{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T21:18:28Z","timestamp":1772486308351,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pgen.1011586","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000}}],"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["206208\/Z\/17\/Z"],"award-info":[{"award-number":["206208\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102175\/B\/13\/Z"],"award-info":[{"award-number":["102175\/B\/13\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000735","name":"University of Cambridge","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000735","name":"University of Cambridge","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["206257\/Z\/17\/Z"],"award-info":[{"award-number":["206257\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["CDA-00032\/2018"],"award-info":[{"award-number":["CDA-00032\/2018"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["899546"],"award-info":[{"award-number":["899546"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-20-CE13-0015"],"award-info":[{"award-number":["ANR-20-CE13-0015"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["28276"],"award-info":[{"award-number":["28276"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>Tissue maintenance is underpinned by resident stem cells whose activity is modulated by microenvironmental cues. Using <jats:italic>Drosophila<\/jats:italic> as a simple model to identify regulators of stem cell behaviour and survival <jats:italic>in vivo<\/jats:italic>, we have identified novel connections between the conserved transmembrane proteoglycan Syndecan, nuclear properties and stem cell function. In the <jats:italic>Drosophila<\/jats:italic> midgut, Syndecan depletion in intestinal stem cells results in their loss from the tissue, impairing tissue renewal. At the cellular level, Syndecan depletion alters cell and nuclear shape, and causes nuclear lamina invaginations and DNA damage. In a second tissue, the developing <jats:italic>Drosophila<\/jats:italic> brain, live imaging revealed that Syndecan depletion in neural stem cells results in nuclear envelope remodelling defects which arise upon cell division. Our findings reveal a new role for Syndecan in the maintenance of nuclear properties in diverse stem cell types.<\/jats:p>","DOI":"10.1371\/journal.pgen.1011586","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T18:59:28Z","timestamp":1738868368000},"page":"e1011586","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties"],"prefix":"10.1371","volume":"21","author":[{"given":"Buffy L.","family":"Eldridge-Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome G.","family":"Bohere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-4523","authenticated-orcid":true,"given":"Chantal","family":"Roubinet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Barthelemy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamsin J.","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Karam","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4007-3311","authenticated-orcid":true,"given":"Golnar","family":"Kolahgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"1","key":"pgen.1011586.ref001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.stem.2023.12.006","article-title":"Hallmarks of stemness in mammalian tissues","volume":"31","author":"J Beumer","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"6","key":"pgen.1011586.ref002","doi-asserted-by":"crossref","first-page":"R207","DOI":"10.1016\/j.cub.2017.02.006","article-title":"Basement membranes","volume":"27","author":"R Jayadev","year":"2017","journal-title":"Curr Biol"},{"key":"pgen.1011586.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2016.12.009","article-title":"The nature and biology of basement membranes","author":"A Pozzi","year":"2017","journal-title":"Matrix Biol"},{"key":"pgen.1011586.ref004","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.ctdb.2018.02.005","article-title":"Basement membranes in development and disease","volume":"130","author":"R Sekiguchi","year":"2018","journal-title":"Curr Top Dev Biol"},{"issue":"7075","key":"pgen.1011586.ref005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature04371","article-title":"Evidence that stem cells reside in the adult Drosophila midgut epithelium","volume":"439","author":"CA Micchelli","year":"2006","journal-title":"Nature"},{"issue":"7075","key":"pgen.1011586.ref006","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature04333","article-title":"The adult Drosophila posterior midgut is maintained by pluripotent stem cells","volume":"439","author":"B