{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:18:56Z","timestamp":1784913536258,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1008838","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000}}],"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1008838","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T17:47:03Z","timestamp":1592329623000},"page":"e1008838","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["ROS regulation of RAS and vulva development in Caenorhabditis elegans"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-3107","authenticated-orcid":true,"given":"Maximilian","family":"Kramer-Drauberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-7461","authenticated-orcid":true,"given":"Ju-Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5425-2815","authenticated-orcid":true,"given":"David","family":"Desjardins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Branicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-5711","authenticated-orcid":true,"given":"Siegfried","family":"Hekimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"issue":"6","key":"pgen.1008838.ref001","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3801","article-title":"Cellular mechanisms and physiological consequences of redox-dependent signalling","volume":"15","author":"KM Holmstrom","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"pgen.1008838.ref002","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological roles of mitochondrial reactive oxygen species","volume":"48","author":"LA Sena","year":"2012","journal-title":"Mol Cell"},{"issue":"4","key":"pgen.1008838.ref003","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.molcel.2012.12.014","article-title":"Redox-dependent control of FOXO\/DAF-16 by transportin-1","volume":"49","author":"M Putker","year":"2013","journal-title":"Mol Cell"},{"issue":"5651","key":"pgen.1008838.ref004","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1126\/science.1087167","article-title":"Redox regulation of germline and vulval development in Caenorhabditis elegans","volume":"302","author":"Y Shibata","year":"2003","journal-title":"Science"},{"issue":"4","key":"pgen.1008838.ref005","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.molcel.2016.07.019","article-title":"Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1\/Nrf2 Antioxidant Response","volume":"63","author":"JM Hourihan","year":"2016","journal-title":"Mol Cell"},{"issue":"1","key":"pgen.1008838.ref006","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.devcel.2014.08.002","article-title":"C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair","volume":"31","author":"S Xu","year":"2014","journal-title":"Dev Cell"},{"key":"pgen.1008838.ref007","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19493","article-title":"NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans","volume":"6","author":"CY Ewald","year":"2017","journal-title":"Elife"},{"issue":"2","key":"pgen.1008838.ref008","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.molmet.2013.02.002","article-title":"Neuronal ROS signaling rather than AMPK\/sirtuin-mediated energy sensing links dietary restriction to lifespan extension","volume":"2","author":"S Schmeisser","year":"2013","journal-title":"Mol Metab"},{"issue":"1","key":"pgen.1008838.ref009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"MP Murphy","year":"2009","journal-title":"Biochem J"},{"issue":"13","key":"pgen.1008838.ref010","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1021\/bi3000879","article-title":"Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation","volume":"51","author":"TK Kundu","year":"2012","journal-title":"Biochemistry"},{"issue":"3","key":"pgen.1008838.ref011","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.taap.2004.01.018","article-title":"Mechanisms that regulate production of reactive oxygen species by cytochrome P450","volume":"199","author":"RC Zangar","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"pgen.1008838.ref012","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"K Bedard","year":"2007","journal-title":"Physiol Rev"},{"issue":"30","key":"pgen.1008838.ref013","doi-asserted-by":"crossref","first-page":"18515","DOI":"10.1074\/jbc.272.30.18515","article-title":"Superoxide anion radical (O2-.), superoxide dismutases, and related matters","volume":"272","author":"I. Fridovich","year":"1997","journal-title":"J Biol Chem"},{"issue":"4","key":"pgen.1008838.ref014","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.freeradbiomed.2009.11.012","article-title":"Hydrogen peroxide is the major oxidant product of xanthine oxidase","volume":"48","author":"EE Kelley","year":"2010","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"pgen.1008838.ref015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/13816128113190990406","article-title":"Hydrogen