{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:27:18Z","timestamp":1792121238318,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1010404","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000}}],"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea government","award":["No. 2019R1A2C2008050"],"award-info":[{"award-number":["No. 2019R1A2C2008050"]}]},{"name":"Team Science Award of Yonsei University College of Medicine","award":["6-2021-0007"],"award-info":[{"award-number":["6-2021-0007"]}]},{"name":"Suh Kyungbae Foundation"},{"name":"Korean Ministry of Science and Information and Communication Technology","award":["No. 2019R1A3B2066619"],"award-info":[{"award-number":["No. 2019R1A3B2066619"]}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>Most somatic mutations that arise during normal development are present at low levels in single or multiple tissues depending on the developmental stage and affected organs. However, the effect of human developmental stages or mutations of different organs on the features of somatic mutations is still unclear. Here, we performed a systemic and comprehensive analysis of low-level somatic mutations using deep whole-exome sequencing (average read depth ~500\u00d7) of 498 multiple organ tissues with matched controls from 190 individuals. Our results showed that early clone-forming mutations shared between multiple organs were lower in number but showed higher allele frequencies than late clone-forming mutations [0.54 vs. 5.83 variants per individual; 6.17% vs. 1.5% variant allele frequency (VAF)] along with less nonsynonymous mutations and lower functional impacts. Additionally, early and late clone-forming mutations had unique mutational signatures that were distinct from mutations that originated from tumors. Compared with early clone-forming mutations that showed a clock-like signature across all organs or tissues studied, late clone-forming mutations showed organ, tissue, and cell-type specificity in the mutation counts, VAFs, and mutational signatures. In particular, analysis of brain somatic mutations showed a bimodal occurrence and temporal-lobe-specific signature. These findings provide new insights into the features of somatic mosaicism that are dependent on developmental stage and brain regions.<\/jats:p>","DOI":"10.1371\/journal.pgen.1010404","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T17:39:15Z","timestamp":1663609155000},"page":"e1010404","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Analysis of low-level somatic mosaicism reveals stage and tissue-specific mutational features in human development"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-5199","authenticated-orcid":true,"given":"Ja Hye","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0202-7800","authenticated-orcid":true,"given":"Shinwon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonju","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Bin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-3450","authenticated-orcid":true,"given":"Myeong-Heui","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Suk","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Jin","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junehawk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-8847","authenticated-orcid":true,"given":"Hoon-Chul","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-0827","authenticated-orcid":true,"given":"Sangwoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"issue":"Suppl 1","key":"pgen.1010404.ref001","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1073\/pnas.0909343106","article-title":"Evolution in health and medicine Sackler colloquium: Somatic evolutionary genomics: mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration","volume":"107","author":"SA Frank","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7518","key":"pgen.1010404.ref002","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nature13448","article-title":"Genome sequencing of normal cells reveals developmental lineages and mutational processes","volume":"513","author":"S Behjati","year":"2014","journal-title":"Nature"},{"issue":"7647","key":"pgen.1010404.ref003","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature21703","article-title":"Somatic mutations reveal asymmetric cellular dynamics in the early human embryo","volume":"543","author":"YS Ju","year":"2017","journal-title":"Nature"},{"issue":"7624","key":"pgen.1010404.ref004","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature19768","article-title":"Tissue-specific mutation accumulation in human adult stem cells during life","volume":"538","author":"F Blokzijl","year":"2016","journal-title":"Nature"},{"issue":"4","key":"pgen.1010404.ref005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41568-021-00335-3","article-title":"Clonal expansion in non-cancer tissues","volume":"21","author":"N Kakiuchi","year":"2021","journal-title":"Nature Reviews Cancer"},{"issue":"11","key":"pgen.1010404.ref006","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/s41593-018-0257-3","article-title":"Somatic