref075","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1073\/pnas.0611511104","article-title":"An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases","volume":"104","author":"J Bischof","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"pgen.1008727.ref076","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/bioinformatics\/btp237","article-title":"pySolo: a complete suite for sleep analysis in Drosophila","volume":"25","author":"GF Gilestro","year":"2009","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"2","key":"pgen.1008727.ref077","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0376-6357(03)00133-5","article-title":"Circadian rhythms of locomotor activity in Drosophila","volume":"64","author":"A Klarsfeld","year":"2003","journal-title":"Behav Processes"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1008727","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1008727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T13:43:33Z","timestamp":1588859013000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1008727"}},"subtitle":[],"editor":[{"given":"Christian","family":"Wegener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":77,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1008727","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/755454","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]}}}