{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:02:46Z","timestamp":1790100166015,"version":"4.0.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20710"],"award-info":[{"award-number":["U24A20710"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025T180490"],"award-info":[{"award-number":["2025T180490"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    Rapid hair follicle cycling requires precise fate commitment and differentiation of hair follicle stem cells. While the essential role of transcription factors in establishing cell identity is well recognized, how cells control its protein synthesis to achieve tissue specificity remains unknown. RNA modifications constitute a pivotal layer of post-transcriptional regulation for protein synthesis. Among them, the\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>7<\/jats:sup>\n                    -methylguanosine (m\n                    <jats:sup>7<\/jats:sup>\n                    G) modification has recently emerged as a critical regulator with diverse functional impacts. Here, we reveal a pivotal role of METTL1, the key enzyme for RNA m\n                    <jats:sup>7<\/jats:sup>\n                    G modification, in hair follicle cycle. Conditional knockout of\n                    <jats:italic>Mettl1<\/jats:italic>\n                    in keratinocytes leads to severe hair follicle developmental dysplasia, impaired regeneration, and disrupted keratinocyte adhesion. Complementarily, keratinocyte-specific knock-in of\n                    <jats:italic>Mettl1<\/jats:italic>\n                    accelerates hair regeneration. Mechanistically, beyond its effects on tRNAs, METTL1 deficiency destabilizes\n                    <jats:italic>HOXC13<\/jats:italic>\n                    mRNA through internal m\n                    <jats:sup>7<\/jats:sup>\n                    G modification, which in turn downregulates the HOXC13\/FOXN1\/DSG4 signaling axis. Our findings establish METTL1-mediated internal mRNA m\n                    <jats:sup>7<\/jats:sup>\n                    G methylation as one of the essential regulatory layers of RNA modification in hair follicle morphogenesis and cycling, operating through the precise post-transcriptional control of a key transcriptional circuit to ensure structural integrity and timely regeneration.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012307","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:24:26Z","timestamp":1790097866000},"page":"e1012307","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["METTL1-mediated m7G modification regulates hair follicle cycle via the HOXC13\/FOXN1\/DSG4 axis"],"prefix":"10.1371","volume":"22","author":[{"given":"Xinyan","family":"Gan","sequence":"first","affiliation":[{"name":"Sichuan University","place":["Chengdu, Sichuan, China"],"department":["State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["Chengdu, Sichuan, China"],"department":["State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology"]},{"name":"West China Hospital of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"],"department":["Department of Oral Implantology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuchan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital","place":["Chengdu, Sichuan, China"],"department":["West China School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghao","family":"Huang","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["Chengdu, Sichuan, China"],"department":["State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["Chengdu, Sichuan, China"],"department":["State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yin","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["Chengdu, Sichuan, China"],"department":["State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["Chengdu, Sichuan, China"],"department":["State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology"]},{"name":"West China Hospital of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"],"department":["Department of Oral Implantology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-0431","authenticated-orcid":true,"given":"Takuma","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Kyushu Dental University","place":["Kitakyushu, Fukuoka, Japan"],"department":["Division of Molecular Signaling and Biochemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-4327","authenticated-orcid":true,"given":"Shoichiro","family":"Kokabu","sequence":"additional","affiliation":[{"name":"Kyushu Dental University","place":["Kitakyushu, Fukuoka, Japan"],"department":["Division of Molecular Signaling and Biochemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-6066","authenticated-orcid":true,"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"],"department":["Department of Dermatology and Venereology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-1081","authenticated-orcid":true,"given":"Quan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Sichuan University","place":["Chengdu, Sichuan, China"],"department":["State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology"]},{"name":"West China Hospital of Stomatology, Sichuan University","place":["Chengdu, Sichuan, China"],"department":["Department of Oral Implantology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"1","key":"pgen.1012307.ref001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/1547691X.2022.2067916","article-title":"Expression and clinical significance of the m6A reader YTHDF2 in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"19","author":"F Yao","year":"2022","journal-title":"J Immunotoxicol"},{"key":"pgen.1012307.ref002","article-title":"CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA","author":"Y 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