{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:52:11Z","timestamp":1791571931371,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.pgen.1012327","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000}}],"reference-count":97,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM152134"],"award-info":[{"award-number":["R35GM152134"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"abstract":"<jats:p>\n                    In animals, plants, and some fungi, Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally repressed chromatin. Here, we identify the histone acetyltransferase RTT109 as a key regulator of PRC2-repressed domains in the model fungus\n                    <jats:italic>Neurospora crassa<\/jats:italic>\n                    . Although RTT109 interacts with the Vps75 homolog Nucleosome Assembly Factor 2 (NAF-2), we show that proper structure and function of PRC2-methylated chromatin require RTT109 catalytic activity but are independent of NAF-2 and H3K56 acetylation. We further demonstrate that H3K27me3 can be stably propagated over multiple rounds of mitosis in the absence of sequence-specific PRC2 targeting, and that RTT109 is essential for maintenance of the repressed state. These findings uncover a replication-linked mechanism for epigenetic memory and establish RTT109 as a key regulator of Polycomb-mediated chromatin inheritance.\n                  <\/jats:p>","DOI":"10.1371\/journal.pgen.1012327","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:46:57Z","timestamp":1791222417000},"page":"e1012327","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic maintenance of PRC2-repressed chromatin requires RTT109 but not H3K56 acetylation"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-280X","authenticated-orcid":true,"given":"Rochelle E.","family":"Yap","sequence":"first","affiliation":[{"name":"University of Georgia","place":["Athens, Georgia, United States of America"],"department":["Department of Microbiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-3487","authenticated-orcid":true,"given":"Felicia","family":"Ebot-Ojong","sequence":"additional","affiliation":[{"name":"University of Georgia","place":["Athens, Georgia, United States of America"],"department":["Department of Genetics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail J.","family":"Ameri-Solanky","sequence":"additional","affiliation":[{"name":"University of Georgia","place":["Athens, Georgia, United States of America"],"department":["Department of Microbiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-8266","authenticated-orcid":true,"given":"Zachary A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"University of Georgia","place":["Athens, Georgia, United States of America"],"department":["Department of Microbiology"]},{"name":"University of 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