{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:47:15Z","timestamp":1781257635532,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.pgen.1010075","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["D17AP00004"],"award-info":[{"award-number":["D17AP00004"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["D17AP00004"],"award-info":[{"award-number":["D17AP00004"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["D17AP00004"],"award-info":[{"award-number":["D17AP00004"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infections typically cause self-limiting gastroenteritis, but in some individuals these bacteria can spread systemically and cause disseminated disease.\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium (STm), which causes severe systemic disease in most inbred mice, has been used as a model for disseminated disease. To screen for new infection phenotypes across a range of host genetics, we orally infected 32 Collaborative Cross (CC) mouse strains with STm and monitored their disease progression for seven days by telemetry. Our data revealed a broad range of phenotypes across CC strains in many parameters including survival, bacterial colonization, tissue damage, complete blood counts (CBC), and serum cytokines. Eighteen CC strains survived to day 7, while fourteen susceptible strains succumbed to infection before day 7. Several CC strains had sex differences in survival and colonization. Surviving strains had lower pre-infection baseline temperatures and were less active during their daily active period. Core body temperature disruptions were detected earlier after STm infection than activity disruptions, making temperature a better detector of illness. All CC strains had STm in spleen and liver, but susceptible strains were more highly colonized. Tissue damage was weakly negatively correlated to survival. We identified loci associated with survival on Chromosomes (Chr) 1, 2, 4, 7. Polymorphisms in\n                    <jats:italic>Ncf2<\/jats:italic>\n                    and\n                    <jats:italic>Slc11a1<\/jats:italic>\n                    , known to reduce survival in mice after STm infections, are located in the Chr 1 interval, and the Chr 7 association overlaps with a previously identified QTL peak called\n                    <jats:italic>Ses2<\/jats:italic>\n                    . We identified two new genetic regions on Chr 2 and 4 associated with susceptibility to STm infection. Our data reveal the diversity of responses to STm infection across a range of host genetics and identified new candidate regions for survival of STm infection.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1010075","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:54:00Z","timestamp":1649858040000},"page":"e1010075","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-2224","authenticated-orcid":true,"given":"Kristin","family":"Scoggin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-0744","authenticated-orcid":true,"given":"Rachel","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsana","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9613-3729","authenticated-orcid":true,"given":"Aravindh","family":"Nagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6124-6344","authenticated-orcid":true,"given":"Maxwell","family":"Sheffield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-2336","authenticated-orcid":true,"given":"Ahmed","family":"Elsaadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-9709","authenticated-orcid":true,"given":"Manuchehr","family":"Aminian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8273-1365","authenticated-orcid":true,"given":"Amy","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-1602","authenticated-orcid":true,"given":"L. Garry","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-9263","authenticated-orcid":true,"given":"Michael","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3538-1635","authenticated-orcid":true,"given":"David W.","family":"Threadgill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-1335","authenticated-orcid":true,"given":"Helene L.","family":"Andrews-Polymenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"pgen.1010075.ref001","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.tim.2009.08.008","article-title":"Life in the inflamed intestine, Salmonella style","volume":"17","author":"RL Santos","year":"2009","journal-title":"Trends Microbiol"},{"key":"pgen.1010075.ref002","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nri3858","article-title":"Hill AVS. Genetic susceptibility to invasive Salmonella disease","volume":"15","author":"JJ Gilchrist","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"pgen.1010075.ref003","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrmicro3420","article-title":"Salmonellae interactions with host processes","volume":"13","author":"DL