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However, the diversity of both pro- and anti-plasticity mechanisms remains incompletely understood. Here, we identify the THAP domain gene\n                    <jats:italic>lin-15A<\/jats:italic>\n                    as a novel factor involved in the natural rectal-to-neuronal Y-to-PDA transdifferentiation in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    . Our genetic analyses show that\n                    <jats:italic>lin-15A<\/jats:italic>\n                    acts in parallel to previously described plasticity factors. Null mutant suggests that, rather than driving the process, LIN-15A licenses its initiation by antagonizing several chromatin-modifying complexes known to safeguard differentiated cell identities. In addition, our data show that even cells developmentally programmed to undergo transdifferentiation exhibit reprogramming barriers. Interestingly,\n                    <jats:italic>lin-15A<\/jats:italic>\n                    is not a core plasticity factor per se but acts as one specifically in the Y cell context. Together, our findings support a model in which diverse molecular activities coordinate controlled cell identity conversions: plasticity factors function as Drivers, while others like\n                    <jats:italic>lin-15A<\/jats:italic>\n                    , termed here transdifferentiation Licensers, attenuate identity safeguarding mechanisms, thereby facilitating transdifferentiation.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012290","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:58:46Z","timestamp":1790359126000},"page":"e1012290","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The SynMuvA lin-15A licenses natural transdifferentiation by antagonizing identity safeguarding mechanisms"],"prefix":"10.1371","volume":"22","author":[{"given":"Sarah Frieda","family":"Becker","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U1298, Universit\u00e9 de Strasbourg","place":["Illkirch, France"],"department":["Department of Development and Stem Cells"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Charlotte","family":"Morin","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U1298, Universit\u00e9 de Strasbourg","place":["Illkirch, France"],"department":["Department of Development and Stem Cells"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lambert","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U1298, Universit\u00e9 de Strasbourg","place":["Illkirch, France"],"department":["Department of Development and Stem Cells"]},{"name":"Current 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