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However, CgHog1 substrates remain unidentified. Here, we show that CgHog1 adversely affects <jats:italic>Cg<\/jats:italic> adherence to host stomach and kidney epithelial cells in vitro, but promotes <jats:italic>Cg<\/jats:italic> survival in the iron-rich gastrointestinal tract niche. Further, CgHog1 interactome and in vitro phosphorylation analysis revealed CgSub2 (putative RNA helicase) to be a CgHog1 substrate, with CgSub2 also governing iron homeostasis and host adhesion. CgSub2 positively regulated <jats:italic>EPA1<\/jats:italic> (encodes a major adhesin) expression and host adherence via its interactor CgHtz1 (histone H2A variant). Notably, both CgHog1 and surplus environmental iron had a negative impact on CgSub2-CgHtz1 interaction, with <jats:italic>CgHTZ1<\/jats:italic> or <jats:italic>CgSUB2<\/jats:italic> deletion reversing the elevated adherence of <jats:italic>Cghog1\u0394<\/jats:italic> to epithelial cells. Finally, the surplus-extracellular iron led to CgHog1 activation, increased CgSub2 phosphorylation, elevated CgSub2-CgHta (canonical histone H2A) interaction, and <jats:italic>EPA1<\/jats:italic> transcriptional activation, thereby underscoring the iron-responsive, CgHog1-induced exchange of histone partners of CgSub2. Altogether, our work mechanistically defines how CgHog1 couples Epa1 adhesin expression with iron abundance, and point towards specific chromatin composition modification programs that probably aid fungal pathogens align their adherence to iron-rich (gut) and iron-poor (blood) host niches.<\/jats:p>","DOI":"10.1371\/journal.pgen.1011281","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T17:46:51Z","timestamp":1715708811000},"page":"e1011281","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Hog1 MAPK substrate governs Candida glabrata-epithelial cell adhesion via the histone H2A variant"],"prefix":"10.1371","volume":"20","author":[{"given":"Mahima Sagar","family":"Sahu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5173-9371","authenticated-orcid":true,"given":"Rajaram","family":"Purushotham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-1700","authenticated-orcid":true,"given":"Rupinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"pgen.1011281.ref001","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tim.2007.02.001","article-title":"MAP kinase pathways as regulators of fungal virulence","volume":"15","author":"E Rom\u00e1n","year":"2007","journal-title":"Trends Microbiol"},{"key":"pgen.1011281.ref002","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bbamcr.2007.05.003","article-title":"Function and Regulation in MAPK Signaling Pathways","volume":"1773","author":"RE Chen","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"pgen.1011281.ref003","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.nutr.23.011702.073139","article-title":"Physiology and molecular biology of dietary iron absorption","volume":"23","author":"S Miret","year":"2003","journal-title":"Annu Rev Nutr"},{"key":"pgen.1011281.ref004","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1111\/febs.13264","article-title":"The mitogen-activated protein kinase CgHog1 is required for iron homeostasis, adherence and virulence in Candida glabrata","volume":"282","author":"VK Srivastava","year":"2015","journal-title":"FEBS J"},{"key":"pgen.1011281.ref005","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.12.1.80","article-title":"Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans","volume":"12","author":"PL Fidel","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"pgen.1011281.ref006","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1186\/1471-2164-14-623","article-title":"Comparative genomics of emerging pathogens in the Candida glabrata clade","volume":"14","author":"T Gabald\u00f3n","year":"2013","journal-title":"BMC Genomics"},{"key":"pgen.1011281.ref007","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1080\/14787210.2020.1792773","article-title":"Host\u2013pathogen interaction in Candida glabrata infection: current knowledge and implications for antifungal therapy","volume":"18","author":"M Rasheed","year":"2020","journal-title":"Expert Rev Anti Infect Ther"},{"key":"pgen.1011281.ref008","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"H Wisplinghoff","year":"2004","journal-title":"Clin Infect