{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:16:52Z","timestamp":1786738612075,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pgen.1009392","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    The natural history of tuberculosis (TB) is characterized by a large inter-individual outcome variability after exposure to\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    . Specifically, some highly exposed individuals remain resistant to\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>tuberculosis<\/jats:italic>\n                    infection, as inferred by tuberculin skin test (TST) or interferon-gamma release assays (IGRAs). We performed a genome-wide association study of resistance to\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>tuberculosis<\/jats:italic>\n                    infection in an endemic region of Southern Vietnam. We enrolled household contacts (HHC) of pulmonary TB cases and compared subjects who were negative for both TST and IGRA (n = 185) with infected individuals (n = 353) who were either positive for both TST and IGRA or had a diagnosis of TB. We found a genome-wide significant locus on chromosome 10q26.2 with a cluster of variants associated with strong protection against\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>tuberculosis<\/jats:italic>\n                    infection (OR = 0.42, 95%CI 0.35\u20130.49,\n                    <jats:italic>P<\/jats:italic>\n                    = 3.71\u00d710\n                    <jats:sup>\u22128<\/jats:sup>\n                    , for the genotyped variant rs17155120). The locus was replicated in a French multi-ethnic HHC cohort and a familial admixed cohort from a hyper-endemic area of South Africa, with an overall OR for rs17155120 estimated at 0.50 (95%CI 0.45\u20130.55,\n                    <jats:italic>P<\/jats:italic>\n                    = 1.26\u00d710\n                    <jats:sup>\u22129<\/jats:sup>\n                    ). The variants are located in intronic regions and upstream of\n                    <jats:italic>C10orf90<\/jats:italic>\n                    , a tumor suppressor gene which encodes an ubiquitin ligase activating the transcription factor p53.\n                    <jats:italic>In silico<\/jats:italic>\n                    analysis showed that the protective alleles were associated with a decreased expression in monocytes of the nearby gene\n                    <jats:italic>ADAM12<\/jats:italic>\n                    which could lead to an enhanced response of Th17 lymphocytes. Our results reveal a novel locus controlling resistance to\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>tuberculosis<\/jats:italic>\n                    infection across different populations.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1009392","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T14:09:18Z","timestamp":1614866958000},"page":"e1009392","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-3235","authenticated-orcid":true,"given":"Jocelyn","family":"Quistrebert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8108-938X","authenticated-orcid":true,"given":"Marianna","family":"Orlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-9428","authenticated-orcid":true,"given":"Gaspard","family":"Kerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi","family":"Ton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguy\u1ec5n Trong","family":"Luong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguy\u1ec5n Thanh","family":"Danh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin B.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-7135","authenticated-orcid":true,"given":"Fabienne","family":"Jabot-Hanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Seeleuthner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinta","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Boisson-Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thu","family":"Huong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Ngoc","family":"Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-4169","authenticated-orcid":true,"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-7150","authenticated-orcid":true,"given":"Christophe","family":"Delacourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-5688","authenticated-orcid":true,"given":"Eileen G.","family":"Hoal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-2226","authenticated-orcid":true,"given":"Alexandre","family":"Alca\u00efs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Hong","family":"Thai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai The","family":"Th\u00e0nh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-6493","authenticated-orcid":true,"given":"Laurent","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-536X","authenticated-orcid":true,"given":"Erwin","family":"Schurr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-6257","authenticated-orcid":true,"given":"Aur\u00e9lie","family":"Cobat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"pgen.1009392.ref001","unstructured":"Global tuberculosis report 2019. 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