peroxide produced by mitochondrial monoamine oxidase catalysis: biological implications","volume":"20","author":"DE Edmondson","year":"2014","journal-title":"Curr Pharm Des"},{"key":"pgen.1008838.ref016","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-pathol-012513-104651","article-title":"Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited","volume":"9","author":"JD Lambeth","year":"2014","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"pgen.1008838.ref017","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0079-6107(98)00058-3","article-title":"Understanding the structure and function of catalases: clues from molecular evolution and in vitro mutagenesis","volume":"72","author":"M Zamocky","year":"1999","journal-title":"Prog Biophys Mol Biol"},{"issue":"11","key":"pgen.1008838.ref018","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.bbagen.2009.04.007","article-title":"Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme","volume":"1790","author":"S Toppo","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"13","key":"pgen.1008838.ref019","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1089\/ars.2012.4599","article-title":"Thioredoxins, glutaredoxins, and peroxiredoxins\u2014molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling","volume":"19","author":"EM Hanschmann","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"pgen.1008838.ref020","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1083\/jcb.201708007","article-title":"Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling","volume":"217","author":"Y Wang","year":"2018","journal-title":"J Cell Biol"},{"issue":"52","key":"pgen.1008838.ref021","doi-asserted-by":"crossref","first-page":"40991","DOI":"10.1074\/jbc.M110.170902","article-title":"Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain","volume":"285","author":"JL Meitzler","year":"2010","journal-title":"J Biol Chem"},{"issue":"26","key":"pgen.1008838.ref022","doi-asserted-by":"crossref","first-page":"17549","DOI":"10.1074\/jbc.M900831200","article-title":"Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans","volume":"284","author":"MC Thein","year":"2009","journal-title":"J Biol Chem"},{"issue":"4","key":"pgen.1008838.ref023","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.200103132","article-title":"Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase\/peroxidase with homology to the phagocyte oxidase subunit gp91phox","volume":"154","author":"WA Edens","year":"2001","journal-title":"J Cell Biol"},{"issue":"11","key":"pgen.1008838.ref024","doi-asserted-by":"crossref","first-page":"e1005923","DOI":"10.1371\/journal.ppat.1005923","article-title":"The Role of Reactive Oxygen Species in Modulating the Caenorhabditis elegans Immune Response","volume":"12","author":"KC McCallum","year":"2016","journal-title":"PLoS Pathog"},{"issue":"10","key":"pgen.1008838.ref025","article-title":"Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging","volume":"7","author":"CY Ewald","year":"2018","journal-title":"Antioxidants (Basel)"},{"issue":"8","key":"pgen.1008838.ref026","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1074\/jbc.271.8.4138","article-title":"Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury","volume":"271","author":"KZ Guyton","year":"1996","journal-title":"J Biol Chem"},{"issue":"7","key":"pgen.1008838.ref027","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1074\/jbc.272.7.4323","article-title":"A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction","volume":"272","author":"HM Lander","year":"1997","journal-title":"J Biol Chem"},{"key":"pgen.1008838.ref028","doi-asserted-by":"crossref","first-page":"38934","DOI":"10.1038\/srep38934","article-title":"Shengmai Formula suppressed over-activated Ras\/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D","volume":"6","author":"Y Liu","year":"2016","journal-title":"Sci Rep"},{"issue":"13","key":"pgen.1008838.ref029","doi-asserted-by":"crossref","first-page":"12438","DOI":"10.1074\/jbc.M414282200","article-title":"Superoxide anion radical modulates the activity of Ras and Ras-related GTPases by a radical-based mechanism similar to that of nitric oxide","volume":"280","author":"J Heo","year":"2005","journal-title":"J Biol Chem"},{"issue":"5","key":"pgen.1008838.ref030","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jmb.2004.12.050","article-title":"Mechanism of free radical nitric oxide-mediated Ras guanine nucleotide dissociation","volume":"346","author":"J Heo","year":"2005","journal-title":"J Mol Biol"},{"issue":"7","key":"pgen.1008838.ref031","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1021\/bi051872m","article-title":"Ras regulation by reactive oxygen and nitrogen species","volume":"45","author":"J