{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:54Z","timestamp":1792788654790,"version":"4.5.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270868"],"award-info":[{"award-number":["32270868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2022YFA0806202"],"award-info":[{"award-number":["2022YFA0806202"]}]},{"name":"Fund of Fudan University and Cao\u2019ejiang Basic Research","id":[{"id":"https:\/\/ror.org\/013q1eq08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A), one of the most abundant chemical modifications on RNA, is installed by METTL3 and several other methyltransferases, including METTL16. Although METTL16 has been characterized in several model organisms, its function in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    remains unknown. Here, we show that, unlike in mammals,\n                    <jats:italic>Drosophila Mettl16<\/jats:italic>\n                    mutants are viable but exhibit multiple developmental and behavioral defects. Both male and female mutants are sterile, with severe gametogenesis defects.\n                    <jats:italic>Mettl16<\/jats:italic>\n                    mutant germ cells can pass the mitotic and meiotic stages, but are defective in spermatid elongation and individualization. Mettl16-GFP localizes predominantly to the nucleus, and its absence does not impair global protein synthesis in wing disc epithelial cells. MeRIP-Seq analysis indicates that Mettl16 loss affects m\n                    <jats:sup>6<\/jats:sup>\n                    A on only a small subset of transcripts, in contrast to the broad effect of Mettl3. We further demonstrate that Mettl16 interacts with U6 snRNA and is required for its m\n                    <jats:sup>6<\/jats:sup>\n                    A modification. Accordingly,\n                    <jats:italic>Mettl16<\/jats:italic>\n                    mutants display widespread alterations in alternative splicing. Together, the pleiotropic phenotypes of\n                    <jats:italic>Mettl16<\/jats:italic>\n                    mutants likely stem from its role in m\n                    <jats:sup>6<\/jats:sup>\n                    A deposition and U6-dependent splicing regulation of specific target transcripts.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012317","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:48:41Z","timestamp":1790272121000},"page":"e1012317","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of the m6A methyltransferase Mettl16 in Drosophila development"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7584-3030","authenticated-orcid":true,"given":"Penghui","family":"Song","sequence":"first","affiliation":[{"name":"Fudan University","place":["Shanghai, China"],"department":["State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Ma","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-5708","authenticated-orcid":true,"given":"Dong","family":"Yan","sequence":"additional","affiliation":[{"name":"Fudan University","place":["Shanghai, China"],"department":["State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"pgen.1012317.ref001","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkad1083","article-title":"MODOMICS: A 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