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We and others previously showed that mutations and duplications affecting the transcription factor\n                    <jats:italic>SOX3<\/jats:italic>\n                    \/\n                    <jats:italic>Sox3<\/jats:italic>\n                    result in hypopituitarism, and this is likely of hypothalamic origin. We demonstrate here that the absence of\n                    <jats:italic>Sox3<\/jats:italic>\n                    predominantly affects the ME with phenotypes that first occur in juvenile animals, despite the embryonic onset of SOX3 expression. In the pituitary, reduction in hormone levels correlates with a lack of endocrine cell maturation. In parallel, ME NG2-glia renewal and oligodendrocytic differentiation potential are affected. We further show that low-dose aspirin treatment, which is known to affect NG2-glia, or changes in gut microbiota, rescue both proliferative defects and hypopituitarism in\n                    <jats:italic>Sox3<\/jats:italic>\n                    mutants. Our study highlights a central role of NG2-glia for ME function during a transitional period of post-natal development and indicates their sensitivity to extrinsic signals.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1011395","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T13:21:18Z","timestamp":1727356878000},"page":"e1011395","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypopituitarism in Sox3 null mutants correlates with altered NG2-glia in the median eminence and is influenced by aspirin and gut microbiota"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-9381","authenticated-orcid":true,"given":"Christophe","family":"Galichet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-5452","authenticated-orcid":true,"given":"Karine","family":"Rizzoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-4179","authenticated-orcid":true,"given":"Robin","family":"Lovell-Badge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"issue":"2","key":"pgen.1011395.ref001","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/cphy.c150023","article-title":"Development of the Neuroendocrine Hypothalamus","volume":"6","author":"S 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