Dis"},{"key":"pgen.1011281.ref009","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/0972-5229.152753","article-title":"Candida glabrata candidemia","volume":"19","author":"A. Chakrabarti","year":"2015","journal-title":"Indian J Crit Care Med"},{"key":"pgen.1011281.ref010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/0972-5229.152757","article-title":"Candida glabrata candidemia: An emerging threat in critically ill patients","volume":"19","author":"A Gupta","year":"2015","journal-title":"Indian J Crit Care Med"},{"key":"pgen.1011281.ref011","first-page":"1","article-title":"Update from a 12-year nationwide fungemia surveillance: Increasing intrinsic and acquired resistance causes concern","volume":"56","author":"KMT Astvad","year":"2018","journal-title":"J Clin Microbiol"},{"key":"pgen.1011281.ref012","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/ofid\/ofy358","article-title":"Twenty years of the SENTRY Antifungal Surveillance Program: Results for Candida species from 1997\u20132016","volume":"6","author":"MA Pfaller","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"pgen.1011281.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-022-07848-8","article-title":"Epidemiologic features, clinical characteristics, and predictors of mortality in patients with candidemia in Alameda County, California; a 2017\u20132020 retrospective analysis","volume":"22","author":"D Meyahnwi","year":"2022","journal-title":"BMC Infect Dis"},{"key":"pgen.1011281.ref014","unstructured":"World Health Organization. WHO fungal priority pathogens list to guide research, development and public health action. Licence: CC BY-NC-SA 3.0 IGO. 2022."},{"key":"pgen.1011281.ref015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cmi.12943","article-title":"Competition of Candida glabrata against Lactobacillus is Hog1 dependent","volume":"20","author":"R Beyer","year":"2018","journal-title":"Cell Microbiol"},{"key":"pgen.1011281.ref016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0161371","article-title":"KRE5 suppression induces cell wall stress and alternative ER stress response required for maintaining cell wall integrity in Candida glabrata","volume":"11","author":"Y Tanaka","year":"2016","journal-title":"PLoS One"},{"key":"pgen.1011281.ref017","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/ecco-jcc\/jjv209","article-title":"Fungal dysbiosis in mucosa-associated microbiota of Crohn\u2019s disease patients","volume":"10","author":"G Liguori","year":"2016","journal-title":"J Crohn\u2019s Colitis"},{"key":"pgen.1011281.ref018","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.medmal.2015.01.007","article-title":"Digestive tract mycobiota: A source of infection","volume":"45","author":"N Gouba","year":"2015","journal-title":"Med Mal Infect"},{"key":"pgen.1011281.ref019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.01412-17","article-title":"The gastrointestinal tract is a major source of echinocandin drug resistance in a murine model of Candida glabrata colonization and systemic dissemination","volume":"61","author":"KR Healey","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"pgen.1011281.ref020","first-page":"331","article-title":"The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases","volume":"16","author":"ML Richard","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"pgen.1011281.ref021","first-page":"I48","article-title":"THE ABSORPTION AND EXCRETION OF IRON FOLLOWING ORAL AND INTRAVENOUS ADMINISTRATION","volume":"94","author":"R McCANCE EW","year":"1938","journal-title":"J Physiol"},{"key":"pgen.1011281.ref022","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/1574-6976.12086","article-title":"Nutritional iron turned inside out: Intestinal stress from a gut microbial perspective","volume":"38","author":"GAM Kortman","year":"2014","journal-title":"FEMS Microbiol Rev"},{"key":"pgen.1011281.ref023","doi-asserted-by":"crossref","first-page":"24715","DOI":"10.1074\/jbc.M116.751529","article-title":"The Phosphoinositide 3-Kinase Regulates Retrograde Trafficking of the Iron Permease CgFtr1 and Iron Homeostasis in Candida glabrata","volume":"291","author":"V Sharma","year":"2016","journal-title":"J Biol Chem"},{"key":"pgen.1011281.