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The first reported case and management of Lassa fever in Plateau State occurred more than 50 years ago. We set out to undertake a three-year epidemiological review of LF cases in Plateau State, North Central Nigeria. This is a retrospective study of all confirmed LF cases in Plateau State between 2016 and 2018. Plateau state Lassa fever- Line list and patient case records were used to extract relevant data. Lassa PCR was carried out at the NCDC accredited Laboratory network. Data analysis was done using STATA version SE14.1. Forty-four persons (44) had confirmed LF over the examined period, 18 (41%) in 2016, 15 (34%) in 2017 and 11 (25%) in 2018. The mean age was 29.7\u00b114.6 years and 53% were males. Sixty-six percent (66%) of the patients resided in rural areas. It affected all local government areas (LGA) in the state except Pankshin, Jos East and Kanke LGAs. Twenty-five percent (25%) of the cases occurred among underprivileged communities of Jos North and another 25% in rural dwellers of Langtang North. Fifty-nine percent (59%) of cases occurred during the 1<jats:sup>st<\/jats:sup> quarter, 27% the 2<jats:sup>nd<\/jats:sup> quarter and 18% the 3<jats:sup>rd<\/jats:sup> quarter of the year. The case fatality rate was 57%. LF is endemic in Plateau State. Prevention strategies must be sustained year round and target the youth, urban and rural underprivileged communities. There is also need for case management improvement to reduce mortality.<\/jats:p>","DOI":"10.1371\/journal.pgph.0000290","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T17:28:11Z","timestamp":1656091691000},"page":"e0000290","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgph.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Epidemiological review of confirmed Lassa fever cases during 2016\u20132018, in Plateau State, North Central Nigeria"],"prefix":"10.1371","volume":"2","author":[{"given":"Simji","family":"Gomerep","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-6495","authenticated-orcid":true,"given":"Martina","family":"Nuwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-0703","authenticated-orcid":true,"given":"Solomon","family":"Butswat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-0996","authenticated-orcid":true,"given":"Joyce","family":"Bartekwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-1031","authenticated-orcid":true,"given":"Solomon","family":"Thliza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9018-9286","authenticated-orcid":true,"given":"Christian","family":"Akude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-7622","authenticated-orcid":true,"given":"Ayanfe","family":"Omololu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-8397","authenticated-orcid":true,"given":"Rachel","family":"Reyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-6395","authenticated-orcid":true,"given":"Tomoko","family":"Makishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Paessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8802-4928","authenticated-orcid":true,"given":"Nathan","family":"Shehu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"pgph.0000290.ref001","author":"DA Enria","year":"2011","edition":"3"},{"issue":"2","key":"pgph.0000290.ref002","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4269\/ajtmh.12-0466","article-title":"A Historical Look at the First Reported Cases of Lassa Fever: IgG Antibodies 40 Years After Acute Infection","volume":"88","author":"N Bond","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"pgph.0000290.ref003","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0035-9203(72)90271-4","article-title":"Lassa fever Epidemiological aspects of the 1970 epidemic, Jos, Nigeria","volume":"66","author":"DE Carey","year":"1972","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"7426","key":"pgph.0000290.ref004","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/bmj.327.7426.1271","article-title":"Lassa fever: epidemiology, clinical features, and social consequences","volume":"327","author":"JK Richmond","year":"2003","journal-title":"Br Med J"},{"issue":"7009","key":"pgph.0000290.ref005","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/bmj.311.7009.857","article-title":"Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice","volume":"311","author":"SP Fisher-Hoch","year":"1995","journal-title":"Br Med J"},{"issue":"3","key":"pgph.0000290.ref006","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/infdis\/155.3.437","article-title":"A prospective study of the epidemiology and ecology of Lassa fever","volume":"155","author":"JB McCormick","year":"1987","journal-title":"J Infect Dis"},{"issue":"1","key":"pgph.0000290.ref007","first-page":"1","article-title":"Lassa fever in West Africa sub-region: an overview.","volume":"44","author":"O Ogbu","year":"2007","journal-title":"J Vector Borne Dis"},{"key":"pgph.0000290.ref008","unstructured":"Nigeria Centre for Disease Control [Internet]. 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