{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:54:11Z","timestamp":1791932051905,"version":"4.3.4"},"reference-count":125,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01-EY013612"],"award-info":[{"award-number":["R01-EY013612"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01-EY031724"],"award-info":[{"award-number":["R01-EY031724"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01-EY024272"],"award-info":[{"award-number":["R01-EY024272"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY012576"],"award-info":[{"award-number":["P30 EY012576"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine the destiny of retinal progenitor cells in part by regulating\n                    <jats:italic>Hes<\/jats:italic>\n                    effector gene activity. There are multiple paralogues for nearly every node in this pathway, which results in numerous instances of redundancy and compensation during development. To dissect such complexity at the earliest stages of eye development, we used seven germline or conditional mutant mice and two spatiotemporally distinct Cre drivers. We perturbed the Notch ternary complex and multiple\n                    <jats:italic>Hes<\/jats:italic>\n                    genes to understand if Notch regulates optic stalk\/nerve head development; and to test intracellular pathway components for their Notch-dependent versus -independent roles during retinal ganglion cell and cone photoreceptor competence and fate acquisition. We confirmed that disrupting Notch signaling universally blocks progenitor cell growth, but delineated specific pathway components that can act independently, such as sustained Hes1 expression in the optic stalk\/nerve head. In retinal progenitor cells, we found that among the genes tested, they do not uniformly suppress retinal ganglion cell or cone differentiation; which is not due differences in developmental timing. We discovered that shifts in the earliest cell fates correlate with expression changes for the early photoreceptor factor Otx2, but not with Atoh7, a factor required for retinal ganglion cell formation. During photoreceptor genesis we also better defined multiple and simultaneous activities for\n                    <jats:italic>Rbpj<\/jats:italic>\n                    and\n                    <jats:italic>Hes1<\/jats:italic>\n                    and identify redundant activities that occur downstream of Notch. Given its unique roles at the retina-optic stalk boundary and cone photoreceptor genesis, our data suggest Hes1 as a hub where Notch-dependent and -independent inputs converge.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1010928","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T13:21:39Z","timestamp":1695734499000},"page":"e1010928","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Notch pathway mutants do not equivalently perturb mouse embryonic retinal development"],"prefix":"10.1371","volume":"19","author":[{"given":"Bernadett","family":"Bosze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-7433","authenticated-orcid":true,"given":"Julissa","family":"Suarez-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illiana","family":"Cajias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-0315","authenticated-orcid":true,"given":"Joseph A.","family":"Brzezinski IV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-4625","authenticated-orcid":true,"given":"Nadean L.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"pgen.1010928.ref001","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/B978-0-12-397265-1.00072-1","volume-title":"Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS. 1","author":"RB Hufnagel","year":"2013"},{"key":"pgen.1010928.ref002","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ydbio.2021.06.005","article-title":"A single-cell guide to retinal development: Cell fate decisions of multipotent retinal progenitors in scRNA-seq","volume":"478","author":"F Shiau","year":"2021","journal-title":"Dev Biol"},{"key":"pgen.1010928.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1895\/wormbook.1.10.2","article-title":"Notch signaling: genetics and structure","volume":"2013","author":"I 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