mosaicism and neurodevelopmental disease","volume":"21","author":"AM D\u2019Gama","year":"2018","journal-title":"Nat Neurosci"},{"issue":"21","key":"pgen.1010404.ref007","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1056\/NEJMra2101920","article-title":"Somatic Mutations in \u201cBenign\u201d Disease.","volume":"384","author":"S Mustjoki","year":"2021","journal-title":"New England Journal of Medicine"},{"issue":"6","key":"pgen.1010404.ref008","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00401-019-02052-6","article-title":"Precise detection of low-level somatic mutation in resected epilepsy brain tissue","volume":"138","author":"NS Sim","year":"2019","journal-title":"Acta Neuropathol"},{"issue":"6","key":"pgen.1010404.ref009","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00401-019-02061-5","article-title":"Dissecting the genetic basis of focal cortical dysplasia: a large cohort study","volume":"138","author":"S Baldassari","year":"2019","journal-title":"Acta Neuropathol"},{"issue":"13","key":"pgen.1010404.ref010","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1016\/j.celrep.2017.11.106","article-title":"Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias","volume":"21","author":"AM D\u2019Gama","year":"2017","journal-title":"Cell Rep"},{"issue":"6375","key":"pgen.1010404.ref011","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1126\/science.aan8690","article-title":"Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis","volume":"359","author":"T Bae","year":"2018","journal-title":"Science (New York, NY)."},{"issue":"6535","key":"pgen.1010404.ref012","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1126\/science.abe0981","article-title":"Early developmental asymmetries in cell lineage trees in living individuals","volume":"371","author":"L Fasching","year":"2021","journal-title":"Science (New York, NY)."},{"issue":"7865","key":"pgen.1010404.ref013","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41586-021-03548-6","article-title":"Lineage tracing of human development through somatic mutations","volume":"595","author":"M Spencer Chapman","year":"2021","journal-title":"Nature"},{"issue":"7876","key":"pgen.1010404.ref014","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41586-021-03790-y","article-title":"Extensive phylogenies of human development inferred from somatic mutations","volume":"597","author":"THH Coorens","year":"2021","journal-title":"Nature"},{"issue":"7876","key":"pgen.1010404.ref015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-021-03786-8","article-title":"Clonal dynamics in early human embryogenesis inferred from somatic mutation","volume":"597","author":"S Park","year":"2021","journal-title":"Nature"},{"issue":"2","key":"pgen.1010404.ref016","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41593-020-00765-6","article-title":"The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing","volume":"24","author":"RE Rodin","year":"2021","journal-title":"Nat Neurosci"},{"issue":"6","key":"pgen.1010404.ref017","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"DN Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"pgen.1010404.ref018","article-title":"Calling Somatic SNVs and Indels with Mutect2.","volume":"861054","author":"D Benjamin","year":"2019","journal-title":"bioRxiv"},{"issue":"1","key":"pgen.1010404.ref019","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/s41467-019-09026-y","article-title":"The use of technical replication for detection of low-level somatic mutations in next-generation sequencing","volume":"10","author":"J Kim","year":"2019","journal-title":"Nature communications"},{"issue":"1","key":"pgen.1010404.ref020","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41467-019-09027-x","article-title":"Deep convolutional neural networks for accurate somatic mutation detection","volume":"10","author":"SME Sahraeian","year":"2019","journal-title":"Nature communications"},{"issue":"7793","key":"pgen.1010404.ref021","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","article-title":"The repertoire of mutational signatures in human cancer","volume":"578","author":"LB Alexandrov","year":"2020","journal-title":"Nature"},{"issue":"5","key":"pgen.1010404.ref022","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2017.09.042","article-title":"Universal Patterns of Selection in Cancer and Somatic Tissues","volume":"171","author":"I Martincorena","year":"2017","journal-title":"Cell"},{"issue":"W1","key":"pgen.1010404.ref023","doi-asserted-by":"crossref","first-page":"W514","DOI":"10.1093\/nar\/gkx367","article-title":"Exploring background mutational processes to decipher cancer genetic heterogeneity","volume":"45","author":"A Goncearenco","year":"2017","journal-title":"Nucleic acids research"},{"issue":"4","key":"pgen.1010404.ref024","doi-asserted-by":"crossref","first-page":"e1006981","DOI":"10.1371\/journal.pcbi.1006981","article-title":"Finding driver mutations in cancer: Elucidating the role of background mutational processes","volume":"15","author":"AL