{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:25:02Z","timestamp":1787250302459,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.pgen.1012239","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000}}],"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","award":["RPG-2022-181"],"award-info":[{"award-number":["RPG-2022-181"]}],"id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"crossref","award":["BB X014584\/1"],"award-info":[{"award-number":["BB X014584\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"crossref","award":["BB\/T008768\/1"],"award-info":[{"award-number":["BB\/T008768\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    The SKN-1\/Nrf transcription factor family is integral to metabolic homeostasis. There are three SKN-1 isoforms in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    , each with different functions. One of these, SKN-1B, is expressed specifically in neurons and controls hermaphrodite behaviour in response to food. In a laboratory environment\n                    <jats:italic>C. elegans<\/jats:italic>\n                    hermaphrodites must allocate energy efficiently between exploratory food-seeking behaviour, reproduction, and survival, whereas males have to balance both food-seeking with mate-seeking exploratory behaviours. Here, we evaluate the role of SKN-1B in male behaviour and show that SKN-1B acts in a sexually dimorphic manner to control exploratory behaviour, mitochondrial morphology, and mitochondrial function. Moreover, we show that SKN-1B is expressed in a sexually dimorphic pattern, and that SKN-1B influences gene expression on a much broader scale in males compared to hermaphrodites. This analysis identified a neuronal signalling pathway, specifically in males between SKN-1B, the TGF-\u03b2 ligand DAF-7 and the chemosensory regulator ODR-10, and that this pathway contributes to increased exploratory behaviour in\n                    <jats:italic>skn-1b<\/jats:italic>\n                    mutant males. Taken together our findings identify SKN-1B as a sex-specific neuronal switch to control food searching and mating behaviours. Sexual dimorphism is essential for optimizing survival and reproductive success and our findings establish SKN-1B as a regulator of sex-specific behavioural and metabolic traits. This work provides new insights into neuronal regulation of metabolism and behaviour, with implications for sex-specific physiological adaptations in other species.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012239","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T17:42:43Z","timestamp":1786642963000},"page":"e1012239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuronal Nrf\/SKN-1B controls a sexually dimorphic neuroendocrine pathway for C. elegans exploratory behaviour"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3100-8060","authenticated-orcid":true,"given":"Noviann","family":"McLean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minaxi S.","family":"Gami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5712-4059","authenticated-orcid":true,"given":"Nathan","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"De Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9832-2575","authenticated-orcid":true,"given":"James","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Ezcurra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-526X","authenticated-orcid":true,"given":"Jennifer M. A.","family":"Tullet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"8","key":"pgen.1012239.ref001","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/gtc.12165","article-title":"Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice","volume":"19","author":"Y Hirotsu","year":"2014","journal-title":"Genes Cells"},{"key":"pgen.1012239.ref002","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.freeradbiomed.2015.06.008","article-title":"SKN-1\/Nrf, stress responses, and aging in Caenorhabditis elegans","volume":"88","author":"TK Blackwell","year":"2015","journal-title":"Free Radic Biol Med"},{"issue":"7144","key":"pgen.1012239.ref003","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature05904","article-title":"Two neurons mediate diet-restriction-induced longevity in C. elegans","volume":"447","author":"NA Bishop","year":"2007","journal-title":"Nature"},{"issue":"3","key":"pgen.1012239.ref004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009358","article-title":"Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety","volume":"17","author":"N Tataridas-Pallas","year":"2021","journal-title":"PLoS Genet"},{"issue":"4","key":"pgen.1012239.ref005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/wdev.136","article-title":"The development of sexual dimorphism: studies of the Caenorhabditis elegans male","volume":"3","author":"SW Emmons","year":"2014","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"pgen.1012239.ref006","article-title":"Male mating behavior","author":"MM Barr","year":"2006","journal-title":"WormBook: the online review of C elegans biology"},{"key":"pgen.1012239.ref007","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/01677063.2020.1789978","article-title":"What about the males? the C. elegans sexually dimorphic nervous system and a CRISPR-based tool to study males in a hermaphroditic species","volume":"34","author":"JD Walsh","year":"2020","journal-title":"J Neurogenet"},{"issue":"8","key":"pgen.1012239.ref008","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.tem.2016.05.004","article-title":"Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans","volume":"27","author":"GA Lemieux","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"pgen.1012239.ref009","doi-asserted-by":"crossref","unstructured":"Davis K, Cheong MC, Park JS, You YJ. Appetite control in C. elegans. Appetite and food intake. 