{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:06:13Z","timestamp":1784837173528,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pgen.1012242","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000}}],"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32330016"],"award-info":[{"award-number":["32330016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFC3400200"],"award-info":[{"award-number":["2022YFC3400200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    Zinc finger proteins (ZFPs or ZNFs) constitute the largest family of transcription factors in mammals; however, their regulatory mechanism remains largely elusive. Here we propose COP (C2H2-ZFP occupancy predictor), a deep learning-based heuristic screening tool that integrates DNA sequence with protein primary and secondary features to assess ZFP genomic enrichments. Applying COP to the mouse clustered protocadherin (\n                    <jats:italic>cPcdh<\/jats:italic>\n                    ) gene locus, we identified dozens of C2H2-ZFPs potentially involved in CTCF-mediated gene regulation with Wiz (widely interspaced zinc finger-containing protein) having the highest number of 12 ZFs. We confirmed Wiz enrichments at all of the CTCF-binding site (CBS) elements across the three\n                    <jats:italic>Pcdh<\/jats:italic>\n                    clusters by Myc-tagging the endogenous\n                    <jats:italic>Wiz<\/jats:italic>\n                    gene. Genetic experiments revealed significant increases of expression levels of the\n                    <jats:italic>cPcdh<\/jats:italic>\n                    genes upon\n                    <jats:italic>Wiz<\/jats:italic>\n                    deletion in both neuronal cells\n                    <jats:italic>in vitro<\/jats:italic>\n                    and in mouse brain\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Finally, integrated ChIP-seq, RNA-seq, and 4C-seq analyses demonstrated that Wiz regulates CTCF\/cohesin occupancy and long-range enhancer-promoter contacts in a genomic-distance biased manner. Together, these findings reveal a key role for\n                    <jats:italic>Wiz<\/jats:italic>\n                    in coupling cohesin occupancy to long-range\n                    <jats:italic>cPcdh<\/jats:italic>\n                    regulation and highlight important functions of C2H2-ZFPs in enhancer-promoter interactions.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012242","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:45:39Z","timestamp":1784223939000},"page":"e1012242","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wiz regulates clustered protocadherin genes by restricting CTCF\/cohesin loop extrusion in a genomic-distance biased manner"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8131-3173","authenticated-orcid":true,"given":"Tianjie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-8570","authenticated-orcid":true,"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7634-4829","authenticated-orcid":true,"given":"Leyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8326-4533","authenticated-orcid":true,"given":"Haiyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-3591","authenticated-orcid":true,"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"6","key":"pgen.1012242.ref001","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(00)80789-8","article-title":"A 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