Brown","year":"2019","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"pgen.1010404.ref025","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41588-019-0572-y","article-title":"Identification of cancer driver genes based on nucleotide context","volume":"52","author":"F Dietlein","year":"2020","journal-title":"Nature Genetics"},{"issue":"7616","key":"pgen.1010404.ref026","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"M Lek","year":"2016","journal-title":"Nature"},{"issue":"5","key":"pgen.1010404.ref027","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1182\/blood-2017-06-746412","article-title":"Aging of hematopoietic stem cells","volume":"131","author":"G de Haan","year":"2018","journal-title":"Blood"},{"issue":"7","key":"pgen.1010404.ref028","doi-asserted-by":"crossref","first-page":"e001926","DOI":"10.1161\/CIRCGEN.118.001926","article-title":"Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis.","volume":"11","author":"P Natarajan","year":"2018","journal-title":"Circ Genom Precis Med"},{"issue":"3","key":"pgen.1010404.ref029","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.cell.2015.12.050","article-title":"Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair","volume":"164","author":"NJ Haradhvala","year":"2016","journal-title":"Cell"},{"issue":"Pt 17","key":"pgen.1010404.ref030","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1242\/jcs.01250","article-title":"DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells","volume":"117","author":"EE Brachman","year":"2004","journal-title":"J Cell Sci"},{"issue":"9","key":"pgen.1010404.ref031","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.celrep.2018.11.014","article-title":"Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.","volume":"25","author":"FG Osorio","year":"2018","journal-title":"Cell Reports"},{"key":"pgen.1010404.ref032","article-title":"Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development","author":"MW Breuss","year":"2020","journal-title":"bioRxiv"},{"issue":"12","key":"pgen.1010404.ref033","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/ng.3441","article-title":"Clock-like mutational processes in human somatic cells","volume":"47","author":"LB Alexandrov","year":"2015","journal-title":"Nat Genet"},{"issue":"7717","key":"pgen.1010404.ref034","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41586-018-0389-3","article-title":"Human glioblastoma arises from subventricular zone cells with low-level driver mutations","volume":"560","author":"JH Lee","year":"2018","journal-title":"Nature"},{"issue":"10","key":"pgen.1010404.ref035","doi-asserted-by":"crossref","DOI":"10.3390\/genes11101138","article-title":"Features of DNA Repair in the Early Stages of Mammalian Embryonic Development.","volume":"11","author":"EV Khokhlova","year":"2020","journal-title":"Genes (Basel)."},{"issue":"5","key":"pgen.1010404.ref036","doi-asserted-by":"crossref","DOI":"10.3390\/genes10050398","article-title":"Preserving Genome Integrity During the Early Embryonic DNA Replication Cycles.","volume":"10","author":"C Kermi","year":"2019","journal-title":"Genes (Basel)."},{"issue":"6375","key":"pgen.1010404.ref037","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aao4426","article-title":"Aging and neurodegeneration are associated with increased mutations in single human neurons","volume":"359","author":"MA Lodato","year":"2018","journal-title":"Science (New York, NY)."},{"issue":"6535","key":"pgen.1010404.ref038","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1126\/science.abe1544","article-title":"Landmarks of human embryonic development inscribed in somatic mutations","volume":"371","author":"S Bizzotto","year":"2021","journal-title":"Science (New York, NY)."},{"issue":"7876","key":"pgen.1010404.ref039","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41586-021-03836-1","article-title":"A body map of somatic mutagenesis in morphologically normal human tissues","volume":"597","author":"R Li","year":"2021","journal-title":"Nature"},{"issue":"1","key":"pgen.1010404.ref040","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s13059-019-1919-5","article-title":"The somatic mutation landscape of the human body","volume":"20","author":"PE Garc\u00eda-Nieto","year":"2019","journal-title":"Genome Biol"},{"issue":"21","key":"pgen.1010404.ref041","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1007\/s00018-021-03931-6","article-title":"Struggle within: evolution and ecology of somatic cell populations","volume":"78","author":"B. Swiatczak","year":"2021","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"7","key":"pgen.1010404.ref042","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41416-019-0721-1","article-title":"Cancer as a disease of old age: changing mutational and microenvironmental landscapes","volume":"122","author":"E Laconi","year":"2020","journal-title":"Br J Cancer"},{"issue":"3","key":"pgen.1010404.ref043","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrg.2015.16","article-title":"Single-cell genome sequencing: current state of the science","volume":"17","author":"C Gawad","year":"2016","journal-title":"Nature Reviews Genetics"},{"key":"pgen.1010404.ref044","author":"S. Andrews","year":"2010","journal-title":"FastQC: a quality control tool for high throughput sequence data"},{"issue":"14","key":"pgen.1010404.ref045","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics (Oxford, England)."