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21688370.2019.1612661","article-title":"Candida Albicans Interactions With The Host: Crossing The Intestinal Epithelial Barrier","volume":"7","author":"L Basmaciyan","year":"2019","journal-title":"Tissue Barriers"},{"key":"pgen.1011281.ref025","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-021-03722-w","article-title":"Adaptive immunity induces mutualism between commensal eukaryotes","volume":"596","author":"KS Ost","year":"2021","journal-title":"Nature"},{"key":"pgen.1011281.ref026","doi-asserted-by":"crossref","first-page":"151490","DOI":"10.1016\/j.ijmm.2021.151490","article-title":"Fungi of the human gut microbiota: Roles and significance","volume":"311","author":"JC P\u00e9rez","year":"2021","journal-title":"Int J Med Microbiol"},{"key":"pgen.1011281.ref027","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chom.2011.07.005","article-title":"An Iron Homeostasis Regulatory Circuit with Reciprocal Roles in Candida albicans Commensalism and Pathogenesis","volume":"10","author":"C Chen","year":"2011","journal-title":"Cell Host Microbe"},{"key":"pgen.1011281.ref028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087128","article-title":"The HOG pathway is critical for the colonization of the mouse gastrointestinal tract by Candida albicans","volume":"9","author":"D Prieto","year":"2014","journal-title":"PLoS One"},{"key":"pgen.1011281.ref029","article-title":"Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicans to iron availability","volume":"13","author":"HEJ Kaba","year":"2013","journal-title":"BMC Microbiol"},{"key":"pgen.1011281.ref030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41591-019-0709-7","article-title":"High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis","volume":"26","author":"B Zhai","year":"2020","journal-title":"Nat Med"},{"key":"pgen.1011281.ref031","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1128\/MCB.21.16.5459-5470.2001","article-title":"High-Copy-Number Expression of Sub2p, a Member of the RNA Helicase Superfamily, Suppresses hpr1 -Mediated Genomic Instability","volume":"21","author":"H-Y Fan","year":"2001","journal-title":"Mol Cell Biol"},{"key":"pgen.1011281.ref032","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0960-9822(01)00529-2","article-title":"The DECD box putative ATPase Sub2p is an early mRNA export factor","volume":"11","author":"TH Jensen","year":"2001","journal-title":"Curr Biol"},{"key":"pgen.1011281.ref033","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1101\/gad.851701","article-title":"Identification and characterization of yUAP\/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56","volume":"15","author":"M Zhang","year":"2001","journal-title":"Genes Dev"},{"key":"pgen.1011281.ref034","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/BJ20140598","article-title":"A systematic analysis reveals an essential role for high-affinity iron uptake system, haemolysin and CFEM domain-containing protein in iron homoeostasis and virulence in Candida glabrata","volume":"463","author":"VK Srivastava","year":"2014","journal-title":"Biochem J"},{"key":"pgen.1011281.ref035","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nature746","article-title":"TREX is a conserved complex coupling transcription with messenger RNA export","volume":"417","author":"K St\u00e4\u00dfer","year":"2002","journal-title":"Nature"},{"key":"pgen.1011281.ref036","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/yea.1231","article-title":"The Saccharomyces cerevisiae Sub2 protein suppresses heterochromatic silencing at telomeres and subtelomeric genes","volume":"22","author":"E Lahue","year":"2005","journal-title":"Yeast"},{"key":"pgen.1011281.ref037","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1126\/science.285.5427.578","article-title":"An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells","volume":"285","author":"BP Cormack","year":"1999","journal-title":"Science (80-)"},{"key":"pgen.1011281.ref038","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40588-023-00190-w","article-title":"The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans","author":"ID Jacobsen","year":"2023","journal-title":"Curr Clin Microbiol Reports"},{"key":"pgen.1011281.ref039","article-title":"SWI\/SNF complex-mediated chromatin remodelling in Candida glabrata is vital for immune evasion","author":"Kundan