{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:56:26Z","timestamp":1787021786883,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pgen.1009551","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000}}],"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY020866"],"award-info":[{"award-number":["R01EY020866"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    Rhodopsins are light-detecting proteins coupled with retinal chromophores essential for visual function. Coincidentally, dysfunctional Rhodopsin homeostasis underlies retinal degeneration in humans and model organisms.\n                    <jats:italic>Drosophila ninaE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>G69D<\/jats:italic>\n                    <\/jats:sup>\n                    mutant is one such example, where the encoded Rh1 protein imposes endoplasmic reticulum (ER) stress and causes light-dependent retinal degeneration. The underlying reason for such light-dependency remains unknown. Here, we report that\n                    <jats:italic>Drosophila fatty acid binding protein<\/jats:italic>\n                    (\n                    <jats:italic>fabp<\/jats:italic>\n                    ) is a gene induced in\n                    <jats:italic>ninaE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>G69D<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>\/+<\/jats:italic>\n                    photoreceptors, and regulates light-dependent Rhodopsin-1 (Rh1) protein clearance and photoreceptor survival. Specifically, our photoreceptor-specific gene expression profiling study in\n                    <jats:italic>ninaE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>G69D<\/jats:italic>\n                    <\/jats:sup>\n                    <jats:italic>\/+<\/jats:italic>\n                    flies revealed increased expression of\n                    <jats:italic>fabp<\/jats:italic>\n                    together with other genes that control light-dependent Rh1 protein degradation.\n                    <jats:italic>fabp<\/jats:italic>\n                    induction in\n                    <jats:italic>ninaE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>G69D<\/jats:italic>\n                    <\/jats:sup>\n                    photoreceptors required vitamin A and its transporter genes. In flies reared under light, loss of\n                    <jats:italic>fabp<\/jats:italic>\n                    caused an accumulation of Rh1 proteins in cytoplasmic vesicles. The increase in Rh1 levels under these conditions was dependent on Arrestin2 that mediates feedback inhibition of light-activated Rh1.\n                    <jats:italic>fabp<\/jats:italic>\n                    mutants exhibited light-dependent retinal degeneration, a phenotype also found in other mutants that block light-induced Rh1 degradation. These observations reveal a previously unrecognized link between light-dependent Rh1 proteostasis and the ER-stress imposing\n                    <jats:italic>ninaE<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>G69D<\/jats:italic>\n                    <\/jats:sup>\n                    mutant that cause retinal degeneration.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1009551","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T13:36:49Z","timestamp":1635514609000},"page":"e1009551","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Drosophila fabp is required for light-dependent Rhodopsin-1 clearance and photoreceptor 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