Heo","year":"2006","journal-title":"Biochemistry"},{"issue":"8","key":"pgen.1008838.ref032","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1021\/bi035275g","article-title":"Mechanism of p21Ras S-nitrosylation and kinetics of nitric oxide-mediated guanine nucleotide exchange","volume":"43","author":"J Heo","year":"2004","journal-title":"Biochemistry"},{"issue":"12","key":"pgen.1008838.ref033","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1021\/bi962790o","article-title":"Structural and functional analysis of a mutant Ras protein that is insensitive to nitric oxide activation","volume":"36","author":"HR Mott","year":"1997","journal-title":"Biochemistry"},{"issue":"4","key":"pgen.1008838.ref034","doi-asserted-by":"crossref","first-page":"e0123918","DOI":"10.1371\/journal.pone.0123918","article-title":"Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S","volume":"10","author":"L Huang","year":"2015","journal-title":"PLoS One"},{"issue":"30","key":"pgen.1008838.ref035","doi-asserted-by":"crossref","first-page":"10507","DOI":"10.1073\/pnas.0711062105","article-title":"Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells","volume":"105","author":"S Ibiza","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 1","key":"pgen.1008838.ref036","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1042\/bj3550145","article-title":"Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines","volume":"355","author":"RJ Mallis","year":"2001","journal-title":"Biochem J"},{"key":"pgen.1008838.ref037","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1038\/ncomms6410","article-title":"Decreased tumorigenesis in mice with a Kras point mutation at C118","volume":"5","author":"L Huang","year":"2014","journal-title":"Nat Commun"},{"key":"pgen.1008838.ref038","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.freeradbiomed.2014.09.027","article-title":"Redox regulation of Rac1 by thiol oxidation","volume":"79","author":"GA Hobbs","year":"2015","journal-title":"Free Radic Biol Med"},{"issue":"48","key":"pgen.1008838.ref039","doi-asserted-by":"crossref","first-page":"14481","DOI":"10.1021\/bi0610101","article-title":"Redox regulation of RhoA","volume":"45","author":"J Heo","year":"2006","journal-title":"Biochemistry"},{"issue":"4","key":"pgen.1008838.ref040","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00726-011-0843-0","article-title":"Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association","volume":"42","author":"SE Permyakov","year":"2012","journal-title":"Amino Acids"},{"key":"pgen.1008838.ref041","doi-asserted-by":"crossref","DOI":"10.1895\/wormbook.1.6.1","volume-title":"Vulval development","author":"PW Sternberg","year":"2005"},{"key":"pgen.1008838.ref042","first-page":"1","volume-title":"Canonical RTK-Ras-ERK signaling and related alternative pathways","author":"MV Sundaram","year":"2013"},{"key":"pgen.1008838.ref043","author":"DJ Reiner"},{"issue":"5","key":"pgen.1008838.ref044","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0092-8674(90)90495-Z","article-title":"let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein","volume":"63","author":"M Han","year":"1990","journal-title":"Cell"},{"issue":"12","key":"pgen.1008838.ref045","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1073\/pnas.1218173110","article-title":"NMR-based functional profiling of RASopathies and oncogenic RAS mutations","volume":"110","author":"MJ Smith","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pgen.1008838.ref046","doi-asserted-by":"crossref","first-page":"21949","DOI":"10.1038\/srep21949","article-title":"The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B","volume":"6","author":"S Lu","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"pgen.1008838.ref047","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/genetics\/150.1.103","article-title":"Genetic analysis of the Caenorhabditis elegans MAP kinase gene mpk-1","volume":"150","author":"MR Lackner","year":"1998","journal-title":"Genetics"},{"issue":"24","key":"pgen.1008838.ref048","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1101\/gad.9.24.3149","article-title":"The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway","volume":"9","author":"GJ Beitel","year":"1995","journal-title":"Genes Dev"},{"issue":"12","key":"pgen.1008838.ref049","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/nchembio.2499","article-title":"A CRISPR screen identifies a pathway required for paraquat-induced cell death","volume":"13","author":"CR Reczek","year":"2017","journal-title":"Nat Chem Biol"},{"issue":"4","key":"pgen.1008838.ref050","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1074\/jbc.M708597200","article-title":"Complex I is the major site of mitochondrial superoxide production by paraquat","volume":"283","author":"HM Cocheme","year":"2008","journal-title":"J Biol