{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:22:35Z","timestamp":1791400955740,"version":"4.3.3"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Key Research and Development Program of the Ministry of Science and Technology","award":["2024YFD1200904"],"award-info":[{"award-number":["2024YFD1200904"]}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    Rice (\n                    <jats:italic>Oryza sativa<\/jats:italic>\n                    L.) is a major staple food crop worldwide. Drought stress induced by extreme weather severely limits its growth and yield. Proteins containing domains of unknown function (DUF) play important roles in plant stress responses, but their regulatory mechanisms remain largely unclear. In this study, we demonstrate that the plasma membrane-localized protein\n                    <jats:italic>OsDUF1223<\/jats:italic>\n                    functions as a negative regulator of drought tolerance in rice seedlings. Under drought stress,\n                    <jats:italic>OsDUF1223<\/jats:italic>\n                    -overexpressing lines exhibited lower survival rates, higher water loss rates, and reduced antioxidant enzyme activities and osmolyte accumulation. Transcriptomic and physiological analyses revealed that\n                    <jats:italic>OsDUF1223<\/jats:italic>\n                    modulates drought responses through ABA signaling and nitrogen response pathways. Collectively, this study elucidates that\n                    <jats:italic>OsDUF1223<\/jats:italic>\n                    regulates drought tolerance at the seedling stage in rice through functional association with the ABA and nitrogen signaling pathways, thereby providing a candidate gene resource for the genetic improvement of drought tolerance in rice.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012295","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:39:25Z","timestamp":1788457165000},"page":"e1012295","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["OsDUF1223 negatively regulates seedling drought tolerance and modulates nitrate-dependent root growth in rice"],"prefix":"10.1371","volume":"22","author":[{"given":"Xiulin","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiang","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]},{"name":"Nanchong Academy of Agricultural Sciences","place":["Nanchong, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-7892","authenticated-orcid":true,"given":"Lihua","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University","place":["Chengdu, China"]},{"name":"Crop Ecophysiology and Cultivation Key Laboratory of Sichuan Province","place":["Chengdu, 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