{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T05:50:27Z","timestamp":1772862627650,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pgen.1010507","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000}}],"reference-count":103,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM058038"],"award-info":[{"award-number":["R01GM058038"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM127687"],"award-info":[{"award-number":["R01GM127687"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM145312"],"award-info":[{"award-number":["R35GM145312"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM134838"],"award-info":[{"award-number":["R35GM134838"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["F32GM119348"],"award-info":[{"award-number":["F32GM119348"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>A hallmark of gastrulation is the establishment of germ layers by internalization of cells initially on the exterior. In<jats:italic>C<\/jats:italic>.<jats:italic>elegans<\/jats:italic>the end of gastrulation is marked by the closure of the ventral cleft, a structure formed as cells internalize during gastrulation, and the subsequent rearrangement of adjacent neuroblasts that remain on the surface. We found that a nonsense allele of<jats:italic>srgp-1\/srGAP<\/jats:italic>leads to 10\u201315% cleft closure failure. Deletion of the SRGP-1\/srGAP C-terminal domain led to a comparable rate of cleft closure failure, whereas deletion of the N-terminal F-BAR region resulted in milder defects. Loss of the SRGP-1\/srGAP C-terminus or F-BAR domain results in defects in rosette formation and defective clustering of HMP-1\/\u237a-catenin in surface cells during cleft closure. A mutant form of HMP-1\/\u237a-catenin with an open M domain can suppress cleft closure defects in<jats:italic>srgp-1<\/jats:italic>mutant backgrounds, suggesting that this mutation acts as a gain-of-function allele. Since SRGP-1 binding to HMP-1\/\u237a-catenin is not favored in this case, we sought another HMP-1 interactor that might be recruited when HMP-1\/\u237a-catenin is constitutively open. A good candidate is AFD-1\/afadin, which genetically interacts with cadherin-based adhesion later during embryonic elongation. AFD-1\/afadin is prominently expressed at the vertex of neuroblast rosettes in wildtype, and depletion of AFD-1\/afadin increases cleft closure defects in<jats:italic>srgp-1\/srGAP<\/jats:italic>and<jats:italic>hmp-1<\/jats:italic><jats:sup><jats:italic>R551\/554A<\/jats:italic><\/jats:sup><jats:italic>\/\u237a-catenin<\/jats:italic>backgrounds. We propose that SRGP-1\/srGAP promotes nascent junction formation in rosettes; as junctions mature and sustain higher levels of tension, the M domain of HMP-1\/\u237a-catenin opens, allowing maturing junctions to transition from recruitment of SRGP-1\/srGAP to AFD-1\/afadin. Our work identifies new roles for \u237a-catenin interactors during a process crucial to metazoan development.<\/jats:p>","DOI":"10.1371\/journal.pgen.1010507","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T18:33:37Z","timestamp":1677868417000},"page":"e1010507","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["SRGP-1\/srGAP and AFD-1\/afadin stabilize HMP-1\/\u237a-catenin at rosettes to seal internalization sites following gastrulation in C. elegans"],"prefix":"10.1371","volume":"19","author":[{"given":"Joel M.","family":"Serre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-1662","authenticated-orcid":true,"given":"Mark 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