Chem"},{"issue":"19","key":"pgen.1008838.ref051","doi-asserted-by":"crossref","first-page":"14186","DOI":"10.1074\/jbc.M700827200","article-title":"Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain","volume":"282","author":"PR Castello","year":"2007","journal-title":"J Biol Chem"},{"issue":"12","key":"pgen.1008838.ref052","doi-asserted-by":"crossref","first-page":"e1000556","DOI":"10.1371\/journal.pbio.1000556","article-title":"A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans","volume":"8","author":"W Yang","year":"2010","journal-title":"PLoS Biol"},{"issue":"4","key":"pgen.1008838.ref053","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1534\/genetics.107.080788","article-title":"A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans","volume":"177","author":"W Yang","year":"2007","journal-title":"Genetics"},{"issue":"6","key":"pgen.1008838.ref054","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0891-5849(89)90066-X","article-title":"The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid","volume":"6","author":"OI Aruoma","year":"1989","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"pgen.1008838.ref055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/acel.12528","article-title":"Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans","volume":"16","author":"D Desjardins","year":"2017","journal-title":"Aging Cell"},{"issue":"2","key":"pgen.1008838.ref056","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/genetics\/146.2.553","article-title":"Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation","volume":"146","author":"DM Eisenmann","year":"1997","journal-title":"Genetics"},{"issue":"15","key":"pgen.1008838.ref057","doi-asserted-by":"crossref","first-page":"R546","DOI":"10.1016\/S0960-9822(99)80349-2","article-title":"Soluble guanylyl cyclases in Caenorhabditis elegans: NO is not the answer","volume":"9","author":"DB Morton","year":"1999","journal-title":"Curr Biol"},{"issue":"1","key":"pgen.1008838.ref058","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1534\/genetics.115.179382","article-title":"High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes","volume":"201","author":"A Paix","year":"2015","journal-title":"Genetics"},{"issue":"37","key":"pgen.1008838.ref059","doi-asserted-by":"crossref","first-page":"26480","DOI":"10.1074\/jbc.R113.467738","article-title":"The redox biochemistry of protein sulfenylation and sulfinylation","volume":"288","author":"M Lo Conte","year":"2013","journal-title":"J Biol Chem"},{"issue":"1","key":"pgen.1008838.ref060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/dbio.2002.0692","article-title":"Downstream targets of let-60 Ras in Caenorhabditis elegans","volume":"247","author":"B Romagnolo","year":"2002","journal-title":"Dev Biol"},{"issue":"5","key":"pgen.1008838.ref061","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-9822(02)00690-5","article-title":"C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation","volume":"12","author":"M Ohmachi","year":"2002","journal-title":"Curr Biol"},{"issue":"6","key":"pgen.1008838.ref062","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0092-8674(95)90205-8","article-title":"The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction","volume":"83","author":"M Sundaram","year":"1995","journal-title":"Cell"},{"issue":"23","key":"pgen.1008838.ref063","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1101\/gad.504808","article-title":"Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans","volume":"22","author":"R Doonan","year":"2008","journal-title":"Genes Dev"},{"issue":"5","key":"pgen.1008838.ref064","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/gerona\/glp020","article-title":"SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation","volume":"64","author":"S Yanase","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"pgen.1008838.ref065","article-title":"Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression","volume":"7","author":"J Jezek","year":"2018","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"pgen.1008838.ref066","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"J Lee","year":"2012","journal-title":"Biochem J"},{"key":"pgen.1008838.ref067","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1741-7007-12-34","article-title":"Mitochondria as signaling organelles","volume":"12","author":"NS Chandel","year":"2014","journal-title":"BMC Biol"},{"issue":"1","key":"pgen.1008838.ref068","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"T. Finkel","year":"2011","journal-title":"J Cell Biol"},{"issue":"3","key":"pgen.1008838.ref069","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis","volume":"163","author":"GS