Ohlstein","year":"2006","journal-title":"Nature"},{"issue":"8","key":"pgen.1011586.ref007","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1073\/pnas.91.8.3334","article-title":"Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan","volume":"91","author":"J Spring","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pgen.1011586.ref008","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00441-009-0829-3","article-title":"Syndecans as receptors and organizers of the extracellular matrix","volume":"339","author":"X Xian","year":"2010","journal-title":"Cell Tissue Res"},{"issue":"15","key":"pgen.1011586.ref009","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1111\/febs.14828","article-title":"Structures and interactions of syndecans","volume":"286","author":"F Gondelaud","year":"2019","journal-title":"FEBS J"},{"issue":"1","key":"pgen.1011586.ref010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0945-053X(03)00010-6","article-title":"Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans","volume":"22","author":"A Yoneda","year":"2003","journal-title":"Matrix Biol"},{"issue":"1","key":"pgen.1011586.ref011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/iep.12112","article-title":"Fell-Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour","volume":"96","author":"JR Couchman","year":"2015","journal-title":"Int J Exp Pathol"},{"issue":"1","key":"pgen.1011586.ref012","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/febs.13940","article-title":"Syndecans - key regulators of cell signaling and biological functions","volume":"284","author":"NA Afratis","year":"2017","journal-title":"FEBS J"},{"key":"pgen.1011586.ref013","doi-asserted-by":"crossref","first-page":"581213","DOI":"10.3389\/fcell.2020.581213","article-title":"Heparan sulfate proteoglycans: key mediators of stem cell function","volume":"8","author":"M Ravikumar","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"pgen.1011586.ref014","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1042\/BST20221085","article-title":"Conformations, interactions and functions of intrinsically disordered syndecans","volume":"51","author":"S Ricard-Blum","year":"2023","journal-title":"Biochem Soc Trans"},{"issue":"7","key":"pgen.1011586.ref015","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","article-title":"Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut","volume":"137","author":"H Jiang","year":"2009","journal-title":"Cell"},{"issue":"2","key":"pgen.1011586.ref016","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ydbio.2011.04.006","article-title":"Syndecan contributes to heart cell specification and lumen formation during Drosophila cardiogenesis","volume":"356","author":"J Knox","year":"2011","journal-title":"Dev Biol"},{"issue":"1","key":"pgen.1011586.ref017","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2016.06.027","article-title":"Knockdown expression of Syndecan in the fat body impacts nutrient metabolism and the organismal response to environmental stresses in Drosophila melanogaster","volume":"477","author":"M Eveland","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"7150","key":"pgen.1011586.ref018","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nature05954","article-title":"A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila","volume":"448","author":"G Dietzl","year":"2007","journal-title":"Nature"},{"issue":"4","key":"pgen.1011586.ref019","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s42255-021-00375-x","article-title":"white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila","volume":"3","author":"A Sasaki","year":"2021","journal-title":"Nat Metab"},{"issue":"6","key":"pgen.1011586.ref020","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.stemcr.2017.04.002","article-title":"Intestinal stem cell pool regulation in Drosophila","volume":"8","author":"Y Jin","year":"2017","journal-title":"Stem Cell Rep"},{"issue":"1","key":"pgen.1011586.ref021","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ydbio.2017.01.004","article-title":"Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge","volume":"424","author":"LPF Resende","year":"2017","journal-title":"Dev Biol"},{"issue":"6","key":"pgen.1011586.ref022","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cub.2004.02.005","article-title":"Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance","volume":"14","author":"KG Johnson","year":"2004","journal-title":"Curr Biol"},{"issue":"29","key":"pgen.1011586.ref023","doi-asserted-by":"crossref","first-page":"11984","DOI":"10.1073\/pnas.0901148106","article-title":"Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface","volume":"106","author":"B Chanana","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pgen.1011586.ref024","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cub.2004.01.006","article-title":"Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit\/robo