},{"key":"pgen.1010404.ref046","volume-title":"Picard: A set of command line tools (in Java) for manipulating high-throughput sequencing (HTS) data and formats such as SAM\/BAM\/CRAM and VCF.","author":"MIT, Havard.","year":"2020"},{"key":"pgen.1010404.ref047","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/0471250953.bi1110s43","article-title":"From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline.","volume":"43","author":"GA Van der Auwera","year":"2013","journal-title":"Current protocols in bioinformatics"},{"issue":"11","key":"pgen.1010404.ref048","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/nar\/gkx193","article-title":"NGSCheckMate: software for validating sample identity in next-generation sequencing studies within and across data types","volume":"45","author":"S Lee","year":"2017","journal-title":"Nucleic acids research"},{"issue":"20","key":"pgen.1010404.ref049","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1093\/bioinformatics\/btw383","article-title":"Vecuum: identification and filtration of false somatic variants caused by recombinant vector contamination","volume":"32","author":"J Kim","year":"2016","journal-title":"Bioinformatics (Oxford, England)."},{"issue":"1","key":"pgen.1010404.ref050","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13059-020-01993-6","article-title":"Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery","volume":"21","author":"J K\u00f6ster","year":"2020","journal-title":"Genome biology"},{"issue":"6","key":"pgen.1010404.ref051","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/nar\/gks1443","article-title":"Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation","volume":"41","author":"M Costello","year":"2013","journal-title":"Nucleic acids research"},{"issue":"D1","key":"pgen.1010404.ref052","doi-asserted-by":"crossref","first-page":"D23","DOI":"10.1093\/nar\/gky1069","article-title":"Database resources of the National Center for Biotechnology Information","volume":"47","author":"EW Sayers","year":"2018","journal-title":"Nucleic acids research"},{"issue":"6","key":"pgen.1010404.ref053","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"WJ Kent","year":"2002","journal-title":"Genome Res"},{"issue":"20","key":"pgen.1010404.ref054","first-page":"e120","article-title":"Umap and Bismap: quantifying genome and methylome mappability","volume":"46","author":"M Karimzadeh","year":"2018","journal-title":"Nucleic acids research"},{"issue":"Database issue","key":"pgen.1010404.ref055","doi-asserted-by":"crossref","first-page":"D493","DOI":"10.1093\/nar\/gkh103","article-title":"The UCSC Table Browser data retrieval tool","volume":"32","author":"D Karolchik","year":"2004","journal-title":"Nucleic acids research"},{"issue":"Web Server issue","key":"pgen.1010404.ref056","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkm306","article-title":"Primer3Plus, an enhanced web interface to Primer3","volume":"35","author":"A Untergasser","year":"2007","journal-title":"Nucleic acids research"},{"issue":"1","key":"pgen.1010404.ref057","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The Ensembl Variant Effect Predictor","volume":"17","author":"W McLaren","year":"2016","journal-title":"Genome biology"},{"issue":"1","key":"pgen.1010404.ref058","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13073-018-0539-0","article-title":"MutationalPatterns: comprehensive genome-wide analysis of mutational processes","volume":"10","author":"F Blokzijl","year":"2018","journal-title":"Genome Medicine"},{"key":"pgen.1010404.ref059","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13059-016-0893-4","article-title":"DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution","volume":"17","author":"R Rosenthal","year":"2016","journal-title":"Genome biology"},{"issue":"W1","key":"pgen.1010404.ref060","doi-asserted-by":"crossref","first-page":"W102","DOI":"10.1093\/nar\/gky406","article-title":"Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures","volume":"46","author":"J Lee","year":"2018","journal-title":"Nucleic acids research"},{"key":"pgen.1010404.ref061","article-title":"Analysis of mutational signatures with yet another package for signature analysis","author":"D H\u00fcbschmann","year":"2020","journal-title":"Genes Chromosomes Cancer"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1010404","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1010404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,19]],"date-time":"2023-02-19T15:55:14Z","timestamp":1676822114000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1010404"}},"subtitle":[],"editor":[{"given":"Marshall S.","family":"Horwitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":61,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1010404","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1010404","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,19]]}}}