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Here, we showed that MTL5 translocates into nuclei of spermatocytes during zygotene-pachytene transition and ensures meiosis advances beyond pachytene stage. MTL5 shows strong interactions with MuvB core complex components, a well-known transcriptional complex regulating mitotic progression, and the zygotene-pachytene transition of MTL5 is mediated by its direct interaction with the component LIN9, through MTL5 C-terminal 443\u2013475 residues. Male\n                    <jats:italic>Mtl5<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>c-mu\/c-mu<\/jats:italic>\n                    <\/jats:sup>\n                    mice expressing the truncated MTL5 (p.Ser445Arg fs*3) that lacks the interaction with LIN9 and is detained in cytoplasm showed male infertility and spermatogenic arrest at pachytene stage, same as that of\n                    <jats:italic>Mtl5<\/jats:italic>\n                    knockout mice, indicating that the interaction with LIN9 is essential for the nuclear translocation and function of MTL5 during meiosis. Our data demonstrated MTL5 translocates into nuclei during the zygotene-pachytene transition to initiate its function along with the MuvB core complex in pachytene spermatocytes, highlighting a new mechanism regulating the progression of male meiosis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1009753","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T13:45:14Z","timestamp":1628862314000},"page":"e1009753","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and 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