{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:12:19Z","timestamp":1789755139287,"version":"4.0.1"},"reference-count":115,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01-CA284362"],"award-info":[{"award-number":["R01-CA284362"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1ZIAHL006126"],"award-info":[{"award-number":["1ZIAHL006126"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    Model organisms may help understand how p53 suppresses tumorigenesis in mammals. In\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , the primary transcriptional target of p53 is the gene encoding the bZip AT-hook protein Xrp1, which is another transcription factor. We report that Xrp1 mediates multiple functions of p53 in the DNA damage response (DDR), contributing to p53-dependent gene transcription and DNA damage-induced apoptosis. In addition to this role as a p53 effector, a p53-independent role for Xrp1 in cell competition has been described. Cell competition can remove cells whose genome has been altered by DNA damage and repair. During cell competition, Xrp1 is induced by RpS12, which acts as a sensor of defective ribosome biogenesis. In irradiated discs, p53-independent RpS12-dependent Xrp1 function began as the DDR came to an end, and was even more prominent if p53 function was reduced. Such p53 inhibition resulted in persistence of DNA damage after irradiation, revealed by \u03b3H2Av accumulation. Thus, Xrp1 limited the accumulation of abnormal cells resulting from genotoxicity through both the acute, p53-dependent DDR, and also a later mechanism consistent with cell competition removing cells where DNA repair did not restore the normal genome. Both these processes might contribute to the tumor suppressor function of p53 in mammals.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012309","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:46:23Z","timestamp":1789753583000},"page":"e1012309","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition"],"prefix":"10.1371","volume":"22","author":[{"given":"Chaitali","family":"Khan","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine","place":["Bronx, New York, United States of America"],"department":["Department of Genetics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser M.","family":"Rusan","sequence":"additional","affiliation":[{"name":"National Institutes of Health","place":["Bethesda, Maryland, United States of America"],"department":["Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-3488","authenticated-orcid":true,"given":"Nicholas E.","family":"Baker","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine","place":["Bronx, New York, United States of America"],"department":["Department of Genetics"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"36","key":"pgen.1012309.ref001","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1038\/sj.onc.1210328","article-title":"p53 directs focused genomic responses in Drosophila","volume":"26","author":"F 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