2017. https:\/\/doi.org\/10.1201\/9781315120171-1","DOI":"10.1201\/9781315120171-1"},{"issue":"9","key":"pgen.1012239.ref010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044748","article-title":"Sex differences in carbohydrate metabolism are linked to gene expression in Caenorhabditis elegans","volume":"7","author":"C Miersch","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"pgen.1012239.ref011","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41467-023-36040-y","article-title":"Sex-specificity of the C. elegans metabolome","volume":"14","author":"RN Burkhardt","year":"2023","journal-title":"Nat Commun"},{"key":"pgen.1012239.ref012","first-page":"27","article-title":"Male-specific behavioral and transcriptomic changes in aging C. elegans neurons","author":"Y Weng","year":"2024","journal-title":"iScience"},{"issue":"3","key":"pgen.1012239.ref013","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2008.01.005","article-title":"Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety","volume":"7","author":"Y You","year":"2008","journal-title":"Cell Metab"},{"key":"pgen.1012239.ref014","article-title":"C. elegans males integrate food signals and biological sex to modulate state-dependent chemosensation and behavioral prioritization","author":"LR Wexler","year":"2020","journal-title":"Current Biology"},{"issue":"5","key":"pgen.1012239.ref015","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.cell.2013.08.001","article-title":"Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans","volume":"154","author":"SW Flavell","year":"2013","journal-title":"Cell"},{"issue":"11","key":"pgen.1012239.ref016","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.exger.2013.07.014","article-title":"Dramatic fertility decline in aging C. elegans males is associated with mating execution deficits rather than diminished sperm quality","volume":"48","author":"I Chatterjee","year":"2013","journal-title":"Exp Gerontol"},{"issue":"3","key":"pgen.1012239.ref017","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1534\/genetics.111.137455","article-title":"Cell excitability necessary for male mating behavior in Caenorhabditis elegans is coordinated by interactions between big current and ether-a-go-go family K(+) channels","volume":"190","author":"B LeBoeuf","year":"2012","journal-title":"Genetics"},{"key":"pgen.1012239.ref018","article-title":"Mitochondrial dynamics: coupling mitochondrial fitness with healthy aging","author":"D Sebasti\u00e1n","year":"2017","journal-title":"Trends in Molecular Medicine"},{"key":"pgen.1012239.ref019","doi-asserted-by":"crossref","unstructured":"Dennis N, Gourlay C, Ezcurra M. A novel C. elegans respirometry assay using low-cost optical oxygen sensors. 2025. https:\/\/doi.org\/10.1101\/2025.05.16.654527","DOI":"10.1101\/2025.05.16.654527"},{"key":"pgen.1012239.ref020","article-title":"The bioenergetic health index: a new concept in mitochondrial translational research","author":"BK Chacko","year":"2014","journal-title":"Clinical Science (London, England: 1979)"},{"issue":"4","key":"pgen.1012239.ref021","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"M Liesa","year":"2013","journal-title":"Cell Metab"},{"issue":"1","key":"pgen.1012239.ref022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085436","article-title":"Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort","volume":"9","author":"S Rose","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"pgen.1012239.ref023","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/s41467-024-48369-z","article-title":"Sex-specific developmental gene expression atlas unveils dimorphic gene networks in C. elegans","volume":"15","author":"R Haque","year":"2024","journal-title":"Nat Commun"},{"key":"pgen.1012239.ref024","first-page":"17","article-title":"Gene Function Prediction Based on Developmental Transcriptomes of the Two Sexes in C. elegans","author":"B Kim","year":"2016","journal-title":"Cell Rep"},{"key":"pgen.1012239.ref025","first-page":"184","article-title":"NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans","author":"E Yemini","year":"2021","journal-title":"Cell"},{"issue":"6","key":"pgen.1012239.ref026","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(01)00600-6","article-title":"Regulation of distinct muscle behaviors controls the C. elegans male\u2019s copulatory spicules during mating","volume":"107","author":"LR Garcia","year":"2001","journal-title":"Cell"},{"key":"pgen.1012239.ref027","first-page":"25","article-title":"Stearoyl-CoA desaturases sustain cholinergic excitation and copulatory robustness in metabolically aging C. elegansmales","author":"J Goncalves","year":"2022","journal-title":"iScience"},{"key":"pgen.1012239.ref028","doi-asserted-by":"crossref","DOI":"10.1016\/0377-0427(87)90125-7","article-title":"Silhouettes: A graphical aid to the interpretation and validation of cluster analysis","volume":"20","author":"PJ Rousseeuw","year":"1987","journal-title":"J Comput Appl Math"},{"issue":"1","key":"pgen.1012239.ref029","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12859-016-1229-9","article-title":"Tissue enrichment analysis for C. elegans genomics","volume":"17","author":"D Angeles-Albores","year":"2016","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"pgen.1012239.ref030","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1474-9726.2009.00501.x","article-title":"Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1\/Nrf","volume":"8","author":"RP Oliveira","year":"2009","journal-title":"Aging Cell"},{"issue":"52","key":"pgen.1012239.ref031","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2308565120","article-title":"A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons","volume":"120","author":"CD Turner","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pgen.1012239.ref032","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gr.114587.110","article-title":"Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans","volume":"21","author":"W Niu","year":"2011","journal-title":"Genome Res"},{"key":"pgen.1012239.ref033","unstructured":"Emmons SW, Sternberg PW. Male development and mating behavior. Cold Spring Harbor Monograph Archive. 1997."