{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:12:07Z","timestamp":1775074327383,"version":"3.50.1"},"reference-count":92,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017115","name":"Oakland University","doi-asserted-by":"publisher","award":["10126"],"award-info":[{"award-number":["10126"]}],"id":[{"id":"10.13039\/100017115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIHR15GM140376-01A1"],"award-info":[{"award-number":["NIHR15GM140376-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p><jats:italic>Drosophila<\/jats:italic> trachea is a premier model to study tube morphogenesis. After the formation of continuous tubes, tube maturation follows. Tracheal tube maturation starts with an apical secretion pulse that deposits extracellular matrix components to form a chitin-based apical luminal matrix (aECM). This aECM is then cleared and followed by the maturation of taenidial folds. Finally, air fills the tubes. Meanwhile, the cellular junctions are maintained to ensure tube integrity. Previous research has identified several key components (ER, Golgi, several endosomes) of protein trafficking pathways that regulate the secretion and clearance of aECM, and the maintenance of cellular junctions. The <jats:italic>Osiris<\/jats:italic> (<jats:italic>Osi<\/jats:italic>) gene family is located at the <jats:italic>Triplo-lethal<\/jats:italic> (<jats:italic>Tpl<\/jats:italic>) locus on chromosome 3R 83D4-E3 and exhibits dosage sensitivity. Here, we show that three <jats:italic>Osi<\/jats:italic> genes (<jats:italic>Osi9<\/jats:italic>, <jats:italic>Osi15<\/jats:italic>, <jats:italic>Osi19<\/jats:italic>), function redundantly to regulate adherens junction (AJ) maintenance, luminal clearance, taenidial fold formation, tube morphology, and air filling during tube maturation. The localization of Osi proteins in endosomes (Rab7-containing late endosomes, Rab11-containing recycling endosomes, Lamp-containing lysosomes) and the reduction of these endosomes in <jats:italic>Osi<\/jats:italic> mutants suggest the possible role of <jats:italic>Osi<\/jats:italic> genes in tube maturation through endosome-mediated trafficking. We analyzed tube maturation in zygotic <jats:italic>rab11<\/jats:italic> and <jats:italic>rab7<\/jats:italic> mutants, respectively, to determine whether endosome-mediated trafficking is required. Interestingly, similar tube maturation defects were observed in <jats:italic>rab11<\/jats:italic> but not in <jats:italic>rab7<\/jats:italic> mutants, suggesting the involvement of Rab11-mediated trafficking, but not Rab7-mediated trafficking, in this process. To investigate whether <jats:italic>Osi<\/jats:italic> genes regulate tube maturation primarily through the maintenance of Rab11-containing endosomes, we overexpressed <jats:italic>rab11<\/jats:italic> in <jats:italic>Osi<\/jats:italic> mutant trachea. Surprisingly, no obvious rescue was observed. Thus, increasing endosome numbers is not sufficient to rescue tube maturation defects in <jats:italic>Osi<\/jats:italic> mutants. These results suggest that <jats:italic>Osi<\/jats:italic> genes regulate other aspects of endosome-mediated trafficking, or regulate an unknown mechanism that converges or acts in parallel with Rab11-mediated trafficking during tube maturation.<\/jats:p>","DOI":"10.1371\/journal.pgen.1010571","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T18:35:36Z","timestamp":1674498936000},"page":"e1010571","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Osiris family genes function as novel regulators of the tube maturation process in the Drosophila trachea"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-6234","authenticated-orcid":true,"given":"Aaron","family":"Scholl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-1146","authenticated-orcid":true,"given":"Istri","family":"Ndoja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-0501","authenticated-orcid":true,"given":"Niraj","family":"Dhakal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-4650","authenticated-orcid":true,"given":"Doria","family":"Morante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-2247","authenticated-orcid":true,"given":"Abigail","family":"Ivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5102-2045","authenticated-orcid":true,"given":"Thomas","family":"Mossington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-7424","authenticated-orcid":true,"given":"Christian","family":"Clemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sruthi","family":"Surapaneni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Powers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-5500","authenticated-orcid":true,"given":"Lan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"pgen.1010571.ref001","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1242\/dev.125.24.4959","article-title":"The 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