signaling","volume":"14","author":"P Steigemann","year":"2004","journal-title":"Curr Biol"},{"issue":"10","key":"pgen.1011586.ref025","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/embor.2011.153","article-title":"Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels","volume":"12","author":"JG Schulz","year":"2011","journal-title":"EMBO Rep"},{"issue":"6","key":"pgen.1011586.ref026","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.celrep.2014.05.024","article-title":"Slit\/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila","volume":"7","author":"B Biteau","year":"2014","journal-title":"Cell Rep"},{"issue":"7","key":"pgen.1011586.ref027","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.celrep.2015.01.051","article-title":"Genome-wide RNAi screen identifies networks involved in intestinal stem cell regulation in Drosophila","volume":"10","author":"X Zeng","year":"2015","journal-title":"Cell Rep"},{"issue":"7","key":"pgen.1011586.ref028","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/cdd.2008.50","article-title":"Regulation of apoptosis in Drosophila","volume":"15","author":"H Steller","year":"2008","journal-title":"Cell Death Differ"},{"key":"pgen.1011586.ref029","doi-asserted-by":"crossref","first-page":"e00886","DOI":"10.7554\/eLife.00886","article-title":"Physiological and stem cell compartmentalization within the Drosophila midgut","volume":"2","author":"A Marianes","year":"2013","journal-title":"Elife"},{"issue":"3","key":"pgen.1011586.ref030","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1073\/pnas.1916820117","article-title":"A cell atlas of the adult Drosophila midgut","volume":"117","author":"R-J Hung","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pgen.1011586.ref031","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/s41467-020-15205-z","article-title":"The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX\/syntenin\/syndecan-4 required for completion of cytokinesis","volume":"11","author":"C Addi","year":"2020","journal-title":"Nat Commun"},{"issue":"3","key":"pgen.1011586.ref032","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cell.2008.12.020","article-title":"Aurora B-mediated abscission checkpoint protects against tetraploidization","volume":"136","author":"P Steigemann","year":"2009","journal-title":"Cell"},{"key":"pgen.1011586.ref033","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/B978-0-12-397920-9.00004-4","article-title":"LINC complex proteins in development and disease","volume":"109","author":"HF Horn","year":"2014","journal-title":"Curr Top Dev Biol"},{"issue":"22","key":"pgen.1011586.ref034","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1002\/1873-3468.14757","article-title":"Dynamic regulation of LINC complex composition and function across tissues and contexts","volume":"597","author":"MC King","year":"2023","journal-title":"FEBS Lett"},{"issue":"1","key":"pgen.1011586.ref035","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cub.2015.11.039","article-title":"Lamin Dysfunction mediates neurodegeneration in Tauopathies","volume":"26","author":"B Frost","year":"2016","journal-title":"Curr Biol"},{"issue":"17","key":"pgen.1011586.ref036","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1091\/mbc.e16-10-0721","article-title":"Emery-Dreifuss muscular dystrophy-linked genes and centronuclear myopathy-linked genes regulate myonuclear movement by distinct mechanisms","volume":"28","author":"MA Collins","year":"2017","journal-title":"Mol Biol Cell"},{"issue":"15","key":"pgen.1011586.ref037","doi-asserted-by":"crossref","first-page":"dev192146","DOI":"10.1242\/dev.192146","article-title":"A polarized nucleus-cytoskeleton-ECM connection in migrating cardioblasts controls heart tube formation in Drosophila","volume":"148","author":"C Dondi","year":"2021","journal-title":"Development"},{"key":"pgen.1011586.ref038","doi-asserted-by":"crossref","first-page":"e73656","DOI":"10.7554\/eLife.73656","article-title":"Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation","volume":"11","author":"J Falo-Sanjuan","year":"2022","journal-title":"Elife"},{"issue":"1","key":"pgen.1011586.ref039","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/19491034.2018.1454168","article-title":"Causes and consequences of genomic instability in laminopathies: replication stress and interferon response","volume":"9","author":"S Graziano","year":"2018","journal-title":"Nucleus"},{"issue":"14","key":"pgen.1011586.ref040","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.3390\/ijms22147281","article-title":"Nuclear envelope integrity in health