Kumar","year":"2023","journal-title":"bioRxiv"},{"key":"pgen.1011281.ref040","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chom.2016.09.008","article-title":"NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7","volume":"20","author":"A Vitenshtein","year":"2016","journal-title":"Cell Host Microbe"},{"key":"pgen.1011281.ref041","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1261\/rna.040048.113","article-title":"Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability","volume":"19","author":"C Saguez","year":"2013","journal-title":"Rna"},{"key":"pgen.1011281.ref042","doi-asserted-by":"crossref","first-page":"17545","DOI":"10.1074\/jbc.M109.084681","article-title":"Late phase of the endoplasmic reticulum stress response pathway is regulated by Hog1 MAP kinase","volume":"285","author":"AA Bicknell","year":"2010","journal-title":"J Biol Chem"},{"key":"pgen.1011281.ref043","doi-asserted-by":"crossref","first-page":"20088","DOI":"10.1074\/jbc.M109.063578","article-title":"The activity of yeast Hog1 MAPK is required during endoplasmic reticulum stress induced by tunicamycin exposure","volume":"285","author":"F Torres-Quiroz","year":"2010","journal-title":"J Biol Chem"},{"key":"pgen.1011281.ref044","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0092-8674(03)00123-5","article-title":"Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin","volume":"112","author":"MD Meneghini","year":"2003","journal-title":"Cell"},{"key":"pgen.1011281.ref045","doi-asserted-by":"crossref","first-page":"18385","DOI":"10.1073\/pnas.0507975102","article-title":"Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling","volume":"102","author":"B Li","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pgen.1011281.ref046","doi-asserted-by":"crossref","first-page":"8985","DOI":"10.1128\/MCB.25.20.8985-8999.2005","article-title":"Domain-Wide Displacement of Histones by Activated Heat Shock Factor Occurs Independently of Swi\/Snf and Is Not Correlated with RNA Polymerase II Density","volume":"25","author":"J Zhao","year":"2005","journal-title":"Mol Cell Biol"},{"key":"pgen.1011281.ref047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1008620","article-title":"Histone H4 dosage modulates DNA damage response in the pathogenic yeast Candida glabrata via homologous recombination pathway","volume":"16","author":"K Kumar","year":"2020","journal-title":"PLoS Genet"},{"key":"pgen.1011281.ref048","doi-asserted-by":"crossref","first-page":"101246","DOI":"10.1016\/j.jbc.2021.101246","article-title":"Replication stress inhibits synthesis of histone mRNAs in yeast by removing Spt10p and Spt21p from the histone promoters","volume":"297","author":"M Bhagwat","year":"2021","journal-title":"J Biol Chem"},{"key":"pgen.1011281.ref049","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cell.2005.08.036","article-title":"Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed\/basal promoters for activation through histone loss","volume":"123","author":"H Zhang","year":"2005","journal-title":"Cell"},{"key":"pgen.1011281.ref050","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2018.05.003","article-title":"Histone variant H2A.Z antagonizes the positive effect of the transcriptional activator CPC1 to regulate catalase-3 expression under normal and oxidative stress conditions","volume":"121","author":"Q Dong","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"pgen.1011281.ref051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2013.00350","article-title":"Sorbic acid stress activates the Candida glabrata high osmolarity glycerol MAP kinase pathway","volume":"4","author":"Z Jandric","year":"2013","journal-title":"Front Microbiol"},{"key":"pgen.1011281.ref052","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024759","article-title":"Intestinal resident yeast Candida glabrata requires Cyb2p-Mediated lactate assimilation to adapt in mouse intestine","volume":"6","author":"K Ueno","year":"2011","journal-title":"PLoS One"},{"key":"pgen.1011281.ref053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13099-018-0277-2","article-title":"A decrease in anaerobic bacteria promotes Candida glabrata overgrowth while \u03b2-glucan treatment restores the gut microbiota and attenuates colitis 06 Biological Sciences 0605 Microbiology","volume":"10","author":"R Charlet","year":"2018","journal-title":"Gut Pathog"},{"key":"pgen.1011281.ref054","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-21422-w","article-title":"Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response","volume":"8","author":"R