LaRock","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"pgen.1010075.ref004","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1086\/650733","article-title":"The global burden of nontyphoidal salmonella gastroenteritis","volume":"50","author":"SE Majowicz","year":"2010","journal-title":"Clin Infect Dis"},{"key":"pgen.1010075.ref005","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4049\/jimmunol.1801247","article-title":"Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross","volume":"202","author":"R Collin","year":"2019","journal-title":"J Immunol"},{"key":"pgen.1010075.ref006","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/S1473-3099(19)30418-9","article-title":"The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017","volume":"19","author":"JD Stanaway","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"pgen.1010075.ref007","unstructured":"CDC. Antibiotic resistance threats in the United States. Centers Dis Control Prev. 2019; 1\u2013113. Available: https:\/\/www.cdc.gov\/drugresistance\/biggest_threats.html"},{"key":"pgen.1010075.ref008","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/431899a","article-title":"Antibiotics at the crossroads","volume":"431","author":"C. 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of Super-shedder Mice Is Characterized by a Unique Neutrophil-dependent Blunting of TH1 Responses","author":"S Gopinath","year":"2013","journal-title":"PLoS Pathog."},{"key":"pgen.1010075.ref016","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00013542-200304000-00002","article-title":"Resistance and susceptibility to Salmonella infections: Lessons from mice and patients with immunodeficiencies","volume":"14","author":"P Mastroeni","year":"2003","journal-title":"Rev Med Microbiol"},{"key":"pgen.1010075.ref017","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s000110050330","article-title":"Macrophage NRAMP1 and its role in resistance to microbial infections","volume":"47","author":"G Govoni","year":"1998","journal-title":"Inflamm Res"},{"key":"pgen.1010075.ref018","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.4049\/jimmunol.176.11.6954","article-title":"Sequencing, Expression, and Functional Analyses Support the Candidacy of Ncf2 in Susceptibility to Salmonella Typhimurium Infection in Wild-Derived Mice","volume":"176","author":"V Sancho-Shimizu","year":"2006","journal-title":"J Immunol"},{"key":"pgen.1010075.ref019","first-page":"1","article-title":"Genetic dissection of the Ity3 locus identifies a role for Ncf2 co-expression modules and suggests Selp as a candidate gene underlying the Ity3.2 locus","volume":"5","author":"RT Khan","year":"2014","journal-title":"Front Immunol."},{"key":"pgen.1010075.ref020","first-page":"9","article-title":"Fine-mapping and phenotypic analysis of the Ity3 salmonella susceptibility locus identify a complex genetic structure","author":"RT Khan","year":"2014","journal-title":"PLoS One"},{"key":"pgen.1010075.ref021","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1128\/IAI.71.9.4873-4882.2003","article-title":"Role of toll-like receptor 4 in macrophage activation and tolerance during Salmonella enterica serovar Typhimurium infection","volume":"71","author":"Q Li","year":"2003","journal-title":"Infect Immun"},{"key":"pgen.1010075.ref022","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.gene.6363732","article-title":"LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4","volume":"2","author":"F Bihl","year":"2001","journal-title":"Genes Immun"},{"key":"pgen.1010075.ref023","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s00335-012-9410-6","article-title":"Status and access to the Collaborative Cross population","volume":"23","author":"CE Welsh","year":"2012","journal-title":"Mamm Genome"},{"key":"pgen.1010075.ref024","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1534\/genetics.111.138032","article-title":"Ten years of the collaborative cross","volume":"190","author":"DW Threadgill","year":"2012","journal-title":"Genetics"},{"key":"pgen.1010075.ref025","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1101\/gr.111310.110","article-title":"Genetic analysis 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Kollmus","year":"2018","journal-title":"Mamm Genome"},{"key":"pgen.1010075.ref036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-12477-2","article-title":"Host genetic background influences diverse neurological responses to viral infection in mice.","volume":"7","author":"CL Brinkmeyer-Langford","year":"2017","journal-title":"Sci Rep"},{"key":"pgen.1010075.ref037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.01516-16","article-title":"Tuberculosis susceptibility and vaccine protection are independently controlled by host genotype","volume":"7","author":"CM Smith","year":"2016","journal-title":"MBio"},{"key":"pgen.1010075.ref038","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.gdata.2016.10.006","article-title":"Identifying protective host gene expression signatures within the spleen during West Nile virus infection in the collaborative cross model","volume":"10","author":"R Green","year":"2016","journal-title":"Genomics 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Aminian","year":"2020","journal-title":"Interface Focus."