and disease: consequences on genome instability and inflammation","volume":"22","author":"BR Gauthier","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"17","key":"pgen.1011586.ref041","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1093\/nar\/gkf496","article-title":"DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis","volume":"30","author":"JP Madigan","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"pgen.1011586.ref042","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.devcel.2013.07.005","article-title":"Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells","volume":"26","author":"J Mathieu","year":"2013","journal-title":"Dev Cell"},{"issue":"6","key":"pgen.1011586.ref043","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/dgd.12741","article-title":"Heparan sulfate proteoglycan molecules, syndecan and perlecan, have distinct roles in the maintenance of Drosophila germline stem cells","volume":"63","author":"Y Hayashi","year":"2021","journal-title":"Dev Growth Differ"},{"issue":"10","key":"pgen.1011586.ref044","first-page":"970","article-title":"Live imaging of neuroblast lineages within intact larval brains in Drosophila","author":"C Cabernard","year":"2013","journal-title":"Cold Spring Harb Protoc"},{"issue":"89","key":"pgen.1011586.ref045","first-page":"51756","article-title":"Live imaging of Drosophila larval neuroblasts","author":"DA Lerit","year":"2014","journal-title":"J Vis Exp"},{"issue":"23","key":"pgen.1011586.ref046","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1242\/dev.080515","article-title":"Drosophila neuroblasts: a model for stem cell biology","volume":"139","author":"CCF Homem","year":"2012","journal-title":"Development"},{"issue":"18","key":"pgen.1011586.ref047","doi-asserted-by":"crossref","first-page":"3973-3983.e4","DOI":"10.1016\/j.cub.2021.06.063","article-title":"Asymmetric nuclear division in neural stem cells generates sibling nuclei that differ in size, envelope composition, and chromatin organization","volume":"31","author":"C Roubinet","year":"2021","journal-title":"Curr Biol"},{"issue":"5","key":"pgen.1011586.ref048","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.yexcr.2012.01.004","article-title":"Requirement of matrix metalloproteinase-1 for intestinal homeostasis in the adult Drosophila midgut","volume":"318","author":"S-H Lee","year":"2012","journal-title":"Exp Cell Res"},{"issue":"1","key":"pgen.1011586.ref049","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ydbio.2013.01.032","article-title":"Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila","volume":"377","author":"G Lin","year":"2013","journal-title":"Dev Biol"},{"issue":"2","key":"pgen.1011586.ref050","doi-asserted-by":"crossref","first-page":"e89387","DOI":"10.1371\/journal.pone.0089387","article-title":"\u03b2\u03bd integrin inhibits chronic and high level activation of JNK to repress senescence phenotypes in Drosophila adult midgut","volume":"9","author":"T Okumura","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"pgen.1011586.ref051","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.stemcr.2014.04.007","article-title":"Drosophila perlecan regulates intestinal stem cell activity via cell-matrix attachment","volume":"2","author":"J You","year":"2014","journal-title":"Stem Cell Rep"},{"key":"pgen.1011586.ref052","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ncb3214","article-title":"Niche appropriation by Drosophila intestinal stem cell tumours","volume":"17","author":"PH Patel","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"10","key":"pgen.1011586.ref053","doi-asserted-by":"crossref","first-page":"e3000041","DOI":"10.1371\/journal.pbio.3000041","article-title":"An alternative mode of epithelial polarity in the Drosophila midgut","volume":"16","author":"J Chen","year":"2018","journal-title":"PLoS Biol"},{"issue":"7","key":"pgen.1011586.ref054","doi-asserted-by":"crossref","first-page":"jcs226860","DOI":"10.1242\/jcs.226860","article-title":"DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking","volume":"132","author":"AM Howard","year":"2019","journal-title":"J Cell Sci"},{"key":"pgen.1011586.ref055","doi-asserted-by":"crossref","first-page":"101835","DOI":"10.1016\/j.redox.2020.101835","article-title":"Context-dependent responses of Drosophila intestinal stem cells to intracellular reactive oxygen species","volume":"39","author":"F Chen","year":"2021","journal-title":"Redox Biol"},{"issue":"5","key":"pgen.1011586.ref056","doi-asserted-by":"crossref","first-page":"dev186106","DOI":"10.1242\/dev.186106","article-title":"Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine","volume":"148","author":"M