Shadel","year":"2015","journal-title":"Cell"},{"issue":"12","key":"pgen.1008838.ref070","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1089\/ars.2010.3215","article-title":"Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?","volume":"13","author":"JM Van Raamsdonk","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"pgen.1008838.ref071","doi-asserted-by":"crossref","first-page":"e1000361","DOI":"10.1371\/journal.pgen.1000361","article-title":"Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans","volume":"5","author":"JM Van Raamsdonk","year":"2009","journal-title":"PLoS Genet"},{"issue":"5","key":"pgen.1008838.ref072","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1534-5807(01)00071-5","article-title":"Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans","volume":"1","author":"J Feng","year":"2001","journal-title":"Dev Cell"},{"issue":"3","key":"pgen.1008838.ref073","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1474-9726.2010.00571.x","article-title":"Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans","volume":"9","author":"W Yang","year":"2010","journal-title":"Aging Cell"},{"issue":"8","key":"pgen.1008838.ref074","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1074\/jbc.M210269200","article-title":"Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol","volume":"278","author":"D Han","year":"2003","journal-title":"J Biol Chem"},{"issue":"3","key":"pgen.1008838.ref075","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bbrc.2012.05.055","article-title":"Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels","volume":"422","author":"MS Lustgarten","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"pgen.1008838.ref076","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1074\/jbc.M603761200","article-title":"Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes","volume":"282","author":"GP Bienert","year":"2007","journal-title":"J Biol Chem"},{"issue":"4","key":"pgen.1008838.ref077","doi-asserted-by":"crossref","first-page":"e0124091","DOI":"10.1371\/journal.pone.0124091","article-title":"Localization of the Dual Oxidase BLI-3 and Characterization of Its NADPH Oxidase Domain during Infection of Caenorhabditis elegans","volume":"10","author":"R van der Hoeven","year":"2015","journal-title":"PLoS One"},{"key":"pgen.1008838.ref078","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2014.07.046","article-title":"Nox family NADPH oxidases: Molecular mechanisms of activation","volume":"76","author":"RP Brandes","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"pgen.1008838.ref079","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1895\/wormbook.1.67.2","article-title":"Small GTPases","volume":"2018","author":"DJ Reiner","year":"2018","journal-title":"WormBook"},{"issue":"2","key":"pgen.1008838.ref080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/dbio.2001.0513","article-title":"ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegans","volume":"241","author":"RS Kishore","year":"2002","journal-title":"Dev Biol"},{"issue":"1","key":"pgen.1008838.ref081","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cell.2016.05.006","article-title":"Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins","volume":"166","author":"S Hanzen","year":"2016","journal-title":"Cell"},{"issue":"5","key":"pgen.1008838.ref082","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1089\/ars.2009.2948","article-title":"Fluorescent protein-based redox probes","volume":"13","author":"AJ Meyer","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"16","key":"pgen.1008838.ref083","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1021\/bi973035t","article-title":"Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation","volume":"37","author":"JM Denu","year":"1998","journal-title":"Biochemistry"},{"issue":"2","key":"pgen.1008838.ref084","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1101\/gad.8.2.160","article-title":"A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans","volume":"8","author":"MR Lackner","year":"1994","journal-title":"Genes Dev"},{"issue":"1","key":"pgen.1008838.ref085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.devcel.2010.12.004","article-title":"Ras effector switching promotes divergent cell fates in C. elegans vulval patterning","volume":"20","author":"TP Zand","year":"2011","journal-title":"Dev Cell"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1008838","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1008838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T22:01:16Z","timestamp":1666994476000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1008838"}},"subtitle":[],"editor":[{"given":"Kaveh","family":"Ashrafi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":85,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1008838","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1008838","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]}}}