},{"key":"pgen.1010075.ref046","first-page":"8","article-title":"gQTL : A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population.","author":"K Konganti","year":"2018","journal-title":"Genes Genomes Genet."},{"key":"pgen.1010075.ref047","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.gene.6363850","article-title":"Identification of genetic loci controlling bacterial clearance in experimental Salmonella enteritidis infection: An unexpected role of Nramp1 (Slc11a1) in the persistence of infection in mice","volume":"3","author":"J Caron","year":"2002","journal-title":"Genes Immun"},{"key":"pgen.1010075.ref048","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/sj.gene.6364234","article-title":"Mapping of interactions and mouse congenic strains identified novel epistatic QTLs controlling the persistence of Salmonella Enteritidis in mice","volume":"6","author":"J Caron","year":"2005","journal-title":"Genes Immun"},{"key":"pgen.1010075.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.00493-15","article-title":"Genetic diversity in the collaborative cross model recapitulates human west nile virus disease outcomes","volume":"6","author":"JB Graham","year":"2015","journal-title":"MBio"},{"key":"pgen.1010075.ref050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1005996","article-title":"A Mouse Model of Chronic West Nile Virus Disease","volume":"12","author":"JB Graham","year":"2016","journal-title":"PLoS Pathog."},{"key":"pgen.1010075.ref051","first-page":"9","article-title":"Modeling Host Genetic Regulation of Influenza Pathogenesis in the Collaborative Cross","author":"MT Ferris","year":"2013","journal-title":"PLoS 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female urinary tract infection.","volume":"5","author":"A Zychlinsky Scharff","year":"2019","journal-title":"JCI insight."},{"key":"pgen.1010075.ref056","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12016-017-8648-x","article-title":"Sexual Dimorphism in Innate Immunity.","volume":"56","author":"S Jaillon","year":"2019","journal-title":"Clin Rev Allergy Immunol"},{"key":"pgen.1010075.ref057","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1126\/scitranslmed.aas9292","article-title":"Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner","volume":"11","author":"B Shutinoski","year":"2019","journal-title":"Sci Transl Med"},{"key":"pgen.1010075.ref058","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10544-006-9007-5","article-title":"A biocompatible microdevice for core body temperature monitoring in the early diagnosis of infectious disease","volume":"9","author":"ED Williamson","year":"2007","journal-title":"Biomed Microdevices"},{"key":"pgen.1010075.ref059","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5582\/irdr.2016.01009","article-title":"Fever as an important resource for infectious diseases research","volume":"5","author":"JJG Plaza","year":"2016","journal-title":"Intractable Rare Dis Res"},{"key":"pgen.1010075.ref060","first-page":"74","article-title":"Thermoregulation as a disease tolerance as a defense strategy","author":"AMP Schieber","year":"2016","journal-title":"Pathog Dis."},{"key":"pgen.1010075.ref061","first-page":"160","article-title":"Telemetric evaluation of body temperature and physical activity as predictors of mortality in a murine model of staphylococcal enterotoxic shock","volume":"50","author":"KD Vlach","year":"2000","journal-title":"Comp Med"},{"key":"pgen.1010075.ref062","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/infdis\/jiu663","article-title":"Feverlike temperature is a virulence regulatory cue controlling the motility and host cell entry of typhoidal Salmonella","volume":"212","author":"D Elhadad","year":"2015","journal-title":"J Infect Dis"},{"key":"pgen.1010075.ref063","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11357-010-9164-6","article-title":"Sex- and age-specific differences in core body temperature of C57Bl\/6 mice","volume":"33","author":"M Sanchez-Alavez","year":"2011","journal-title":"Age (Omaha)."},{"key":"pgen.1010075.ref064","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1073\/pnas.1411030112","article-title":"Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells","volume":"112","author":"EF Foxman","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pgen.1010075.ref065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1007847","article-title":"Inflammatory monocytes provide a niche for Salmonella 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