Charlet","year":"2018","journal-title":"Sci Rep"},{"key":"pgen.1011281.ref055","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1099\/jmm.0.47049-0","article-title":"Candida glabrata colonizes but does not often disseminate from the mouse caecum","volume":"56","author":"CL Wells","year":"2007","journal-title":"J Med Microbiol"},{"key":"pgen.1011281.ref056","article-title":"Hypoxic conditions promote Candida glabrata colonization in the intestinal tract and EPA6 plays a significant role in hypoxic adhesion to intestinal cells","author":"T. Shinohara","journal-title":"bioRxiv"},{"key":"pgen.1011281.ref057","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/jn\/128.2.175","article-title":"Increases in the concentrations of available iron in response to dietary iron supplementation are associated with changes in crypt cell proliferation in rat large intestine","volume":"128","author":"EK Lund","year":"1998","journal-title":"J Nutr"},{"key":"pgen.1011281.ref058","doi-asserted-by":"crossref","DOI":"10.3390\/jof4020067","article-title":"Candida glabrata\u2019s genome plasticity confers a unique pattern of expressed cell wall proteins","volume":"4","author":"E L\u00f3pez-Fuentes","year":"2018","journal-title":"J Fungi"},{"key":"pgen.1011281.ref059","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/mmi.14488","article-title":"De novo genome assembly of Candida glabrata reveals cell wall protein complement and structure of dispersed tandem repeat arrays","volume":"113","author":"Z Xu","year":"2020","journal-title":"Mol Microbiol"},{"key":"pgen.1011281.ref060","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1093\/nar\/gkp512","article-title":"Developmentally regulated MAPK pathways modulate heterochromatin in Saccharomyces cerevisiae","volume":"37","author":"Y Mazor","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"pgen.1011281.ref061","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001322","article-title":"Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing","volume":"7","author":"T Nevitt","year":"2011","journal-title":"PLoS Pathog"},{"key":"pgen.1011281.ref062","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01782-16","article-title":"A novel hybrid iron regulation network combines features from pathogenic and nonpathogenic yeasts","volume":"7","author":"F Gerwien","year":"2016","journal-title":"MBio"},{"key":"pgen.1011281.ref063","first-page":"1041","article-title":"The regulation of iron homeostasis in the fungal human pathogen Candida glabrata","volume":"165","author":"F Devaux","year":"2019","journal-title":"Microbiol (United Kingdom)"},{"key":"pgen.1011281.ref064","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061058","article-title":"Dietary Iron Concentration May Influence Aging Process by Altering Oxidative Stress in Tissues of Adult Rats","volume":"8","author":"LF Arruda","year":"2013","journal-title":"PLoS One"},{"key":"pgen.1011281.ref065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41522-019-0097-2","article-title":"Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron","volume":"5","author":"F La Carpia","year":"2019","journal-title":"npj Biofilms Microbiomes"},{"key":"pgen.1011281.ref066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2017.01055","article-title":"The fungal pathogen Candida glabrata does not depend on surface 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Zenklusen","year":"2002","journal-title":"Mol Cell Biol"},{"key":"pgen.1011281.ref070","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1128\/MCB.00234-06","article-title":"Tho1, a Novel hnRNP, and Sub2 Provide Alternative Pathways for mRNP Biogenesis in Yeast THO Mutants","volume":"26","author":"S Jimeno","year":"2006","journal-title":"Mol Cell Biol"},{"key":"pgen.1011281.ref071","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a019364","article-title":"Histone variants and epigenetics","volume":"7","author":"S Henikoff","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"pgen.1011281.ref072","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S1097-2765(03)00497-0","article-title":"A Snf2 Family ATPase Complex Required for Recruitment of the Histone H2A Variant Htz1","volume":"12","author":"NJ Krogan","year":"2003","journal-title":"Mol 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