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Histone acetylation is generally associated with active gene transcription. Genetic deletion of both alleles of the\n                    <jats:italic>Kat6a<\/jats:italic>\n                    gene in mice causes developmental defects including anterior homeotic transformation, cleft palate, interrupted aortic arch and cardiac septal defects. Loss of KAT6A impairs expression of HOX, DLX and TBX genes, which are essential for body segment identity specification, palate, heart and aortic arch development. However, the effects of loss of KAT6A on chromatin modifications and gene expression in neural cells, which are relevant to normal brain development and function, is still poorly understood. In this study, we used an automated high-throughput chromatin profiling method and RNA sequencing in mouse neural system and progenitor cells to assess the effects of loss of one or two alleles of\n                    <jats:italic>Kat6a<\/jats:italic>\n                    on gene expression, histone acetylation and methylation. We also assessed occupancy by a trithorax group protein and RNA polymerase II. Our data suggests two modes of action for KAT6A: (1) acetylation of histone H3 on lysine 23 at promoters and enhancers and (2) recruitment of the trithorax group protein MLL1 (KMT2A) to promote the expression of developmental genes, including SOX and homeodomain genes. Together, these two functions appear to be required for normal gene expression in neural progenitors and essential for proliferation and neuronal differentiation.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012133","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:43:15Z","timestamp":1777916595000},"page":"e1012133","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["KAT6A is essential for developmental control gene expression in neural stem and progenitor cells"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3853-9381","authenticated-orcid":true,"given":"Anne 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Miyamoto","year":"2020","journal-title":"Cell Rep"},{"issue":"7568","key":"pgen.1012133.ref078","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nature15251","article-title":"Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth","volume":"525","author":"J Zhu","year":"2015","journal-title":"Nature"},{"issue":"12","key":"pgen.1012133.ref079","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1073\/pnas.0407523102","article-title":"The RNA-binding protein HuD regulates neuronal cell identity and maturation","volume":"102","author":"W Akamatsu","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"pgen.1012133.ref080","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1101\/gad.475408","article-title":"The T-box transcription factor Eomes\/Tbr2 regulates neurogenesis in the cortical subventricular zone","volume":"22","author":"SJ Arnold","year":"2008","journal-title":"Genes 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