{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:46:32Z","timestamp":1777873592785,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pgen.1012124","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000}}],"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program-Creation and Application of New Disease-Resistant Wheat Germplasm in the Southwest Wheat-growing Area","award":["2024YFD1201202"],"award-info":[{"award-number":["2024YFD1201202"]}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["SCCXTD-2024-11"],"award-info":[{"award-number":["SCCXTD-2024-11"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    Balancing growth and stress adaptation is essential for optimizing crop productivity, yet the transcriptional mechanisms underlying this trade-off in wheat remain poorly understood. Here, we identify the WRKY transcription factor\n                    <jats:italic>TaWRKY58<\/jats:italic>\n                    as a key repressor coordinating plant architecture and drought response. Loss-of-function mutants of\n                    <jats:italic>TaWRKY58<\/jats:italic>\n                    exhibit increased plant height and early flowering, accompanied by elevated gibberellin levels, while overexpression restores wild-type phenotypes. Under drought stress,\n                    <jats:italic>TaWRKY58<\/jats:italic>\n                    represses soluble sugar accumulation, and its mutants show enhanced drought tolerance. Using DAP-seq, we identified genome-wide binding sites of TaWRKY58 and uncovered a W-box-like motif enriched in its target promoters. Electrophoretic mobility shift and dual-luciferase assays confirmed that TaWRKY58 directly binds to and represses two key targets:\n                    <jats:italic>TaLRR<\/jats:italic>\n                    , encoding a leucine-rich repeat protein, and\n                    <jats:italic>TaBCS1<\/jats:italic>\n                    , encoding a mitochondrial AAA\n                    <jats:sup>\u207a<\/jats:sup>\n                    ATPase. Mutants of\n                    <jats:italic>TaLRR<\/jats:italic>\n                    and\n                    <jats:italic>TaBCS1<\/jats:italic>\n                    display dwarfism and drought hypersensitivity, respectively, mirroring aspects of the\n                    <jats:italic>TaWRKY58<\/jats:italic>\n                    overexpression phenotype. Our data support a model in which\n                    <jats:italic>TaWRKY58<\/jats:italic>\n                    functions as a transcriptional repressor in a coherent regulatory module that fine-tunes growth and stress adaptation by modulating signaling and energy metabolism. This mechanism offers a potential strategy for breeding wheat with optimized yield stability under fluctuating environments.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012124","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:54:33Z","timestamp":1777053273000},"page":"e1012124","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The transcription factor TaWRKY58 coordinates growth and drought sensitivity in wheat by repressing TaLRR and TaBCS1"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7372-6596","authenticated-orcid":true,"given":"Yazhou","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anyu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xufei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyue","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiantao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1077-1362","authenticated-orcid":true,"given":"Yuming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"3","key":"pgen.1012124.ref001","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/jipb.13828","article-title":"WRKY 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