Ferguson","year":"2021","journal-title":"Development"},{"issue":"5","key":"pgen.1011586.ref057","doi-asserted-by":"crossref","first-page":"e3001635","DOI":"10.1371\/journal.pbio.3001635","article-title":"Integrin-ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium","volume":"20","author":"M Mlih","year":"2022","journal-title":"PLoS Biol"},{"key":"pgen.1011586.ref058","doi-asserted-by":"crossref","first-page":"e72836","DOI":"10.7554\/eLife.72836","article-title":"Vinculin recruitment to \u03b1-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine","volume":"11","author":"J Bohere","year":"2022","journal-title":"Elife"},{"issue":"2","key":"pgen.1011586.ref059","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.devcel.2019.05.027","article-title":"Mechanical function of the nucleus in force generation during epithelial morphogenesis","volume":"50","author":"A Ambrosini","year":"2019","journal-title":"Dev Cell"},{"issue":"1","key":"pgen.1011586.ref060","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1038\/s41467-018-06277-z","article-title":"Nuclear lamina dysfunction triggers a germline stem cell checkpoint","volume":"9","author":"LJ Barton","year":"2018","journal-title":"Nat Commun"},{"issue":"9","key":"pgen.1011586.ref061","doi-asserted-by":"crossref","first-page":"dev186171","DOI":"10.1242\/dev.186171","article-title":"Survival of Drosophila germline stem cells requires the chromatin-binding protein Barrier-to-autointegration factor","volume":"147","author":"T Duan","year":"2020","journal-title":"Development"},{"issue":"2","key":"pgen.1011586.ref062","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/dev.083139","article-title":"Adhesion in the stem cell niche: biological roles and regulation","volume":"140","author":"S Chen","year":"2013","journal-title":"Development"},{"issue":"1","key":"pgen.1011586.ref063","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1038\/s41598-018-23065-3","article-title":"Autophagy maintains stem cells and intestinal homeostasis in Drosophila","volume":"8","author":"P Nagy","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"pgen.1011586.ref064","doi-asserted-by":"crossref","first-page":"19080","DOI":"10.1038\/s41598-020-75867-z","article-title":"Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila","volume":"10","author":"A Sharma","year":"2020","journal-title":"Sci Rep"},{"issue":"11","key":"pgen.1011586.ref065","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s00018-010-0298-6","article-title":"Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner","volume":"67","author":"A Keller-Pinter","year":"2010","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"pgen.1011586.ref066","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41580-022-00480-z","article-title":"Mechanics and functional consequences of nuclear deformations","volume":"23","author":"Y Kalukula","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"pgen.1011586.ref067","doi-asserted-by":"crossref","first-page":"a039685","DOI":"10.1101\/cshperspect.a039685","article-title":"Mechanical forces in nuclear organization","volume":"14","author":"YA Miroshnikova","year":"2022","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"pgen.1011586.ref068","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41563-019-0567-1","article-title":"Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway","volume":"19","author":"A Chronopoulos","year":"2020","journal-title":"Nat Mater"},{"key":"pgen.1011586.ref069","doi-asserted-by":"crossref","first-page":"120947","DOI":"10.1016\/j.biomaterials.2021.120947","article-title":"Molecular tension in syndecan-1 is regulated by extracellular mechanical cues and fluidic shear stress","volume":"275","author":"V Le","year":"2021","journal-title":"Biomaterials"},{"issue":"1","key":"pgen.1011586.ref070","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1038\/s41467-021-27384-4","article-title":"Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury","volume":"12","author":"DJ-K Hu","year":"2021","journal-title":"Nat Commun"},{"key":"pgen.1011586.ref071","doi-asserted-by":"crossref","first-page":"e76010","DOI":"10.7554\/eLife.76010","article-title":"An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine","volume":"11","author":"M Marchetti","year":"2022","journal-title":"Elife"},{"issue":"3","key":"pgen.1011586.ref072","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tcb.2020.11.009","article-title":"Actin on and around the nucleus","volume":"31","author":"PM Davidson","year":"2021","journal-title":"Trends Cell Biol"},{"issue":"6","key":"pgen.1011586.ref073","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.3390\/ijms22063178","article-title":"Regulation of nuclear mechanics and the impact on