},{"issue":"6751","key":"pgen.1012239.ref034","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/43913","article-title":"A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans","volume":"401","author":"MM Barr","year":"1999","journal-title":"Nature"},{"issue":"23","key":"pgen.1012239.ref035","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.cub.2008.10.050","article-title":"Sensory regulation of C. elegans male mate-searching behavior","volume":"18","author":"A Barrios","year":"2008","journal-title":"Curr Biol"},{"key":"pgen.1012239.ref036","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/jnr.23912","article-title":"Sexual modulation of sex-shared neurons and circuits in Caenorhabditis elegans","volume":"95","author":"DS Portman","year":"2017","journal-title":"J Neurosci Res"},{"issue":"7","key":"pgen.1012239.ref037","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1101\/gad.1066503","article-title":"daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway","volume":"17","author":"W Li","year":"2003","journal-title":"Genes Dev"},{"issue":"5291","key":"pgen.1012239.ref038","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.274.5291.1389","article-title":"Control of C. elegans Larval Development by Neuronal Expression of a TGF-\u03b2 Homolog","volume":"274","author":"P Ren","year":"1996","journal-title":"Science"},{"issue":"6","key":"pgen.1012239.ref039","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0092-8674(00)81068-5","article-title":"odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl","volume":"84","author":"P Sengupta","year":"1996","journal-title":"Cell"},{"key":"pgen.1012239.ref040","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21166","article-title":"Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans","volume":"6","author":"ZA Hilbert","year":"2017","journal-title":"Elife"},{"issue":"34","key":"pgen.1012239.ref041","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.1523\/JNEUROSCI.1746-04.2004","article-title":"Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate","volume":"24","author":"J Lipton","year":"2004","journal-title":"J Neurosci"},{"issue":"21","key":"pgen.1012239.ref042","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.cub.2014.09.032","article-title":"Sex, age, and hunger regulate behavioral prioritization through dynamic modulation of chemoreceptor expression","volume":"24","author":"DA Ryan","year":"2014","journal-title":"Curr Biol"},{"issue":"6363","key":"pgen.1012239.ref043","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/355838a0","article-title":"Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons","volume":"355","author":"JG White","year":"1992","journal-title":"Nature"},{"issue":"10","key":"pgen.1012239.ref044","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s00018-019-03024-5","article-title":"Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans","volume":"76","author":"JJ Byrne","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"24","key":"pgen.1012239.ref045","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1016\/j.cub.2015.10.057","article-title":"Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis","volume":"25","author":"J Wang","year":"2015","journal-title":"Curr Biol"},{"key":"pgen.1012239.ref046","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/bse0470053","article-title":"Mitochondrial proton and electron leaks","volume":"47","author":"M Jastroch","year":"2010","journal-title":"Essays Biochem"},{"key":"pgen.1012239.ref047","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44425","article-title":"Endoplasmic reticulum-associated SKN-1A\/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity","volume":"8","author":"NJ Lehrbach","year":"2019","journal-title":"Elife"},{"key":"pgen.1012239.ref048","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.semcdb.2014.06.001","article-title":"Mating behavior, male sensory cilia, and polycystins in Caenorhabditis elegans","volume":"33","author":"R O\u2019Hagan","year":"2014","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"pgen.1012239.ref049","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"issue":"18","key":"pgen.1012239.ref050","doi-asserted-by":"crossref","DOI":"10.1242\/dev.199687","article-title":"Visualizing the organization and differentiation of the male-specific nervous system of C. elegans","volume":"148","author":"T Tekieli","year":"2021","journal-title":"Development"},{"issue":"7","key":"pgen.1012239.ref051","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.celrep.2015.04.024","article-title":"RNAi Interrogation of Dietary Modulation of Development, Metabolism, Behavior, and Aging in C. elegans","volume":"11","author":"R Xiao","year":"2015","journal-title":"Cell Rep"},{"issue":"15","key":"pgen.1012239.ref052","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"AM Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"8","key":"pgen.1012239.ref053","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"D Kim","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"7","key":"pgen.1012239.ref054","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Y Liao","year":"2014","journal-title":"Bioinformatics"},{"issue":"12","key":"pgen.1012239.ref055","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"key":"pgen.1012239.ref056","first-page":"22","article-title":"Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death","author":"ER Galimov","year":"2018","journal-title":"Cell Rep"},{"issue":"7","key":"pgen.1012239.ref057","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202402735","article-title":"Timing of TORC1 inhibition dictates Pol III involvement in Caenorhabditis elegans longevity","volume":"7","author":"Y Malik","year":"2024","journal-title":"Life Sci Alliance"},{"issue":"6909","key":"pgen.1012239.ref058","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature01135","article-title":"Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans","volume":"419","author":"LA Herndon","year":"2002","journal-title":"Nature"},{"issue":"4","key":"pgen.1012239.ref059","article-title":"Disruption of genes associated with Charcot-Marie-Tooth type 2 lead to common behavioural, cellular and molecular defects in Caenorhabditis elegans","volume":"15","author":"MS Soh","year":"2020","journal-title":"PLoS One"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1012239","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1012239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:43:09Z","timestamp":1787247789000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1012239"}},"subtitle":[],"editor":[{"given":"Benjamin","family":"Podbilewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1012239","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}