DNA damage","volume":"22","author":"\u00c1 Dos Santos","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"9","key":"pgen.1011586.ref074","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.tcb.2021.03.014","article-title":"Interphase microtubules in nuclear organization and genome maintenance","volume":"31","author":"M Shokrollahi","year":"2021","journal-title":"Trends Cell Biol"},{"issue":"11","key":"pgen.1011586.ref075","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/s41563-023-01657-3","article-title":"The laminin-keratin link shields the nucleus from mechanical deformation and signalling","volume":"22","author":"Z Kechagia","year":"2023","journal-title":"Nat Mater"},{"issue":"2","key":"pgen.1011586.ref076","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.devcel.2019.09.010","article-title":"Active fluctuations of the nuclear envelope shape the transcriptional dynamics in oocytes","volume":"51","author":"M Almonacid","year":"2019","journal-title":"Dev Cell"},{"issue":"23","key":"pgen.1011586.ref077","doi-asserted-by":"crossref","first-page":"e103957","DOI":"10.15252\/embj.2019103957","article-title":"Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation","volume":"39","author":"S Biedzinski","year":"2020","journal-title":"EMBO J"},{"issue":"20","key":"pgen.1011586.ref078","doi-asserted-by":"crossref","first-page":"13988","DOI":"10.1074\/jbc.M112.444737","article-title":"Molecular mediators for raft-dependent endocytosis of syndecan-1, a highly conserved, multifunctional receptor","volume":"288","author":"K Chen","year":"2013","journal-title":"J Biol Chem"},{"issue":"1\u20133","key":"pgen.1011586.ref079","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0014-5793(03)00712-9","article-title":"Identification of a novel Ezrin-binding site in syndecan-2 cytoplasmic domain","volume":"547","author":"F Gran\u00e9s","year":"2003","journal-title":"FEBS Lett"},{"key":"pgen.1011586.ref080","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fimmu.2020.00227","article-title":"Syndecans in Inflammation at a Glance","volume":"11","author":"S Gopal","year":"2020","journal-title":"Front Immunol"},{"key":"pgen.1011586.ref081","doi-asserted-by":"crossref","first-page":"100312","DOI":"10.1016\/j.ctarc.2021.100312","article-title":"Syndecans in cancer: a review of function, expression, prognostic value, and therapeutic significance","volume":"27","author":"D Czarnowski","year":"2021","journal-title":"Cancer Treat Res Commun"},{"key":"pgen.1011586.ref082","first-page":"1","article-title":"Using FlyBase: a database of Drosophila genes and genetics","author":"FlyBase Consortium","year":"2022","journal-title":"Methods Mol Biol"},{"issue":"21","key":"pgen.1011586.ref083","doi-asserted-by":"crossref","first-page":"e101346","DOI":"10.15252\/embj.2018101346","article-title":"Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila","volume":"38","author":"T Reiff","year":"2019","journal-title":"EMBO J"},{"issue":"10","key":"pgen.1011586.ref084","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1261\/rna.061184.117","article-title":"Enzymatic production of single-molecule FISH and RNA capture probes","volume":"23","author":"I Gaspar","year":"2017","journal-title":"RNA"},{"issue":"7","key":"pgen.1011586.ref085","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"pgen.1011586.ref086","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/ncomms2763","article-title":"Dual role of myosin II during Drosophila imaginal disc metamorphosis","volume":"4","author":"S Aldaz","year":"2013","journal-title":"Nat Commun"},{"issue":"3","key":"pgen.1011586.ref087","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/cells11030347","article-title":"Current methods and pipelines for image-based quantitation of nuclear shape and nuclear envelope abnormalities","volume":"11","author":"AFJ Janssen","year":"2022","journal-title":"Cells"},{"issue":"2","key":"pgen.1011586.ref088","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.stem.2015.11.004","article-title":"Regulation of ribosome biogenesis and protein synthesis controls germline stem cell differentiation","volume":"18","author":"CG Sanchez","year":"2016","journal-title":"Cell Stem Cell"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1011586","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1011586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:53:01Z","timestamp":1739386381000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1011586"}},"subtitle":[],"editor":[{"given":"Pablo","family":"Wappner","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":88,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1011586","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}